1. microRNA-181b targets MLK2 in HL-60 cells
- Author
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Hong Chen, Yan Mi, Ming Fang, and Qun Chen
- Subjects
Base Sequence ,Cell Survival ,Gene Expression Regulation, Leukemic ,Reverse Transcriptase Polymerase Chain Reaction ,Blotting, Western ,Microrna 181b ,Myeloid leukemia ,HL-60 Cells ,Biology ,MAP Kinase Kinase Kinases ,Transfection ,General Biochemistry, Genetics and Molecular Biology ,Leukemia, Myeloid, Acute ,MicroRNAs ,Apoptosis ,hemic and lymphatic diseases ,microRNA ,Cancer research ,Humans ,General Agricultural and Biological Sciences ,neoplasms ,Cell Proliferation ,General Environmental Science - Abstract
microRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation and development. We showed miR-181b to be highly expressed in acute myeloid leukemia (AML). Furthermore, miR-181b contributed to proliferation of AML cells by targeting MLK2. Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.
- Published
- 2010
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