1. Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness
- Author
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Jitse S. Amelink, Merel C. Postema, Xiang-Zhen Kong, Dick Schijven, Amaia Carrión-Castillo, Sourena Soheili-Nezhad, Zhiqiang Sha, Barbara Molz, Marc Joliot, Simon E. Fisher, and Clyde Francks
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Biology (General) ,QH301-705.5 - Abstract
Abstract Language is supported by a distributed network of brain regions with a particular contribution from the left hemisphere. A multi-level understanding of this network requires studying its genetic architecture. We used resting-state imaging data from 29,681 participants (UK Biobank) to measure connectivity between 18 left-hemisphere regions involved in multimodal sentence-level processing, as well as their right-hemisphere homotopes, and interhemispheric connections. Multivariate genome-wide association analysis of this total network, based on genetic variants with population frequencies >1%, identified 14 genomic loci, of which three were also associated with asymmetry of intrahemispheric connectivity. Polygenic dispositions to lower language-related abilities, dyslexia and left-handedness were associated with generally reduced leftward asymmetry of functional connectivity. Exome-wide association analysis based on rare, protein-altering variants (frequencies
- Published
- 2024
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