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3 results on '"Meng-Fei Chen"'

1. Cholinergic neuronal differentiation of bone marrow mesenchymal stem cells in rhesus monkeys

Author

Feng Yan Zhang, Meng Fei Chen, Xue Rong Sun, Ge Song, Ying Qi, Jian Ge, and Ru Zhang Jiang

Subjects
animal structures, Cellular differentiation, Bone Marrow Cells, Tretinoin, Biology, General Biochemistry, Genetics and Molecular Biology, Membrane Potentials, Basal (phylogenetics), chemistry.chemical_compound, medicine, Animals, Hedgehog Proteins, General Environmental Science, Neurons, Neurotransmitter Agents, Forskolin, Colforsin, Mesenchymal stem cell, Cell Differentiation, Mesenchymal Stem Cells, Synapsin, Nestin, Macaca mulatta, Acetylcholine, Cell biology, nervous system, chemistry, embryonic structures, Immunology, Cholinergic, General Agricultural and Biological Sciences, Biomarkers, medicine.drug
Abstract

The purpose of the present study was to determine the best cholinergic neuronal differentiation method of rhesus monkey bone marrow mesenchymal stem cells (BMSCs). Four methods were used to induce differentiation, and the groups were assigned accordingly: basal inducing group (culture media, bFGF, and forskolin); SHH inducing group (SHH, inducing group); RA inducing group (RA, basal inducing group); and SHH+RA inducing group (SHH, RA, and basal inducing group). All groups displayed neuronal morphology and increased expression of nestin and neuron-specific enolase. The basal inducing group did not express synapsin, and cells from the SHH inducing group did not exhibit neuronal resting membrane potential. In contrast, results demonstrated that BMSCs from the RA and SHH+RA inducing groups exhibited neuronal resting membrane potential, and cells from the SHH+RA inducing group expressed higher levels of synapsin and acetylcholine. In conclusion, the induction of cholinergic differentiation through SHH+RA was determined to be superior to the other methods.

Published
2010
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3. An Investigation of Transient Effects in PoIy(3-hexylthiophenes) Based Thin Film Transistors Caused by Oxygen and Water Molecules.

Author

Chia-Hao Chang, Meng-Fei Chen, and Chao-Hsin Chien

Subjects
THIN film transistors, OXYGEN, HYSTERESIS, WATER, MOLECULES
Abstract

In this article, we investigate hysteresis behavior observed in the current-voltage transfer curve of regioregular poly(3-hexylthio-phene)(P3HT) based thin film transistors (PTFTs) using bi-directional voltage sweeping. According to the results of our experiments, the hysteresis effects were closely related to oxygen (O2) and water (H2O) molecules residing in the P3HT active layer. As a result, we hypothesized that O2 and H2O in the P3HT could form two kinds of dopants, i.e., stable and transient states. Stable state dopants, which are commonly thought to be of the acceptor-type dopants, could induce holes in the channel region contributing to better on-current. On the contrary, transient state dopants were found to be unable to induce holes, however could enable the formation of polarization agents and create hysteresis. These two types of dopants seem have a common origin, thus they could be converted into each other through the combination of specific processes and applied external bias. From the viewpoint of device operation stability, except on-current level and characteristics including threshold voltage, off-current magnitude and on/off ratio, the impact of hysteresis should garner the attention of those pursuing high performance PTFTs. [ABSTRACT FROM AUTHOR]

Published
2011
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