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Bu çalışmada, çift fazlı (α+M) küresel grafitli dökme demirlerde (ÇF-KGDD) martenzit hacim oranı-mekanik özellikler-dislokasyon yoğunluğu arasındaki ilişkiler incelenmiştir. Farklı faz hacim oranlarında martenzit ve ötektoid öncesi ferritten oluşan çift fazlı mikroyapılar 770°C, 775°C ve 780°C ara kritik kısmi östenitleme sıcaklıklarından oda sıcaklığındaki suda soğutularak üretilmiştir. Mikroyapı karakterizasyon çalışmaları optik mikroskop, taramalı elektron mikroskobu (SEM) ve X-Işını kırınım (XRD) analizi teknikleri kullanılarak gerçekleştirilmiştir. Mekanik özelliklerin belirlenmesi için çekme ve sertlik testleri yapılmıştır. Dislokasyon yoğunluğu XRD desenlerinden faydalanılarak Williamson-Hall (W-H) eşitliği ile hesaplanmıştır. Artan arakritik östenitleme sıcaklığıyla martenzit hacim oranı ve dislokasyon yoğunluğunun arttığı belirlenmiştir. Martenzit hacim oranı arttıkça sertlik, akma ve çekme dayanımı arttığı, toplam % uzama azaldığı ve kırılma modunun sünekten-gevreğe geçtiği gözlemlenmiştir.

Elektrikli araçların kullanımı artarken araçların ağırlığının azaltılması ise yakıt tasarrufu için elzemdir. Bu ise sacların kesit kalınlığının azaltılması ile mümkündür. Araç ağırlığının yaklaşık %70’ini demir esaslı malzemeler oluşturduğundan bu yolla büyük oranda ağırlık tasarrufu yapılabilmektedir. İnce sacların çarpışma anında yeterince koruyamama riski vardır. Bu yüzden araştırmalar hem yüksek mukavemet hem de şekillendirilebilirlik dengesi sunan İleri Yüksek Mukavemetli Çelikler (İYMÇ) üzerinde yoğunlaşmıştır. Özellikle, 3. Nesil İYMÇ’ler araştırmacıların ilgisini çekmektedir. Bunlar birinci nesilden daha yüksek mekanik özellikler vadederken, 2. Nesile kıyasla ucuzdurlar. 3. Nesil İYMÇ’ler genellikle çok fazlı mikroyapıya sahiptir ve fazların mikroyapıda bulundukları oranda çeliğin özelliklerini etkilemektedirler. Böylece farklı özelliklere sahip fazların sinerjetik etkisi ile çeliğin özellikleri istenildiği gibi ayarlanabilmektedir. Bu fazların içerisinde kalıntı östenit (KÖ) fazı, bu fazın miktarı ve kararlılığı önemlidir. Yüksek miktarda ve iyi kararlılığa sahip KÖ, deformasyon ile aşama aşama martensite dönüşerek plastik kararsızlığı yüksek gerinim bölgelerine ötelemekte ve çeliğin hasara uğramasını geciktirmektedir. Bu mekanizma TRIP etkisi olarak adlandırılmaktadır. Bu durum çeliklerin yüksek mekanik özelliklere sahip olmasının başlıca sebebidir. Yapılan bu inceleme ile TRIP mekanizması, dönüşüm kinetiği ve KÖ kararlılığını etkileyen faktörler incelenmiştir. 3. Nesil İYMÇ’lerinden Su Verme ve Paylaştırma Çelikleri, Orta Mn’lı Çelikler ve Karbürsüz Beynitik Çelikler irdelenerek termomekanik ve ısıl işlem süreçlerinin mikroyapıya etkisi açıklanmıştır.

The virus called Covid-19, which emerged in the last months of 2019 in Wuhan city of China's Hubei province, spread to the whole world in a short time. The Covid-19 virus, which is highly contagious from person to person, has had important effects in Turkey as well as in the world. These effects have emerged in areas such as social, political and economic, especially in the field of health. In recent years, the Covid-19 epidemic has emerged as the most important test of political powers in social, political, economic fields and especially in health. The Covid-19 outbreak has an important place in order to see and measure the preparations of the Ministries of Health for crises beforehand. This study has an important place in order to evaluate the preparations of the Ministry of Health in Turkey with all health institutions and organizations for this process and the social response to their performance in this process. This study was carried out in order to measure the perception of the Ministry of Health in informing, raising awareness and services in the society during the Covid-19 epidemic, which was declared a "Pandemic" by the World Health Organization. In this study, a quantitative research method was used, and the obtained data were collected by questionnaire technique. The data obtained were analyzed and interpreted with the SPSS program. As a result of the analysis of the data obtained with the participation of 411 participants throughout Turkey, it was concluded that the studies and activities carried out by the Ministry of Health of the Republic of Turkey in the first period of the Covid-19 epidemic created a positive image in the society.

This study investigated whether the systemic immune-inflammation index (SII) is an independent predictor of contrast-induced nephropathy (CIN) in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. TAVR patients (n = 130) were included in the study. The patients were divided into 2 groups: those who developed CIN [CIN (+)] and those who did not [CIN (−)]. The SII was calculated as the ratio of the product of the total neutrophil count and the total platelet count to the lymphocyte count. CIN developed in 20 (15.3%) patients after TAVR. White blood cell count (7.66 ± 1.75 vs 6.78 ± 1.71 103/mm3 P = .038), neutrophil count (5.1 (3.9–6.7) vs 4.2 (3.5-5.1) 103/mm3 P = .024), neutrophillymphocyte ratio (4.20 (2.39–7.00) vs 2.75 (2.06-3.88), P = .010) and SII index (1069 (616–1514) vs 598 (426-955), P = .003) were at higher levels in patients with CIN. In addition, the SII index was an independent predictor for the development of CIN. The SII index, which can be easily calculated from a complete blood count, is an independent predictor of CIN in patients undergoing TAVR for severe aortic stenosis.

Aim Chest computed tomography (CT) imaging plays a diagnostic and prognostic role in Coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate and compare predictive capacity of main pulmonary artery diameter (MPA), ascending aorta diameter (AAo), and MPA‐to‐AAo ratio to determine in‐hospital mortality in COVID‐19 patients. Materials and methods This retrospective study included 255 hospitalized severe or critical COVID‐19 patients. MPA was measured at the level of pulmonary artery bifurcation perpendicular to the direction of the vessel through transverse axial images and AAo was measured by using the same CT slice at its maximal diameter. MPA‐to‐AAo ratio was calculated by division of MPA to AAo. Results Multivariate logistic regression model yielded MPA ≥29.15 mm (OR: 4.95, 95% CI: 2.01–12.2, p = 0.001), MPA (OR: 1.28, 95% CI: 1.13–1.46, p

Objectives Post-hypoxia hypoxia-inducible factor (HIF)-1α activation plays a vital role in colorectal cancer (CRC) angiogenesis. Although glucose metabolism is induced in some cancer types via HIF-1α, the prognostic significance of HIF-1α in CRC and its correlation with 18fluorinefluorodeoxyglucose (18F-FDG) uptake in positron emission tomography (PET) remain controversial. This study aims to investigate the association between 18F-FDG/PET parameters and HIF-1α expression in CRC. Methods Thirty-six histopathologically confirmed patients with CRC who had 18F-FDG/PET scans before surgery were enrolled in the study. The correlations between the maximum standardized uptake value (SUVmax), SUVmean, metabolic tumor volume (MTV), total lesion glycolysis, HIF-1α overexpression, and histopathological features were evaluated. Results The tumor location, tumor diameter, perineural invasion, lymphovascular invasion, T and N stage were not significantly correlated with HIF-1α overexpression. In contrast, the tumor differentiation was negatively correlated with HIF-1α expression (r=-0.332, p=0.048). None of the 18F-FDG/PET parameters was significantly correlated with HIF-1α overexpression. A significant relationship was found between tumor differentiation, tumor necrosis percentage, and MTV (p=0.030, p=0.020). Conclusion The expected association between HIF-1α overexpression and 18F-FDG/PET parameters was not found in this study. However, there was a relationship between MTV, tumor differentiation, and tumor necrosis percentage. Hence, further studies are required to predict the pathological and prognostic courses of CRC using a diagnostic 18F-FDG/PET evaluation.

Objectives The metabolic activities of tumors can be calculated volumetrically during positron emission tomography/computed tomography (PET/CT) imaging using metabolic tumor volume (MTV) and total lesion glycolysis (TLG). This study aimed to evaluate the roles of MTV and TLG in predicting the malignancy risk of incidental thyroid nodules detected by PET/CT imaging. Methods Active metabolic areas of each section were manually drawn by region of interest to calculate the MTV of nodules, and all obtained values were then summed. TLG, the product of mean standardized uptake value and MTV, was calculated by multiplying two values. All participants underwent thyroid ultrasonography imaging. All nodules were divided into risk classes according to the European Thyroid Image Reporting and Data System (EU-TIRADS) that was developed by the European Thyroid Association. The American Thyroid Association Guidelines were used to determine which thyroid nodules would undergo thyroid fine-needle biopsy (FNAB). Results were classified according to the Bethesda scoring system. Results TLG levels were significantly higher in malignant or malignant-suspicious nodules than in benign nodules (p=0.013). Although MTV levels were high in malignant or malignant-suspicious nodules than in benign and non-diagnostic nodules, it was statistically insignificant at limit values (p=0.079). Areas under curve (AUC) were 0.726 (p=0.005) and AUC: 0.668 (p=0.039) for TLG and MTV, respectively. The 2.3 g cut-off value of TLG has a sensitivity of 85.7% and specificity of 59.0%. The 1.7 mL cut-off value of MTV has a sensitivity of 78.6% and specificity of 60.4%. Conclusion We believe that TLG evaluation will be useful in predicting high-risk malignancy or malignancy suspicion based on EU-TIRADS risk classification of incidental thyroid nodules detected in PET/CT images. We believe that unnecessary thyroid FNABs can be avoided for thyroid incidental nodules if such relation and cut-off values are determined and that it will be useful in hastening the operation of the necessary patients.

Dünya 2020 yılında ’’Pandemi’’ ifadesinin tüm anlamı ve gerçekliği ile yüzleşti ve Pandemi ile mücadelenin ancak toplumsal uyum ile sağlanabileceği gerçeği bu sürecin değişmez tek doğrusu oldu. Bu süreç içerisinde Süleyman Demirel Üniversitesi Hastanesi olarak gelişmeleri başından bu yana çok ciddiye alarak takip ettik, hastanemizin alışık olmadığı çalışma düzenine geçmeye dair kararları almakta çok hızlı ve dikkatli, hastanemizin alışık olduğu çalışma düzenine geri dönmek ile ilgili kararları almakta ise yavaş ve yine bir o kadar dikkatli bir tutum sergiledik. Sonuç itibariyle sizlere sunmuş olduğumuz bu kaynak Pandeminin hastanemizde nasıl yönetildiği hakkında önemli bir arşiv niteliği taşıması ve gelecekte tekrar yaşanabilecek yeni bir Pandemi için de rehber kaynak olması ümit edilerek hazırlanmıştır. Pandemi henüz bitmiş değildir, toplumsal uyumun bu süreçteki tartışmasız tek doğru olduğu gerçeği ile alınan tüm kararlara ve önlemlere azami ölçüde dikkat edilmesi gerekmektedir.

Objective Medullary thyroid cancer (MTC) originates from parafollicular cells (C cell) and produces calcitonin (CT). Basal serum CT was used in the diagnosis and treatment of MTC. If basal CT level is 100 pg/ml or higher, it is likely to have MTC, but if basal CT level is below 10 pg/ml, the probability of developing thyroid disease is low. In cases with basal CT level between 10-100 pg/ml, pentagastrin-stimulated (PS) CT level is studied to evaluate MTC and C cell hyperplasia (CHH). This study aimed to determine cut-off value for basal and PS peak CT level for diagnosis of MTC. Patients-methods We retrospectively reviewed files of patients presented to endocrine outpatient clinic of Ege University, Medicine School, between 2010 and 2019, 176 patients with basal CT level of 10-100 pg/ml and patients with PS test were included to the study. Findings The ROC analysis was used to determine cut-off value for basal CT that can discriminate cases with MTC and those with nodular goiter. Cut-off value for basal CT was calculated as 46.5 pg/ml (specificity; 100 %, sensitivity; 74 %). In the ROC analysis for peak PS CT, cut-off value was calculated as 285 pg/ml (specificity:100 %; sensitivity:82 %). When peak CT level was > 290 pg/ml in PS test, both specificity and sensitivity for MTC were determined as 100 %. The PS peak CT level > 285 pg/ml was significant for MTC diagnosis while level of 117-274 pg/ml was significant for CHH. Conclusion In this study, cut-off value was calculated as 46.5 pg/ml for basal CT whereas 285 pg/ml for PS peak CT in the diagnosis of preoperative MTC. Key words: Medullary thyroid cancer, C cell hyperplasia, Calcitonin, Pentagastrin, Cut-off.

The differences in the manner of discourse in media, whose primary function is to inform, have focused on many studies on communication. The media with different political orientations and audiences from different backgrounds might reproduce events based on their ideologies and presentation ways. Thus, ideology can lead to different perceptions of reality by affecting the representation of newspapers. The study aims to present reviews of how the opening of the Hagia Sofia to worship on 24 July 2020 has been covered by the media by focusing on how it has been reported to the audience and the selection and production of the discourse. Besides, the study's primary purpose is to investigate the differences between the dominant discourse and discourses of different ideological structures when reporting the same events in the news presentation in question. Critical discourse analysis is employed to review the two groups of newspapers with opposing ideologies: Sabah and Yeni Şafak representing the conservatives, and Sözcü and Cumhuriyet represent the left-wing. The analyses are limited to the newspapers' first pages after the first Friday prayer after Hagia Sophia was opened to worship. The results reveal that both groups have covered the opening of the Hagia Sofia for Friday prayer, embedding their ideologies and that they have tried to intensify their ideological campaigns through their manner of discourse., Temel işlevi haber verme olan medyanın olayları aktarırken gösterdiği farklı söylem biçimleri birçok iletişim araştırmasına konu olmuştur. Farklı siyasal yönelimleri, sunum biçimleri ve okuyucu kitleleri olan medya kurumları, kurdukları söylemlerle olayları kendi ideolojileri çerçevesinde yeniden üretebilmektedirler. Böylece ideoloji gazetelerin temsiline etki ederek birbirinden farklı gerçeklik algılarına yol açabilmektedir. Bu çalışma 24 Temmuz 2020 tarihinde Ayasofya’nın ibadete açılışının Türk yazılı basında nasıl haberleştirildiğini, söylemlerin nasıl üretildiğini, sözcüklerin nasıl seçildiğini ve hedef kitleye nasıl aktarıldığını ortaya koymayı amaçlamaktadır. Ayrıca söz konusu haberlerin sunuluşunda egemen söylem ve farklı ideolojik yapılara ait söylemlerin aynı olayları aktarırken gösterdiği farklılıkların araştırılması çalışmanın temel amacıdır. Bu kapsamda çalışmada, iki farklı ideolojik yapıya sahip olan Sabah, Yeni Şafak (muhafazakâr basını temsilen) gazeteleri ile Sözcü, Cumhuriyet (sol basını temsilen) gazetelerinin eleştirel söylem analizi bağlamında incelenmiştir. Analizler, Ayasofya’nın ibadete açılmasının ardından kılınan ilk cuma namazı sonrası gazetelerin ilk sayfaları ile sınırlı tutulmuştur. Yapılan analizlerin sonucunda, gazetelerin Ayasofya’nın ibadete açılış haberini kendi ideolojilerine paralel olarak sunduğu ve kurdukları söylem aracılığıyla ideolojik mücadeleyi sürdürdükleri görülmüştür.

Objective: Although the efficacy of the visual interpretation of 99mTc-MIBI myocardial perfusion imaging has been repeatedly confirmed in the diagnostic and prognostic evaluation of coronary artery disease (CAD), the efficacy of the automated quantitative evaluation dependent on computer programs is controversial. In our study, we compared automated quantitative data, such as the sum stress score (SSS) and the sum difference score (SDS), with coronary angiography results. We investigated the ability of SSS and SDS values to predict coronary artery disease. Method: SSS and SDS are measurements used in the global scoring of myocardial perfusion. While SSS indicates the degree of ischemia, SDS defines the reversibility degree of ischemia. In the global scoring of myocardial perfusion, when the SSS was 4 and above, MPI was evaluated as positive. In the coronary angiography, a stenosis value of >50% was evaluated as positive. We divided the SSS into three groups; mild (4-8), moderate (9-12), and advanced (>13) hypoperfusion. We divided the SDS into two groups as below and above 10%. We compared the subsequent quantitative data with the results of the three groups of coronary angiographies ( 70% stenosis). Results: A total of 104 patients who underwent angiography were included in the study. The accuracy in detecting positivity between the general quantitative MPI and angiography methods of the patients was calculated as 80.8%. The agreement value was found to be significant (Kappa=0.602; p

Objectives In this study, we aimed to investigate whether Ga-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) scanning is adequate to predict intermediate risk, high risk, or oligometastatic prostate cancer (PCa) as an initial staging modality. Methods The Ga-68 PSMA PET/CT scan images of 50 PCa patients pathologically proven by transrectal ultrasound guided biopsy were evaluated retrospectively. The association of standard uptake value maximum (SUVmax) value of the area with the highest PSMA expression within the primary tumor with the risk groups and metastatic burden is investigated. Results The SUVmax value was 6.18 in oligometastatic patients where it was measured as 10.93 in patients with higher metastatic burden (p=0.037). The cut-off SUVmax value for multiple metastases was 7.96 (p=0.047). According to the regression model, SUVmax value has a positive influence [odds ratio (OR)=1.42], which was statistically significant (p=0.038). SUVmax values for intermediate and high risk patients were 6.91 and 11.44, respectively (p=0.014). The cut-off SUVmax value for the high risk group was 10.55 (p=0.006). In the regression model, SUVmax value has a positive influence (OR=1.198), which was statistically significant (p=0.021). Conclusion In this paper, we demonstrated the association between SUVmax value of primary tumor and Gleason score. Our results also allowed us to suggest that primary tumor SUVmax is a sufficiently accurate predictor of D'Amico risk groups in newly diagnosed PCa cases. Additionally, Ga-68 PSMA PET/CT turns out to be a useful tool in determining oligometastatic PCa, which requires a different treatment approach.

Objectives: We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activity assessment. To the best of our knowledge, this is the first study to compare the volumetric metabolic activity parameters according to the morphologic parameters of the nodules. Methods: In this retrospective study, 18F-FDG positron emission tomography and computed tomography scans performed between 2011 and 2018 were evaluated by a nuclear and diagnostic radiologist. One hundred thirteen patients with SPNs with biopsy-proven diagnosis were included. SPNs were classified as solid, partially solid (PS), and ground glass opacity (GGO). Results: SPN diameter, SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and density were significantly higher in the malignant group. SUVmax, MTV, TLG increased in direct proportion to the diameter. There was no a significant difference between GGO, PS, and solid nodules in terms of SUVmax values. MTV and TLG values increased in parallel with the density of the nodules, but this increase was only significant in the malignant group. There was a significant difference between SPNs

WOS: 000429745000008, Triple-A syndrome is a rare, multi-systemic disease and is characterized by adrenal insufficiency, achalasia, or alacrima. The symptoms may also involve neurologic manifestations, including pyramidal findings and peripheral motor neuropathy. Other findings include autonomic dysfunction and cerebellar ataxia. In the present study, we present the case of two siblings with triple-A syndrome with neurologic manifestations. The neurologic abnormalities can lead to misdiagnosis owing to resemblance to the manifestations of other neurologic disorders. Therefore, the cases with triple-A syndrome should be carefully evaluated and examined for clinical and neurophysiologic signs.

A 52-year-old woman presented with a complaint of neck swelling. The patient showed signs of hyperparathyroidism: hypercalcemia, and hypophosphatemia. Tc-99m MIBI dual-phase parathyroid scintigraphy and SPECT revealed increased activity in a regular-bordered, “doughnut”-shaped mass on the left side of the thyroid gland with a central hypoactive area. The cervical ultrasound identified a mixed echoic thyroid nodule with a central large cystic portion, and no parathyroid gland abnormality. Total thyroidectomy and parathyroid exploration was performed. Pathological evaluation of the resected thyroid specimen reported a giant intra-thyroidal hemorrhagic parathyroid adenoma.Boyunda şişlik şikayeti ile başvuran elli iki yaşında kadın hastada hiperkalsemi, hipofosfatemi ile hiperparatiroidizm saptandı. Yapılan Tc-99m MIBI dual faz paratiroid sintigrafisinde ve SPECT çalışmasında tiroid bezinin sol lobunu kaplayan, ortasında hipoaktif alanlar izlenen, artmış aktivite tutulumu gösteren “doughnut” görünümlü lezyon izlendi. Boyun ultrasonografide sol lobun üst ve orta kesiminde ortasında kistik komponent görülen, karışık ekoda tiroid nodülü gözlendi, ancak paratiroid patolojisi izlenmedi. Hastaya total tiroidektomi ve paratiroid eksplorasyonu yapıldı. Tiroid cerrahi spesimeninin patolojik deperlendirmesi dev intratiroidal hemorajik paratiroid adenomu olarak raporlandı.

Purpose: The growing prevalence of obesity has become a major concern. The efficacy of medical treatment, diet and behavior therapy in morbidly obese patients is limited. Obesity surgery is a treatment option for selected morbidly obese patients. Material and Method: Data of 47 patients (n=39 women, 8 men) who underwent bariatric surgery were investigated. Results: Out of 47 patients, 20 underwent Roux-en-Y gastric bypass (RYGB) (43%) and 27 had sleeve gastrectomy (SG) (57%). The mean age of the patients was 37±9.5 (19-59) years. 17% of patients were men and 83% were women. In the analysis of data on weight that could be found for 31 out of 47 patients, we detected preoperative and postoperative (1st and 3rd month) mean weight values as 125.4±15.9 kg, 112.7±13.2 kg (p

Background/aim: This study aimed to evaluate traumatic thorax complications in post-CPR patients and to investigate whether or not there has been a decrease in these complications since the adoption of current chest compression recommendations. Materials and methods: Post-CPR patients with return of spontaneous circulation (ROSC) were admitted between January 2014 and January 2016 were analyzed retrospectively. Patients admitted to the ED in 2014 were resuscitated according to 2010 AHA CPR guidelines, while those admitted to the ED in 2015 were resuscitated according to current ERC CPR guidelines. Results: The study population comprised 48 male and 35 female patients. Of the 2010 AHA guideline patients, 39.21% experienced pulmonary contusion, while 54.83% of 2015 ERC guideline patients had pulmonary contusion. It was found that 11.76% of 2010 AHA guideline patients and 3.22% of 2015 ERC guideline patients had pneumothorax, while 9.8% of 2010 AHA guideline patients and 12.9% of 2015 ERC guideline patients experienced hemothorax. Incidence rates of lung contusion, pneumothorax, and hemothorax were higher in patients with rib fractures. Conclusion: In this study, traumatic thoracic complications were investigated in patients with ROSC after CPR. The incidence of CRP-related injuries did not decrease on application of the new 2015 ERC CPR guideline recommendations. The most common injury in this study was rib fracture, followed by sternal fracture, lung contusion, hemothorax, and pneumothorax. Statistically, rib fracture had a positive relationship with lung contusion, hemothorax, and pneumothorax.

This study examines the level of knowledge of and attitudes toward biotechnology of preservice teachers from Lebanon, Lithuania, Slovakia and Turkey. Data were gathered from a total of 768 preservice teachers from these four countries. The Biotechnology Knowledge Questionnaire and the Biotechnology Attitude Questionnaire were used for data collection. Three-way MANOVA was conducted to analyze the cross-cultural data. The results revealed that preservice teachers’ knowledge of biotechnology in all four samples was below average. The results also demonstrated that there were significant differences in attitude towards biotechnology among preservice teachers in the four countries. In addition, significant gender differences were observed between male and females. Implications for teaching and further research are discussed. Key words: biotechnology, knowledge, attitude, cross-cultural.

Background: Diabetic foot ulcers and lower extremity amputations are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular diseases are major reasons for the development of diabetic foot ulcer. Most of the studies showed that hyperhomocysteinemia is related with microvascular and macrovascular complications in diabetic patients. In addition, hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhomocysteinemia with diabetic foot ulcers. Materials and Methods: Fifty-one patients with diabetic foot ulcers, 35 diabetes patients without foot ulcers and 60 healthy individuals were enrolled in the study. Wagner classification of diabetic foot ulcers was used. Plasma homocysteine levels were measured by Florescence Polarization Immunoassay.Results: The median age was 60.0±10.5 years (Range: 38-85 years) in diabetic foot ulcer group, 57.8±9.6 years (range: 41-74 years) in diabetic group and 55.6±6.8 years (range: 40-70 years) in control group (p=0.062). The groups were similar in terms of mean age and sex distribution. The mean homocysteine levels were 10.7 μmol/l (range: 7-22 μmol/l) in control group, 16.27 μmol/l (range: 8.1-31.8 μmol/l) in diabetic foot ulcer group, 13.38 μmol/l (range: 7/23.6 μmol/l) in diabetic group and were showing statistically significant difference between the groups (p0.05). Multiple logistic regression analysis showed that, peripheral neuropathy and hyperhomocysteinemia (OR 10.558, p=0.008 and OR 1.186, p=0.013, respectively) were independent risk factors for the development of diabetic foot ulcer. Conclusion: Serum homocysteine values are associated with diabetic foot ulcer. Türk Jem 2011; 15: 106-10

Objective: In this study, we aimed to investigate the effect of glycemic regulation, duration of diabetes and antidiabetic treatment on the quality of life (QOL) and to detect other factors that may affect QOL in type 2 diabetic patients using the short form-36 quality of life scale (SF-36). Materials and Methods: One hundred patients diagnosed with type 2 diabetes (according to the American Diabetes Association criteria) upon admission to the Endocrinology clinic of Adana Numune Training and Research Hospital between 1 July 2007 and 31 October 2007 were included in the study. One hundred healthy age- and gender-matched cases were also included as a control group. QOL assessments were made using the SF-36, and blood and urine samples were also collected. Results: In this study, we found several factors that affect QOL parameters. We detected a specific impairment in QOL among diabetic patients compared to healthy control subjects. The presence of more complications, neuropathy, retinopathy, low education level, lack of diabetes education, insulin treatment, inadequate metabolic control, long duration of disease, concomitant chronic disease and being a woman were all additional factors found to negatively affect the QOL. Conclusions: While our results mostly support the current literature, we believe that physiologic, demographic, and behaviour/attitude characteristics should be evaluated together with diabetic complications. Therefore, along with achieving metabolic control, attempts to identify risky patients are gaining importance as a way to improve the QOL of patients with type 2 diabetes. Turk Jem 2008; 12: 68-72