9 results on '"Mbabazi, Pamela Sabina"'
Search Results
2. Association of schistosomiasis and HIV infections: A systematic review and meta-analysis
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Patel, Pragna, Rose, Charles E., Kjetland, Eyrun F., Downs, Jennifer A., Mbabazi, Pamela Sabina, Sabin, Keith, Chege, Wairimu, Watts, D. Heather, and Secor, W. Evan
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- 2021
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3. Monitoring equity in universal health coverage with essential services for neglected tropical diseases: an analysis of data reported for five diseases in 123 countries over 9 years
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Fitzpatrick, Christopher, Bangert, Mathieu, Mbabazi, Pamela Sabina, Mikhailov, Alexei, Zouré, Honorat, Polo Rebollo, Maria, Robalo Correia e Silva, Magda, and Biswas, Gautam
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- 2018
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4. A Multicountry Comparison of Three Coverage Evaluation Survey Sampling Methodologies for Neglected Tropical Diseases.
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Gass, Katherine, Deming, Michael, Bougma, Roland, Drabo, Franck, Tukahebwa, Edridah Muheki, Mkwanda, Square, Velasquez, Reina Teresa, Mejia, Rosa Elena, and Mbabazi, Pamela Sabina
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- 2020
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5. Comparison of World Health Organization and Demographic and Health Surveys data to estimate sub-national deworming coverage in pre-school aged children.
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Lo, Nathan C., Gupta, Ribhav, Addiss, David G., Bendavid, Eran, Heft-Neal, Sam, Mikhailov, Alexei, Montresor, Antonio, and Mbabazi, Pamela Sabina
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DEMOGRAPHIC surveys ,HEALTH surveys ,WORLD health ,PARASITIC diseases ,MIDDLE-income countries - Abstract
Background: The key metric for monitoring the progress of deworming programs in controlling soil-transmitted helminthiasis (STH) is national drug coverage reported to the World Health Organization (WHO). There is increased interest in utilizing geographically-disaggregated data to estimate sub-national deworming coverage and equity, as well as gender parity. The Demographic and Health Surveys (DHS) offer a potential source of sub-national data. This study aimed to compare deworming coverage routinely reported to WHO and estimated by DHS in pre-school aged children to inform global STH measurement and evaluation. Methodology: We compared sub-national deworming coverage in pre-school aged children reported to WHO and estimated by DHS aligned geospatially and temporally. We included data from Burundi (2016–2017), Myanmar (2015–2016), and the Philippines (2017) based on data availability. WHO provided data on the date and sub-national coverage per mass drug administration reported by Ministries of Health. DHS included maternally-reported deworming status within the past 6 months for each child surveyed. We estimated differences in sub-national deworming coverage using WHO and DHS data, and performed sensitivity analyses. Principal findings: We compared data on pre-school aged children from 13 of 18 districts in Burundi (N = 6,835 in DHS), 11 of 15 districts in Myanmar (N = 1,462 in DHS) and 16 of 17 districts in the Philippines (N = 7,594 in DHS) following data exclusion. The national deworming coverages estimated by DHS in Burundi, Myanmar, and the Philippines were 75.5% (95% CI: 73.7%-77.7%), 47.0% (95% CI: 42.7%-51.3%), and 48.0% (95% CI: 46.0%-50.0%), respectively. The national deworming coverages reported by WHO in Burundi, Myanmar, and the Philippines were 80.1%, 93.6% and 75.7%, respectively. The mean absolute differences in district-level coverage reported to WHO and estimated by DHS in Burundi, Myanmar, and the Philippines were 9.5%, 41.5%, and 24.6%, respectively. Across countries, coverage reported to WHO was frequently higher than DHS estimates (32 of 40 districts). National deworming coverage from DHS estimates were similar by gender within countries. Conclusions and significance: Agreement of deworming coverage reported to WHO and estimated by DHS data was heterogeneous across countries, varying from broadly compatible in Burundi to largely discrepant in Myanmar. DHS data could complement deworming data reported to WHO to improve data monitoring practices and serve as an independent sub-national source of coverage data. Author summary: Soil-transmitted helminths are parasitic worms that infect an estimated 1 billion people globally, primarily in low- and middle-income countries. One of the main strategies to reduce the prevalence of these parasitic infections is through preventive chemotherapy—the periodic widespread treatment of an entire at-risk population (e.g. children) with albendazole or mebendazole. The World Health Organization (WHO) tracks the progress of mass deworming programs by estimating the national coverage of these programs through aggregation of local health district program reports, which represent the proportion of at-risk people in a country that are reported to have received deworming treatment. In this study, we used an alternative source of data from the Demographic and Health Surveys (DHS) that provides maternally-reported child deworming treatment to estimate coverage in pre-school aged children and was subsequently compared to data reported to WHO. We conducted this comparison of deworming coverage at a sub-national level for three countries with available data: Burundi, Myanmar, and the Philippines. Coverage reported to WHO and estimated by DHS were broadly consistent in Burundi, highly discrepant in Myanmar, and varied in agreement for the Philippines. These differences may be explained by variability in the medication distribution monitoring practices, quality of national validation systems, and mis-reporting due to albendazole receipt through non-STH related public health campaigns (e.g. lymphatic filariasis treatment). This analysis suggests that in specific settings, DHS data can complement deworming coverage data reported to WHO, serving as an independent source of high-resolution data to improve monitoring and evaluation of deworming programs globally. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Ruling out early trimester pregnancy when implementing community-based deworming programs.
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St-Denis, Kariane, Blouin, Brittany, Rahme, Elham, Casapia, Martin, Montresor, Antonio, Mupfasoni, Denise, Mbabazi, Pamela Sabina, and Gyorkos, Theresa W.
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COMMUNITY-based programs ,PREGNANCY tests ,PREGNANT women ,PREGNANCY ,DECISION trees - Abstract
Background: Large-scale deworming programs have, to date, mostly targeted preschool- and school-age children. As community-based deworming programs become more common, deworming will be offered to women of reproductive age. The World Health Organization recommends preventive chemotherapy be administered to pregnant women only after the first trimester. It is therefore important for deworming programs to be able to identify women in early pregnancy. Our objective was to validate a short questionnaire which could be used by deworming program managers to identify and screen out women in early pregnancy. Methodology/Principal findings: In May and June 2018, interviewers administered a questionnaire, followed by a pregnancy test, to 1,203 adult women living in the Peruvian Amazon. Regression analyses were performed to identify questions with high predictive properties (using the pregnancy test as the gold standard). Test parameters were computed at different decision tree nodes (where nodes represented questions). With 106 women confirmed to be pregnant, the positive predictive value of asking the single question 'Are you pregnant?' was 100%, at a 'cost' of a false negative rate of 1.9% (i.e. 21 women were incorrectly identified as not pregnant when they were truly pregnant). Additional questions reduced the false negative rate, but increased the false positive rate. Rates were dependent on both the combination and the order of questions. Conclusions/Significance: To identify women in early pregnancy when deworming programs are community-based, both the number and order of questions are important. The local context and cultural acceptability of different questions should inform this decision. When numbers are manageable and resources are available, pregnancy tests can be considered at different decision tree nodes to confirm pregnancy status. Trade-offs in terms of efficiency and misclassification rates will need to be considered to optimize deworming coverage in women of reproductive age. Author summary: To date, large-scale deworming programs have strategically targeted the high risk groups of school-age and preschool-age children in worm-endemic areas using the highly cost-effective existing infrastructure of schools. To achieve elimination of worm-attributable morbidity, however, adult populations will also need to be treated. The World Health Organization considers women of reproductive age to also be a high risk group for worm-attributable morbidity and they will be increasingly included in large-scale community-based deworming programs. Although deworming treatment is considered safe and effective at any time, it is recommended that pregnant women in the first trimester be excluded from deworming treatment. Therefore, program managers need to have a screening tool in order to rule out early trimester pregnant women during deworming program implementation. To respond to this need, we evaluated the predictive properties of a parsimonious set of questions in a study population of adult women of reproductive age in a worm-endemic region of the Peruvian Amazon. We present several question scenarios to assist program managers in using questions to rule out early trimester pregnant women. Adapted to local cultural settings, such a screening tool can optimize deworming coverage in women of reproductive age. [ABSTRACT FROM AUTHOR]
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- 2020
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7. Catalyzing NTD gender and equity research: A call for papers.
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Means, Arianna Rubin, Krentel, Alison, Theobald, Sally, Dean, Laura, Mbabazi, Pamela Sabina, Elphick-Pooley, Thoko, Fleming, Fiona M., Jacobson, Julie, Simpson, Sarah, and Ducker, Camilla
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TROPICAL medicine ,GENDER inequality ,THERAPEUTICS ,VERTICAL transmission (Communicable diseases) ,GENDER role - Abstract
The article offers information on catalyzing Neglected Tropical Diseases (NTD) gender and equity research. Topics discussed include significance of the NTD program predicated opportunity to treat disease, prevent morbidity and disability, and interrupt infection transmission among large populations; addresses the issue of gender equity, organizational, policy, and practice activities; and sex and gender roles can profound effect on healthcare access and health outcomes.
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- 2018
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8. Short Report: Contributions of Non-Governmental Organizations to WHO Targets for Control of Soil-Transmitted Helminthiases.
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Gallo, Kerry, Mikhailov, Alexei, Hailemeskal, Meklit Berhan, Koporc, Kim, Mbabazi, Pamela Sabina, and Addiss, David
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- 2013
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9. Examining the Relationship between Urogenital Schistosomiasis and HIV Infection.
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Mbabazi, Pamela Sabina, Andan, Olivia, Fitzgerald, Daniel W., Chitsulo, Lester, Engels, Dirk, and Downs, Jennifer A.
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HIV infections , *SCHISTOSOMIASIS , *PARASITIC diseases , *SCHISTOSOMA haematobium , *HIV infection transmission , *HIV seroconversion , *GENITALIA infections - Abstract
Background: Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is widespread and causes substantial morbidity on the African continent. The infection has been suggested as an unrecognized risk factor for incident HIV infection. Current guidelines recommend preventive chemotherapy, using praziquantel as a public health tool, to avert morbidity due to schistosomiasis. In individuals of reproductive age, urogenital schistosomiasis remains highly prevalent and, likely, underdiagnosed. This comprehensive literature review was undertaken to examine the evidence for a cause-effect relationship between urogenital schistosomiasis and HIV/AIDS. The review aims to support discussions of urogenital schistosomiasis as a neglected yet urgent public health challenge. Methodology/Principal Findings: We conducted a systematic search of the literature including online databases, clinical guidelines, and current medical textbooks. We describe plausible local and systemic mechanisms by which Schistosoma haematobium infection could increase the risk of HIV acquisition in both women and men. We also detail the effects of S. haematobium infection on the progression and transmissibility of HIV in co-infected individuals. We briefly summarize available evidence on the immunomodulatory effects of chronic schistosomiasis and the implications this might have for populations at high risk of both schistosomiasis and HIV. Conclusions/Significance: Studies support the hypothesis that urogenital schistosomiasis in women and men constitutes a significant risk factor for HIV acquisition due both to local genital tract and global immunological effects. In those who become HIV-infected, schistosomal co-infection may accelerate HIV disease progression and facilitate viral transmission to sexual partners. Establishing effective prevention strategies using praziquantel, including better definition of treatment age, duration, and frequency of treatment for urogenital schistosomiasis, is an important public health priority. Our findings call attention to this pressing yet neglected public health issue and the potential added benefit of scaling up coverage of schistosomal treatment for populations in whom HIV infection is prevalent. Author Summary: Urogenital schistosomiasis is a parasitic infection caused by a worm, Schistosoma haematobium, which lives in the bloodstream of infected individuals. It affects at least 112 million people, mostly in sub-Saharan Africa, and has been suggested to be a risk factor for becoming infected with HIV. We reviewed publications in order to examine whether it seems likely that this parasitic infection could be a risk factor for HIV. Evidence from many types of studies supports the hypothesis that urogenital schistosomiasis does increase a person's risk of becoming infected with HIV. Studies also suggest that individuals who have both urogenital schistosomiasis and HIV have a more aggressive HIV infection and can more easily transmit HIV to their sexual partners. Praziquantel is an oral, nontoxic, inexpensive medication that is safe in pregnancy and is recommended for treatment of schistosomiasis. In areas where both infections co-exist, regular administration of praziquantel both to young girls and to sexually-active women may be an important approach to reducing HIV transmission. Our findings support the importance of making praziquantel more available to people who live in areas of the world where both urogenital schistosomiasis and HIV infection are widespread. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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