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Curcumin has protective actions in neuropsychiatric disorders, acting as a neuroprotective agent. As a first approach, the study aimed at a systematic review of the potential effects of curcumin on cognitive performance for attention-deficit-hyperactivity disorder (ADHD). This research was carried out in the databases of PubMed, Embase, SciELO, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and the Grey literature. Upon discovering the scarcity of relevant studies, and knowing that curcumin might have an ADHD hyperactive and anxious behavior, the study proposed to evaluate the effects of curcumin in an ADHD phenotype of spontaneously hypertensive Wistar rats (SHR). No studies were found that related to curcumin and ADHD. Fifteen SHRs were then divided into separate groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field Test), anxiety and impulsivity (Elevated Plus-Maze, and Social Interaction), and memory (Y-Maze, and the Object Recognition Test) were all performed. The animals that were treated with curcumin showed less anxious and hyperactive behavior, as seen in the Open Field Test and the Social Interaction Test. Anxious behavior was measured by the EPM and was not modulated by any treatment. The results of the Y-Maze Test demonstrated that curcumin improved spatial memory. In the Object Recognition Test, neither the short nor the long-term memory was improved. The treatments that were used in this study beneficially modulated the anxious and hyperactive behavior of the SHR.

Aim To report the intentional replantation of a maxillary central incisor with a crown-root fracture. Summary An 11-year-old girl was referred to a paediatric clinic with an extensive crown-root fracture of the maxillary right central incisor (tooth 11) with pulp exposure. Radiographs revealed that tooth 11 had a periapical radiolucent lesion, which suggested pulpal necrosis. The treatment option chosen was planned extraction and immediate intentional replantation of tooth 11 in a more coronal position. Sixteen years after treatment, tooth 11 was aesthetically and functionally sound, suggesting that the treatment was successful. Key learning point Intentional replantation may be considered as a treatment option for teeth with crown-root fractures.

Introduction: Hyperhomocysteinemia has been identified as a risk factor for peripheral vascular disease. Objective: The main objective was doing a review of literature on homocysteine as a risk factor for cardiovascular disease. Methods: It was performed a descriptive bibliographic research in the electronic libraries SciELO and PubMed. Results: In this review twenty two scientific articles were included. Some studies showed an association between hyperhomocysteinemia and cardiovascular risk, placing the former as an important risk factor for vascular disease today. However, there are no conclusive studies demonstrating the hyperhomocysteinemia as an independent predictor of cardiovascular risk, for some authors it may be a consequence of a previous vascular event and not a risk factor. Conclusion: Although several studies have shown an association between hyperhomocysteinemia and cardiovascular risk, additional studies are needed to clarify whether the hyperhomocysteinemia is a cause or consequence of cardiovascular disease, and elucidate the pro-atherosclerotic mechanisms associated with hyperhomocysteinemia.