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Your search keyword '"Matozaki, Takashi"' showing total 193 results
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193 results on '"Matozaki, Takashi"'

2. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Published
2023
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6. Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002–2022).

Author

Setiawan, Jajar, Rizal, Dicky Moch, Sofyantoro, Fajar, Priyono, Dwi Sendi, Septriani, Nur Indah, Mafiroh, Wulan Usfi, Kotani, Takenori, Matozaki, Takashi, and Putri, Wahyu Aristyaning

Abstract

Aim: This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. Methods: The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. Result: A total of 840 documents were analyzed, averaging 42 publications annually. The USA (n = 296) led in publications, followed by China (n = 127), Japan (n = 91) and the UK (n = 75). Since 2011, research has surged, particularly in China, which emerged as a prominent center. Conclusion: The findings highlight significant growth in organoid research, promising future organ transplantation. Research trends integrate tissue engineering, gene modification and induced pluripotent stem cell technologies, reflecting a move toward personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium

Author

Murata, Yoji, Kotani, Takenori, Supriatna, Yana, Kitamura, Yasuaki, Imada, Shinya, Kawahara, Kohichi, Nishio, Miki, Daniwijaya, Edwin Widyanto, Sadakata, Hisanobu, Kusakari, Shinya, Mori, Munemasa, Kanazawa, Yoshitake, Saito, Yasuyuki, Okawa, Katsuya, Takeda-Morishita, Mariko, Okazawa, Hideki, Ohnishi, Hiroshi, Azuma, Takeshi, Suzuki, Akira, and Matozaki, Takashi

Published
2015

9. LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice.

Author

Sui, Yunlong, Hoshi, Namiko, Ohgaki, Ryuichi, Kong, Lingling, Yoshida, Ryutaro, Okamoto, Norihiro, Kinoshita, Masato, Miyazaki, Haruka, Ku, Yuna, Tokunaga, Eri, Ito, Yuki, Watanabe, Daisuke, Ooi, Makoto, Shinohara, Masakazu, Sasaki, Kengo, Zen, Yoh, Kotani, Takenori, Matozaki, Takashi, Tian, Zibin, and Kanai, Yoshikatsu

Subjects
INTESTINAL tumors, GENE expression, SMALL intestine, MICE, TUMOR growth, CELL proliferation
Abstract

Background: Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood. Methods: To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an ApcMin/+ background (LAT1fl/fl; vil-cre; ApcMin/+), which were subject to analysis; organoids derived from those mice were also analyzed. Results: This study showed that LAT1 was constitutively expressed in normal crypt base cells, and its conditional deletion in the intestinal epithelium resulted in fewer Paneth cells. LAT1 deletion reduced tumor size and number in the small intestine of ApcMin/+ mice. Organoids derived from LAT1-deleted ApcMin/+ intestinal crypts displayed fewer spherical organoids with reduced Wnt/β-catenin target gene expression, suggesting a low tumor-initiation capacity. Wnt3 expression was decreased in the absence of LAT1 in the intestinal epithelium, suggesting that loss of Paneth cells due to LAT1 deficiency reduced the risk of tumor initiation by decreasing Wnt3 production. Conclusions: LAT1 affects intestinal tumor development in a cell-extrinsic manner through reduced Wnt3 expression in Paneth cells. Our findings may partly explain how nutrient availability can affect the risk of tumor development in the intestines. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.

Author

Okamoto, Takeshi, Murata, Yoji, Hasegawa, Daiichiro, Yoshida, Makiko, Tanaka, Daisuke, Ueda, Takashi, Hazama, Daisuke, Oduori, Okechi S., Komori, Satomi, Takai, Tomoko, Saito, Yasuyuki, Kotani, Takenori, Kosaka, Yoshiyuki, Maniwa, Yoshimasa, and Matozaki, Takashi

Abstract

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a+CD207+ dendritic cells (DCs). SIRPα is a transmembrane protein highly expressed in myeloid cells such as DCs and macrophages. Here we show that SIRPα is a potential therapeutic target for LCH. We found that SIRPα is expressed in CD1a+ cells of human LCH lesions as well as in CD11c+ DCs in the spleen, liver, and lung of a mouse model of LCH (BRAFV600ECD11c mouse), in which an LCH‐associated active form of human BRAF is expressed in a manner dependent on the mouse Cd11c promoter. BRAFV600ECD11c mice manifested markedly increased numbers of CD4+ T cells, regulatory T cells, and macrophages as well as of CD11c+MHCII+ DCs in the spleen. Monotherapy with a mAb to SIRPα greatly reduced the percentage of CD11c+MHCII+ DCs in peripheral blood, LCH‐like lesion size in the liver, and the number of CD11c+MHCII+ DCs in the spleen of the mutant mice. Moreover, this mAb promoted macrophage‐mediated phagocytosis of CD11c+ DCs from BRAFV600ECD11c mice, whereas it had no effects on the viability or CCL19‐dependent migration of such CD11c+ DCs or on their expression of the chemokine genes Ccl5, Ccl20, Cxcl11, and Cxcl12. Our results thus suggest that anti‐SIRPα monotherapy is a promising approach to the treatment of LCH that is dependent in part on the promotion of the macrophage‐mediated killing of LCH cells. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Author

Koga, Takako, Inui, Masanori, Inoue, Kazuya, Kim, Sunhwa, Suematsu, Ayako, Kobayashi, Eiji, Iwata, Toshio, Ohnishi, Hiroshi, Matozaki, Takashi, Kodama, Tatsuhiko, Taniguchi, Tadatsugu, Takayanagi, Hiroshi, and Takai, Toshiyuki

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Takako Koga [1, 2, 6]; Masanori Inui [3, 6]; Kazuya Inoue [3]; Sunhwa Kim [1]; Ayako Suematsu [1, 2]; Eiji Kobayashi [3]; Toshio Iwata [3]; Hiroshi Ohnishi [4]; Takashi [...]

Published
2004
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20. The Role of Type-2 Conventional Dendritic Cells in the Regulation of Tumor Immunity.

Author

Saito, Yasuyuki, Komori, Satomi, Kotani, Takenori, Murata, Yoji, and Matozaki, Takashi

Subjects
TUMOR prevention, DENDRITIC cells, IMMUNE checkpoint inhibitors, IMMUNITY, TUMORS, CANCER vaccines, IMMUNOTHERAPY, PHARMACODYNAMICS
Abstract

Simple Summary: Recent studies revealed that type-2 conventional dendritic cells (cDC2s) play an important role in antitumor immunity by promoting cytotoxic T-cell responses and helper T-cell differentiation. This review outlines the role of cDC2s in tumor immunity and summarizes the latest progress regarding their potential in cancer vaccination and cDC2-targeted cancer immunotherapy. Conventional dendritic cells (cDCs) orchestrate immune responses to cancer and comprise two major subsets: type-1 cDCs (cDC1s) and type-2 cDCs (cDC2s). Compared with cDC1s, which are dedicated to the activation of CD8+ T cells, cDC2s are ontogenically and functionally heterogeneous, with their main function being the presentation of exogenous antigens to CD4+ T cells for the initiation of T helper cell differentiation. cDC1s play an important role in tumor-specific immune responses through cross-presentation of tumor-derived antigens for the priming of CD8+ T cells, whereas little is known of the role of cDC2s in tumor immunity. Recent studies have indicated that human cDC2s can be divided into at least two subsets and have implicated these cells in both anti- and pro-tumoral immune responses. Furthermore, the efficacy of cDC2-based vaccines as well as cDC2-targeted therapeutics has been demonstrated in both mouse models and human patients. Here we summarize current knowledge about the role of cDC2s in tumor immunity and address whether these cells are beneficial in the context of antitumor immune responses. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: synergistic role of phosphotyrosine and intracellular Ca2+ concentration

Author

Nakamura, Tomoe Y., Yamamoto, Itaru, Nishitani, Hideo, Matozaki, Takashi, Suzuki, Toshiya, Wakabayashi, Shigeo, Shigekawa, Munekazu, and Goshima, Kiyota

Subjects
Neutrophils -- Research, Oxidizing agents -- Usage, Biological sciences
Abstract

The peeling of different types of cells from the substratum during cell shrinkage is caused by the neutrophil-derived oxidant NH2Cl, through the mechanisms of phosphotyrosine dephosphorylation and a rise in the intracellular Ca2+ concentration. This peeling off is restricted by a coating of Fn on the substratum.

Published
1995

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