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357 results on '"Massad, L. Stewart"'

1. Phase I Trial of Stereotactic MRI-Guided Online Adaptive Radiation Therapy (SMART) for the Treatment of Oligometastatic Ovarian Cancer

Author

Henke, Lauren E., Stanley, Jennifer A., Robinson, Clifford, Srivastava, Amar, Contreras, Jessika A., Curcuru, Austen, Green, Olga L., Massad, L. Stewart, Kuroki, Lindsay, Fuh, Katherine, Hagemann, Andrea, Mutch, David, McCourt, Carolyn, Thaker, Premal, Powell, Matthew, Markovina, Stephanie, Grigsby, Perry W., Schwarz, Julie K., and Chundury, Anupama

Published
2022
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9. Recommendations for Use of p16/Ki67 Dual Stain for Management of Individuals Testing Positive for Human Papillomavirus.

Author

Clarke, Megan A., Wentzensen, Nicolas, Perkins, Rebecca B., Garcia, Francisco, Arrindell, Deborah, Chelmow, David, Cheung, Li C., Darragh, Teresa M., Egemen, Didem, Guido, Richard, Huh, Warner, Locke, Alexander, Lorey, Thomas S., Nayar, Ritu, Risley, Carolann, Saslow, Debbie, Smith, Robert A., Unger, Elizabeth R., and Massad, L. Stewart

Published
2024
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11. Declining Prevalence of Trichomonas vaginalis Diagnosed by Wet Mount in a Cohort of U.S. Women With and Without HIV.

Author

Daubert, Elizabeth M., Dionne, Jodie, Atrio, Jessica, Knittel, Andrea K., Kassaye, Seble G., Seidman, Dominika, Long, Amanda, Brockmann, Susan, Ofotokun, Igho, Fischl, Margaret A., Massad, L. Stewart, and Weber, Kathleen M.

Subjects
TRICHOMONAS vaginalis, SEXUAL partners, FEMALE condoms, RESEARCH funding, HIV-positive persons, MULTIPLE regression analysis, DISEASE prevalence, STRUCTURAL equation modeling, DESCRIPTIVE statistics, AGE distribution, UNSAFE sex, LONGITUDINAL method, PAP test, RESEARCH, MICROSCOPY, MEDICAL screening, MIXED infections, SYMPTOMS
Abstract

Background: Women living with HIV (WLWH) are often coinfected with Trichomonas vaginalis (TV), and annual screening is recommended. Our goal was to assess differences in TV prevalence at study entry and over time in enrollment cohorts of the Women's Interagency HIV Study. Methods: In a multisite study, TV was diagnosed by wet mount microscopy. Prevalence was determined across four enrollment waves: 1994–1995, 2001–2002, 2011–2012, and 2013–2015. Generalized estimating equation multivariable logistic regression models assessed changes in visit prevalence across waves after controlling for HIV disease severity and other risks. Results: At 63,824 person-visits (3,508 WLWH and 1,262 women without HIV), TV was diagnosed by wet mount at 1979 visits (3.1%). After multivariable adjustment, HIV status was not associated with TV detection, which was more common among younger women, women with multiple partners, and irregular condom use. All enrollment waves showed a decline in TV detection over time, although p-value for trend did not reach significance for most recent waves. To explore the potential utility of screening among WLWH, we assessed rates of TV detection among women without appreciable vaginal discharge on examination. Initial TV prevalence among asymptomatic women was 3.5%, and prevalence decreased to 0.5%–1% in the most recent wave (2013–2015) (p-trend <0.0001). Conclusions: In this cohort, TV rates are low among WLWH, and HIV does not increase TV risk. Screening may benefit newly diagnosed WLWH, women with risk factors, or those receiving care sporadically but is unlikely to further reduce the low rate of TV among women in care, especially older women without multiple partners. The clinical trials registration number for WIHS is NCT00000797. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Trends in Bacterial Vaginosis Prevalence in a Cohort of U.S. Women with and at Risk for HIV.

Author

Massad, L. Stewart, Daubert, Elizabeth M., Evans, Charlesnika T., Minkoff, Howard, Kassaye, Seble, Dionne-Odom, Jodie, Seidman, Dominika, Murphy, Kerry, Alcaide, Maria L., Adimora, Adaora A., Sheth, Anandi N., Golub, Elizabeth T., French, Audrey L., and Weber, Kathleen M.

Subjects
*HIV-positive persons, *HIV infections, *RESEARCH, *BACTERIAL vaginitis, *CONFIDENCE intervals, *RETROSPECTIVE studies, *HIV seroconversion, *RISK assessment, *SEVERITY of illness index, *LOGISTIC regression analysis, *ODDS ratio, *WOMEN'S health
Abstract

Background: Women with human immunodeficiency virus (HIV) often have bacterial vaginosis (BV). The goal of this analysis was to assess how BV prevalence changed over time and across U.S. regions in enrollment cohorts of the Women's Interagency HIV Study. Methods: In a multisite study, BV was diagnosed retrospectively when pH and two of three other Amsel criteria were met. Prevalence was determined across four recruitment waves: 1994–5, 2001–2, 2011–2, and 2013–5. Generalized estimating equation multivariable logistic regression models assessed changes in visit prevalence across waves after controlling for HIV disease severity and other risks. Results: Among 4,790 women (3,539 with HIV and 1,251 without HIV), BV was diagnosed at 7,870 (12%) of 64,444 visits. Baseline prevalence across enrollment waves was 15.0%–19.2%, but declined in all cohorts, with prevalence in the initial cohort falling to 3.9% in the 1994–5 cohort after up to 21 years of continuous observation. Prevalence varied within U.S. regions. HIV status was not associated with BV. Conclusion: BV prevalence decreased with time in study. Prevalence varied across sites, but was not uniformly increased or decreased in any U.S. region. Clinical Trials.gov identifier: NCT00000797. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Pathology correlates of a papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion

Author

Al-Nourhji, Omar, Beckmann, Michael J., Markwell, Stephen J., and Massad, L. Stewart

Subjects
Pap test -- Analysis, Squamous cell carcinoma -- Diagnosis, Squamous cell carcinoma -- Demographic aspects, Squamous cell carcinoma -- Research, Cervix dysplasia -- Diagnosis, Cervix dysplasia -- Demographic aspects, Cervix dysplasia -- Research, Health
Published
2008

40. Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results

Author

Harris, Tiffany G., Palefsky, Joel M., Burk, Robert D., Massad, L. Stewart, Anastos, Kathryn, Ji Yon Bang, Minkoff, Howard, Hall, Charles B., Bacon, Melanie C., Sliverberg, Michael J., Watts, D. Heather, Levine, Alexandra M., Xue, Xiaonan, Strickler, Howard D., and Melnick, Sandra L.

Subjects
HIV infection -- Diagnosis, Papillomavirus infections -- Risk factors, Papillomavirus infections -- Diagnosis, Cancer -- Diagnosis, Cancer -- Risk factors
Abstract

A determination of the incidence of squamous intraepithelial lesions (SILs) in HIV-seropositive women with normal cytology results, by baseline human papillomavirus (HPV) DNA results is done. The results suggest that similar cervical cancer screening practices would be applicable to both HIV-seronegative and HIV-seropositive women.

Published
2005

41. 2001 consensus guidelines for the management of women with cervical cytological abnormalities. (Consensus Statement)

Author

Wright, Thomas C. Jr., Cox, J. Thomas, Massad, L. Stewart, Twiggs, Leo B., and Wilkinson, Edward J.

Subjects
Cervix dysplasia -- Care and treatment
Abstract

Guidelines for treating women whose Pap smear is labeled as atypical squamous cells is presented based on the recommendations of a panel of 121 experts. This type of Pap smear is abnormal but is not always cancerous., Objective To provide evidence-based consensus guidelines for the management of women with cervical cytological abnormalities and cervical cancer precursors. Participants A panel of 121 experts in the diagnosis and management of cervical cancer precursors, including representatives from 29 professional organizations, federal agencies, and national and international health organizations, were invited to participate in a consensus conference sponsored by the American Society for Colposcopy and Cervical Pathology (ASCCP). Evidence and Consensus Process Guidelines for the management of women with cervical cytological abnormalities were developed through a multistep process. Starting 6 months before the conference, working groups developed draft management guidelines based on formal literature reviews of English-language articles published in 1988-2001, as well as input from the professional community at large, obtained using interactive Internet-based bulletin boards. On September 6-8, 2001, the ASCCP Consensus Conference was held in Bethesda, Md. Guidelines with supporting evidence were presented and underwent discussion, revision, and voting. Conclusions Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASCUS) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (ASC-H). Women with ASC-US should be managed using a program of 2 repeat cytology tests, immediate colposcopy, or DNA testing for high-risk types of human papillomavirus (HPV). Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening. In most instances, women with ASC-H, low-grade squamous intraepithelial lesion, HSIL, and atypical glandular cells should be referred for immediate colposcopic evaluation.

Published
2002

45. Evolution of cervical abnormalities among women with HIV-1: evidence from surveillance cytology in the Women's Interagency HIV Study

Author

Massad, L. Stewart, Ahdieh, Linda, Benning, Lorie, Minkoff, Howard, Greenblatt, Ruth M., Watts, Heather, Miotti, Paolo, Anastos, Kathryn, Moxley, Michael, Muderspach, Laila I., and Melnick, Sandra

Subjects
HIV infection -- Complications, Cervix dysplasia -- Risk factors, Health
Abstract

Most HIV-infected women will not develop precancerous cervix abnormalities, according to a study of 1,639 HIV-infected women and 452 HIV-negative women. Only 6% of the HIV-infected women developed such changes.

Published
2001

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