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Liquefaction can cause significant damage to the built environment; therefore, assessing the liquefaction hazard in a seismically active region is essential to minimize the risk. This study attempted to evaluate the liquefaction potential of the south-central coastal areas of Bangladesh by calculating the liquefaction potential index (LPI) considering a scenario earthquake of Mw ​= ​7.5 having a peak ground acceleration of 0.15g. For calculating LPI, both standard penetration test blow count (SPT-N) and shear wave velocity (Vs) data have been used in this study. The results show that the study area's LPI values vary from 0 to 37. A liquefaction hazard map is prepared for the area using the calculated LPI values from Vs data shows about 8% of the study area is very highly susceptible to liquefaction hazard, whereas 62% of the area falls under high hazard-prone area while about 28% and 2% area of the study have respectively low (0

Changes in river bank location have wide consequences on floodplain communities and the sustainability of floodplain ecosystems. Although river dynamics are monitored globally and locally, understanding the impact of riverine dynamics on land use change remains a challenge. Bangladesh, part of the Bengal Delta, is mostly made up of alluvial deposits and is crisscrossed by so many rivers. Jamuna is one of the prominent rivers in this region. This study presents a consistent evaluation of the dynamics of the Jamuna river and ensuing changes in land use over 48 years (1972–2020) depending on satellite observations and geospatial analysis. Changes in the presence of water were used to estimate the advance/retreat of the banks and loss/gain of land along 257 perpendicular transects along the common pattern of the centerlines of the river. We found that the overall loss of agricultural land was about 535.01 km2, sevenfold of the gained agricultural land. Other land use losses were bare lands 136.73 km2, waterbodies 80.37 km2, settlement 67.28 km2 and vegetation 132.79 km2 against 48.47 km2, 3.52 km2, 23.76 km2 and 6.14 km2 land use gains respectively. Agricultural land loss impacts the livelihood of the floodplain dwellers and settlement loss causes internal migration. This pattern of land use change driven by the river dynamics has created newer environmental challenges and additionally, climate change may intricate the situation in the future. The findings of this study throw insight into the fact and may aid in sustainable river training measures and floodplain management.

Aim – to find regular patterns in the morphometric characteristics for the bodies of the cervical vertebrae when performing measurements in the axial (transverse) plane in men and women with different severity of degenerative-dystrophic changes of the cervical spine. Material and methods. The material of the study was the tomograms of 75 men and 128 women aged 18 to 84 years, obtained on magnetic resonance tomographs with a magnetic field strength of 1 Tl and 1.5 Tl. The data was divided into several groups according to the patients' sex and severity of degenerative-dystrophic changes of the cervical spine. The length and width of the vertebral bodies in the axial plane were measured with the subsequent calculation of their ratio. Results. Significant differences were found between the 1st and 2nd groups for the width of C7-C4 in women, as well as for the length of C3 and width of C3, C2 in men. Significant difference in the ratio of the sizes of vertebral bodies was registered in the 1st and 2nd groups of women at the level of C7. When comparing the data of all observation groups among men, significant differences were noted in the 2nd and 3rd groups for C7, C6, C3. With progression of degenerative-dystrophic changes, the differences in length were significant for C7-C4, C2 vertebrae in the 1st group, for C7-C5, C2 – in the 2nd and C7, C6, C4-C2 in the 3rd group. In the group of men with pronounced changes in the cervical spine region, in most cases there was an increase in coefficients (with significant differences in data for the 2nd and 3rd groups). Conclusion. Among men, significant differences were observed between the 2nd and 3rd groups for C7, C6, C3. For the C2 vertebra, significant differences were noted, taking into account sex, for length in the 1st and 3rd groups, width – in the 1st and 2nd groups, when assessing the mutual ratio of the sizes of the vertebral bodies – in the 2nd and 3rd groups.

Abstract The rise in temperatures and changes in other meteorological variables have exposed millions of people to health risks in Bangladesh, a densely populated, hot, and humid country. To better assess the threats climate change poses to human health, the wet bulb globe temperature (WBGT) is an important indicator of human heat stress. This study utilized high-resolution reanalysis data from the fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF ERA5) to analyze the spatiotemporal changes in outdoor WBGT across Bangladesh from 1979 to 2021, employing Liljegren's model. The study revealed an increase in the annual average WBGT by 0.08–0.5 °C per decade throughout the country, with a more pronounced rise in the southeast and northeast regions. Additionally, the number of days with WBGT levels associated with high and extreme risks of heat-related illnesses has shown an upward trend. Specifically, during the monsoon period (June to September), there has been an increase of 2–4 days per decade, and during the pre-monsoon period (March to May), an increase of 1–3 days per decade from 1979 to 2021. Furthermore, the results indicated that the escalation in WBGT has led to a five-fold increase in affected areas and a three-fold increase in days of high and extreme heat stress during the monsoon season in recent years compared to the earlier period. Trend and relative importance analyses of various meteorological variables demonstrated that air temperature is the primary driver behind Bangladesh's rising WBGT and related health risks, followed by specific humidity, wind speed, and solar radiation.

This article examines English language teaching (ELT) policy, textbooks, and pedagogy in the neo-nationalist era that followed 9/11 in Muslim-majority Bangladesh. Informed by the Douglas Fir Group's transdisciplinary framework of second language learning, the examination substantiates the ideologies of "economization," "de-Islamization" and "awamization," which coalesce into the overarching ideology of "secularization" of ELT as a response to the global war on terror and the rise of neo-nationalism in South Asia. This secular response to forces and developments in global, regional, and local contexts marks the distinctiveness of Bangladeshi ELT compared with other Muslim societies, which have sought to develop students' awareness of religious and cultural values while teaching English. The secularization of ELT can be explained by the rise of Hindutva nationalism in India and the latter's influence on the ruling Bangladesh Awami League government which has been in power for over 14 years. The article attests to the complex, multilayered ELT ideology shaped by local, regional, and global forces and interests, suggesting the formation of a national/social imaginary that seeks alliance with secular Muslims and non-Muslim communities at home and in the region and excludes practicing Muslims in both contexts.

Diabetes mellitus (Type 2) is a major world health problem spreading speedily throughout the world. It is a chronic illness that necessitates long-term therapy and care. Therefore, the therapy to treat and manage the disease should not only be safe and effective but should also be affordable. In countries like India, the cost of the therapy must be economical so that it can be easily afforded by common people. This review article mainly focuses on the novel drug dapagliflozin, a SGLT-2 inhibitor, and discusses its various aspects. It acts independently of the insulin pathway by inhibiting the reuptake of glucose in the renal tubules, allowing glycosuria to take place. This helps decrease blood glucose levels. Dapagliflozin is effective as both, monotherapy and combination therapy depending on the severity of the case as indicated by multiple studies. Since, only one daily dose is sufficient, this may be a more reasonable option for many low-income group patients. Many new medications are in development but dapagliflozin could be the major turning factor in managing T2DM along with metformin, sulfonylurea, insulin, pioglitazone, and DPP-4 inhibitors as mono or combination therapy.

Principal component analysis (PCA) can reduce the subjectivity of Water quality index (WQI) models by reducing parametric dimension and has gained immense attention in exploring water quality among researchers. Therefore, this study focuses on developing a novel WQI model for 4 Dhaka-based rivers namely Buriganga, Turag, Balu, and Shitalakhya following PCA as a method for selecting and weighting water quality parameters. The dataset includes 12 water quality parameters from 19 sites of these rivers sourced from the Department of Environment (DoE), Bangladesh. Correlation analysis followed by PCA, was conducted to decrease the parameter count from 12 to 7. The Measure of Sampling Adequacy (MSA) was found to be 0.853 in the Kaiser-Meyer-Olkin (KMO) test and Bartlett’s test of sphericity was significant at an alpha level of 0.05 indicating the dataset was suitable for factor analysis. Sub-indexing was introduced with the quality rating curves provided by the National Sanitation Foundation (NSF)-WQI model and modified rating curves for specific parameters with statistical dispersion. The calculated WQI values for 209 samples ranged from 36 (Bad) to 82 (Good) on a scale of 100. More than 70 % of the samples were in the medium or bad, and the rest were in the good category. The trend in WQI across the rivers indicated higher values during the wet season, attributed to the dilation from local rainfall. By incorporating a well-distributed dataset spanning several years, this statistical approach effectively minimizes the subjectivity and bias in developing WQI models for rivers in Dhaka, contributing to more robust future model development. Moreover, this study introduces a modern approach for assessing the river water quality of Dhaka city that can be incorporated into the river pollution control strategies.

This article draws on a framework based on Bernstein's three-message systems of schooling and Ball's notion of policy cycle to examine how the human capital development goal incorporated into the Bangladesh secondary English curriculum has been translated into pedagogy and assessment practices. Data were collected from classroom observations and teacher and principal interviews and document analysis. Findings indicate that while the curriculum has emphasized human capital development as an important English language education policy goal, pedagogy and assessment appear to be pursuing divergent goals and are mediated by local structures shaped by the colonial past and the current political economic context. The article highlights how human capital development is inadequate for substantive pedagogical and assessment practices and contributes to comparative education policy enactment studies by revealing how neoliberally oriented global education policy trends of human capital development unfold locally in schooling contexts in developing societies, namely, Bangladesh.

ABSTRACTThis scoping review summarises the findings of research conducted on cancer screening in Bangladesh, including the prevalence, awareness, barriers, and evaluation of screening programmes, by performing a comprehensive search of electronic databases and gray literature. 25 studies that met inclusion criteria were included in the final analysis. Most of the studies were about screening for cervical cancer, were quantitative, were cross-sectional, and were conducted in hospital settings. The main challenges to screening uptake were shyness, fear, a lack of knowledge, and an inadequate understanding of the concept of screening. Visual inspection with acetic acid (VIA) was found to be a simple and cost-efficient way to detect early-stage cervical cancer. However, breast self-examination (BSE) was reported to be insufficient. Education was found to have a positive impact on cancer screening knowledge and practice, but more needs to be done to improve screening rates, such as the utilisation of media, particularly in rural areas. The results of this scoping review highlight Bangladesh's low cancer screening prevalence and uptake and suggest that targeted awareness campaigns and enhanced access to screening services are required to increase cancer screening uptake and reduce the cancer burden in Bangladesh.

AbstractDeltas like the Ganges-Brahmaputra Delta (GBD) experience significant land subsidence due to overlaying load, consolidation, sediment compaction, regional tectonics, and human activity. The southwestern region of Bangladesh, marked by its low-lying floodplain with compressible sediments, experiences significant land subsidence. However, accurate assessments for these areas are very scarce, often focusing on the point-based measurements. This study employed Interferometric Synthetic Aperture Radar analysis, spanning from 2014 to 2022, to effectively measure land subsidence, and visualize it spatially. In the study area, subsidence rates were found to be ranging from 3 to 20 mm/year, with most areas experiencing 3-10 mm/year. While some areas show higher rates of 10-13 mm/year, very few exceeded 14 mm/year. The average subsidence rate was 5.98 mm/year, demonstrating significant spatial variability, with higher rates in Gopalganj, Patuakhali, Bhola, Barishal, and other areas. The findings were validated based on existing Global navigation satellite system (GNSS) data points, affirming their reliability. Despite minor discrepancies with other measurements at specific points, the overall results align well with existing data. This comprehensive analysis provides a detailed assessment of land subsidence in the southwestern region of Bangladesh, highlighting significant spatial variability and offering valuable insights for future coastal development and risk mitigation strategies.

Although lexical borrowing from the English language into Bangla has been reported in the literature, not many studies have investigated the nature and the extent to which this borrowing has taken place in relation to Bangla short stories. This study examined five Bangla short stories, which were selected based on purposive sampling. Our analysis of the textual data drew upon thematic analysis. The findings of the study illustrated four types of borrowings, which were classified as 'with Bangla equivalents', 'without Bangla equivalents', 'with close Bangla equivalents', and 'hybridised'. The borrowed words were further studied to understand the domains in which lexical borrowing took place. Findings reported in this study indicate that an increasing number of English lexis is gradually getting their place within creative writings published in Bangla. These findings provide the basis for the argument that while lexical borrowings can enrich Bangla, this practice may also contribute to marginalising the language by replacing some of its lexis. The study contributes to our understanding of the nature of lexical borrowings from the English language into the contemporary short stories written in Bangla, notably by illustrating the domains in which the borrowings have taken place.

This manuscript presents a novel state-of-the-art cyber-physical water testbed, namely the AI and Cyber for Water and Agriculture testbed (ACWA). ACWA is motivated by the aim to advance water resources' management using AI and cybersecurity experimentation. The main objective of ACWA is to address pressing challenges in the water and agricultural domains by utilising cutting-edge AI and data-driven technologies. These challenges include cyberbiosecurity, resources' management, access to water, sustainability, and data-driven decision-making, among others. To address such issues, ACWA is built consisting of topologies, sensors, computational clusters, pumps, tanks, smart water devices, as well as databases and AI models that control the system. Moreover, we present ACWA simulator, which is a software-based water digital twin. The simulator is based on fluid and constituent transport principles that produce a theoretical time series of a water distribution system. It creates a benchmark for comparing the theoretical approach with real-life outcomes via the physical ACWA testbed. ACWA data are available to AI and water sector researchers and are hosted in an online public repository. In this paper, the system is introduced and compared with existing water testbeds; additionally, use cases are described along with novel outcomes, such as datasets, software, and AI models. HIGHLIGHTS ACWA is a novel cyber-physical testbed for testing, validating, and experimenting with intelligent water systems and AI.; The testbed consists of multiple sensors, computational nodes, pumps, pipes, valves, tanks, and other computational components.; Open water domain datasets with multiple variables are publicly available via ACWA, including ones that enable the testing of Cyberbiosecurity and AI deployments in water systems.; ACWA is the first data generator of its kind (hardware and software) in the water domain.;

Background Flexor tendon injury zone V is a multicomponent soft tissue injury involving tendons, nerves, and vessels. Outcome assessment of repair thus requires evaluation of the hand as a whole rather than solely evaluating tendon function. The purpose of this Preferred Reporting Items for Systematic Reviews and Meta-Analyses -compliant systematic review was to identify and assess the components of outcome measures used in flexor zone V.

The use of (test) performance data for governing school and teachers' work, defined as datafication, has emerged as a global trend in education. However, how this trend plays out in relation to English language education in the local context, particularly in developing societies, has not received notable attention. Taking Bangladesh secondary education as a case, and drawing on Pierre Bourdieu's conceptual resources, this study highlights how datafication unfolds in schooling contexts and examines the "relations" between this trend and English language teachers' dispositions and pedagogical practices. The study employs a qualitative case study and draws on principal and teacher interviews, and classroom observation as data sources. Findings reveal that datafication has emerged as a practical logic of the schooling field, guiding schools and teachers' dispositions in specific ways, which contribute to reductive practices. Data also indicate teachers' capacity to mediate between competing logics and innovate practices, which are situated and "local." Based on these findings, this article argues that understanding the interplay between the specific logics of schooling, language education policy and teachers' structuring dispositions is key not only to understanding the nature of pedagogical practices, but also to establishing meaningful "relations" between policy and schooling practices amid growing datafication.

Although washback has been widely explored by applied linguists and education researchers, little attention has been paid to teacher agency in relation to it. It is critical to understand how language teachers navigate their pedagogy and respond to the broader curricular goals at a time when schools and teachers are being governed using examination and test data as accountability mechanisms. Drawing on data from classroom observations and interviews with two English teachers from a rural Bangladeshi school, this article illustrates how these teachers exercised their agency even under strong political pressure to improve students' test data. The findings indicate that traditional understanding of washback as deterministic may be insufficient to account for the complex ways in which teachers may respond to broader educational goals in the context of washback. The study concludes with theoretical, empirical, and pedagogic implications for washback research and teacher education.

Background: A novel nanosomal paclitaxel lipid suspension (NPLS), free from Cremophor EL (CrEL) and ethanol, was developed to address the solvent-related toxicities associated with conventional paclitaxel formulation. Objective: To evaluate the efficacy and safety of NPLS versus CrEL-based paclitaxel (conventional paclitaxel) in patients with metastatic breast cancer (MBC). Design: A prospective, open-label, randomized, multiple-dose, parallel, phase II/III study. Methods: Adult (18–65 years) female patients with MBC who had previously failed at least one line of chemotherapy were randomized (2:2:1) to NPLS 175 mg/m 2 every 3 weeks (Q3W, n = 48, arm A), NPLS 80 mg/m 2 every week (QW, n = 45, arm B) without premedication or conventional paclitaxel (Taxol ® , manufactured by Bristol-Myers Squibb, Princeton, NJ, USA) 175 mg/m 2 Q3W ( n = 27, arm C) with premedication. In the extension study, an additional 54 patients were randomized (2:1) to arm A ( n = 37) or arm C ( n = 17). Results: Pooled data from the primary study and its extension phase included 174 patients. The primary endpoint was the overall response rate (ORR). As per intent-to-treat analysis, ORR was significantly better in the NPLS QW arm as compared to conventional paclitaxel [44.4% (20/45) versus 22.7% (10/44), ( p = 0.04)]. An improvement in ORR with NPLS Q3W versus conventional paclitaxel arm [29.4% (25/85) versus 22.7% (10/44)] ( p = 0.53) was observed. Disease control rates observed were improved with NPLS Q3W versus conventional paclitaxel Q3W (77.7% versus 72.7%, p = 0.66) and with NPLS QW versus conventional paclitaxel Q3W (84.4% versus 72.7%, p = 0.20), although not significant. A lower incidence of grade III/IV peripheral sensory neuropathy, vomiting, and dyspnea was reported with NPLS Q3W versus conventional paclitaxel Q3W arms. Conclusion: NPLS demonstrated an improved tumor response rate and a favorable safety profile versus conventional paclitaxel. NPLS 80 mg/m 2 QW demonstrated a significantly better response versus conventional paclitaxel 175 mg/m 2 Q3W. Trial registration: Clinical Trial Registry-India (CTRI), CTRI/2010/091/001344 Registered on: 18 October 2010 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjEzNQ==&Enc=&userName=CTRI/2010/091/001344), CTRI/2015/07/006062 Registered on: 31 July 2015 (https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MTE2Mjc=&Enc=&userName=CTRI/2015/07/006062)

The salinisation of freshwater resources is a priority concern in Asian mega-deltas including the Bengal Basin of Bangladesh where the livelihoods, ecosystem services and health of coastal populations are increasingly under threat. Understanding trends and variations in surface water salinity is required to inform sustainable use of freshwater supplies in the face of hydrological regimes intensified by global environmental change. We interrogate 86 time series of fortnightly records of in situ surface water salinity between 1990 and 2019. Statistical and geospatial techniques were employed to characterise spatiotemporal distributions and trends in surface water salinity and identify key drivers of change in the coastal region of Bangladesh. The observed spatiotemporal structure in surface water salinity is primarily controlled by the magnitude and seasonality of river discharge entering the delta. In the moribund delta north of the Sundarbans, the contour between fresh and brackish water migrates seasonally between ~20 and ~40 km northward during the dry season. Abrupt increases in surface water salinity are observed throughout the coastal region in response to variations in upstream river discharge; the prominence of these events highlights their importance in driving salinity increases. Areas which are better connected to more voluminous seasonal river discharge (active delta), show greater recovery to these episodic inundations by cyclones than those less-well flushed by river discharge (moribund delta). Our reported observations provide a baseline for understanding the consequences of global environmental change and informing more climate-resilient adaptation strategies in coastal environments of Bangladesh and other Asian mega-deltas.

Abstract Humans continuously interact with physical, chemical, and biological environments that influence their health, safety, and quality of life. Sensing devices, such as electrochemical sensors that translate environmental qualities into electrical signals, are crucial for detecting biomarker concentrations in various biofluids. However, the understanding of electrochemical sensing is often incomplete, necessitating further study of chemical reactions and sensor‐electrode interactions for healthcare applications. This review analyzes crucial topics in chemical reactions in electrochemical sensing environments. First, the dynamics of chemical energy, the roles of acidic and alkaline fluids, chemical reaction tendencies, thermodynamic equilibria, Gibbs free energy, water dissociation, and the pH scale are discussed. Sensor materials or biomarkers undergo oxidation and reduction reactions in electrochemical sensing. Oxygen‐derived radicals and nonradical reactive species significantly influence biochemical reactions, cellular responses, and clinical outcomes. Then, the review delves into the impact of oxidation reduction reactions on human pathophysiology, redox reactions in hemoglobin, redox environments in human serum albumin and cells/tissues, and thermodynamics of biological redox reactions. Finally, recent advances in electrochemical techniques are presented and research challenges and future perspectives in electrochemical sensing for health applications are addressed.

A proper assessment of the water allocation system and water–food production relationships is essential to identify water use reduction potentials and enhance crop water productivity in dry areas. However, limited data on crop-specific water uses and water losses in the system, especially in developing and transition countries, prevent consistent diagnosis of issues in water systems. A modeling framework based on maximum entropy approach was implemented here to simultaneously assess water system structure and ‘water use-crop production’ relationships. The framework allowed for the analysis of long-term changes in conveyance efficiency, crop-specific water application, and irrigation water productivity between 1980 and 2021 in the Khorezm region in the lower reaches of the Amu Darya Basin in Central Asia. The results showed that conveyance losses were more than 30% in the system, and approximately 40% of the water allocated to the region went to rice and cotton production, indicating the possibility of water use reduction in these three areas. Conveyance efficiency and cotton water productivity improved in drier years in the region, owing to the wide implementation of temporary and low-cost drought management measures. The expected increase in the frequency and magnitude of droughts may require long-term investment-demanding strategies for drought management to enhance the sustainable livelihoods in the region.

Aim to evaluate the correlation between the course of vertebral arteries and veins and the results of calculations of hemodynamic parameters during ultrasound with functional tests. Material and methods. In the observation, 252 volunteers were examined using Samsung SonoAce R7 and GE Logiq F6 equipment. The hemodynamics was studied at the level of the second segment of the vertebral arteries and veins at rest, when turning, tilting and lifting the head. The results were processed using Microsoft Excel 2007 with subsequent statistical analysis. Results. 504 vascular complexes were analyzed without taking into account the visualization side. When assessing the arteries, the highest maximum blood flow velocity was registered when lifting the head in women with a rectilinear course of the vessels. In the group of men with non-rectilinear course of vessels, the lowest average blood flow velocity was registered when tilting the head. The highest volume flow was recorded in case of non-rectilinear vascular course in women when lifting the head. For vertebral veins, the highest indicators of maximum and minimum venous blood flow rates were observed in men with a rectilinear course of vessels when lifting the head. The highest values of the average flow velocity and volume flow were noted in men who had a rectilinear course of the vessels. The maximum values of the calculated venous volume flow were registered in groups with rectilinear vascular course: in men up to 19.4214.85 ml/min. (Me 12.45 ml/min.), in women 18.52 15.30 ml/min. (Me 10.50 ml/min.). Conclusion. The data obtained by the study contributes to improving the software and analysis of individual changes during patient examination, helps to evaluate the effectiveness of treatment and rehabilitation, as well as to analyze multifactorial models.

Landslides pose a serious risk to life and property in the mountainous regions around the globe. Understanding the interplay of landslide conditioning and triggering factors is essential for lessening the impacts caused by the hazard. Cox's Bazar — a coastal mountainous district in Bangladesh is recurrently affected by rainfall-triggered landslides. Based on analysis of 14 experiential landslides and combination of gauged and satellite rainfall estimates for the period from 2003 to 2019, the present study determines three landslide-triggering rainfall thresholds for the Cox's Bazar District (CBD): 1. Intensity-Duration (ID) threshold derived in this study revealed that any rainfall event with an intensity of ≥4.04 ​mm/h if prolonging for ≥12h can cause slope failures; 2. Event-Duration (ED) threshold suggested that a normalized cumulative event rainfall (EMAP) of 0.15 for one day is expected to trigger landslides; and 3. threshold calculated using randomly chosen antecedent rainfall expressed best distinction on 30-day rainfall and the equation of the threshold came out as Rth ​= ​64–0.02 Ra30. The recurrence probability of the derived antecedent rainfall threshold and likely landslides was determined through the Poisson distribution. Moreover, we assess the landslide susceptibility of the district with a coupled use of Frequency Ratio (FR) statistical measure and Geographic Information System (GIS). Considering the combined role of selected conditioning factors, the landslide susceptibility status of the CBD was quantified and classified into probability intervals. The accuracy of the susceptibility maps was assessed through the Relative Landslide Density Index (R-Index) that used a field landslide inventory, comprising well distributed 891 events. Moreover, gridded population data was superimposed on the derived susceptibility maps to understand the risk levels of people. The derivation of landslide-triggering rainfall thresholds and spatial susceptibility assessment has been useful to propose a low-cost Landslide Early Warning System (LEWS) which can contribute in alleviating the adverse effects of landslide hazard in the CBD.

Abstract Severe failure of improperly designed and poorly constructed structures may occur due to the amplified and prolonged ground motion during an earthquake, and hence prediction of the ground motion characteristics at the soil surface is crucial. In this study, based on the prepared simplified engineering geomorphic map, we performed a one-dimensional (1D) nonlinear site response analysis for seismic site characterization of the recently proposed Detailed Area Plan (DAP) area of Dhaka City, the Capital of Bangladesh. The engineering geomorphic unit-based map was prepared from image analysis and verified with the collected borehole data and surface geology map. The study area was classified into three major geomorphic units and seven sub-units subject to the subsurface soil profiles. Nine earthquake time histories, seven from the PEER NGA WEST2 data set and two synthetics, and seven identified subsurface soil profiles were used for nonlinear site response analysis, along with the BNBC 2020 uniform hazard spectrum as the target spectrum. For the selected earthquake ground motions, the near-surface soil response of the DAP area showed de-amplification of acceleration in the short period and amplification of acceleration in the long period. The amplified long-period acceleration could cause severe damage in inappropriately designed and poorly constructed long-period structures. The outcome of this study could be used to prepare a seismic risk-sensitive land use plan for the future development of the DAP of Dhaka City.

Abstract Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.

RESUMO A interação entre Atenção Primária à Saúde (APS) e especializada é tão relevante quanto crítica. O cuidado às Pessoas Vivendo com HIV/Aids (PVHA), que era realizado em ambulatórios especializados, recentemente, passou a se dar também pela APS, considerando seu potencial de ampliar o acesso. A partir de estudo de caso realizado em uma região municipal do Rio de Janeiro entre 2018 e 2019, discutiu-se tal problemática, destacando como resultados: desconhecimento/hesitação dos profissionais da atenção especializada sobre a atenção básica quanto à sua capacidade de cuidar das PVHA; priorização de investimento material, simbólico e político na atenção básica; quase inexistência de canais de diálogo entre serviços; entre outros. Na experiência estudada, a interface entre APS e atenção especializada tem se dado mais em uma lógica binária e de isolamento que em uma perspectiva de interação e gestão (compartilhada) do cuidado, que seria esperada em uma conformação de rede de atenção. Apesar dos potenciais ganhos de acesso e ‘racionalização’ do uso do especialista (infectologista), tais resultados indicam a necessidade de fortalecer processos e mecanismos de comunicação e interação entre profissionais de diferentes tipos de serviços, além de dispositivos de coordenação dos cuidados, como apoio matricial e prontuário eletrônico integrado em rede.

β-lactamases are a diverse class of enzymes produced by bacteria that present a major cause for resistance to β-lactams. In this study we analysed 159 fecal samples from dairy cows, for the presence of presumptive ESBL, AmpC, and carbapenemase-producing E. coli. Phylotyping was done using Clermont phylo-typing method, targeting arpA, ChuA, and YjaA genes, along with the DNA fragment TspE4.C2. Convetional PCR method was used to confirm the presence of bla genes among 39 phenotypically confirmed ESBL producing E. coli. The results showed presence of CTX-M, SHV, TEM and OXA1 bla genes in 28 (71.79%), 1 (2.56%), 29 (74.35%), 2 (5.12%) of isolates, respectively Twenty (51.28%) isolates showed presence of both blaCTX-M and TEM genes. The strain that carried the blaSHV gene was found to carry blaTEM gene as well, while one of the strains that carried blaOXA1 gene was also carrying blaCTX-M and TEM gene. The ration between isolates and phylo-groups was as follows: 9 (23.07%) strains were assigned to phyllo-group D; 14 (35.89%) to phyllo-group B; 16 (41.02%) to phyllo-group A. Out of the 39 strains where bla genes were identified, 29 (74.35%) were categorized as multi drug resistant.

Seasonal variation observations were conducted in the coastal waters of St. Martin's Island in the Bay of Bengal to examine the influence of physical processes and the distribution pattern of nutrients in the ocean water. Pollution evaluation indices, health index and statistical techniques were incorporated to assess the heavy metal contamination. Two seasons, cool dry winter and pre-monsoon hot, were considered for sampling from 12 stations around the island. The Cool dry winter season has higher nutrient concentrations than the Pre-monsoon Hot season. The concentration of nutrients appeared as follows: Silicate > Nitrate > Ammonia > Phosphate > Nitrite. PCA and Pearson's Correlation showed that fresh water from nearby rivers, deep water upwelling, and, in some situations, modest anthropogenic sources are crucial. Hence, low DO and phosphate levels during the pre-monsoon hot season indicate there is a planktonic process like photosynthesis prevailing. The island's north-western and south-eastern regions have higher nutrient concentrations, which may be seasonal and due to wind action. Pb, Cu, As, Cr, Cd, and Zn were also considered to comprehend the island's geo-chemical perspectives and ecological and human health risks. The Pre-monsoon Heavy Metal Pollution Index (HPI) and Heavy Metal Evaluation Index (HEI) demonstrated that some places are much higher than the threshold limit, even though no significantly higher value was detected in the cool winter season. The Nemerow Index, the Total Ecological Risk Index (TERI), indicated that heavy metal contamination was severe to moderate and low to moderate. Finally, Pearson's correlation showed the association between physical and chemical characteristics, similar to PCA and Pearson's correlation for nutrients and heavy metals. Thus, this research may help shed light on the state of the seas around St. Martin's Island. This study may also provide explicit insights for the authority to take the necessary measures to preserve marine ecology and the associated terrestrial ecosystem.

Abstract Background Airway complications are frequent after lung transplantation (LT), as they affect up to 23% of recipients. The implication of perioperative extracorporeal membrane oxygenation (ECMO) support and haemodynamic instability has never been specifically assessed. The first aim of this study was to explore the impact of perioperative ECMO support on bronchial anastomotic dehiscence (BAD) at Day 90 after LT. Methods This prospective observational monocentric study analysed BAD in all consecutive patients who underwent LT in the Bichat Claude Bernard Hospital, Paris, France, between January 2016 and May 2019. BAD visible on bronchial endoscopy and/or tomodensitometry was recorded. A univariate analysis was performed (Fisher’s exacts and Mann–Whitney tests), followed by a multivariate analysis to assess independent risk factors for BAD during the first 90 days after LT (p

Objective: Resveratrol is a polyphenolic compound that possesses strong antioxidant and anti-inflammatory activities. This study evaluated the effects of resveratrol on oxidative stress, fibrosis and multiple genes regulation in the kidneys of high fat (HF) diet-fed rats. Methods: Wistar rats were fed with HF diet for eight weeks. These rats were also treated with resveratrol for eight weeks. Finally, kidney tissue samples were isolated from all sacrificed rats. The histological changes, creatinine and uric acid levels, oxidative stress parameters such as malondialdehyde (MDA), nitric oxide, and advanced oxidation protein product (AOPP) levels were analyzed. The antioxidant enzymes such as catalase, superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels; gene expression of inflammatory and fibrosis-related genes namely, inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta1 (TGF-β1), and collagen-1 were assessed. Moreover, gene expression of oxidative stress-related genes such as nuclear factor erythroid 2–related factor 2 (Nrf-2), SOD, catalase, and glutathione reductase, were also assessed. Results: HF diet-fed rats showed increased creatinine and uric acid levels in plasma which were lowered by resveratrol treatment. The study findings also revealed that resveratrol counterbalanced the oxidative stress and prevented the expression of the inflammatory genes; restored the catalase and SOD activities followed by the up-regulation of antioxidant genes expression in the kidneys of HF diet-fed rats. HF diet caused the Nrf-2 down-regulation followed by the decreased expression of HO-1 and HO-2 genes, which was restored by resveratrol treatment. Moreover, the histological assessment showed lipotoxicity and increased fibrosis in the kidneys of HF diet-fed rats. Resveratrol prevented the kidney fibrosis probably by limiting oxidative stress, inflammation, and down-regulating TGF-β1 mediated signaling pathway. Conclusion: In conclusion, resveratrol treatment showed beneficial effects in preventing oxidative stress and fibrosis in the kidneys of HF diet-fed rats probably by modulating the gene expression of oxidative stress and inflammation related factors and enzymes.

Bangladesh, a country that lies on the north shores of the Bay of Bengal, has been blessed with a plethora of natural resources. St. Martin's Island, the only coral island in Bangladesh, is undoubtedly regarded as one of the most prized possessions. It is rich in biodiversity, but truly scientific information on it is lacking. In the present investigation, 14 stations adjacent to St. Martin's Island within the Bay of Bengal were sampled for determining the composition, spatial distribution, species richness, and diversity of pelagic zooplankton. Samples were collected in the pre-monsoon hot season. From the community of zooplankton, 34 species were reported. Most of the species belonged to copepods. Besides, Polychaeta and Cirripedia were also present in the community. The most significant species belonged to Oithona, Canthocalanus, Balanus, Euterpina, and Microsetella. Total zooplankton standing crop varied from 45,000-125,000 ind/m3 and the highest number of species (8) were observed at station 7. Strong variability in the distribution of species was observed in the studied stations. The number of genera collected at each station varied from 4 - 8. Data on species richness (Df) varied from 1.30-3.04 and that of the Shannon-Wiener Index (H) from 1.33-1.93. The species composition of zooplankton and the species richness and the diversity index of the population was comparable to the other studies carried out in the Central and Western Bay of Bengal.

We have proposed a novel method for assessing landslide risk by applying cutting-edge geospatial technologies and combining hazard, exposure, and vulnerability components. The Kutupalong Rohingya Camp (KRC) in Cox's Bazar, Bangladesh, was taken as a case study area. The district was hosting over one million Rohingya refugees from Myanmar, fleeing genocide and crimes against humanity. Extensive vegetation removal, hill cutting, exceptionally dense camps, fragile shelters, unstable soils, and excess monsoon rainfall were linked to yearly landslides. At first, ten landslide factor maps were produced, and a detailed fieldwork-based landslide inventory was conducted. Next, we applied various statistical and knowledge-based approaches for landslide susceptibility modelling. The most accurate susceptibility map was utilised to produce landslide hazard maps for different rainfall return periods. Next, we used population and shelter density data for exposure mapping and integrated age and gender-based factors for social vulnerability analysis. The hazard, exposure, and vulnerability maps were combined to produce the landslide risk map. Finally, we calculated shelters and refugee populations at risk for different scenarios. Camp 10 had the highest risk value, and historical landslide events validated the results. This study is replicable in a similar context and can be scaled up. It provides authentic information on landslide disaster scenarios that should be adopted in the decision-making process to reduce future impacts of catastrophic hydrometeorological disasters in the KRC and surrounding host community areas.

Abstract This article critically investigates a catastrophic rainfall-induced landslide event that occurred on 27 July 2021 in the Kutupalong Rohingya Camp (KRC) in Cox’s Bazar, Bangladesh, from geological and geomorphological perspectives. Large-scale anthropogenic interventions mainly caused the disastrous landslide event in the KRC in addition to intense rainfall. Before the landslide occurrence, about 300 mm of cumulative rainfall was recorded in the previous seven days and 120 mm of rainfall during the landslide event. A preliminary investigation was conducted to understand the extent, causative factors, and landslide characteristics. The landslide is of mud-flow type, but on the nearby slope, slumping was also visible. The landslide length was about 33 m, width 31 m, and area 612 m2. The approximate volume of slope materials displaced during the landslide event was about 2450 m3. The displaced slope materials mainly were silt and sand. The landslide event caused five fatalities and damaged nearly 5000 shelters in the KRC area. The devastation from such a small landslide event was attributed to dense households on the slope’s hilltop, slope, and toe. The camp areas and host communities are subjected to frequent and fatal landslides in the years to come due to intense human interventions and climatic conditions. The modifications of the slopes have been reducing the cohesion and the shear strength of the slope materials. Therefore, it is recommended to undertake proper mitigation and preparedness measures, including developing and implementing a landslide early warning system to address the emerging humanitarian crisis in the KRC and its surroundings.

Objective: The aim of this study was to evaluate the post-marketing safety, tolerability, immunogenicity and efficacy of Bevacizumab (manufactured by Hetero Biopharma) in a broader population of patients with solid tumors. Patients And Methods: This phase IV, prospective, multi-centric clinical study was carried out in Indian patients with solid malignancies (metastatic colorectal cancer, non-squamous non-small-cell lung cancer, metastatic renal cell carcinoma) treated with Bevacizumab between April 2018 and July 2019. This study included 203 patients from 16 tertiary care oncology centers across India for safety assessment, of which a subset of 115 patients who have consented were also evaluated for efficacy and immunogenicity. This study was prospectively registered in the Clinical Trial Registry of India (CTRI), and was commenced only after receiving approval from the competent authority (Central Drugs Standard Control Organization, CDSCO). Results: Out of the 203 enrolled patients, 121 (59.6%) patients reported 338 adverse events (AEs) during this study. Of 338 reported AEs, 14 serious adverse events (SAEs) were reported by 13 patients including 6 fatal SAEs, assessed as unrelated to the study medication and 7 non-fatal SAEs, 5 assessed as related, and 3 unrelated to Bevacizumab. Most AEs reported in this study (33.9%) were general disorders and administration site conditions, followed by gastrointestinal disorders (29.1%). The most frequently reported AEs were diarrhea (11.3%), asthenia (10.3%), headache (8.9%), pain (7.4%), vomiting (7.9%), and neutropenia (5.9%). At the end of the study, 2 (1.75%) of 69 patients reported antibodies to Bevacizumab without affecting safety and efficacy. However, at the end of 12 months, no patient had reported antibodies to Bevacizumab. Complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) were reported in 18.3%, 22.6%, 9.6%, and 8.7% of patients, respectively. The overall response rate (CR + PR) was reported in 40.9% of patients at the end of the study. Disease control rate (DCR), also known as the clinical benefit rate (CBR) was reported in 50.4% of patients. Conclusions: Bevacizumab (Cizumab, Hetero Biopharma) was observed to be safe, well tolerated, lacking immunogenicity, and efficacious in the treatment of solid tumors. The findings of this phase IV study of Bevacizumab, primarily as a combination therapy regimen suggest its suitability and rationality for usage in multiple solid malignancies. Clinical Trial Registry Number: CTRI/2018/4/13371 [Registered on CTRI http://ctri.nic.in/Clinicaltrials/advsearch.php : 19/04/2018]; Trial Registered Prospectively.