106 results on '"Magistri P"'
Search Results
2. Immunosuppression in liver transplant oncology: position paper of the Italian Board of Experts in Liver Transplantation (I-BELT)
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Cillo, Umberto, Carraro, Amedeo, Avolio, Alfonso W., Cescon, Matteo, Di Benedetto, Fabrizio, Giannelli, Valerio, Magistri, Paolo, Nicolini, Daniele, Vivarelli, Marco, and Lanari, Jacopo
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- 2024
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3. Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes
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Guidetti, Cristiano, Müller, Philip C., Magistri, Paolo, Jonas, Jan Philipp, Odorizzi, Roberta, Kron, Philipp, Guerrini, Gianpiero, Oberkofler, Christian E., Di Sandro, Stefano, Clavien, Pierre-Alain, Petrowsky, Henrik, and Di Benedetto, Fabrizio
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- 2024
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4. Current role and perspectives of living donor liver transplantation for hepatocellular carcinoma: systematic review of the past 20 years
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Di Sandro, Stefano, Centonze, Leonardo, Catellani, Barbara, Odorizzi, Roberta, Caracciolo, Daniela, Guidetti, Cristiano, Magistri, Paolo, Esposito, Giuseppe, Guerrini, Gian Piero, and Di Benedetto, Fabrizio
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- 2024
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5. Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
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Rampioni Vinciguerra, Gian Luca, Capece, Marina, Reggiani Bonetti, Luca, Nigita, Giovanni, Calore, Federica, Rentsch, Sydney, Magistri, Paolo, Ballarin, Roberto, Di Benedetto, Fabrizio, Distefano, Rosario, Cirombella, Roberto, Vecchione, Andrea, Belletti, Barbara, Baldassarre, Gustavo, Lovat, Francesca, and Croce, Carlo M.
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- 2024
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6. Robotic ALPPS for primary and metastatic liver tumours: short-term outcomes versus open approach
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Magistri, Paolo, Guidetti, Cristiano, Catellani, Barbara, Caracciolo, Daniela, Odorizzi, Roberta, Frassoni, Samuele, Bagnardi, Vincenzo, Guerrini, Gian Piero, Di Sandro, Stefano, and Di Benedetto, Fabrizio
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- 2024
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7. Suplementasi Besi-Folat Pada Wanita Pekerja: Anemia Defisiensi Besi Dan Produktivitas Kerja
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Putri Mira Magistri, Evynatra Evynatra, and Desmawati Desmawati
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suplementasi besi-folat ,wanita pekerja ,produktivitas kerja ,anemia defisiensi besi ,Nursing ,RT1-120 ,Medicine (General) ,R5-920 - Abstract
Status gizi, khususnya kecukupan zat besi, menjadi faktor krusial yang memengaruhi produktivitas kerja terkusus pekerja perempuan. Anemia pada wanita usia subur menimbulkan risiko pada kesehatan dan produktivitas. Suplementasi zat besi dan asam folat di tempat kerja diusulkan sebagai solusi untuk mengatasi anemia dan meningkatkan kesejahteraan pekerja wanita. Review ini bertujuan untuk memotret kompleksitas isu ini dan mendesak perlunya perhatian pada kesehatan dan produktivitas pekerja Wanita. Anemia, terutama disebabkan kekurangan zat besi, menjadi isu kesehatan global yang merugikan, terutama di kalangan pekerja. Keterkaitan langsung antara zat besi dan produktivitas kerja, terutama pada pekerja wanita, ditegaskan. Hasil penelitian menunjukkan bahwa suplementasi zat besi, terutama dengan dosis pagi tunggal, dapat meningkatkan kadar hemoglobin dan produktivitas kerja. Implikasi kebijakan melibatkan peningkatan akses terhadap suplementasi zat besi dan perbaikan pola makan untuk mendukung kesejahteraan pekerja wanita. Dapat disimpulkan bahwa pentingnya mengidentifikasi dan mengatasi kekurangan zat besi dengan suplementasi besi-folat pada wanita pekerja adalah kunci untuk mencegah anemia defisiensi besi dan meningkatkan produktivitas serta kesejahteraan tenaga kerja.
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- 2024
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8. Clinical Outcomes of Robotic Resection for Perihilar Cholangiocarcinoma: A First, Multicenter, Trans-Atlantic, Expert-Center, Collaborative Study
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Sucandy, Iswanto, Marques, Hugo P., Lippert, Trenton, Magistri, Paolo, Coelho, Joao Santos, Ross, Sharona B., Chumbinho, Beatriz, Di Sandro, Stefano, and DiBenedetto, Fabrizio
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- 2024
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9. Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
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Gian Luca Rampioni Vinciguerra, Marina Capece, Luca Reggiani Bonetti, Giovanni Nigita, Federica Calore, Sydney Rentsch, Paolo Magistri, Roberto Ballarin, Fabrizio Di Benedetto, Rosario Distefano, Roberto Cirombella, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre, Francesca Lovat, and Carlo M. Croce
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Medicine ,Biology (General) ,QH301-705.5 - Abstract
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to thrive and progress in a challenging tumor microenvironment. Dysregulation of the onco-suppressor miR-15a has been extensively documented in PDAC. Here, we identified the transcription factor Fos-related antigen-2 (Fra-2) as a miR-15a target mediating the adaptive mechanism of PDAC to nutrient deprivation. We report that the IGF1 signaling pathway was enhanced in nutrient deprived PDAC cells and that Fra-2 and IGF1R were significantly overexpressed in miR-15a downmodulated PDAC patients. Mechanistically, we discovered that miR-15a repressed IGF1R expression via Fra-2 targeting. In miR-15a-low context, IGF1R hyperactivated mTOR, modulated the autophagic flux and sustained PDAC growth in nutrient deprivation. In a genetic mouse model, Mir15aKO PDAC showed Fra-2 and Igf1r upregulation and mTOR activation in response to diet restriction. Consistently, nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent manner. Overall, our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.
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- 2024
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10. Voluminous Extracardiac Adult Rhabdomyoma of the Neck: A Case Presentation
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Riccardo Maglio, Scicchitano Francesco, Magistri Paolo, Valabrega Stefano, D'Angelo Francesco, and Ramacciato Giovanni
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Surgery ,RD1-811 - Abstract
Introduction. Rhabdomyomas of the head and neck are exceptionally rare benign mesenchymal tumors. Rare cases have been reported to involve other sites of the body including the head and neck regions. Case Presentation. We report a case of voluminous extracardiac adult rhabdomyoma affecting adult patients and initially seen as slowly growing, indolent neoplasms. The patient is a seventy-year old male Italian patient. Conclusion. Adult extracardiac rhabdomyoma is a rare benign tumor that may present with symptoms that vary from aerodigestive tract obstruction to remaining asymptomatic for many years. Although histology is very characteristic, several differential diagnoses have to be considered. To our knowledge, this is the first case of voluminous adult-type symptomless rhabdomyoma.
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- 2012
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11. Liver resection versus radiofrequency ablation in octogenarian patients for hepatocellular carcinoma: a propensity score multicenter analysis
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Filippo, Rosalinda, Conticchio, Maria, Ratti, Francesca, Inchingolo, Riccardo, Gelli, Maximiliano, Anelli, Ferdinando Massimiliano, Laurent, Alexis, Vitali, Giulio Cesare, Magistri, Paolo, Assirati, Giacomo, Felli, Emanuele, Wakabayashi, Taiga, Pessaux, Patrick, Piardi, Tullio, Di Benedetto, Fabrizio, de’Angelis, Nicola, Briceno, Delgado Francisco Javier, Rampoldi, Antonio Gaetano, Adam, Renè, Cherqui, Daniel, Aldrighetti, Luca, and Memeo, Riccardo
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- 2023
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12. Robotic Left Hepatectomy with en bloc Caudatectomy and Multiple Biliary Anastomosis for Perihilar Cholangiocarcinoma
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Di Benedetto, Fabrizio, Magistri, Paolo, Catellani, Barbara, Guerrini, Gian Piero, and Di Sandro, Stefano
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- 2023
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13. AFP score and metroticket 2.0 perform similarly and could be used in a 'within-ALL' clinical decision tool
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Federico Piñero, Charlotte Costentin, Helena Degroote, Andrea Notarpaolo, Ilka FSF. Boin, Karim Boudjema, Cinzia Baccaro, Aline Chagas, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrizio Dibenedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Sebastián Marciano, Claire Vanlemmens, Stefano Fagiuoli, Flair Carrilho, Daniel Cherqui, Patrizia Burra, Hans Van Vlierberghe, Quirino Lai, Marcelo Silva, Fernando Rubinstein, Christophe Duvoux, Filomena Conti, Olivier Scatton, Pierre Henri Bernard, Claire Francoz, Francois Durand, Sébastien Dharancy, Marie-lorraine Woehl, Alexis Laurent, Sylvie Radenne, Jérôme Dumortier, Armand Abergel, Louise Barbier, Pauline Houssel-Debry, Georges Philippe Pageaux, Laurence Chiche, Victor Deledinghen, Jean Hardwigsen, J. Gugenheim, M. altieri, Marie Noelle Hilleret, Thomas Decaens, Paulo Costa, Elaine Cristina de Ataide, Emilio Quiñones, Margarita Anders, Adriana Varón, Alina Zerega, Alejandro Soza, Martín Padilla Machaca, Diego Arufe, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Ricardo Chong Menéndez, Martín Maraschio, Luis G. Podestá, Lucas McCormack, Juan Mattera, Adrian Gadano, Jose Huygens Parente García, Giulia Magini, Lucia Miglioresi, Martina Gambato, Cecilia D’Ambrosio, Alessandro Vitale, Michele Colledan, Domenico Pinelli, Paolo Magistri, Giovanni Vennarecci, Marco Colasanti, Valerio Giannelli, Adriano Pellicelli, Callebout Eduard, Iesari Samuele, Dekervel Jeroen, Schreiber Jonas, Pirenne Jacques, Verslype Chris, Ysebaert Dirk, Michielsen Peter, Lucidi Valerio, Moreno Christophe, Detry Olivier, Delwaide Jean, Troisi Roberto, and Lerut Jan Paul
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Prediction ,reclassification ,recurrence ,transplantation ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Two recently developed composite models, the alpha-fetoprotein (AFP) score and Metroticket 2.0, could be used to select patients with hepatocellular carcinoma (HCC) who are candidates for liver transplantation (LT). The aim of this study was to compare the predictive performance of both models and to evaluate the net risk reclassification of post-LT recurrence between them using each model’s original thresholds. Methods: This multicenter cohort study included 2,444 adult patients who underwent LT for HCC in 47 centers from Europe and Latin America. A competing risk regression analysis estimating sub-distribution hazard ratios (SHRs) and 95% CIs for recurrence was used (Fine and Gray method). Harrell’s adapted c-statistics were estimated. The net reclassification index for recurrence was compared based on each model’s original thresholds. Results: During a median follow-up of 3.8 years, there were 310 recurrences and 496 competing events (20.3%). Both models predicted recurrence, HCC survival and survival better than Milan criteria (p
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- 2023
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14. Hydrogen Carriers: Scientific Limits and Challenges for the Supply Chain, and Key Factors for Techno-Economic Analysis
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Davide Clematis, Daria Bellotti, Massimo Rivarolo, Loredana Magistri, and Antonio Barbucci
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hydrogen carrier ,compressed hydrogen ,liquefied hydrogen ,ammonia ,methanol ,LOHC ,Technology - Abstract
Hydrogen carriers are one of the keys to the success of using hydrogen as an energy vector. Indeed, sustainable hydrogen production exploits the excess of renewable energy sources, after which temporary storage is required. The conventional approaches to hydrogen storage and transport are compressed hydrogen (CH2) and liquefied hydrogen (LH2), which require severe operating conditions related to pressure (300–700 bar) and temperature (T < −252 °C), respectively. To overcome these issues, which have hindered market penetration, several alternatives have been proposed in the last few decades. In this review, the most promising hydrogen carriers (ammonia, methanol, liquid organic hydrogen carriers, and metal hydrides) have been considered, and the main stages of their supply chain (production, storage, transportation, H2 release, and their recyclability) have been described and critically analyzed, focusing on the latest results available in the literature, the highlighting of which is our current concern. The last section reviews recent techno-economic analyses to drive the selection of hydrogen carrier systems and the main constraints that must be considered. The analyzed results show how the selection of H2 carriers is a multiparametric function, and it depends on technological factors as well as international policies and regulations.
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- 2023
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15. Laparoscopic versus open right posterior sectionectomy: an international, multicenter, propensity score-matched evaluation
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van der Heijde, Nicky, Ratti, Francesca, Aldrighetti, Luca, Benedetti Cacciaguerra, Andrea, Can, Mehmet F., D’Hondt, Mathieu, Di Benedetto, Fabrizio, Ivanecz, Arpad, Magistri, Paolo, Menon, Krishna, Papoulas, Michail, Vivarelli, Marco, Besselink, Marc G., and Abu Hilal, Mohammed
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- 2021
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16. Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation
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Simone Lasagni, Filippo Leonardi, Alessandra Pivetti, Lorenza Di Marco, Federico Ravaioli, Matteo Serenari, Stefano Gitto, Rosina Maria Critelli, Fabiola Milosa, Adriana Romanzi, Serena Mancarella, Francesco Dituri, Mattia Riefolo, Barbara Catellani, Paolo Magistri, Dante Romagnoli, Ciro Celsa, Marco Enea, Nicola de Maria, Filippo Schepis, Antonio Colecchia, Calogero Cammà, Matteo Cescon, Antonietta d’Errico, Fabrizio di Benedetto, Gianluigi Giannelli, Maria Luz Martinez-Chantar, and Erica Villa
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hepatocellular carcinoma ,liver transplantation ,recurrence ,angiopoietin-2 ,survival ,neoangiogenesis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundThough the precise criteria for accessing LT are consistently being applied, HCC recurrence (HCC-R_LT) still affects more than 15% of the patients. We analyzed the clinical, histopathological, and biological features of patients with HCC to identify the predictive factors associated with cancer recurrence and survival after LT.MethodsWe retrospectively analyzed 441 patients with HCC who underwent LT in our center. Overall, 70 (15.8%) of them developed HCC-R_LT. We matched them by age at transplant and etiology with 70 non-recurrent patients. A comparable cohort from the Liver Transplant Centre of Bologna served as validation. The clinical and biochemical characteristics and pre-LT criteria (Milan, Metroticket, Metroticket_AFP, and AFP model) were evaluated. Histological analysis and immunohistochemistry for angiopoietin-2 in the tumor and non-tumor tissue of explanted livers were performed. Patients’ follow-up was until death, last clinical evaluation, or 31 December 2021. In patients with HCC-R_LT, the date of diagnosis of recurrence and anatomical site has been reported; if a biopsy of recurrence was available, histologic and immunohistochemical analyses were also performed.ResultsPatients were followed up for a mean period of 62.7 ± 54.7 months (median, 39 months). A higher risk of HCC-R_LT was evident for factors related indirectly (AFP) or directly (endothelial angiopoietin-2, microvascular invasion) to biological HCC aggressiveness. In multivariate analysis, only angiopoietin-2 expression was independently associated with recurrence. Extremely high levels of endothelial angiopoietin-2 expression were also found in hepatic recurrence and all different metastatic locations. In univariate analysis, MELD, Metroticket_AFP Score, Edmondson–Steiner grade, microvascular invasion, and endothelial angiopoietin-2 were significantly related to survival. In multivariate analysis, angiopoietin-2 expression, Metroticket_AFP score, and MELD (in both training and validation cohorts) independently predicted mortality. In time-dependent area under receiver operating characteristic curve analysis, the endothelial angiopoietin-2 expression had the highest specificity and sensitivity for recurrence (AUC 0.922, 95% CI 0.876–0.962, p < 0.0001).ConclusionsEndothelial angiopoietin-2 expression is a powerful independent predictor of post-LT tumor recurrence and mortality, highlighting the fundamental role of tumor biology in defining the patients’ prognosis after liver transplantation. The great advantage of endothelial angiopoietin-2 is that it is evaluable in HCC biopsy before LT and could drive a patient’s priority on the waiting list.
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- 2022
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17. Heat pump integration in a real poly-generative energy district: A techno-economic analysis
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S. Barberis, M. Rivarolo, D. Bellotti, and L. Magistri
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Distributed generation ,Techno-economic analysis ,Poly-generative energy districts ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
This paper presents a techno-economic feasibility analysis related to a heat pump installation in a poly-generative energy district to convert the overproduction of electricity into thermal power, easy to be stored in thermal storage tanks. The heat pump technology is already used for thermal/cooling energy production in different areas although application in energy districts in a power-to-heat modality to improve management of electrical/thermal energy demands is still limited.In this research, the installation of a heat pump in the poly-generative smart grid located at the University of Genoa Campus is presented. A time dependent one-year techno-economic analysis of the energy district is performed, throughout a model built with a software developed by the authors. The integration of the heat pump in the energy district is analysed, comparing the energetic, environmental and economic performance to the present configuration of the poly-generative energy district. The results show that the heat pump introduction grants several advantages, such as a reduction in gas consumption (24 ton/year, −15%) and an increase in the annual energy efficiency of cogenerative prime movers which can work for a higher number of hours (+23%) close to the design point.
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- 2022
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18. From Listing to Recovery: A Review of Nutritional Status Assessment and Management in Liver Transplant Patients
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Federico Ravaioli, Nicola De Maria, Lorenza Di Marco, Alessandra Pivetti, Riccardo Casciola, Carlo Ceraso, Gabriella Frassanito, Martina Pambianco, Maddalena Pecchini, Chiara Sicuro, Laura Leoni, Stefano Di Sandro, Paolo Magistri, Renata Menozzi, Fabrizio Di Benedetto, and Antonio Colecchia
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chronic liver disease ,malnutrition ,nutrition ,ACLD ,advanced liver diseases ,liver transplantation ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Liver transplantation (LT) is a complex surgical procedure requiring thorough pre- and post-operative planning and care. The nutritional status of the patient before, during, and after LT is crucial to surgical success and long-term prognosis. This review aims to assess nutritional status assessment and management before, during, and after LT, with a focus on patients who have undergone bariatric surgery. We performed a comprehensive topic search on MEDLINE, Ovid, In-Process, Cochrane Library, EMBASE, and PubMed up to March 2023. It identifies key factors influencing the nutritional status of liver transplant patients, such as pre-existing malnutrition, the type and severity of liver disease, comorbidities, and immunosuppressive medications. The review highlights the importance of pre-operative nutritional assessment and intervention, close nutritional status monitoring, individualised nutrition care plans, and ongoing nutritional support and monitoring after LT. The review concludes by examining the effect of bariatric surgery on the nutritional status of liver transplant recipients. The review offers valuable insights into the challenges and opportunities for optimising nutritional status before, during, and after LT.
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- 2023
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19. Laparoscopic major hepatectomy for hepatocellular carcinoma in elderly patients: a multicentric propensity score‑based analysis
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Delvecchio, Antonella, Conticchio, Maria, Ratti, Francesca, Gelli, Maximiliano, Anelli, Ferdinando Massimiliano, Laurent, Alexis, Vitali, Giulio Cesare, Magistri, Paolo, Assirati, Giacomo, Felli, Emanuele, Wakabayashi, Taiga, Pessaux, Patrick, Piardi, Tullio, Di Benedetto, Fabrizio, de’Angelis, Nicola, Briceño-Delgado, Javier, Adam, Rene, Cherqui, Daniel, Aldrighetti, Luca, and Memeo, Riccardo
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- 2021
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20. Major robotic hepatectomies: technical considerations
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Magistri, Paolo, Assirati, Giacomo, Ballarin, Roberto, Di Sandro, Stefano, and Di Benedetto, Fabrizio
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- 2021
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21. Vena cava replacement and major hepatectomy for liver tumors: international multicenter retrospective cohort study.
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Di Benedetto, Fabrizio, Magistri, Paolo, Marcon, Francesca, Soubrane, Olivier, Mello, Felipe Pedreira, Coelho, Joao Santos, Fernandez, Andre Renaldo, Frassoni, Samuele, Bagnardi, Vincenzo, Singhal, Ashish, Rotellar, Fernando, Hernandez-Alejandro, Roberto, Alikhanov, Ruslan, Fernandes, Eduardo de Souza M., Cauchy, Francois, Muiesan, Paolo, Di Sandro, Stefano, and Marques, Hugo Pinto
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Introduction: Involvement of the inferior vena cava (IVC) and hepatic veins has been considered a relative contraindication to hepatic resection for primary and metastatic liver tumors. However, patients affected by tumors extending to the IVC have limited therapeutic options and suffer worsening of quality of life due to IVC compression. Methods: Cases of primary and metastatic liver tumors with vena cava infiltration from 10 international centers were collected (7 European, 1 US, 2 Brazilian, 1 Indian) were collected. Inclusion criteria for the study were major liver resection with concomitant vena cava replacement. Clinical data and short-term outcomes were analyzed. Results: Thirty-six cases were finally included in the study. Median tumor max size was 98 mm (range: 25-250). A biliary reconstruction was necessary in 28% of cases, while a vascular reconstruction other than vena cava in 34% of cases. Median operative time was 462 min (range: 230-750), with 750 median ml of estimated blood loss and a median of one pRBC transfused intraoperatively (range: 0-27). Median ICU stay was 4 days (range: 1-30) with overall in-hospital stay of 15 days (range: 3-46), postoperative CCI score of 20.9 (range: 0-100), 12% incidence of PHLF grade B-C. Five patients died in a 90-days interval from surgery, one due to heart failure, one due to septic shock, and three due to multiorgan failure. With a median follow-up of 17 months (interquartile range: 11-37), the estimated 5 years overall survival was 48% (95% CI: 27-66%), and 5-year cumulative incidence of tumor recurrence was 55% (95% CI: 33-73%). Conclusions: Major liver resections with vena cava replacement can be performed with satisfactory results in expert HPB centers. This surgical strategy represents a feasible alternative for otherwise unresectable lesions and is associated with favorable prognosis compared to nonoperative management, especially in patients affected by intrahepatic cholangiocarcinoma. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Robotic Versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients.
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Sijberden, Jasper P., Hoogteijling, Tijs J., Aghayan, Davit, Ratti, Francesca, Ek-Khoon Tan, Morrison-Jones, Victoria, Lanari, Jacopo, Haentjens, Louis, Kongyuan Wei, Tzedakis, Stylianos, Martinie, John, Bordom, Daniel Osei, Zimmitti, Giuseppe, Crespo, Kaitlyn, Magistri, Paolo, Russolillo, Nadia, Conci, Simone, Görgec, Burak, Cacciaguerra, Andrea Benedetti, and D'Souza, Daniel
- Abstract
Objective: To compare the perioperative outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. Background: Clear advantages of RLS over LLS have rarely been demonstrated, and the associated costs of robotic surgery are generally higher than those of laparoscopic surgery. Therefore, the exact role of the robotic approach in minimally invasive liver surgery remains to be defined. Methods: In this international retrospective cohort study, the outcomes of patients who underwent RLS and LLS for all indications between 2009 and 2021 in 34 hepatobiliary referral centers were compared. Subgroup analyses were performed to compare both approaches across several types of procedures: (1) minor resections in the anterolateral (2, 3, 4b, 5, and 6) or (2) posterosuperior segments (1, 4a, 7, 8), and (3) major resections ( ≥3 contiguous segments). Propensity score matching was used to mitigate the influence of selection bias. The primary outcome was textbook outcome in liver surgery (TOLS), previously defined as the absence of intraoperative incidents ≥ grade 2, postoperative bile leak ≥grade B, severe morbidity, readmission, and 90-day or in-hospital mortality with the presence of an R0 resection margin in case of malignancy. The absence of a prolonged length of stay was added to define TOLS+. Results: Among the 10.075 included patients, 1.507 underwent RLS and 8.568 LLS. After propensity score matching, both groups constituted 1.505 patients. RLS was associated with higher rates of TOLS (78.3% vs 71.8%, P < 0.001) and TOLS+ (55% vs 50.4%, P = 0.026), less Pringle usage (39.1% vs 47.1%, P < 0.001), blood loss (100 vs 200 milliliters, P < 0.001), transfusions (4.9% vs 7.9%, P = 0.003), conversions (2.7% vs 8.8%, P < 0.001), overall morbidity (19.3% vs 25.7%, P < 0.001), and microscopically irradical resection margins (10.1% vs. 13.8%, P = 0.015), and shorter operative times (190 vs 210 minutes, P = 0.015). In the subgroups, RLS liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. Background: Clear advantages of RLS over LLS have rarely been demonstrated, and the associated costs of robotic surgery are generally higher than those of laparoscopic surgery. Therefore, the exact role of the robotic approach in minimally invasive liver surgery remains to be defined. Methods: In this international retrospective cohort study, the outcomes of patients who underwent RLS and LLS for all indications between 2009 and 2021 in 34 hepatobiliary referral centers were compared. Subgroup analyses were performed to compare both approaches across several types of procedures: (1) minor resections in the anterolateral (2, 3, 4b, 5, and 6) or (2) posterosuperior segments (1, 4a, 7, 8), and (3) major resections ( ≥3 contiguous segments). Propensity score matching was used to mitigate the influence of selection bias. The primary outcome was textbook outcome in liver surgery (TOLS), previously defined as the absence of intraoperative incidents ≥ grade 2, postoperative bile leak ≥grade B, severe morbidity, readmission, and 90-day or in-hospital mortality with the presence of an R0 resection margin in case of malignancy. The absence of a prolonged length of stay was added to define TOLS+. Results: Among the 10.075 included patients, 1.507 underwent RLS and 8.568 LLS. After propensity score matching, both groups constituted 1.505 patients. RLS was associated with higher rates of TOLS (78.3% vs 71.8%, P < 0.001) and TOLS+ (55% vs 50.4%, P = 0.026), less Pringle usage (39.1% vs 47.1%, P < 0.001), blood loss (100 vs 200 milliliters, P < 0.001), transfusions (4.9% vs 7.9%, P = 0.003), conversions (2.7% vs 8.8%, P < 0.001), overall morbidity (19.3% vs 25.7%, P < 0.001), and microscopically irradical resection margins (10.1% vs. 13.8%, P = 0.015), and shorter operative times (190 vs 210 minutes, P = 0.015). In the subgroups, RLS tended to have higher TOLS rates, compared with LLS, for minor resections in the posterosuperior segments (n = 431 per group, 75.9% vs 71.2%, P = 0.184) and major resections (n = 321 per group, 72.9% vs 67.5%, P = 0.086), although these differences did not reach statistical significance. Conclusions: While both produce excellent outcomes, RLS might facilitate slightly higher TOLS rates than LLS. [ABSTRACT FROM AUTHOR]
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- 2024
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23. A multi-criteria approach for assessment of maritime sector energy systems
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Montagna G.N., Piccardo S., Lamberti T., Magistri L., and Rivarolo M.
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Environmental sciences ,GE1-350 - Abstract
This paper describes a multi-criteria tool for the performance comparison of alternative and conventional on board energy systems for maritime sector, both for hotel and propulsion loads, depending on the mission taken into account. The tool, named HELM (Helper for Energy Layouts in Maritime applications), carries out this analysis based on an extended and up-to-date market database of many technologies in terms of power units and suitable fuel storage systems. A wide range of maps has been created, correlating costs, volumes, weights, emissions and fuel environmental hazards with the installed power and the operational hours, given by the user as input. In this work, different maritime vessels typologies are investigated and the choice of the best solution is performed for each one, considering the single evaluation parameters. It is worth noting that the multi-criteria analysis carried out has a general approach, allowing it to give preliminary information on the energy system, in order to respect new requirements (e.g. more and more stringent normative in terms of pollutant emissions in ports and restricted areas). HELM can be used for many design approaches, either for a new ship project or for already existing ships retrofit; furthermore, the database can be easily extended to other generation and storage technologies.
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- 2023
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24. Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions
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Velmeshev, Dmitry, Magistri, Marco, Mazza, Emilia Maria Cristina, Lally, Patrick, Khoury, Nathalie, D’Elia, Evan Ross, Bicciato, Silvio, and Faghihi, Mohammad Ali
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- 2020
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25. Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL
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Guo, Fengjie, Luo, Yuan, Jiang, Xiaoyu, Lu, XiaoQing, Roberti, Domenico, Lossos, Chen, Kunkalla, Kranthi, Magistri, Marco, Rui, Lixin, Verdun, Ramiro, Vega, Francisco, Moy, Vincent T., and Lossos, Izidore S.
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- 2020
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26. Not just minor resections: robotic approach for cystic echinococcosis of the liver
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Magistri, Paolo, Pecchi, Annarita, Franceschini, Erica, Pesi, Benedetta, Guadagni, Simone, Catellani, Barbara, Assirati, Giacomo, Guidetti, Cristiano, Guerrini, Gian Piero, Tarantino, Giuseppe, Ballarin, Roberto, Codeluppi, Mauro, Morelli, Luca, Coratti, Andrea, and Di Benedetto, Fabrizio
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- 2019
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27. International study on the outcome of locoregional therapy for liver transplant in hepatocellular carcinoma beyond Milan criteria
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Helena Degroote, Federico Piñero, Charlotte Costentin, Andrea Notarpaolo, Ilka F. Boin, Karim Boudjema, Cinzia Baccaro, Aline Lopes Chagas, Philippe Bachellier, Giuseppe Maria Ettorre, Jaime Poniachik, Fabrice Muscari, Fabrio Di Benedetto, Sergio Hoyos Duque, Ephrem Salame, Umberto Cillo, Adrián Gadano, Claire Vanlemmens, Stefano Fagiuoli, Fernando Rubinstein, Patrizia Burra, Daniel Cherqui, Marcelo Silva, Hans Van Vlierberghe, Christophe Duvoux, Filomena Conti, Olivier Scatton, Pierre Henri Bernard, Claire Francoz, Francois Durand, Sébastien Dharancy, Marie-lorraine Woehl, Alexis Laurent, Sylvie Radenne, Jérôme Dumortier, Armand Abergel, Louise Barbier, Pauline Houssel-Debry, Georges Philippe Pageaux, Laurence Chiche, Victor Deledinghen, Jean Hardwigsen, J. Gugenheim, M. Altieri, Marie Noelle Hilleret, Thomas Decaens, Aline Chagas, Paulo Costa, Elaine Cristina de Ataide, Emilio Quiñones, Sebastián Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Alejandro Soza, Martín Padilla Machaca, Diego Arufe, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Ricardo Chong Menéndez, Martín Maraschio, Luis G. Podestá, M. Fauda, A. Gonzalez Campaña, Lucas McCormack, Juan Mattera, Adrian Gadano, Ilka S.F. Fatima Boin, Jose Huygens Parente García, Flair Carrilho, Giulia Magini, Lucia Miglioresi, Martina Gambato, Fabrizio Di Benedetto, Cecilia D’Ambrosio, Alessandro Vitale, Michele Colledan, Domenico Pinelli, Paolo Magistri, Giovanni Vennarecci, Marco Colasanti, Valerio Giannelli, Adriano Pellicelli, Cizia Baccaro, Callebout Eduard, Iesari Samuele, Dekervel Jeroen, Schreiber Jonas, Pirenne Jacques, Verslype Chris, Ysebaert Dirk, Michielsen Peter, Lucidi Valerio, Moreno Christophe, Detry Olivier, Delwaide Jean, Troisi Roberto, and Lerut Jan Paul
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Hepatocellular carcinoma ,Downstaging ,UCSF downstaging protocol ,All-comers ,Alpha-foetoprotein ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Good outcomes after liver transplantation (LT) have been reported after successfully downstaging to Milan criteria in more advanced hepatocellular carcinoma (HCC). We aimed to compare post-LT outcomes in patients receiving locoregional therapies (LRT) before LT according to Milan criteria and University of California San Francisco downstaging (UCSF-DS) protocol and ‘all-comers’. Methods: This multicentre cohort study included patients who received any LRT before LT from Europe and Latin America (2000–2018). We excluded patients with alpha-foetoprotein (AFP) above 1,000 ng/ml. Competing risk regression analysis for HCC recurrence was conducted, estimating subdistribution hazard ratios (SHRs) and corresponding 95% CIs. Results: From 2,441 LT patients, 70.1% received LRT before LT (n = 1,711). Of these, 80.6% were within Milan, 12.0% within UCSF-DS, and 7.4% all-comers. Successful downstaging was achieved in 45.2% (CI 34.8–55.8) and 38.2% (CI 25.4–52.3) of the UCSF-DS group and all-comers, respectively. The risk of recurrence was higher for all-comers (SHR 6.01 [p
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- 2021
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28. De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases
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Alessia Paganelli, Paolo Magistri, Shaniko Kaleci, Johanna Chester, Claudia Pezzini, Barbara Catellani, Silvana Ciardo, Alice Casari, Francesca Giusti, Sara Bassoli, Stefano Di Sandro, Giovanni Pellacani, Francesca Farnetani, and Fabrizio Di Benedetto
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liver transplant ,LTR ,immunosuppression ,skin cancer ,NMSC ,risk factor ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers.
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- 2022
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29. A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise
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Farzaneh Modarresi, Roya Pedram Fatemi, Seyedeh Fatemeh Razavipour, Natalie Ricciardi, Madina Makhmutova, Nathalie Khoury, Marco Magistri, Claude-Henry Volmar, Claes Wahlestedt, and Mohammad Ali Faghihi
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Knockout mouse ,BDNF ,Exercise ,Learning ,Memory ,Antisense RNA ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Brain-derived neurotrophic factor (Bdnf) expression is tightly controlled at the transcriptional and post-transcriptional levels. Previously, we showed that inhibition of noncoding Bdnf antisense (Bdnf-AS) RNA upregulates Bdnf protein. Here, we generated a Bdnf-antisense knockout (Bdnf-AS KO) mouse model by deleting 6 kilobases upstream of Bdnf-AS. After verifying suppression of Bdnf-AS, baseline behavioral tests indicated no significant difference in knockout and wild type mice, except for enhanced cognitive function in the knockout mice in the Y-maze. Following acute involuntary exercise, Bdnf-AS KO mice were re-assessed and a significant increase in Bdnf mRNA and protein were observed. Following long-term involuntary exercise, we observed a significant increase in nonspatial and spatial memory in novel object recognition and Barnes maze tests in young and aged Bdnf-AS KO mice. Our data provides evidence for the beneficial effects of endogenous Bdnf upregulation and the synergistic effect of Bdnf-AS knockout on exercise and memory retention.
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- 2021
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30. Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling
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Xiaoyu Jiang, Xiaoqing Lu, Yu Zhang, Leda Lacaria, Brett J. Schuchardt, David C. Mikles, Marco Magistri, Idoia García-Ramírez, Isidro Sanchez-Garcia, Amjad Farooq, Ramiro E. Verdun, Midhat H. Abdulreda, Vincent T. Moy, and Izidore S. Lossos
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Specialties of internal medicine ,RC581-951 - Abstract
Abstract: Human germinal center (GC)–associated lymphoma (HGAL) is an adaptor protein expressed in GC B cells. HGAL regulates cell motility and B-cell receptor (BCR) signaling, processes that are central for the successful completion of the GC reaction. Herein, we demonstrate phosphorylation of HGAL by Syk and Lyn kinases at tyrosines Y80, Y86, Y106Y107, Y128, and Y148. The HGAL YEN motif (amino acids 107-109) is similar to the phosphopeptide motif pYXN used as a binding site to the growth factor receptor–bound protein 2 (Grb2). We demonstrate by biochemical and molecular methodologies that HGAL directly interacts with Grb2. Concordantly, microscopy studies demonstrate HGAL-Grb2 colocalization in the membrane central supramolecular activation clusters (cSMAC) following BCR activation. Mutation of the HGAL putative binding site to Grb2 abrogates the interaction between these proteins. Further, this HGAL mutant localizes exclusively in the peripheral SMAC and decreases the rate and intensity of BCR accumulation in the cSMAC. Furthermore, we demonstrate that Grb2, HGAL, and Syk interact in the same complex, but Grb2 does not modulate the effects of HGAL on Syk kinase activity. Overall, the interplay between the HGAL and Grb2 regulates the magnitude of BCR signaling and synapse formation.
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- 2019
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31. EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia
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Andrea L. Johnstone, Jiaqi J. O'Reilly, Annika J. Patel, Zhihong Guo, Nadja S. Andrade, Marco Magistri, Lubov Nathanson, Rustam Esanov, Brooke H. Miller, Gustavo Turecki, Shaun P. Brothers, Zane Zeier, and Claes Wahlestedt
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miR-132, EZH1, microRNA ,Epigenetics ,Schizophrenia ,Prefrontal cortex ,Antipsychotics ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: With the capacity to modulate gene networks in an environmentally-sensitive manner, the role of epigenetic systems in mental disorders has come under intense investigation. Dysregulation of epigenetic effectors, including microRNAs and histone-modifying enzymes, may better explain the role of environmental risk factors and the observed heritability rate that cannot be fully attributed to known genetic risk alleles. Here, we aimed to identify novel epigenetic targets of the schizophrenia-associated microRNA 132 (miR-132). Methods: Histone modifications were quantified by immunodetection in response to viral-mediated overexpression of miR-132 while a luminescent reporter system was used to validate targets of miR-132 in vitro. Genome-wide profiling, quantitative PCR and NanoSting were used to quantify gene expression in post-mortem human brains, neuronal cultures and prefrontal cortex (PFC) of mice chronically exposed to antipsychotics. Following viral-mediated depletion of Enhancer of Zeste 1 (EZH1) in the murine PFC, behaviors including sociability and motivation were assessed using a 3-chambered apparatus and forced-swim test, respectively. Results: Overexpression of miR-132 decreased global histone 3 lysine 27 tri-methylation (H3K27me3), a repressive epigenetic mark. Moreover, the polycomb-associated H3K27 methyltransferase, EZH1, is regulated by miR-132 and upregulated in the PFC of schizophrenics. Unlike its homolog EZH2, expression of EZH1 in the murine PFC decreased following chronic exposure to antipsychotics. Viral-mediated depletion of EZH1 in the mouse PFC attenuated sociability, enhanced motivational behaviors, and affected gene expression pathways related to neurotransmission and behavioral phenotypes. Conclusions: EZH1 is dysregulated in schizophrenia, sensitive to antipsychotic medications, and a brain-enriched miR-132 target that controls neurobehavioral phenotypes.
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- 2018
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32. Registration of spatio-temporal point clouds of plants for phenotyping.
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Nived Chebrolu, Federico Magistri, Thomas Läbe, and Cyrill Stachniss
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Medicine ,Science - Abstract
Plant phenotyping is a central task in crop science and plant breeding. It involves measuring plant traits to describe the anatomy and physiology of plants and is used for deriving traits and evaluating plant performance. Traditional methods for phenotyping are often time-consuming operations involving substantial manual labor. The availability of 3D sensor data of plants obtained from laser scanners or modern depth cameras offers the potential to automate several of these phenotyping tasks. This automation can scale up the phenotyping measurements and evaluations that have to be performed to a larger number of plant samples and at a finer spatial and temporal resolution. In this paper, we investigate the problem of registering 3D point clouds of the plants over time and space. This means that we determine correspondences between point clouds of plants taken at different points in time and register them using a new, non-rigid registration approach. This approach has the potential to form the backbone for phenotyping applications aimed at tracking the traits of plants over time. The registration task involves finding data associations between measurements taken at different times while the plants grow and change their appearance, allowing 3D models taken at different points in time to be compared with each other. Registering plants over time is challenging due to its anisotropic growth, changing topology, and non-rigid motion in between the time of the measurements. Thus, we propose a novel approach that first extracts a compact representation of the plant in the form of a skeleton that encodes both topology and semantic information, and then use this skeletal structure to determine correspondences over time and drive the registration process. Through this approach, we can tackle the data association problem for the time-series point cloud data of plants effectively. We tested our approach on different datasets acquired over time and successfully registered the 3D plant point clouds recorded with a laser scanner. We demonstrate that our method allows for developing systems for automated temporal plant-trait analysis by tracking plant traits at an organ level.
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- 2021
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33. Vacuum-assisted management of surgical site infections after liver transplantation: 15-year experience in a tertiary hepatobiliary center
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Magistri, Paolo, Olivieri, Tiziana, Serra, Valentina, Tarantino, Giuseppe, Assirati, Giacomo, Pecchi, Annarita, Ballarin, Roberto, and Di Benedetto, Fabrizio
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- 2019
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34. Physician Attitudes and Perceptions of Complementary and Alternative Medicine (CAM): A Multicentre Italian Study
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Massimiliano Berretta, Luca Rinaldi, Rosaria Taibi, Paolo Tralongo, Alberto Fulvi, Vincenzo Montesarchio, Giordano Madeddu, Paolo Magistri, Sabrina Bimonte, Marco Trovò, Patrizia Gnagnarella, Arturo Cuomo, Marco Cascella, Arben Lleshi, Guglielmo Nasti, Sergio Facchini, Francesco Fiorica, Raffaele Di Francia, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Aurelio Guglielmino, Marco Danova, Sabrina Rossetti, Alfonso Amore, Anna Crispo, and Gaetano Facchini
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complementary medicine ,alternative medicine ,physicians ,cancer ,treatment ,Italian survey ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: Complementary and Alternative Medicine (CAM) interventions are widely used by patients with chronic disorders, including cancer, and may interact with cancer treatment. Physicians are often unaware of this, probably due to poor patient-physician communication on CAM. The purpose of this study was to evaluate physicians' knowledge, attitudes and practice patterns regarding CAM in a survey conducted in Italy.Methods: A questionnaire was administered to 438 physicians (11 Italian hospitals) who predominantly treat patients with chronic disease, to collect personal and professional data and information on attitudes toward CAM and its possible role in Conventional Medicine (CM).Results: Of the 438 participants, most were specialists in oncology (18%), internal medicine (17%), surgery (15%), and radiotherapy (11%). Most worked at university (44%) or research hospitals (31%). Forty-two percent of participants believed that CAM could have an integrative role within CM. Oncologists were the physicians who were best informed on CAM (58%). Physicians working at research institutes or university hospitals had a greater knowledge of CAM than those employed at general hospitals (p < 0.0001), and those who were also involved in research activity had a greater knowledge of CAM than those who were not (p < 0.003). Length of work experience was significantly related to CAM knowledge. Moreover, 55% of participants suggest CAM interventions to their patients and 44% discuss CAM with them. The best-known interventions were acupuncture, Aloe vera and high-dose vitamin C.Conclusion: CAM use by patients with chronic disease and/or cancer has become a topical issue for the scientific community and for physicians. Knowing the reasons that prompt these patients to use CAM and guiding them in their decisions would improve treatment and outcomes and also benefit healthcare systems. Our findings contribute to a greater understanding of CAM knowledge, attitudes, and practice among Italian physicians. Further research is needed to identify the more effective CAM treatments and to work toward an integrated healthcare model.
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- 2020
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35. Recommended vaccinations for asplenic and hyposplenic adult patients
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Paolo Bonanni, Maddalena Grazzini, Giuditta Niccolai, Diana Paolini, Ornella Varone, Alessandro Bartoloni, Filippo Bartalesi, Maria Grazia Santini, Simonetta Baretti, Carlo Bonito, Paola Zini, Maria Teresa Mechi, Fabrizio Niccolini, Lea Magistri, Maria Beatrice Pulci, Sara Boccalini, and Angela Bechini
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asplenic ,hyposplenic ,infectious diseases ,prevention ,recommendations ,splenectomy ,vaccinations ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Asplenic or hyposplenic (AH) individuals are particularly vulnerable to invasive infections caused by encapsulated bacteria. Such infections have often a sudden onset and a fulminant course. Infectious diseases (IDs) incidence in AH subjects can be reduced by preventive measures such as vaccination. The aim of our work is to provide updated recommendations on prevention of infectious diseases in AH adult patients, and to supply a useful and practical tool to healthcare workers for the management of these subjects, in hospital setting and in outpatients consultation. A systematic literature review on evidence based measures for the prevention of IDs in adult AH patients was performed in 2015. Updated recommendations on available vaccines were consequently provided. Vaccinations against S. pneumoniae, N. meningitidis, H. influenzae type b and influenza virus are strongly recommended and should be administered at least 2 weeks before surgery in elective cases or at least 2 weeks after the surgical intervention in emergency cases. In subjects without evidence of immunity, 2 doses of live attenuated vaccines against measles-mumps-rubella and varicella should be administered 4–8 weeks apart from each other; a booster dose of tetanus, diphtheria and pertussis vaccine should be administered also to subjects fully vaccinated, and a 3-dose primary vaccination series is recommended in AH subjects with unknown or incomplete vaccination series (as in healthy people). Evidence based prevention data support the above recommendations to reduce the risk of infection in AH individuals.
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- 2017
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36. First Case of Full Robotic ALPPS for Intrahepatic Cholangiocarcinoma
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Di Benedetto, Fabrizio and Magistri, Paolo
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- 2021
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37. Clean fuels synthesis from green hydrogen: a techno-economic comparative analysis
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Bellotti Daria, Rivarolo Massimo, and Magistri Loredana
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Environmental sciences ,GE1-350 - Abstract
In this paper, two different power-to-fuel solutions for sustainable fuel synthesis are investigated from the energetic, environmental, and economic standpoints. Both the solutions consider a pressurized PEM electrolysis section, fed by renewable sources, where high purity green Hydrogen is produced. Then, two separate processes are investigated for the synthesis of two distinct chemicals. In the first case, the hydrogen is mixed with CO2, sequestered by an industrial plant, and captured a carbon capture system (CCS): the two gases are sent to a pressurized reactor for methanol synthesis. In the second case, the hydrogen is mixed with N2, obtained from an industrial air separation unit (ASU), and sent to a reactor for ammonia synthesis. Both the synthesis processes are performed at high pressures and temperatures, thus a thermodynamic analysis is mandatory in order to calculate the overall efficiencies. In both cases, the power to fuel plants are investigated also in economic terms. Methanol synthesis presents a slightly higher efficiency compared to ammonia, while the two solutions are very similar from the economic standpoint. The sale of the co-produced oxygen allows for an improvement in economic terms for both cases and can be a key point in order to reach economic sustainability, together with the expected reduction in PEM electrolysers capital cost.
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- 2021
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38. Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome
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J. Hsiao, T.Y. Yuan, M.S. Tsai, C.Y. Lu, Y.C. Lin, M.L. Lee, S.W. Lin, F.C. Chang, H. Liu Pimentel, C. Olive, C. Coito, G. Shen, M. Young, T. Thorne, M. Lawrence, M. Magistri, M.A. Faghihi, O. Khorkova, and C. Wahlestedt
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Dravet syndrome ,SCN1A ,Long non-coding RNA ,Natural antisense transcript ,AntagoNAT ,Oligonucleotide-based compound ,Medicine ,Medicine (General) ,R5-920 - Abstract
Dravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-function mutation in the voltage-gated sodium channel gene SCN1A. There are currently no treatments, but the upregulation of SCN1A healthy allele represents an appealing therapeutic strategy. In this study we identified a novel, evolutionary conserved mechanism controlling the expression of SCN1A that is mediated by an antisense non-coding RNA (SCN1ANAT). Using oligonucleotide-based compounds (AntagoNATs) targeting SCN1ANAT we were able to induce specific upregulation of SCN1A both in vitro and in vivo, in the brain of Dravet knock-in mouse model and a non-human primate. AntagoNAT-mediated upregulation of Scn1a in postnatal Dravet mice led to significant improvements in seizure phenotype and excitability of hippocampal interneurons. These results further elucidate the pathophysiology of Dravet syndrome and outline a possible new approach for the treatment of this and other genetic disorders with similar etiology.
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- 2016
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39. Integrated Planar Solid Oxide Fuel Cell: Steady-State Model of a Bundle and Validation through Single Tube Experimental Data
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Paola Costamagna, Simone Grosso, Rowland Travis, and Loredana Magistri
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integrated planar solid oxide fuel cell (IP-SOFC) ,electrochemical reaction ,heat and mass transport ,modelling ,model validation ,Technology - Abstract
This work focuses on a steady-state model developed for an integrated planar solid oxide fuel cell (IP-SOFC) bundle. In this geometry, several single IP-SOFCs are deposited on a tube and electrically connected in series through interconnections. Then, several tubes are coupled to one another to form a full-sized bundle. A previously-developed and validated electrochemical model is the basis for the development of the tube model, taking into account in detail the presence of active cells, interconnections and dead areas. Mass and energy balance equations are written for the IP-SOFC tube, in the classical form adopted for chemical reactors. Based on the single tube model, a bundle model is developed. Model validation is presented based on single tube current-voltage (I-V) experimental data obtained in a wide range of experimental conditions, i.e., at different temperatures and for different H2/CO/CO2/CH4/H2O/N2 mixtures as the fuel feedstock. The error of the simulation results versus I-V experimental data is less than 1% in most cases, and it grows to a value of 8% only in one case, which is discussed in detail. Finally, we report model predictions of the current density distribution and temperature distribution in a bundle, the latter being a key aspect in view of the mechanical integrity of the IP-SOFC structure.
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- 2015
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40. SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
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Paolo Magistri, Cecilia Battistelli, Raffaele Strippoli, Niccolò Petrucciani, Teijo Pellinen, Lucia Rossi, Livia Mangogna, Paolo Aurello, Francesco D'Angelo, Marco Tripodi, Giovanni Ramacciato, and Giuseppe Nigri
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colon cancer ,hedgehog pathway ,SMO inhibition ,EMT ,cell plasticity ,cell invasiveness ,Therapeutics. Pharmacology ,RM1-950 - Abstract
HIGHLIGHTSPreliminary results of this work were presented at the 2016 Academic Surgical Congress, Jacksonville (FL), February 2–4 2016 (Original title: Selective Smo-Inhibition Interferes With Cellular Energetic Metabolism In Colorectal Cancer)This study was funded by “Sapienza—University of Rome” (Funds for young researchers) and “AIRC” (Italian Association for Cancer Research)Hedgehog inhibitor was kindly provided by Genentech, Inc.®.Colon Cancer (CC) is the fourth most frequently diagnosed tumor and the second leading cause of death in the USA. Abnormalities of Hedgehog pathway have been demonstrated in several types of human cancers, however the role of Hedgehog (Hh) in CC remain controversial. In this study, we analyzed the association between increased mRNA expression of GLI1 and GLI2, two Hh target genes, and CC survival and recurrence by gene expression microarray from a cohort of 382 CC patients. We found that patients with increased expression of GLI1 showed a statistically significant reduction in survival. In order to demonstrate a causal role of Hh pathway activation in the pathogenesis of CC, we treated HCT 116, SW480 and SW620 CC cells lines with GDC-0449, a pharmacological inhibitor of Smoothened (SMO). Treatment with GDC-0449 markedly reduced expression of Hh target genes GLI1, PTCH1, HIP1, MUC5AC, thus indicating that this pathway is constitutively active in CC cell lines. Moreover, GDC-0449 partially reduced cell proliferation, which was associated with upregulation of p21 and downregulation of CycD1. Finally, treatment with the same drug reduced migration and three-dimensional invasion, which were associated with downregulation of Snail1, the EMT master gene, and with induction of the epithelial markers Cytokeratin-18 and E-cadherin. These results were confirmed by SMO genetic silencing. Notably, treatment with 5E1, a Sonic Hedgehog-specific mAb, markedly reduced the expression of Hedgehog target genes, as well as inhibited cell proliferation and mediated reversion toward an epithelial phenotype. This suggests the existence of a Hedgehog autocrine signaling loop affecting cell plasticity and fostering cell proliferation and migration/invasion in CC cell lines. These discoveries encourage future investigations to better characterize the role of Hedgehog in cellular plasticity and invasion during the different steps of CC pathogenesis.
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- 2018
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41. Hepatitis delta virus (hdv) replication through hbv integrants in hcc recurrence after liver transplantation.
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Di Marco, L., De Maria, N., Pivetti, A., Colecchia, A., Romanzi, A., Spallanzani, A., Guaraldi, G., Dolci, G., Ciusa, G., Di Benedetto, F., Magistri, P., Di Sandro, S., Degasperi, E., Anolli, M.P., Lampertico, P., Giosa, D., Lombardo, D., Raimondo, G., and Pollicino, T.
- Abstract
A PWID man, HCV/HBV-HDV/HIV-infected, underwent liver transplantation (LT) for HCC in 2012 at the age of 52 years. HCC tissue showed high HDV-RNA (88,400 copies/cell), low total HBV-DNA (0.00001 c/c), and HBVcccDNA0.00008 c/c), without detectable HBV-RNA. High-throughput HBV integration sequencing (HBIS) identified 657 HBV integration sites.HBV integrants were predominantly represented by HBx gene sequences. After LT, Tacrolimus, Bictegravir/Emtricitabine/TAF, and anti-HBs immunoglobulin were administered, yielding HBsAg, HDV-RNA, and HCV-RNA negativity. In 2018, HBsAg reversion was observed with undetectable HBV-DNA and HDV-RNA >19,000 c/ml. In 2019, HDV-related hepatitis occurred. Intrahepatic HBcAg, HBsAgHBV DNA, HBVcccDNA, and HBV-RNA were undetectable. HDV RNA concentrations were very high in the liver (3,920,000 c/c) but low in the serum (214 IU/mL). CT scan (CTs) suspected an isolated HCC recurrence in the left adrenal gland, confirmed by adrenalectomy. Real-time PCR in the tumor from the adrenal gland revealed high levels of HDV RNA (5.5 c/c) but low levels of HBV DNA (0.00009 c/c) and HBVcccDNA (0.00001 c/c). HBV RNA was undetectable. HBIS identified 3497 HBV integrations, most of which included HBs gene sequences. After adrenalectomy, HBsAg and HDV-RNA became undetectable. Anti-HBs immunoglobulin was continued with Everolimus. In 2021, CTs showed two HCC nodules in the liver and one in the right adrenal gland. TACE was performed, and TKI therapy was started. In 2023, new HDV hepatitis occurred, with HDV-RNA>3,631,360 UI/ml and HBV-DNA <10UI/ml. For the progression of HCC, RFA on the right adrenal gland was performed, and Bulevirtide was started. After 3 months, HDV-RNA was 48,638 c/ml, and transaminases were normal. This case demonstrates HDV replication in extrahepatic HCC recurrence, despite low levels of HBVcccDNA. The decreased HDV RNA levels after RFA and BLV therapy suggest that HCC metastases may serve as HBsAg production sites following HBV integration. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Robotic right colectomy: A worthwhile procedure? Results of a meta-analysis of trials comparing robotic versus laparoscopic right colectomy
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Niccolή Petrucciani, Dario Sirimarco, Giuseppe R Nigri, Paolo Magistri, Marco La Torre, Paolo Aurello, Francesco D′Angelo, and Giovanni Ramacciato
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Colon ,colorectal ,laparoscopic ,right colectomy ,robotic ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Robotic right colectomy (RRC) is a complex procedure, offered to selected patients at institutions highly experienced with the procedure. It is still not clear if this approach is worthwhile in enhancing patient recovery and reducing post-operative complications, compared with laparoscopic right colectomy (LRC). Literature is still fragmented and no meta-analyses have been conducted to compare the two procedures. This work aims at reducing this gap in literature, in order to draw some preliminary conclusions on the differences and similarities between RRC and LRC, focusing on short-term outcomes. Materials and Methods: A systematic literature review was conducted to identify studies comparing RRC and LRC, and meta-analysis was performed using a random-effects model. Peri-operative outcomes (e.g., morbidity, mortality, anastomotic leakage rates, blood loss, operative time) constituted the study end points. Results: Six studies, including 168 patients undergoing RRC and 348 patients undergoing LRC were considered as suitable. The patients in the two groups were similar with respect to sex, body mass index, presence of malignant disease, previous abdominal surgery, and different with respect to age and American Society of Anesthesiologists score. There were no statistically significant differences between RRC and LRC regarding estimated blood loss, rate of conversion to open surgery, number of retrieved lymph nodes, development of anastomotic leakage and other complications, overall morbidity, rates of reoperation, overall mortality, hospital stays. RRC resulted in significantly longer operative time. Conclusions: The RRC procedure is feasible, safe, and effective in selected patients. However, operative times are longer comparing to LRC and no advantages in peri-operative and post-operative outcomes are demonstrated with the use of the robotic surgical system.
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- 2015
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43. Liver transplantation for iatrogenic injuries secondary to cholecystectomy: a systematic review.
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Guidetti, Cristiano, Pang, Ning Q., Catellani, Barbara, Magistri, Paolo, Caracciolo, Daniela, Guerrini, Gian P., Pecchi, Annarita, Di Sandro, Stefano, and Di Benedetto, Fabrizio
- Abstract
Introduction: Iatrogenic injury to the liver hilum during cholecystectomy is a severe surgical complication, with liver transplantation (LT) as the final drastic solution. The authors report the experience of our center and conduct a review of the literature on the outcomes of LT performed in this setting. Methods: Data sources included MEDLINE, EMBASE, and CENTRAL from inception to 19 June 2022. Studies reporting on patients treated with LT for liver hilar injuries following cholecystectomy were included. Incidence, clinical outcomes, and survival data were synthesized through a narrative review. Results: Twenty-seven articles were identified, including 213 patients. Eleven (40.7%) articles highlighted deaths within 90-days post-LT. Post-LT mortality was reported in 28 (13.1%) patients. Severe complications (≥Clavien III) occurred in at least 25.8% (n =55) of patients. Within larger cohorts, 1-year overall survival (OS) was 76.5-84.3%, and 5-year OS was 67.2-83.0%. The authors also highlight our own experience managing 14 patients with liver hilar injury secondary to cholecystectomy, of which two required LT. Conclusion: While short-term morbidity and mortality is significant, available long-term data suggests reasonable OS in these patients following LT. Future studies are necessary to better understand the relationship between different types of liver hilar injury, transplant indication, and outcomes of LT in this setting. [ABSTRACT FROM AUTHOR]
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- 2023
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44. Design and development of a laboratory for the study of PEMFC system for marine applications
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Borgogna Gerardo, Speranza Enrico, Lamberti Thomas, Nicola Traverso Alberto, Magistri Loredana, Gadducci Eleonora, Massardo Aristide Fausto, and Olivieri Paolo
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Environmental sciences ,GE1-350 - Abstract
Climate change is driving the introduction of strict emission limits in the shipping sector favoring the introduction of alternative fuels, among which hydrogen. While the storage energy density of this energy vector is a key challenge that makes way to a variety of different solutions, from fossil fuel reformers to sodium borohydride systems, fuel cell systems are generally considered among the future ideal energy converters. Nevertheless very few fuel cell marine applications are available worldwide, none of them is related to a ship application, mainly because of the high power requirements. Fuel cells are relatively new in the shipping sector, up to now no civil industrial system has been commercialized yet while military applications rely only on the U212 submarine of the Italian and German Navy. The lack of favorable niche markets coupled with the strong conservative and traditional design principles held back the investment for optimized marine systems. For this reason, present and past projects made use of conveniently adapted automotive technologies into pilot demos, with particular focus on Proton Exchange Membrane Fuel Cell (PEMFC). However, ships requirements are largely different from automotive ones, not only for the power size that are in the range of MWs instead of kWs. On the other side, in order to take advantage of large scale production as well as of the modularity of fuel cell technology, the integrations of automotive or stationary based fuel cell subsystems, already available on the market, inside a dedicate modular marine system seems to be the solution pursued by many shipbuilders and contemplated by regulatory authorities. In hybrid system configurations, fuel cells are considered in combinations with batteries, another important technology under development, in order to take advantage of the superior energy performances of fuel cell systems and the highly power discharge dynamics of batteries. The need of fuel cell power systems for ships is pushing towards the creation of knowledge that requires laboratories able to challenge the abovementioned issues in order to give answers to shipbuilders and at a lower level also to rule makers.
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- 2019
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45. Thermodynamic and economic analysis of a plant for the CO2 hydrogenation for methanol production
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Bellotti Daria, Dierks Matthias, Moellenbruck Florian, Magistri Loredana, Görner Klaus, and Oeljeklaus Gerd
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Environmental sciences ,GE1-350 - Abstract
A major goal of politics, society, and industry is the reduction of carbon dioxide (CO2) emissions in order to prevent anthropogenic climate change and an increase in earth’s temperature. In addition, the expansion of renewable energies and the use of nuclear power, CO2 capturing (e.g. from exhaust gases), is regarded as a promising strategy to reduce global CO2 emissions. In this context, the Power-to-X technologies can provide an innovative energy storage concept by combining the main trends of energy systems aiming at high shares of renewable energies, reduction of CO2 emissions and sector coupling. A promising approach is the production of methanol as a chemical raw material or fuel. The goal of this paper is to present (i) an extensive thermodynamic analysis for the methanol production from carbon dioxide and hydrogen and (ii) an economic analysis for the process based on the thermodynamic studies. The thermodynamic analysis was carried out in the simulation tool Aspen Plus™ in order to investigate the impact of the operating temperature and pressure on the performance of the synthesis unit. Based on the thermodynamic results, an economic analysis has been performed in order to define the most feasible solution. For a defined optimal operating temperature, the fixed and operating costs and the methanol production cost were evaluated for different operating pressures. Finally, a sensitivity analysis has been performed in order to define the minimum methanol selling price that allows for a payback period of 10 years for different values of the electrical energy purchasing price.
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- 2019
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46. Control Strategies for solar façade panels coupled with a Heat Pump and interacting with a District Heating Network
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Rattazzi D., Rossi I., Magistri L., and Erich S.J.F.
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District Heating Network ,Control Strategy ,Predictive Control. ,Environmental sciences ,GE1-350 - Abstract
This work aims to understand the potential of an innovative technology for solar energy harvesting in a District Heating Network (DHN). The considered technology is aesthetic solar façade thermal panel. In order to guarantee the temperatures required by a 3rd generation DHN (around 75°C), a Heat Pump, using as cold source the heat from the panels, is necessary. It is worth noting that the coupling between façade panels and Heat Pump requires accurate evaluations. The optimum condition for the façade panels is to work at low temperatures (close to ambient or even below), while the Heat Pump reaches high Coefficient Of Performance (COP) when the temperature difference between hot and cold sources is minimized. In the first part of the study, a system model has been built using Matlab SIMULINK using results of tests on the panels already performed inside the H2020 ENVISION project. Different colours are considered. In the second part, a predictive mode-based strategy has been defined and tuned on the system in order to guarantee the best system performances in interaction with the DHN. This work will allow to understand whether this technology is feasible in the presented scenario and this layout can improve local energy exchange.
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- 2019
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47. A design tool for the performances comparison of innovative energy systems for naval applications
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Rattazzi D., Rivarolo M., Lamberti T., and Magistri L.
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Environmental sciences ,GE1-350 - Abstract
This paper aims to develop a tool for the performances comparison of innovative energy systems on board ships, both for concentrated and distributed generation applications. In the first part of the study, the tool database has been developed throughout a wide analysis of the available market solutions in terms of energy generation devices (i.e. fuel cells, internal combustion engines, micro gas turbines), fuels (hydrogen, natural gas, diesel) and related storage technologies. Many of these data have been collected also thanks to the laboratory experience of the authors’ research group on different innovative energy systems. From the database, a wide range of maps has been created, correlating costs, volumes, weights and emissions with the installed power and the operational hours required, given by the user as input. The tool highlights the best solution according to the different relevance chosen by the user for each key parameter (i.e. costs, volumes, emissions). In the second part, two different case studies are presented in order to underline how the installed power, the different ship typology and the user requirements affect the choice of the best solution. It is worth noting that the methodology has a general value, as the tool can be applied to both the design of new ships, and to the retrofit of already existing ships in order to respect new requirements (e.g. more and more stringent normative in terms of pollutant emissions in ports and restricted areas). Furthermore, the database can be easily extended to other generation and storage technologies.
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- 2019
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48. Techno-economic analysis for the assessment of heat pump integration in a real poly-generative energy district
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Barberis Stefano, Robello Paola, Rattazzi Diego, Rivarolo Massimo, Bellotti Daria, and Magistri Loredana
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Environmental sciences ,GE1-350 - Abstract
The present research study aims at analysing technical and economic feasible solutions for heat pumps integration in energy districts for polygeneration purpose and particularly to store excess of electricity via Power-to-heat schemes considering that, from previous researchers’ works, thermal storage has been identified as the most remunerative and easy to handle storage technology to maximise self-consumption in polygeneration grids. This technology is already developed and currently employed for conditioning of residential, commercial and industrial buildings. However, studies regarding the analysis of heat pumps’ integration in energy districts for distributed generation are still limited. The potential advantages of its employment in this context are fuel savings, a lower emission level and the possibility to couple it with local renewable energy sources (i.e. solar panels, wind turbines) and traditional generators (i.e. engines, micro gas turbines) in order to increase flexibility in operational terms. In this paper, a performance analysis of the poly-generation energy district installed at the University of Genoa Campus, located in Savona, is analysed throughout a whole year: the model is implemented using a dedicated software tool, developed by Thermochemical Power Group. Different solutions for the integration of the heat pump, including size optimization, are investigated, considering the real data related to the University of Genoa Campus: the final aim of the analysis is to determinate the best operational strategy, minimizing variable costs (i.e. fuel) and evaluating the economic feasibility of heat pump installation in the energy district. This work has been also redacted as a preliminary analysis for solar-coupled HP integration (from a optimized management point of view) to be performed in the demonstration campaign of H2020 ENVISION Project*, where both RINA Consulting and University of Genova collaborate.
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- 2019
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49. Oncological Impact of M-Tor Inhibitor Immunosuppressive Therapy after Liver Transplantation for Hepatocellular Carcinoma: Review of the Literature
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Giuseppe Tarantino, Paolo Magistri, Roberto Ballarin, Raffaele Di Francia, Massimiliano Berretta, and Fabrizio Di Benedetto
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Liver Transplantation ,HCC ,Hepatocellular Carcinoma ,mTOR ,Everolimus ,temsirolimus ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Hepatocellular Carcinoma (HCC) represents the fifth most common malignancy and the third cancer-related cause of death worldwide. Hepatitis B (HBV) and C (HCV) viral infections and alcohol abuse are the principal etiological factors for HCC. Liver transplantation (LT) is oncologically the preferable approach to HCC, as it can remove all the intrahepatic tumor foci, and also the oncogenic cirrhotic liver. The use of mTOR inhibitors (mTORi) for immunosuppression after LT for HCC has been proposed due to rapamycin antitumor activity. We decided to review the literature to clarify the oncological role of mTORi after liver transplantation for HCC, analyzing both present condition and future perspectives.Material and Methods: A systematic literature search was performed using PubMed, EMBASE, Scopus and the Cochrane Library Central. The search was limited to studies in humans and to those reported in the English language in the period of time between January 2005 and December 2015. Results: The literature search yielded 93 articles; after duplicates were removed, 77 titles and abstracts were reviewed. Most relevant data and papers are herein reported and discussed.Conclusions: So far, the use of mTORi is encouraging in terms of oncological outcomes for patients underwent LT for HCC, both for prevention and treatment of HCC recurrence although definitive data are still awaited.
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- 2016
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50. Log Odds of Positive Lymph Nodes (LODDS): What Are Their Role in the Prognostic Assessment of Gastric Adenocarcinoma?
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Aurello, Paolo, Petrucciani, Niccolò, Nigri, Giuseppe R., La Torre, Marco, Magistri, Paolo, Tierno, Simone, D’Angelo, Francesco, and Ramacciato, Giovanni
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- 2014
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