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The structure of "Si-liquid film-Si" was constructed by simulating the semi-solid structure of high-silicon Al alloys, and the effects of temperature and thickness on the stress–strain characteristics of Al–Si eutectic liquid film were studied to reveal the hot cracking process of high-silicon Al alloys. [ABSTRACT FROM AUTHOR]

Compared with traditional portland cementitious material, alkali-activated material (AAM) had the advantages of low carbon emission, energy saving, excellent durability, strength, and high temperature resistance. It has been proved that the addition of a fiber or nano-particle could improve the mechanical properties of AAM. The fresh and hardened properties of nano-CaCO3 (NCC) and polypropylene fiber (PPF) reinforced AAM were studied in this paper. The hybrid effects of PPF with various volume fractions (0%, 4%, and 8%), aspect ratios (0–464.52), and NCC with various content (0%, 1%, and 2%) on the slump spread, flow rate, flexural strength, compressive strength, and ultrasonic velocity of AAM were investigated. For flowability, the mixture with 0.4% 6 mm and 0.4% 12 mm PPF was the optimal, showing a positive hybrid effect. The hybrid use of PPF and NCC significantly improved the flexural strength, but the compressive strength was not significantly improved. The hybrid effect factors for compressive strength were lower than those for flexural strength. The positive hybrid effect of strength was most obvious when the nano-CaCO3 was 1%. The threshold for fiber factors was 200. Microstructure studies showed that the bridging effect of PPFs can limit the crack development and enhance the strength of AAM. Nano-CaCO3 promoted the denseness of AAM and bond between fiber and matrix. The hybrid of PPF in different lengths and NCC could decrease fiber consumption, reducing the cost and promoting the engineering application of fiber-reinforced AAMs. The effect of hybridization of calcium carbonate nano-particles with polypropylene fibers on the fresh and hardening properties of alkali-activated materials has practical applications in the construction industry. One of its main advantages is its excellent flowability, which allows the material to be self-consolidating. This property allows it to be used effectively in areas such as post-tensioned grouting, pipe concrete, and other grouting processes, where the material flows effortlessly and fills voids efficiently. In addition, the mixing effect of the CaCO3 -nano-particles and the polypropylene fibers enhances the stability and strength of the material, which further enhances the durability and structural stability of the concrete elements. Overall, this blend has excellent flow and self-consolidation properties, making it an important choice for applications such as postgrouting and reinforced concrete construction. [ABSTRACT FROM AUTHOR]

Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid tumor ablation, which holds great hope for the refractory and recurrent cancers, such as triple negative breast cancer (TNBC). The clinical translation of hafnium oxide (HfO2), commercially named as NBTXR3, has aroused new research focus on single‐component inorganic nanomedicines as clinical candidates. Herein, the single‐component MnWO4 is first reported as a new kind of Fenton‐like agent yet radiosensitizer for TNBC treatment undergoing the synergistic CDT/RT mechanism. MnWO4 nanorods are synthesized via a simple one‐pot hydrothermal method and then undergo a layer‐by‐layer PEGylation to obtain bioavailable MnWO4‐PEG (MWP). MWP‐based Fenton‐like reaction efficacy depends on reaction time, temperatures, pH values, and MWP concentrations. Mn‐triggered chemodynamic effect delays RT‐induced DNA damage repair and sorts cell cycles distribution toward radiosensitive phases, while W‐mediated radiosensitization improves the tumoral H2O2 overexpression to enhance CDT, remarkably amplifying of the intracellular oxidative stress to boost 4T1 cell apoptosis. In vitro and in vivo evaluations further demonstrate the effectiveness and biosafety of MWP‐based synergistic therapy. Considering the potential magnetic resonance and computed tomography imaging capabilities, MWP can be expected as an intelligent cancer theranostics for imaging‐guided cancer therapy in clinic in the future. [ABSTRACT FROM AUTHOR]

With the gradual development of OLED display, the industry's requirements for display quality are getting higher and higher. Among them, crosstalk (H) is an important indicator to evaluate display quality. In research, crosstalk (H) has been greatly improved by adjusting the parasitic capacitance between driving transistor gate and scan signal (Cs2_vg). The results show that the crosstalk (H) value of Low Temperature Polycrystalline Oxide (LTPO) products can be reduced from 1.72% to 1.11% at 120Hz refresh frequency, also does not worsen other display effects after all optical inspection. [ABSTRACT FROM AUTHOR]

Based on a large number of measured data of line crosstalk, this paper focuses on the analysis of the mechanism of line crosstalk of single ram and dual ram products under the Empyrean circuit level simulation software, and verifies the relevant conclusions through simulation. By studying the causes of line crosstalk, various measures to improve this problem are put forward. [ABSTRACT FROM AUTHOR]

In this study, a novel driving circuit which could extend scan pulse width was proposed and integrated into AMOLED panel. Each scan circuit in gate‐in‐panel region contains four groups of clock signals, while the pixel circuit in active area incorporates dual data line design, in combination with a 1:4 demux circuit in the down border. The measured just noticeable difference values of short‐term and medium‐term image sticking were decreased by more than 25% in LTPS AMOLED modules. This work offers a feasible and effective method to improve the image quality in future flexible AMOLED displays. [ABSTRACT FROM AUTHOR]

Our research found that there are some low‐brightness application scenarios in the process of using the mobile phone. The smart interface option of the mobile phone is called "dark scene mode/dark color mode". Under this mode, the brightness of the mobile phone is adjusted to the lowest level, the background interface is black, the font displayed is white or the color with gray scale. When read a novel or drag the phone interface, the white text displayed on the screen is dimmer and the color is changed, which is called "Motion blur". In the research process, we compared the TFT device of low‐temperature poly‐silicon with that OLED device of organic light‐emitting material. The research results showed that under low brightness, Motion blurred has been showed different response states when OLED material or its related process parameters has been changed.while the TFT device of low‐temperature poly‐silicon only responded under the condition of high brightness. When brightness decreases, there is a weak correlation between the effects on Motion blurs [ABSTRACT FROM AUTHOR]

Steel-fiber-reinforced recycled coarse aggregate concrete (SFRCAC) has great potential for use in structural members due to environmental and economic reasons. A comparison of SF's reinforcing effect on the strength of RCAC with natural recycled coarse aggregate concrete (NCAC) was conducted through experiments and analysis. Three types of steel fiber—milling (MF), shear-wave (SWF), and both-end hooked (BF)—were used. The SF volume fraction ( V f ) was taken as 0, 0.5%, 1.0%, 1.5%, and 2%. The results show that SF has a similar reinforcing effect on NCAC and RCAC. The reinforcing effect of SF on the strength of RCAC is relevant to the strength of the RCAC matrix. The suitable content range of SF is from 0.5% to 1.5% in terms of the reinforcement effects on the compressive strength ( f fcu ) and splitting tensile strength ( f fts ) of RCAC. SF with a higher aspect ratio (AR) has a better reinforcing effect on the splitting tensile strength ( f fts ) and flexural strength ( f ftm ) of RCAC. The equations of f fts / f ts and f ftm / f tm with the characteristic parameters of steel fiber ( λ f ) were put forward to accurately determine the dosage of SF. [ABSTRACT FROM AUTHOR]

The building sector is responsible for approximately 40% of global energy consumption and carbon emissions, making it a key area of focus in addressing the urgent global challenge of climate change and in achieving the 1.5-degree target. This study concentrated on building decarbonization, using bibliometric and network visualization analyses based on a dataset of 2494 publications retrieved from the Web of Science up to 25 June 2023. Findings revealed a rapid growth in publications, with China being the largest contributor (approximately 31%). Notably, the journals of Cleaner Production and Applied Energy emerged as the most influential journal in this field. Although leadership teams and authors have gained prominence, cross-national collaboration and communication among them remain limited. Furthermore, an analysis of keywords and co-citations revealed that the main research themes and hotspots encompass "energy", "life cycle assessment", "storage", and related "models" and decarbonization "strategies". As the field progresses, a clear trend toward multidisciplinary integration and diversified research directions and content was observed. Researchers can further concentrate their efforts on countries with historically limited research but substantial emissions, and enhance international collaboration and interdisciplinary integration. Overall, this study offers valuable insights for researchers and facilitates future investigations in the field of building decarbonization. [ABSTRACT FROM AUTHOR]

In this study, fresh lotus leaves at two maturity stages were processed to tea products by different methods (white-tea process, green-tea process and black-tea process). The volatile compounds, phytochemical profiles and antioxidant activities of lotus-leaf tea were investigated. A total of 81 volatile components were identified with HS-GC-IMS. The mature lotus-leaf tea showed more volatile compounds than the tender lotus-leaf tea. The lotus leaf treated with the white-tea process had more aroma components than other processing methods. In addition, six types of phenolic compounds, including luteolin, catechin, quercetin, orientin, hyperoside and rutin were identified in the lotus-leaf tea. The mature leaves treated with the green-tea process had the highest levels of TPC (49.97 mg gallic acid/g tea) and TFC (73.43 mg rutin/g tea). The aqueous extract of lotus-leaf tea showed positive scavenging capacities of DPPH and ABTS radicals, and ferric ion reducing power, whereas tender lotus leaf treated with the green-tea process exhibited the strongest antioxidant activity. What is more, the antioxidant activities had a significant positive correlation with the levels of TPC and TFC in lotus-leaf tea. Our results provide a theoretical basis for the manufacture of lotus-leaf-tea products with desirable flavor and health benefits. [ABSTRACT FROM AUTHOR]

A model of Trusted Measurement supporting behavior measurement based on trusted connection architecture (TCA) with three entities and three levels is proposed, and a frame to illustrate the model is given. The model synthesizes three trusted measurement dimensions including trusted identity, trusted status and trusted behavior, satisfies the essential requirements of trusted measurement, and unified the TCA with three entities and three levels.

The effects of three types of polysaccharides (dextrin, β‐cyclodextrin, and maltodextrin) used as carriers at various levels (1%, 3%, and 5%) on the physicochemical and antioxidant properties of freeze‐dried mulberry powders (MP) were investigated. The types and levels of carriers influenced moisture, solubility, total anthocyanin contents, and color profiles of MP. The MP produced with 5% of β‐cyclodextrin (MP‐C) and 5% of maltodextrin (MP‐M) were found to have the highest solubility, retention ratio of anthocyanins, and color values among all the MP samples. The addition of β‐cyclodextrin and maltodextrin decreased the particle size due to the increase of the spherical shape and the smooth surface. The MP‐C and MP‐M were found to show positive scavenging capacities on ABTS+ and DPPH radicals. Our results indicated that β‐cyclodextrin and maltodextrin had the potential to be used as a carrier agent to produce freeze‐dried mulberry powders. Novelty impact statement: The types and levels of polysaccharide carriers influenced the physicochemical properties of mulberry powders.Mulberry powders produced with β‐cyclodextrin and maltodextrin showed valuable physicochemical characteristics.Mulberry powders had potential scavenging activities on ABTS+ and DPPH radicals. [ABSTRACT FROM AUTHOR]

Approximately 90% of the cholesterol content of the body is derived from de novo synthesis and the enterohepatic circulation. As numerous studies have shown previously, one egg per day intake has little impact of cholesterol balance in human body. Therefore, this study assumed that intake of up two eggs a day has little effect on biomarkers of cardiovascular diseases (CVDs) risk in Chinese young adults. With the increase in egg intake, total cholesterol, low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and choline all increased among all the groups as the study progressed from autumn to winter (p <.05). However, there were no differences in the plasma triglycerides, LDL‐C/HDL‐C ratio, glucose, liver enzymes, C‐reactive protein, and urinary microalbumin during the diet periods. Subjects who ate eggs at breakfast felt less hungry and more satisfied, which were relative with decreased fasting plasma ghrelin level (p <.05). Furthermore, egg‐derived cholesterol appeared to upregulate the mRNA levels of low‐density lipoprotein receptor and lecithin–cholesterol acyltransferase, and downregulate cholesteryl ester transfer protein and flavin‐containing monooxygenase 3 mRNA levels in isolated peripheral blood mononuclear cells. These results demonstrate that intake of up to two eggs a day had little effect on biomarkers of CVDs in young, healthy Chinese college students and provided useful evidence for the dietary guidelines regarding egg consumption. [ABSTRACT FROM AUTHOR]

The firefighting IoT platform links multiple firefighting subsystems. The data of each subsystem belongs to the sensitive data of the profession. Failure prediction is a crucial topic for firefighting IoT platforms, because failures may cause equipment injuries. Currently, in the maintenance of fire IoT terminal equipment, fault prediction based on equipment time series has not been included. The use of intelligent technology to continuously predict the failure of firefighting IoT equipment can not only eliminate the intervention of regular maintenance but also provide early warning of upcoming failures. In order to solve this problem, we propose a vertical federated learning framework based on LSTM fault classification network (LstFcFedLear). The advantage of this framework is that it can encrypt and integrate the data on the entire firefighting IoT platform to form a new dataset. After the synthesized data is trained through each model, the optimal model parameters can be finally updated. At the same time, it can ensure that the data of each business system is not leaked. The framework can predict when IoT equipment will fail in the future and then provide what measures should be used. The experimental results show that the LstFcFedLear model provides an effective method for fault prediction, and its results are comparable to the baseline. [ABSTRACT FROM AUTHOR]

Because the genomic information of lingonberry (Vaccinium vitis-idaea L.) is not available, the mechanism underlying the flavonoid metabolism in the fruits of this species is still unknown. The objective of this study was to obtain a comprehensive transcriptome assembly during lingonberry fruit development and characterize the key genes associated with the flavonoid metabolism in lingonberry. Our transcriptome data of lingonberry was obtained with next-generation sequencing technology. The expression patterns of key genes were analysed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The results showed that the total flavonoid content and the total anthocyanin content gradually increased during the lingonberry fruit development process. In total, about 169 million sequencing raw reads were obtained and de novo assembled into 67,836 unigenes, and 38,460 unigenes had been annotated from public databases. The average size of unigenes was 1040 nt, and the N50 value was 1718 nt. Among the unigenes mapped to KEGG pathways, 2697 (10.95%) were assigned to the category of 'Biosynthesis of secondary metabolites', 1533 unigenes were predicted to be associated with flavonoid biosynthesis, transport and regulation. We also found 10,022 candidate genes expressed differentially between green and white fruits, with 5335 differentially expressed genes uncovered between white and red fruits and 14,364 ones between green and red fruits. A comprehensive transcriptome assembly of lingonberry was generated, with data representing gene expression profiles throughout fruit development and ripening processes in lingonberry. Our results provide further insights into the molecular mechanisms of flavonoid metabolism. [ABSTRACT FROM AUTHOR]

The Hengshan massif is an exhumed, mid-crustal, plutonic–metamorphic dome formed during Cretaceous crustal extension in the Jiangnan orogenic belt, central South China. Multiple thermochronometers (mica 40 Ar/ 39 Ar, apatite fission track and zircon (U–Th)/He) are applied to its footwall along a slip-parallel transect to quantify its thermal history and cooling rate, and the slip magnitude, rate, initial geometry and kinematic evolution of the low-angle Hengshan detachment fault. Our thermochronological data, in conjunction with previous ages, indicate that (1) footwall rocks cooled from ~ 700 °C to ~ 60 °C in less than 60 Myr (136–80 Ma) at variable rates ranging from ~ 50 °C/Myr to ~ 13 °C/Myr, (2) the Hengshan detachment fault accommodated ~ 8–12 km of total slip at variable slip rates from 0.14 to 1 mm/yr during tectonic exhumation, (3) the footwall has been tilted ~ 26°–50° to the east since slip began, indicating that the low-angle Hengshan detachment fault initiated at a steep dip and was passively rotated to a more gentle orientation during subsequent normal slip. This study provides compelling evidence supporting that the low-angle detachment fault in the extensional dome can be generated by the reactivation and passive rotation of an initially steep reverse fault during normal slip. In addition, our thermochronological data constrain the time of extension in the Hengshan dome between 136 and 80 Ma, which implies that the back-arc extension within South China associated with the rollback of the Paleo-Pacific slab might have lasted until at least 80 Ma. [ABSTRACT FROM AUTHOR]

• Coupling link of urbanization (UR) and real estate market (REM) is studied as systems. • To build a coordinated growth simulation model of UR and REM using system dynamics. • To predict future evolution trends of UR and REM and propose predictive measures. Urbanization (UR) and the real estate market (REM) are closely related to the improvement of human living quality. However, there are fewer simulation studies on the future coordinated development path of UR and REM. Thus, this paper takes Chongqing, China as an example, and considers UR and REM as systems, where the former is divided into demographic, economic, spatial, and social UR, and the latter contains investment, supply, demand, and price. This study estimates the coordinated development links between UR and REM in 2001–2019 utilizing a VAR model and a coupling coordination evaluation model, and simulates the coordinated development path of both in 2020–2030 using system dynamics. Specifically, natural continuation type (NCT), urbanization priority type (UPT), real estate priority type (REPT), and coordinated development type (CDT) are installed using system dynamics. The results reveal that (1) the coordinated development level between UR and REM improves from serious imbalance in 2001 to good coordination in 2019; (2) the sequences of target variables under four scenarios are disparate; (3) the sequence of comprehensive development index regarding UR and REM in 2020–2030 is NCT > CDT > UPT > REPT, and CDT > REPT > UP ≈ NCT, respectively; (4) the order of coordinated development degree of both in 2020–2030 is CDT > REPT > NCT > UPT, i.e., the first-best development path is CDT. The study provides insights and methods for other Chinese inland cities or developing countries with increasing REM. [ABSTRACT FROM AUTHOR]

Widespread Cretaceous volcanic basins are common in eastern South China and are crucial to understanding how the Circum-Pacific and Tethyan plate boundaries evolved and interacted with one another in controlling the tectonic evolution of South China. Lithostratigraphic units in these basins are grouped, in ascending order, into the Early Cretaceous volcanic suite (K1V), the Yongkang Group (K1-2), and the Jinqu Group (K2). SHRIMP U-Pb zircon geochronological results indicate that (1) the Early Cretaceous volcanic suite (K1V) erupted at 136–129 Ma, (2) the Yongkang Group (K1-2) was deposited from 129 Ma to 91 Ma, and (3) the deposition of the Jinqu Group (K2) post-dated 91 Ma. Structural analyses of fault-slip data from these rock units delineate a four-stage tectonic evolution of the basins during Cretaceous to Palaeogene time. The first stage (Early to middle Cretaceous time, 136–91 Ma) was dominated by NW–SE extension, as manifested by voluminous volcanism, initial opening of NE-trending basins, and deposition of the Yongkang Group. This extension was followed during Late Cretaceous time by NW–SE compression that inverted previous rift basins. During the third stage in Late Cretaceous time, possibly since 78.5 Ma, the tectonic stress changed to N–S extension, which led to basin opening and deposition of the Jinqu Group along E-trending faults. This extension probably lasted until early Palaeogene time and was terminated by the latest NE–SW compressional deformation that caused basin inversion again. Geodynamically, the NW–SE-oriented stress fields were associated with plate kinematics along the Circum-Pacific plate boundary, and the extension–compression alternation is interpreted as resulting from variations of the subducted slab dynamics. A drastic change in the tectonic stress field from NW–SE to N–S implies that the Pacific subduction-dominated back-arc extension and shortening were completed in the Late Cretaceous, and simultaneously, that Neo-Tethyan subduction became dominant and exerted a new force on South China. The ongoing Neo-Tethyan subduction might provide plausible geodynamic interpretations for the Late Cretaceous N–S extension-dominated basin rifting, and the subsequent Cenozoic India–Asia collision might explain the early Palaeogene NE–SW compression-dominated basin inversion. [ABSTRACT FROM PUBLISHER]

Due to large energy consumption and carbon emissions (ECCE) in the building sector, there is huge potential for carbon emission reduction, and this will strongly influence peak carbon emissions and carbon neutrality in the future. To get a better sense of the current research situation and future trends and to provide a valuable reference and guidance for subsequent research, this study presents a summary of carbon peak and carbon neutrality (CPCN) in buildings using a bibliometric approach. Three areas are addressed in the review through the analysis of 364 articles published from 1990–2021: (1) Which countries, institutions, and individuals have conducted extensive and in-depth research on CPCN in buildings, and what is the status quo of their collaboration and contributions? (2) What subjects and topics have aroused wide interest and enthusiasm among scholars, and what are their time trajectories? (3) What journals and authors have grabbed the attention of many scholars, and what are the research directions related to them? Moreover, we propose future research directions. Filling these gaps will enrich the research body of CPCN and overcome current limitations by developing more methods and exploring other practical applications. [ABSTRACT FROM AUTHOR]

A timely analysis for carbon emission reduction in buildings is an effective global response to the crisis of climate change. The logarithmic mean Divisia index (LMDI) decomposition analysis approach has been extensively used to assess the carbon emission reduction potential of the buildings sector. In order to simplify the calculation process and to expand its application scope, a new open-source Python tool (PyLMDI) developed in this article is used to compute the results of LMDI decomposition analysis, including multiplicative and additive decomposition. Users can quickly obtain the decomposition result by initializing the input data through a simple class data structure. In addition, the carbon emissions from commercial buildings are used as a numerical example to demonstrate the function of PyLMDI. In summary, PyLMDI is a potential calculation tool for index decomposition analysis that can provide calculation guidance for carbon emission reduction in the buildings sector. The data and codes for the numerical example are also included. [ABSTRACT FROM AUTHOR]

The rapid growth of energy consumption in commercial building operations has hindered the pace of carbon emission reduction in the building sector in China. This study used historical data to model the carbon emissions of commercial building operations, the LASSO regression was applied to estimate the model results, and the whale optimization algorithm was used to optimize the nonlinear parameter. The key findings show the following: (1) The major driving forces of carbon emissions from commercial buildings in China were found to be the population size and energy intensity of carbon emissions, and their elastic coefficients were 0.6346 and 0.2487, respectively. (2) The peak emissions of the commercial building sector were 1264.81 MtCO2, and the peak year was estimated to be 2030. Overall, this study analyzed the historical emission reduction levels and prospective peaks of carbon emissions from China's commercial buildings from a new perspective. The research results are helpful for governments and decision makers to formulate effective emission reduction policies and can also provide references for the low-carbon development of other countries and regions. [ABSTRACT FROM AUTHOR]

Carbon neutrality has positive impacts on people, nature and the economy, and buildings represent the "last mile" sector in the transition to carbon neutrality. Carbon neutrality is characterized by the decarbonization of operations and maintenance, in addition to zero emissions in electricity and other industry sectors. Taking China's commercial buildings as an example, this study is the first to perform an extensive data analysis for a step-wise carbon neutral roadmap of building operations via the analysis of a dynamic emission scenario. The results reveal that the carbon emissions abatement of commercial building operations from 2001 to 2018 was 1460.85 (±574.61) mega-tons of carbon dioxide (Mt CO2). The carbon emissions of commercial building operations will peak in the year 2039 (±5) at 1364.31 (±258.70) Mt, with emission factors and energy intensity being the main factors influencing the carbon peak. To move toward carbon neutral status, an additional 169.73 Mt CO2 needs to be cut by 2060, and the low emission path toward carbon neutrality will lead to the realization of the carbon peak of commercial buildings in 2024, with total emissions of 921.71 Mt. It is believed that cutting emissions from the operation of buildings in China will require a multi-sectoral synergistic strategy. It is suggested that government, residents, enterprises, and other stakeholders must better appreciate the challenges to achieve a substantial carbon reduction and the need for urgent action in the building sector in order to achieve carbon neutrality. [ABSTRACT FROM AUTHOR]

Long non-coding RNAs (lncRNAs) were reported to be involved in tumorigenesis and progression of hepatocellular carcinoma (HCC). Microvascular invasion (MVI) is an independent predictor for early recurrence and overall survival in postoperative patients with HCC. However, the mechanisms how lncRNAs affect HCC and MVI remain elusive. By RNA sequencing (RNA-seq) in a series of 65 HCC samples and 30 paired adjacent non-tumor liver tissue, we identified a novel lncRNA AC104958.2 that was significantly upregulated in HCC tissues and associated with MVI. Overexpression of AC104958.2 obviously elevated cell viability, metastasis, invasion and epithelial-mesenchymal transition (EMT), while knockout of AC104958.2 mediated by CRISPR/Cas9 technique showed the opposite effects. In addition, the interaction between AC104958.2 and Poly (rC) binding protein 2 (PCBP2) was identified by RNA pull down and mass spectrometry (MS), which was further validated by RNA immunoprecipitation (RIP). PCBP2 was also upregulated in HCC and associated with MVI. High expression of both AC104958.2 and PCBP2 was correlated with tumor size, TNM stage and MVI in HCC. Overexpression of PCBP2 greatly increased the cell viability, metastasis, invasion and EMT. Moreover, actinomycin D assay showed that overexpression of PCBP2 enhanced the RNA stability of AC104958.2. In conclusion, our study showed that a novel lncRNA AC104958.2 exerted oncogenic roles in HCC and might be a promising biomarker and therapeutic target. • AC104958.2 is a novel lncRNA identified to be upregulated in HCC tissues and associated with MVI. • Knockout of AC104958.2 inhibited cell proliferation, invasion, migration and EMT. • AC104958.2 interacted with PCBP2. • PCBP2 was upregulated in HCC and enhanced the RNA stability of AC104958.2. [ABSTRACT FROM AUTHOR]

Lotus seed epicarp, the main by-product of lotus seed processing, is abundant in polyphenols. In this study, polyphenols in lotus seed epicarp were separated by Sephadex LH-20 gel filtration chromatography to yield Fraction-I (F-I), Fraction-II (F-II), and Fraction-III (F-III). The polyphenol compounds in the three fractions were identified by UPLC-MI-TOF-MS. Six kinds of polyphenol compounds including cyanidin-3-O-glucoside, procyanidin trimer, and phlorizin were identified in F-I, and prodelphinidin dimer B, procyanidin dimer, and quercetin hexoside isomer were found in F-II. However, there was only procyanidin dimer identified in F-III. The in vitro antioxidant activities of the three fractions were also investigated. We found F-I, F-II, and F-III had strong potential antioxidant activities in the order of F-III > F-II > F-I. Our results suggested that polyphenols from lotus seed epicarp might be suitable for use as a potential food additive. [ABSTRACT FROM AUTHOR]

Rapid urbanization has brought huge development dividends to China. At the same time, its negative effects have aroused people's attention. For example, a large amount of cultivated land has been occupied for urban expansion and construction. Using exploratory spatial data analysis (ESDA) and the spatial Durbin model (SDM), we analyzed the spatial distribution of cultivated land occupation for construction (CLOC) and its driving factors in 31 provinces in China from 2005 to 2016. The results indicated that (1) the CLOC rate presented a significant spatial clustering feature, and its distribution showed a new trend of "homogenization" after the year 2012; (2) as the core driving factor, the population urbanization rate significantly promoted the growth of the CLOC rate in the local province, while showing a negative effect on that rate in the neighboring provinces; (3) in addition, behind the new trend of the CLOC rate, there was a transformation from being "investment driven" to being "population and industry driven". Therefore, this paper suggests that the government should link each city's construction land supply to the constantly changing trend of population migrations in China. Further, promoting the tertiary industry can be a win–win strategy for easing the tension between cultivated land and construction land. [ABSTRACT FROM AUTHOR]

With the gradual slowdown of economic growth in China, the Chinese government proposed the task of supply-side reform. As a vital part of China's economy, supply-side reform in the real estate market is particularly important. Using 29 provinces (divided into seven regions) in China as examples, this paper empirically studies the supply-side efficiency of China's real estate market using data envelopment analysis (DEA) for the period of 2012–2016. The results showed that (1) the main problem of low supply-side efficiency in the Chinese real estate market is the low land-use efficiency, with a redundancy rate of 60.59% in China's land space pending development; and (2) China's southeastern coastal region, with the highest supply-side efficiency in the real estate market, reached a level of decreasing returns, and it is no longer appropriate to increase the supply-side efficiency by expanding the market scale. However, the southwestern region and the Yangtze River's middle region, which both have lower supply-side efficiency, can improve the land utilization ratio and technology investment to change the current situations. The study results suggest (1) improving the construction land development efficiency by adjusting the input and output of the market according to the specific conditions of each city, and (2) promoting the supply-side reform of China's real estate market and sustainable urbanization. [ABSTRACT FROM AUTHOR]