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Sera from 31 of 146 patients with cystic fibrosis (CF) contained levels of serum alkaline phosphatase (AP) which were elevated by age-related criteria. Prominent liver isoenzyme bands were present after polyacrylamide gel electrophoresis of all 31 abnormal sera. larger than normal amounts of bone and intestinal AP were not present in these sera. These findings indicate that liver abnormalities consistently are responsible for elevations of total AP in sera of patients with CF. Several causes of high liver A? levels in CF patients were identified: chronic hepatic congestion, drug hepatosoxiclty, overt biliary cirrhosis, and most commonly subclinical focal biliary cirrhosis. [ABSTRACT FROM AUTHOR]

Measurements of the water content of the air in a "mist tent" revealed only .026 to .029 gm of water per liter of air in jet-type tents and .044 to .075 gm of water per liter of air in ultrasonic tents. Forty-one cystic fibrosis patients who showed persistent pulmonary function test evidence of hyperinflation and airway obstruction despite intensive, comprehensive home therapy, including the use of a jet-type mist tent, were studied after two pre-substitution control periods, after 1 month in an ultrasonic mist tent, and then 1 month and 4 months after return to the jet-type tent. During the 1 month in the ultrasonic mist tent significant changes in the direction of improvement were observed in all parameters of pulmonary function studied. Reversal of these changes was observed 1 month after return to the jet-type tent. These results provide objective evidence of the value of "mist tent" therapy in the treatment of the obstructive pulmonary lesion of cystic fibrosis and of the effectiveness of the ultrasonic nebulizer, at least for the short-term treatment of patients with advanced pulmonary disease. Pediatrics, 41:723, 1968, PANCREATIC CYSTIC FIBROSIS, RESPIRATORY FUNCTION TESTS. RESPIRATORY TRACT DISEASES--THERAPY, INHALATION THERAPY, MUST TENT THERAPY. [ABSTRACT FROM AUTHOR]

Comments on the efficacy of mist tent therapy in treatment of patients with cystic fibrosis. Distinction with humidification; Aim of nebulization therapy; Information on the physical principles governing the deposition of particulate material in the lung.

Examines the use of a heparin lock in the intermittent administration of intravenous drugs. Treatment of overwhelming bacteremias and other bacterial infections such as osteomyelitis, meningitis and endocarditis; Absence of a complication in the use of intravenous therapy.