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We present two unusual cases of microvascular thrombosis in the immediate posttransplant period resulting in graft loss. The first was a 20-year-old female with a cadaveric renal transplant with immediate graft dysfunction due to microthrombi of probable donor origin, with nonrecovery of renal function nine months’ posttransplant. The second was a 23-year-old male with unrelated live kidney transplant with hyperacute rejection due to anti-endothelial antibodies.

Background: Vacuum assisted closure is procedure to aid in improved wound healing. This negative pressure wound therapy can be used in cases of both acute and chronic wounds. Objectives: To find out pattern of wound healing while using vacuum assisted closure for healing chronic non healing ulcers. Materials and methods: It was a prospective study conducted among patients admitted to the Department of General Surgery. Participant included had chronic non healing ulcer due to various etiologies. The study period was from October 2021 to December 2021. 50 participants were enrolled into the study. The data was compiled and analyzed using SPSS version 26. Results: The wound healing was better after day 3. There was significant positive change in wound healing with P value of less than 0.05 over the follow up period. No other factor was found to influence wound healing. Conclusion: Vacuum assisted closure would enhance wound healing among those suffering from chronic non-healing ulcer. [ABSTRACT FROM AUTHOR]