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2. Phase I trial of metastatic renal cell carcinoma with oral capecitabine and thalidomide

Author

Brossart, Peter, Müller, Stefan C., Gorschlüter, Marcus, Kim, Young, Hauser, Stefan, Kraemer, Anja, and Schmidt-Wolf, Ingo G. H.

Subjects
metastasized renal cell carcinoma, 5-FU, thalidomide, phase I trial, Medicine
Abstract

Background: The highly vascular nature of renal carcinoma cells suggests that inhibition of angiogenesis may be beneficial in this disease. Thalidomide has been described as inhibitor of the fibroblast growth factor (FGF) and the vascular endothelial growth factor (VEGF). Therefore and in consideration of the promising response rates of the combination of IL-2, IFN-alpha and 5-FU [1] in metastatic renal cancer, we found it reasonable to test the combination of 5-FU and thalidomide. Thus, we conducted a phase I trial to determine safety, side effects and responses to such a treatment. Methods: Patients with metastasized renal cell cancer after nephrectomy and progress after IL-2 and interferon treatment, received oral 5-FU at a dose of 1250 mg/qm2 twice a day for two weeks, then after pausing a week, the oral application was restarted. In addition, oral thalidomide was applied constantly at a maximum dose of 400 mg/d. The combined therapy was given for three months. The primary endpoint was duration until disease progression, the secondary endpoint the response to treatment. Response was determined by CT scans three months after the end of treatment. Results: In total, 12 male patients participated in the trial and received the combined oral therapy. Concerning clinical response, one mixed response (8%), a stable disease in 4/12 patients (33%) and progression was seen in 7 patients (58%). The survival from the start of the therapy showed a median of 21 months with three patients being alive. At present, the longest survival after the therapy is 51 months. Conclusions: The combination of oral 5-FU and thalidomide showed clinical response with tolerable side effects. Further studies will be required to assess the outcome of this treatment regimen.

Published
2009

7. Effect of Hospital and Surgeon Case Volume on Perioperative Quality of Care and Short-term Outcomes After Radical Cystectomy for Muscle-invasive Bladder Cancer: Results From a European Tertiary Care Center Cohort

Author

Bartsch, Georg, Brookman-May, Sabine, Buchner, Alexander, Durschnabel, Melanie, Ellinger, Jörg, Froehner, Michael, Georgieva, Galia, Gördük, Murat, Grimm, Marc-Oliver, Hadaschik, Boris, Haferkamp, Axel, Hakenberg, Oliver W., Hartmann, Florian, Herrmann, Edwin, Hertle, Lothar, Hohenfellner, Markus, Janetschek, Georg, Kraischits, Nicole, Krausse, Annerose, Lusuardi, Lukas, Michel, Maurice S., Moritz, Rudolf, Müller, Stefan C., Novotny, Vladimir, Nuhn, Philipp, Pahernik, Sascha, Palisaar, Rein-Jüri, Ponholzer, Anton, Protzel, Chris, Roigas, Jan, Schmid, Marianne, Schramek, Paul, Seitz, Christian, Sikic, Danijel, Stief, Christian G., Syring, Isabella, Vallo, Stefan, Wagenlehner, Florian M., Weidner, Wolfgang, Wirth, Manfred P., Vetterlein, Malte W., Meyer, Christian P., Leyh-Bannurah, Sami-Ramzi, Mayr, Roman, Gierth, Michael, Fritsche, Hans-Martin, Burger, Maximilian, Keck, Bastian, Wullich, Bernd, Martini, Thomas, Bolenz, Christian, Pycha, Armin, Hanske, Julian, Roghmann, Florian, Noldus, Joachim, Bastian, Patrick J., Gilfrich, Christian, May, Matthias, Rink, Michael, Chun, Felix K.-H., Dahlem, Roland, Fisch, Margit, and Aziz, Atiqullah

Published
2017
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9. The Use of Neoadjuvant Chemotherapy in Patients With Urothelial Carcinoma of the Bladder: Current Practice Among Clinicians

Author

Martini, Thomas, Gilfrich, Christian, Mayr, Roman, Burger, Maximilian, Pycha, Armin, Aziz, Atiqullah, Gierth, Michael, Stief, Christian G., Müller, Stefan C., Wagenlehner, Florian, Roigas, Jan, Hakenberg, Oliver W., Roghmann, Florian, Nuhn, Philipp, Wirth, Manfred, Novotny, Vladimir, Hadaschik, Boris, Grimm, Marc-Oliver, Schramek, Paul, Haferkamp, Axel, Colleselli, Daniela, Kloss, Birgit, Herrmann, Edwin, Fisch, Margit, May, Matthias, and Bolenz, Christian

Published
2017
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11. Harnableitungen mit oder ohne simple Zystektomie in der Salvage-Therapie benigner Erkrankungen des unteren Harntraktes.

Author

Lutz, Malin A., Le, Quynh Chi, Müller, Matthias, Müller, Stefan C., Rosenbaum, Clemens M., Vetterlein, Malte W., and Kluth, Luis A.

Subjects
CYSTECTOMY, URINARY fistula, URINARY diversion, URINARY organs, URINARY organ diseases, SALVAGE therapy, BLADDER diseases, MEDICAL needs assessment
Abstract

Copyright of Die Urologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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16. A matched-pair analysis on survival and response rates between German and non-German cancer patients treated at a Comprehensive Cancer Center

Author

Budde, Marie K., Kuhn, Walther, Keyver-Paik, Mignon-Denise, Bootz, Friedrich, Kalff, Jörg C., Müller, Stefan C., Bieber, Thomas, Brossart, Peter, Vatter, Hartmut, Herrlinger, Ulrich, Wirtz, Dieter C., Schild, Hans H., Kristiansen, Glen, Pietsch, Thorsten, Aretz, Stefan, Geiser, Franziska, Radbruch, Lukas, Reich, Rudolf H., Strassburg, Christian P., Skowasch, Dirk, Essler, Markus, Ernstmann, Nicole, Landsberg, Jennifer, Funke, Benjamin, and Schmidt-Wolf, Ingo G. H.

Published
2019
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17. Prostate Cancer Unit Initiative in Europe: A position paper by the European School of Oncology

Author

Valdagni, Riccardo, Van Poppel, Hendrik, Aitchison, Michael, Albers, Peter, Berthold, Dominik, Bossi, Alberto, Brausi, Maurizio, Denis, Louis, Drudge-Coates, Lawrence, De Santis, Maria, Feick, Günther, Harrison, Chris, Haustermans, Karin, Hollywood, Donal, Hoyer, Morton, Hummel, Henk, Mason, Malcolm, Mirone, Vincenzo, Müller, Stefan C., Parker, Chris, Saghatchian, Mahasti, Sternberg, Cora N., Tombal, Bertrand, van Muilekom, Erik, Watson, Maggie, Wesselmann, Simone, Wiegel, Thomas, Magnani, Tiziana, and Costa, Alberto

Published
2015
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19. Comprehensive Evaluation of Prostate Specific Membrane Antigen Expression in the Vasculature of Renal Tumors: Implications for Imaging Studies and Prognostic Role

Author

Spatz, Sophia, Tolkach, Yuri, Jung, Klaus, Stephan, Carsten, Busch, Jonas, Ralla, Bernhard, Rabien, Anja, Feldmann, Georg, Brossart, Peter, Bundschuh, Ralph A., Ahmadzadehfar, Hojjat, Essler, Markus, Toma, Marieta, Müller, Stefan C., Ellinger, Jörg, Hauser, Stefan, and Kristiansen, Glen

Published
2018
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21. Zig-zag structures in silver dichromate precipitate.

Author

Carvalho, Débora, Müller, Stefan C., Rahne, Torsten, Tsuji, Kinko, and Polezhaev, Andrey

Subjects
*PRECIPITATION (Chemistry), *SILVER
Abstract

Precipitation patterns are commonly concentric rings forming in a Petri dish or parallel bands appearing in a test tube (Liesegang phenomenon). The rings frequently consist of a number of convex segments that are separated from each other by spaces devoid of precipitate resulting in small gaps (dislocations). Along these gaps, the so-called zig-zag structures can form, which connect one side of a gap with its opposite side. We observe that the occurrence of zig-zags requires a minimum thickness of the reactive layer (≥ 0.8 mm). This fact together with microscopic evidence indicates their three-dimensional character. One finds that at the very beginning of the precipitation reaction a curling process starts in the corresponding contour lines. These observations suggest structures of a helicoid with the axis perpendicular to the plane of the reaction–diffusion front to pass through the layer. Zig-zags are not parallel to the reaction plane, i.e., they are not formed periodically, but evolve continuously as a rotating spiral wave. Thus, their topology is closely related to helices in a test tube. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta

Author

Aziz, Atiqullah, Gierth, Michael, Rink, Michael, Schmid, Marianne, Chun, Felix K., Dahlem, Roland, Roghmann, Florian, Palisaar, Rein-Jüri, Noldus, Joachim, Ellinger, Jörg, Müller, Stefan C., Pycha, Armin, Martini, Thomas, Bolenz, Christian, Moritz, Rudolf, Herrmann, Edwin, Keck, Bastian, Wullich, Bernd, Mayr, Roman, Fritsche, Hans-Martin, Burger, Maximilian, Bastian, Patrick J., Seitz, Christian, Brookman-May, Sabine, Xylinas, Evanguelos, Shariat, Shahrokh F., Fisch, Margit, May, Matthias, and the PROMETRICS 2011 Research Group

Published
2015
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25. Gender-specific differences in cancer-specific survival after radical cystectomy for patients with urothelial carcinoma of the urinary bladder in pathologic tumor stage T4a

Author

May, Matthias, Bastian, Patrick J., Brookman-May, Sabine, Fritsche, Hans-Martin, Tilki, Derya, Otto, Wolfgang, Bolenz, Christian, Gilfrich, Christian, Trojan, Lutz, Herrmann, Edwin, Moritz, Rudolf, Tiemann, Arne, Müller, Stefan C., Ellinger, Jörg, Buchner, Alexander, Stief, Christian G., Wieland, Wolf F., Höfner, Thomas, Hohenfellner, Markus, Haferkamp, Axel, Roigas, Jan, Zacharias, Mario, Nuhn, Philipp, and Burger, Maximilian

Published
2013
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28. Analysis of Sex Differences in Cancer-Specific Survival and Perioperative Mortality Following Radical Cystectomy: Results of a Large German Multicenter Study of Nearly 2500 Patients with Urothelial Carcinoma of the Bladder

Author

Otto, Wolfgang, May, Matthias, Fritsche, Hans-Martin, Dragun, Duska, Aziz, Atiqullah, Gierth, Michael, Trojan, Lutz, Herrmann, Edwin, Moritz, Rudolf, Ellinger, Jörg, Tilki, Derya, Buchner, Alexander, Höfner, Thomas, Brookman-May, Sabine, Nuhn, Philipp, Gilfrich, Christian, Roigas, Jan, Zacharias, Mario, Denzinger, Stefan, Hohenfellner, Markus, Haferkamp, Axel, Müller, Stefan C., Kocot, Arkadius, Riedmiller, Hubertus, Wieland, Wolf F., Stief, Christian G., Bastian, Patrick J., and Burger, Maximilian

Published
2012
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30. External Validation of a Risk Model to Predict Recurrence-Free Survival After Radical Cystectomy in Patients With Pathological Tumor Stage T3N0 Urothelial Carcinoma of the Bladder

Author

May, Matthias, Bastian, Patrick J., Brookman-May, Sabine, Fritsche, Hans-Martin, Bolenz, Christian, Gilfrich, Christian, Otto, Wolfgang, Trojan, Lutz, Herrmann, Edwin, Müller, Stefan C., Ellinger, Jörg, Buchner, Alexander, Stief, Christian G., Tilki, Derya, Wieland, Wolf F., Hohenfellner, Markus, Haferkamp, Axel, Roigas, Jan, Zacharias, Mario, Nuhn, Philipp, and Burger, Maximilian

Published
2012
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36. MP58-16 PREDICTION OF CANCER-SPECIFIC SURVIVAL IN PATIENTS WITH RADICAL CYSTECTOMY FOR BLADDER CANCER USING ARTIFICIAL NEURAL NETWORKS

Author

Nuhn, Philipp, Aziz, Atiqullah, May, Matthias, Staehler, Michael, Gierth, Michael, Ellinger, Jörg, Müller, Stefan C., Wagenlehner, Florian, Weidner, Wolfgang, Moritz, Rudolf, Herrmann, Edwin, Hartmann, Florian, Grimm, Marc-Oliver, Protzel, Chris, Hakenberg, Oliver, Lusuardi, Lukas, Janetschek, Günter, Gördük, Murat, Roigas, Jan, Burger, Maximilian, Fisch, Margit, Stief, Christian G., Bastian, Patrick, Grimm, Tobias, and Buchner, Alexander

Published
2015
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38. p53 Predictive Value for pT1-2 N0 Disease at Radical Cystectomy

Author

Shariat, Shahrokh F., Lotan, Yair, Karakiewicz, Pierre I., Ashfaq, Raheela, Isbarn, Hendrik, Fradet, Yves, Bastian, Patrick J., Nielsen, Matthew E., Capitanio, Umberto, Jeldres, Claudio, Montorsi, Francesco, Müller, Stefan C., Karam, Jose A., Heukamp, Lukas C., Netto, George, Lerner, Seth P., Sagalowsky, Arthur I., and Cote, Richard J.

Published
2009
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41. Chemical Waves

Author

Ross, John, Müller, Stefan C., and Vidal, Christian

Published
1988

46. Association Between the Number of Dissected Lymph Nodes During Pelvic Lymphadenectomy and Cancer-Specific Survival in Patients with Lymph Node–Negative Urothelial Carcinoma of the Bladder Undergoing Radical Cystectomy

Author

May, Matthias, Herrmann, Edwin, Bolenz, Christian, Brookman-May, Sabine, Tiemann, Arne, Moritz, Rudolf, Fritsche, Hans-Martin, Burger, Maximilian, Trojan, Lutz, Michel, Maurice S., Wülfing, Christian, Müller, Stefan C., Ellinger, Jörg, Buchner, Alexander, Stief, Christian G., Tilki, Derya, Wieland, Wolf F., Gilfrich, Christian, Höfner, Thomas, Hohenfellner, Markus, Haferkamp, Axel, Roigas, Jan, Zacharias, Mario, and Bastian, Patrick J.

Published
2011
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