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7. Cancer risk in living kidney donors

Author

Engels, Eric A., Fraser, Gary E., Kasiske, Bertram L., Snyder, Jon J., Utt, Jason, Lynch, Charles F., Li, Jie, Pawlish, Karen S., Brown, Sandra, Yu, Kelly J., and Pfeiffer, Ruth M.

Published
2022
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9. Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators.

Author

Dennis, Leslie K., Langston, Marvin E., Beane Freeman, Laura, Canales, Robert A., and Lynch, Charles F.

Subjects
NUCLEAR activation analysis, TRACE elements, TOENAILS, ARSENIC, AGRICULTURE, PROSTATE cancer
Abstract

Prostate cancer is a common cancer among males in the US, but little is known about its risk factors, including trace elements. The primary aim of this study was to examine prostate cancer and its association with arsenic and selenium in toenails. We conducted a small, nested case-control study of men residing in Iowa within the Agricultural Health Study cohort, where we also collected toenail samples to test for arsenic and other trace elements. Toenail samples were sent for neutron activation analysis aimed at long-lived trace elements, including arsenic. Logistic regression was used to estimate odds ratios (ORs) for trace element exposures and prostate cancer. A total of 66 prostate cancer cases and 173 healthy controls returned questionnaires, over 99% of which included toenail samples. An increased risk was seen for the highest levels of arsenic (OR = 3.4 confidence interval (CI) of 1.3–8.6 and OR = 2.2, 95% CI of 0.9–5.6) and the highest level of selenium (2.0, 95% CI of 1.0–4.0). These data also show detectable levels of over 50% for 14 of 22 elements detected in the toenails. The association seen here with arsenic and prostate cancer further supports ecological studies finding an association with community levels of arsenic and prostate cancer incidence and mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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10. NCI SEER-Linked Virtual Tissue Repository Pilot.

Author

Sanchez, Pamela, Dyke, Alison L Van, Petkov, Valentina I, Yuan, Yao, Bonds, Sarah, Valenzuela, Connor, Tuan, Alyssa W, Moravec, Radim, Altekruse, Sean F, Singhi, Aatur D, Serdy, Kate M, Wu, Yun, Cress, Rosemary D, Doherty, Jennifer A, Mueller, Lloyd, Hernandez, Brenda Y, Lynch, Charles F, Tucker, Thomas C, Wu, Xiao-Cheng, and Matrisian, Lynn

Published
2024
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13. Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer: The WECARE Study

Author

Bernstein, Jonine L., Capanu, Marinela, Orlow, Irene, Robson, Mark, Olsen, Jørgen H., Malone, Kathleen E., Stovall, Marilyn, Blackmore, Kristina, Harris, Irene, Langballe, Rikke, O’Brien, Cecilia, Weathers, Rita, West, Michele, Hunter, Lisa, Goldstein, Judy, Ramos, Elaine, Carlson, Lauren E., Watt, Gordon P., Tonorezos, Emily S., Chow, Eric J., Yu, Anthony F., Woods, Meghan, Lynch, Charles F., John, Esther M., Mellemkjӕr, Lene, Brooks, Jennifer D., Knight, Julia A., Reiner, Anne S., Liang, Xiaolin, Smith, Susan A., Bernstein, Leslie, Dauer, Lawrence T., Cerviño, Laura I., Howell, Rebecca M., Shore, Roy E., and Boice, John D., Jr.

Published
2021
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16. Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research

Author

Yuan, Yao, Van Dyke, Alison L., Petkov, Valentina I., Hussey, Sarah, Moravec, Radim, Altekruse, Sean F., Sandoval, Mayra, Cress, Rosemary D., Mueller, Lloyd M., Mogi, Alan, Hernandez, Brenda Y., Selk, Freda R., Lynch, Charles F., Tucker, Thomas C., Lynch, Mary Anne, Lefante, Christina, Wu, Xiao-Cheng, Sweeney, Carol, Doherty, Jennifer A., and Penberthy, Lynne S.

Subjects
Oncology, Experimental -- Equipment and supplies, Pathological laboratories -- Laws, regulations and rules, Cancer -- Research, Diagnostic specimens -- Laws, regulations and rules -- Management, Government regulation, Company business management, Health
Abstract

* Context.--The Surveillance, Epidemiology, and End Results (SEER) cancer registry program is currently evaluating the use of archival, diagnostic, formalin-fixed, paraffin-embedded (FFPE) tissue obtained through SEER cancer registries, functioning as honest brokers for deidentified tissue and associated data. To determine the feasibility of this potential program, laboratory policies for sharing tissue for research needed to be assessed. Objective.--To understand the willingness of pathology laboratories to share archival diagnostic tissue for cancer research and related policies. Design.--Seven SEER registries administered a 27-item questionnaire to pathology laboratories within their respective registry catchment areas. Only laboratories that processed diagnostic FFPE specimens and completed the questionnaire were included in the analysis. Results.--Of the 153 responding laboratories, 127 (83%) responded that they process FFPE specimens. Most (n = 88; 69%) were willing to share tissue specimens for research, which was not associated with the number of blocks processed per year by the laboratories. Most laboratories retained the specimens for at least 10 years. Institutional regulatory policies on sharing deidentified tissue varied considerably, ranging from requiring a full Institutional Review Board review to considering such use exempt from Institutional Review Board review, and 43% (55 of 127) of the laboratories did not know their terms for sharing tissue for research. Conclusions.--This project indicated a general willingness of pathology laboratories to participate in research by sharing FFPE tissue. Given the variability of research policies across laboratories, it is critical for each SEER registry to work with laboratories in their catchment area to understand such policies and state legislation regulating tissue retention and guardianship. doi: 10.5858/arpa.2019-0474-OA, With the rise of personalized medicine for cancer treatment, there is an increasing demand to profile molecular features of tumors. (1) Not only is the procedure for acquiring fresh tumor [...]

Published
2021
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17. A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study

Author

Bernstein, Jonine L., Brooks, Jennifer D., Boice, John D., Jr., Shore, Roy E., Reiner, Anne S., Smith, Susan A., Bernstein, Leslie, Knight, Julia A., Lynch, Charles F., John, Esther M., Malone, Kathleen E., Mellemkjaer, Lene, Langballe, Rikke, Liang, Xiaolin, Woods, Meghan, Tischkowitz, Marc, Concannon, Patrick, and Stram, Daniel O.

Published
2020
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38. Stomach Cancer Following Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer: A Pooled Analysis of Three International Studies with a Focus on Radiation Effects

Author

Gilbert, Ethel S., Curtis, Rochelle E., Hauptmann, Michael, Kleinerman, Ruth A., Lynch, Charles F., Stovall, Marilyn, Smith, Susan A., Weathers, Rita, Andersson, Michael, Dores, Graça M., Fraumeni,, Joseph F., Fossa, Sophie D., Hall, Per, Hodgson, David C., Holowaty, Eric J., Joensuu, Heikki, Johannesen, Tom B., Langmark, Froydis, Kaijser, Magnus, Pukkala, Eero, Rajaraman, Preetha, Storm, Hans H., Vaalavirta, Leila, van den Belt-Dusebout, Alexandra W., Aleman, Berthe M., Travis, Lois B., Morton, Lindsay M., and van Leeuwen, Flora E.

Published
2017

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