Search

This study segmented the time series of gaze behavior from nineteen children with autism spectrum disorder (ASD) and 20 children with typical development in a face-to-face conversation. A machine learning approach showed that behavior segments produced by these two groups of participants could be classified with the highest accuracy of 74.15%. These results were further used to classify children using a threshold classifier. A maximum classification accuracy of 87.18% was achieved, under the condition that a participant was considered as 'ASD' if over 46% of the child's 7-s behavior segments were classified as ASD-like behaviors. The idea of combining the behavior segmentation technique and the threshold classifier could maximally preserve participants' data, and promote the automatic screening of ASD.

Few eye tracking studies have examined how people with autism spectrum disorder (ASD) visually attend during live interpersonal interaction, and none with the Chinese population. This study used an eye tracker to record the gaze behavior in 20 Chinese children with ASD and 23 children with typical development (TD) when they were engaged in a structured conversation. Results demonstrated that children with ASD looked significantly less at the interlocutor's mouth and whole-face, and more at background. Additionally, gaze behavior was found to vary with the conversational topic. Given the great variability in eye tracking findings in existing literature, future explorations might consider investigating how fundamental factors (i.e., participant's characteristics, tasks, and context) influence the gaze behavior in people with ASD.

This study investigated the oculomotor performance in children with autism spectrum disorder (ASD) during a face-to-face conversation. A head mounted eye tracker recorded the eye movements in 20 children with ASD and 23 children with typical development (TD). Group comparisons were conducted on the randomness and the quantity of eye movement. The amount of time needed to reveal group difference was also examined. Results showed that the randomness of eye movement was significantly higher at all examined time durations, and the amount of eye movement was significantly greater within 3 s in the ASD group. These findings demonstrated an atypical pattern of oculomotor dynamics in children ASD, which might facilitate the objective identification of ASD during daily social interaction.

Our study investigated the feasibility of using head movement features to identify individuals with autism spectrum disorder (ASD). Children with ASD and typical development (TD) were required to answer ten yes--no questions, and they were encouraged to nod/shake head while doing so. The head rotation range (RR) and the amount of rotation per minute (ARPM) in the pitch (head nodding direction), yaw (head shaking direction) and roll (lateral head inclination) directions were computed, and further fed into machine learning classifiers as the input features. The maximum classification accuracy of 92.11% was achieved with the decision tree classifier with two features (i.e., RR_Pitch and ARPM_Yaw). Our study suggests that head movement dynamics contain objective biomarkers that could identify ASD.

BackgroundThere are differences in executive function between major depressive episode patients with or without psychotic symptoms， and childhood trauma may affect the executive function of patients with major depressive episode. Previous research studies predominantly focused on adult patients with major depressive episode， with a lack of studies specifically focusing on adolescent patients with major depressive episode.ObjectiveTo investigate the differences in executive function among adolescent patients with major depressive episode， with or without psychotic symptoms and childhood trauma.MethodsA total of 112 hospitalized adolescent patients with major depressive episode who met the criteria of the International Classification of Diseases， tenth edition （ICD-10） were included in the study. The participants were recruited from the Department of Child and Adolescent Psychiatry， Shenzhen Kangning Hospital during the period from August 2020 to November 2021. Additionally， 27 healthy controls were recruited through public advertisements. The Cambridge Neuropsychological Test Automated Battery （CANTAB） was used to assess executive function through the administration of the Motor Screening Task （MOT）， Spatial Working Memory（SWM） and Rapid Visual Information Processing （RVP） modules. Childhood Trauma Questionnaire-Short Form （CTQ-SF） was used to assess the trauma type.ResultsCompared with healthy controls， adolescent patients with major depressive episode had a longer mean delay （Z=-3.407， P=0.001） in the MOT task. In the SWM task， the patients had a higher total number of intergroup error responses （Z=-3.291， P=0.001）， a higher total number of intragroup error responses （Z=-3.461， P=0.001）， more total number of double error responses （Z=-3.218， P=0.001）， a higher total error responses （Z=-3.312， P=0.001）， higher strategy scores （Z=-2.437， P=0.015） and longer average delay time （Z=-2.055， P=0.040）. In the RVP task， the patients had fewer hits （Z=-3.196， P=0.001）， more misses （Z=-3.179， P=0.001）， fewer rejections （Z=-2.772， P=0.006）， lower hit probability （Z=-3.187， P=0.001） and lower A´ scores （Z=-3.070， P=0.002）.Compared with adolescent patients with major depressive episode without psychotic symptoms， those with psychotic symptoms had a lower total number of double error responses （Z=-2.566， P=0.010） in SWM task. Compared with adolescent patients with major depressive episode who did not experience emotional neglect， those who experienced emotional neglect had longer average delay time （Z=-3.183， P=0.001） in MOT task， fewer total hits （Z=-2.445， P=0.014）， more total missed reports （Z=-2.467， P=0.014）， lower hit probability （Z=-2.445， P=0.014） and lower A´scores （Z=-2.089， P=0.037） in RVP task. Adolescent patients with major depressive episode who had experienced emotional abuse had longer average delay time in MOT task than those who had not experienced emotional abuse （Z=-2.552， P=0.011）.ConclusionAdolescent patients with major depressive episode exhibit abnormalities in a majority of executive function domains. Specifically， those without psychotic symptoms and with childhood trauma demonstrate significantly impaired executive function. ［Funded by Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties （number， SZGS013）， Basic and Applied Basic Research Fund of Guangdong Province （number， 2019A1515110047）， Shenzhen Science and Technology Planning Project （number， JCYJ20190809155019338）］

Objective To investigate the expression of ITGBL1 in hepatocellular carcinoma (HCC) and its role in promoting the proliferation, migration, and invasion of HCC cell lines. Methods RT-qPCR and immunohistochemistry were used in investigating ITGBL1 expression in 12 pairs of fresh HCC and adjacent normal liver tissue samples and 160 paraffin HCC specimens. The relationships of ITGBL1 expression level with clinicopathological parameters and prognosis were analyzed. HUH7 cell line with the stable overexpression of ITGBL1 and LM3 cell line with stable downregulated expression of ITGBL1 were constructed. The effects of ITGBL1 on the proliferation, migration, and invasion of HCC cells were examined by CCK8 assay, wound-healing assay, and Transwell invasion assay. Results The expression levels of ITGBL1 gene and protein in tumor tissues were higher than those in surrounding liver tissues. The high expression of ITGBL1 was correlated with serum AFP level, tumor capsular invasion, vascular invasion, tumor differentiation, and clinical stage (P < 0.05). The results of Kaplan-Meier analysis showed that patients with high expression of ITGBL1 had shorter DFS. In vitro, increased ITGBL1 expression promoted HCC cell proliferation, migration, and invasion, whereas ITGBL1 knockdown inhibited these processes. Conclusion ITGBL1 expression is highly expressed in HCC tissues, and ITGBL1 can increase the proliferation, migration, and invasion of HCC cells. However, the mechanism needs further study.

Objective To introduce and explore the application of Moodle E-learning Platform in teaching of the course of Health Assessment for nursing students upgraded from junior college to university. Methods A cluster random sampling method was used to select students who were upgraded from junior college to university from grade 2021. Students from two classes were divided into two groups: study group(n=118) and control group (n=123). In the control group, the theoretical and practical curriculums were toughed in a traditional way, and the teaching mode based on Moodle E-learning Platform was introduced into in teaching of the course of Health Assessment in the study group. The outcomes of theoretical and practical tests were measured and compared between study group and control group. A questionnaire survey was conducted to assess students’ satisfaction with teaching. Results Students in the study group achieved higher scores of physical examination practice and theoretical test compared with those in the control group (P＜0. 01). In the control group, 123 questionnaires were distributed and 120 effective questionnaires were recovered, with an effective recovery rate of 97. 56%. In the observation group, 118 questionnaires were distributed and 116 effective questionnaires were recovered, with an effective recovery rate of 98. 31%. The outcomes of questionnaire survey showed that scores of all dimensions of satisfaction assessment in the study group were higher than those in the control group (P＜0. 01). Conclusion An effective and interactive network course based on Moodle E-learning Platform can stimulate students' interest in learning and cultivate students' ability of problem-solving and cooperation skills. The Moodle E-learning Platform plays an important role in promoting the teaching reform and the cultivation of senior nursing talents. (目的 介绍和探讨基于Moodle平台的教学模式在专升本学生《健康评估》教学中的应用。方法 采用随机整群抽样, 选取学校2021级专升本护理专业两个班级的学生为研究对象, 分为试验组(n=118)和对照组(n=123)。对照组进行一学期的传统理论授课(32学时)和操作课学习(16学时); 试验组传统理论授课同对照组, 操作课程采用基于Moodle平台的教学模式。对比两组学生操作和理论成绩, 评价学生满意度。结果 试验组学生体格检查操作和理论成绩均高于对照组学生, 差异有统计学意义(P＜0. 01)。对照组发放问卷123份, 回收有效问卷120份, 有效回收率97. 56%, 向试验组发放问卷118份, 回收有效问卷116份, 有效回收率98. 31%。学生对课程教学满意度评价结果显示, 试验组学生所有维度评分均优于对照组, 差异有统计学意义(P＜0. 01)。结论 基于Moodle平台的教学模式能够建立一个有效的、交互性强的网络课程, 激发学生的学习兴趣, 培养学生探究问题和协作的能力, 对教学改革和培养高级护理人才有重要的促进作用。)

Background Hypoparathyroidism is one of the common complications of radical thyroidectomy, but there are few studies on differentiated thyroid cancer. Objective To investigate the influencing factors of hypoparathyroidism in patients with differentiated thyroid carcinoma after radical thyroidectomy. Methods A total of 166 patients with differentiated thyroid carcinoma who underwent radical thyroidectomy from 940 Hospital of PLA Joint Logistics Support Force from June 2018 to December 2020 were included, and their clinical data were collected, including gender, age, body mass index (BMI), tumor site, tumor size, blood supply of lesion, whether there is capsule invasion, surgical method, scope of lymph node dissection, whether there is use of carbon nanoparticles, parathyroid gland resection. Also, this study monitors preoperative and postoperative serum PTH and follow-up monitoring levels of Ca2+. Results Among the 166 patients, the incidence of postoperative hypoparathyroidism was 28.31% (47/166), among which the incidence of temporary hypoparathyroidism was 21.68% (36/166) and the incidence of permanent hypoparathyroidism was 6.63% (11/166). There were statistically significant differences between patients with normal parathyroid function and patients with hypoparathyroidism in gender, age, tumor location, membranous invasion, surgical method, lymph node dissection and the use of carbon nanotube (P