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34. Development and Item Selection of the Inflammatory Bowel Disease Patient-reported Outcomes Scale Based on Theories of Traditional Chinese Medicine

Author

Jianfeng LUO, Jiangtao HOU, Zhengkun HOU, Bin PENG, Huibiao LI, Shiying LIU, Zhenfan HE, Jiamin ZHONG, Shijing ZHANG, Fengbin LIU, Xinlin CHEN

Subjects
inflammatory bowel disease, patient-reported outcomes, tcm theories, quality of life, item selection, construction of scale, Medicine
Abstract

Background The prevalence of inflammatory bowel disease (IBD) increases annually in China. The integrated traditional Chinese and western medicine is helpful to alleviate and control symptoms of IBD. Quality of life (QoL) is an important index to evaluate the clinical efficacy of IBD. However, there are few studies about IBD patient-reported outcomes (PROs) based on TCM theories. Objective To determine the framework and items, and then use them to develop the IBD PROs scale using TCM theories. Methods Under the guidance of the TCM theory of "body and mind harmony, and man's adaptation to his total environment" , literature review, core-group discussion and expert consultation were carried out. The conceptual framework and item pool of the draft of an IBD PROs scale were developed, then the corresponding items were determined, forming the draft of the IBD PROs scale. Then the draft scale was pre-tested in IBD patients treated in Department of Spleen and Stomach Diseases, the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January to June 2021. The dispersion tendency, Cronbach's α and correlation analysis were used for further item selection. Results The final IBD PROs scale is composed of two domains: body and mind harmony (12 body-related items, and 9 mind-related items) and man's adaptation to his total environment (6 items) . Conclusion The IBD PROs scale developed based on theories of TCM could be used to evaluate the QoL of IBD patients. But further clinical research is still needed to verify its reliability and validity.

Published
2022
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48. HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC.

Author

Qian, Kang, Li, Wei, Ren, Shangqing, Peng, Weilin, Qing, Bei, Liu, Xinlin, Wei, Xiong, Zhu, Liang, Wang, Yapeng, and Jin, Xin

Subjects
PROTEIN-tyrosine kinase inhibitors, RENAL cell carcinoma, SUNITINIB, DRUG resistance, STAT proteins
Abstract

Drug resistance after long‐term use of Tyrosine kinase inhibitors (TKIs) has become an obstacle for prolonging the survival time of patients with clear cell renal cell carcinoma (ccRCC). Here, genome‐wide CRISPR‐based screening to reveal that HDAC8 is involved in decreasing the sensitivity of ccRCC cells to sunitinib is applied. Mechanically, HDAC8 deacetylated ETS1 at the K245 site to promote the interaction between ETS1 and HIF‐2α and enhance the transcriptional activity of the ETS1/HIF‐2α complex. However, the antitumor effect of inhibiting HDAC8 on sensitized TKI is not very satisfactory. Subsequently, inhibition of HDAC8 increased the expression of NEK1, and up‐regulated NEK1 phosphorylated ETS1 at the T241 site to promote the interaction between ETS1 and HIF‐2α by impeded acetylation at ETS1‐K245 site is showed. Moreover, TKI treatment increased the expression of HDAC8 by inhibiting STAT3 phosphorylation in ccRCC cells is also found. These 2 findings highlight a potential mechanism of acquired resistance to TKIs and HDAC8 inhibitors in ccRCC. Finally, HDAC8‐in‐PROTACs to optimize the effects of HDAC8 inhibitors through degrading HDAC8 and overcoming the resistance of ccRCC to TKIs are synthesized. Collectively, the results revealed HDAC8 as a potential therapeutic candidate for resistance to ccRCC‐targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Design and Analysis of Rehabilitation Evaluation System for Finger Rehabilitation Robot.

Author

Lu, Guangda, Liu, Xinlin, Zhang, Qiuyue, Zhao, Zhuangzhuang, Li, Runze, and Li, Zheng

Subjects
ROBOTIC exoskeletons, STROKE patients, EVALUATION methodology, REHABILITATION, GESTURE
Abstract

The current rehabilitation evaluation methods for patients with hand dysfunction face issues such as inconsistent standards and incomplete quantification processes. To address these challenges, this paper introduces a rehabilitation evaluation system that integrates various rehabilitation training modes and leverages an exoskeleton finger rehabilitation robot. This system is carefully designed and thoroughly analyzed based on the diverse training modes offered by the rehabilitation robot. Twenty stroke patients and six healthy subjects were recruited to perform grasping of static objects and gesture movement experiments, which were evaluated by Brunnstrom's motor evaluation and rehabilitation evaluation tests, respectively, and the results were compared. The experimental results showed that the results of the robotic rehabilitation evaluation of the 20 patients were consistent with the clinical Brunnstrom motor grades, which verified the accuracy of the rehabilitation evaluation system that was designed in this study. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Seasonal Effects of Constructed Wetlands on Water Quality Characteristics in Jinshan Lake: A Gate Dam Lake (Zhenjiang City, China).

Author

Li, Xiao, Liu, Xinlin, Zhang, Yulong, Liu, Jing, Huang, Yang, and Li, Jian

Subjects
*CONSTRUCTED wetlands, *WATER quality management, *WATER quality, *URBAN lakes, *LAKE restoration, *WATER quality monitoring
Abstract

Simple Summary: In this study, we investigated the seasonal effects of constructed wetlands on water quality characteristics in a gate dam lake. The research reveals pronounced seasonal changes in the lake's water environment index. During winter, nitrate nitrogen and BOD5 interact significantly, jointly becoming the primary factors restricting lake water quality. In summer, the constructed wetlands effectively improve TN levels. Furthermore, water depth plays a regulatory role in Chl-a content, ammonia–nitrogen, and nitrite–nitrogen by influencing light penetration and water temperature. Urban lakes commonly suffer from nutrient over-enrichment, resulting in water quality deterioration and eutrophication. Constructed wetlands are widely employed for ecological restoration in such lakes but their efficacy in water purification noticeably fluctuates with the seasons. This study takes the constructed wetland of Jinshan Lake as an example. By analyzing the water quality parameters at three depths during both summer and winter, this study explores the influence of the constructed wetland on the water quality of each layer during different seasons and elucidates the potential mechanisms underlying these seasonal effects. The results indicate that the constructed wetland significantly enhances total nitrogen (TN) concentration during summer and exhibits the capacity for nitrate–nitrogen removal in winter. However, its efficacy in removing total phosphorus (TP) is limited, and may even serve as a potential phosphorus (P) source for the lake during winter. Water quality test results of different samples indicated they belong to Class III or IV. Restrictive factors varied across seasons: nitrate–nitrogen and BOD5 jointly affected water quality in winter, whereas TP predominantly constrained water quality in summer. These results could provide a reference for water quality monitoring and management strategies of constructed wetlands in different seasons in Jiangsu Province. [ABSTRACT FROM AUTHOR]

Published
2024
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