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Clinically, patients with cardiovascular disease widely have psycho-psychological problems, which interact with each other and aggravate the disease state. Psycho-cardiology is a discipline formed by the intersection and integration of cardiology and psychology, which emphasizes the attention to cardiovascular diseases and the mental state of patients. Experts from the Psycho-cardiology Group of the Psychosomatic Medicine Society of the Chinese Medical Association formulated Chinese Expert Consensus on the Construction Standardization of Psycho-cardiology Outpatient after reviewing literature and conducting discussions, in order to improve the diagnosis and treatment capacity of psycho-cardiology in China, promote medical institutions at all levels to set up psycho-cardiology outpatient, and continuously improve the medical service system of psycho-cardiology in China.

The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival of individuals afflicted with LUAD. However, there is currently a lack of reliable signatures for identifying patients who would benefit from immunotherapy. We conducted a comparative analysis of two immunotherapy cohorts (OAK and POPLAR) and utilized single‐factor COX regression to identify genes that significantly impact the prognosis of LUAD. Based on the TCGA‐LUAD dataset, we employed a combination of 101 machine learning algorithms to construct a model and selected the optimal model. The model was validated on five GEO datasets and compared with 144 previously published signatures to assess its performance. Subsequently, we explored the underlying biological mechanisms through tumor mutation burden analysis, enrichment analysis, and immune infiltration analysis. An immunotherapy prognostic prediction signature (IPPS) was constructed based on 13 genes, showing robust performance in the TCGA‐LUAD dataset. IPPS exhibited consistent predictive accuracy in the validation cohorts. Compared to 144 previously published signatures, IPPS consistently ranked among the top in terms of C‐index values. Further exploration revealed differences between high and low‐IPPS groups in terms of tumor mutation burden, pathway enrichment, and immune infiltration. IPPS demonstrates strong predictive capabilities for the prognosis of LUAD patients, offering the potential to identify suitable candidates for immunotherapy and contribute to precision treatment strategies for LUAD. [ABSTRACT FROM AUTHOR]

High ion conductivity is required for polybenzimidazole ion solvating membranes (ISM) to decrease the operational KOH concentration, and thus, improve the alkaline stability of ISM in an electrolyzer. Herein, gel-state ISM with a sponge-like inner structure and a dense surface was developed based on poly (2,2′-(1,4-naphthalene)-5,5′-bibenzimidazole) (NPBI), yielding more volume for KOH uptake. As a result, the Gel-NPBI membrane exhibited excellent mechanical properties, outstanding alkaline stability (2 M KOH at 80 °C for 285 days), and impressive ion conductivity even in 2 M KOH solutions (190 mS cm−1 at 80 °C) as compared to the ISMs prepared with dense membranes with/without phosphoric acid pretreatment (PK-NPBI and K-NPBI). Thus, the resulting Gel-NPBI membrane achieved superior electrolyzer performance with a high current density of 2.5 A cm−2 at 1.8 V (80 °C, 2 M KOH) using platinum-group-metal catalysts. Impressively, we identified that the high operation voltage resulted in the thinning of ISMs during the working of in situ electrolyzer devices probably due to the oxidative degradation near the anodic side of ISMs that cannot have been gained from the previous reports. Following up on these findings, the cell with Gel-NPBI membrane in a KOH solution of low concentration demonstrated a lifetime of 1780 h under 0.5 A cm−2 using PGM-free electrodes. [ABSTRACT FROM AUTHOR]

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.

Mercury emissions from human activities persist in the environment, posing risks to humans and ecosystem, and are regulated by the Minamata Convention. Understanding the historical emissions of mercury is critical for explaining the presence of mercury in the environment. In recent years, some studies have looked at the historical trends of atmospheric emission inventory. The spatial resolution of inventories for relatively recent years have improved. However, limited inventories have combined both long time scales and high spatial resolution, which is essential for evaluating the legacy impacts of anthropogenic mercury emissions, particularly in regions with high levels of mercury emissions. Here we compile a new comprehensive point source database by fusing multiple data source, and integrate it with previous China Atmospheric Mercury Emission Model to create an annual point source and gridded emission inventory for China covering 1978–2021. Integrating point source emission inventory (P-CAME) improves the accuracy of the gridded emissions, reducing the normalized mean error for all grids by 108 % compared to not using point sources in the most recent year of 2021. The improved gridded emissions inventory notably enhances the simulation of atmospheric mercury concentrations, particularly in urban areas. P-CAME inventory resulted in a 20–23 % reduction in the normalized mean bias. The improved gridded emission data identifies potential polluted grids characterized by high cumulative emissions. It indicates that 20 % of cumulative emissions originate from just 0.3 % of the grids, primarily distributed in Gansu, Yunnan, and Hunan Provinces. These areas are predominantly dominated by non-ferrous metal smelters or a mix of emissions sources including coal-fired industries and cement production. With the improvements in simulation accuracy and the identification of highly polluted regions, this updated inventory would greatly facilitate the assessment of mercury exposure, legacy impacts, and effective management of cross-media mercury pollution. [ABSTRACT FROM AUTHOR]

Ubiquitination, a post-translational modification, refers to the covalent attachment of ubiquitin molecules to substrates. This modification plays a critical role in diverse cellular processes such as protein degradation. The specificity of ubiquitination for substrates is regulated by E3 ubiquitin ligases. Dysregulation of ubiquitination has been associated with numerous diseases, including cancers. In our study, we first investigated the protein expression patterns of E3 ligases across 12 cancer types. Our findings indicated that E3 ligases tend to be up-regulated and exhibit reduced tissue specificity in tumors. Moreover, the correlation of protein expression between E3 ligases and substrates demonstrated significant changes in cancers, suggesting that E3-substrate specificity alters in tumors compared to normal tissues. By integrating transcriptome, proteome, and ubiquitylome data, we further characterized the E3-substrate regulatory patterns in lung squamous cell carcinoma. Our analysis revealed that the upregulation of the SKP2 E3 ligase leads to excessive degradation of BRCA2, potentially promoting tumor cell proliferation and metastasis. Furthermore, the upregulation of E3 ubiquitin–protein ligase TRIM33 was identified as a biomarker associated with a favorable prognosis by inhibiting the cell cycle. This work exemplifies how leveraging multi-omics data to analyze E3 ligases across various cancers can unveil prognosis biomarkers and facilitate the identification of potential drug targets for cancer therapy. [ABSTRACT FROM AUTHOR]

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433. [ABSTRACT FROM AUTHOR]

We report here a series of alkyl group-modified trimesic amide molecules (TAs) with excellent anion transport activities. Among them, TA6, with the highest ion transport activity and excellent selectivity, efficiently transports anions across the membrane in the order of ClO4− > I− > NO3− > Br− > Cl−, with an EC50 value as low as 17.6 nM (0.022 mol% relative to lipid molecules) for ClO4−, which outperforms other anions by 5- to 22-folds and manifests as the best perchlorate transporter ever reported. [ABSTRACT FROM AUTHOR]

Unlike many other biologically relevant ions (Na+, K+, Ca2+, Cl−, etc) and protons, whose cellular concentrations are closely regulated by highly selective channel proteins, Li+ ion is unusual in that its concentration is well tolerated over many orders of magnitude and that no lithium‐specific channel proteins have so far been identified. While one naturally evolved primary pathway for Li+ ions to traverse across the cell membrane is through sodium channels by competing with Na+ ions, highly sought‐after artificial lithium‐transporting channels remain a major challenge to develop. Here we show that sulfur‐containing organic nanotubes derived from intramolecularly H‐bonded helically folded aromatic foldamers of 3.6 Å in hollow cavity diameter could facilitate highly selective and efficient transmembrane transport of Li+ ions, with high transport selectivity factors of 15.3 and 19.9 over Na+ and K+ ions, respectively. [ABSTRACT FROM AUTHOR]

Chronic wounds, depending on the bacteria that caused the infection, can be associated with an extreme acidic or basic pH. Therefore, the application of pH-responsive hydrogels has been instigated for the delivery of therapeutics to chronic wounds. Herein, with the aim of developing a flexible pH-responsive hydrogel, we functionalized hydrophilic polyurethanes with either cationic (polyethylene imine) or anionic (succinic anhydride) moieties. A comprehensive physicochemical characterization of corresponding polymers was carried out. Particularly, when tested in aqueous buffers, the surface charge of hydrogel films was closely correlated with the pH of the buffers. The loading of the cationic and anionic hydrogel films with various compound models (bromophenol blue; negatively charged or Pyronin Y; positively charged) showed that the electrostatic forces between the polymeric backbone and the compound model will determine the ultimate release rate at any given pH. The potential application of these films for chronic wound drug delivery was assessed by loading them with an antibiotic (ciprofloxacin). In vitro bacterial culturing was performed using Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Results showed that at the same drug dosage, different release profiles achievable from cationic and anionic polyurethanes can yield different degrees of an antibacterial effect. Overall, our results suggest the potential application of cationic and anionic hydrophilic polyurethanes as flexible pH-responsive materials for the delivery of therapeutics to chronic wounds. [ABSTRACT FROM AUTHOR]

The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug‐loaded biopolymeric coatings for biomedical implants are highlighted. [ABSTRACT FROM AUTHOR]

For compounds each containing a phenylalanine moiety with its two ends amidated to have a 15-crown-5 unit and an alkyl chain, a simple tuning of the alkyl chain length delivered a K+-selective channel with a record-high K+/Na+ selectivity of 20.1. [ABSTRACT FROM AUTHOR]

Purpose: The effect of scinderin (SCIN) on cancer progression has been studied, but its role in glioma remains unknown. This study describes the value of SCIN for the diagnosis, prognosis, and treatment of glioma. Methods: The expression of SCIN was analyzed using the GEPIA, Oncomine, cBioPortal, and CGGA databases. GO/KEGG enrichment analysis of similar genes to SCIN were performed using the R software package, and the protein–protein interaction (PPI) network was analyzed by the STRING and GeneMANIA databases. The correlations of mRNA expression between SCIN and MMP2/9 were analyzed by TCGA glioma. Simultaneously, the TISIDB and TIMER databases were used to analyze the correlation between SCIN and immune infiltration. Finally, SCIN and MMP2/9 protein expression among different grades of glioma was performed and the results were obtained via immunohistochemistry and Western blot assays. We used the Kaplan–Meier method and Cox proportional hazards model to assess the impact of SCIN and MMP2/9 on glioma patients' survival. The correlations between SCIN and MMP2/9 were analyzed by immunohistochemistry and Western blot assays. Results: SCIN was upregulated in glioma patients with a poor prognosis. The GO and KEGG enrichment analysis showed the functional relationship between SCIN and the immune cell activation and regulation. In addition, the expression of SCIN was related to MMP2/9 in glioma. The correlation analysis showed that SCIN expression was associated with tumor purity and immune infiltration. SCIN and MMP2/9 are negative prognostic factors resulting in worsening glioma patients' survival. Conclusion: Our studies demonstrated that SCIN expression was associated with MMP2/9, immune infiltration, and a poor prognosis in glioma. SCIN may serve as a potential prognostic marker and an immune therapy target for glioma. [ABSTRACT FROM AUTHOR]

In our work, we defined new operations in a new way in connection with vague hyper soft sets. These operations are vague hyper soft sets, vague hyper soft subsets, vague hyper soft complements, vague hyper soft null sets, vague hyper soft absolute sets, vague hyper soft union and vague hyper soft intersection. On the basis of these new operations vague hyper soft topology is defined. In addition, the concept of some generalized vague hyper soft open sets are reflected in vague hyper soft topology. Among these generalized vague hyper soft open sets vague hyper soft α-open set is selected to produce different structures. Finally, on the basis of this vague hyper soft α-open set some more results are addressed. Non-validity of some results are diffused with appropriate examples. [ABSTRACT FROM AUTHOR]

In order to solve the problems of large size, difficult transport, low automation and poor control accuracy of existing raise driller, this paper uses the system integration and control technology of center articulated chassis structure, floating frame design, PLC program control and remote intelligent control, and mechanical structure, power matching, intelligent walking problem, automatic drilling was studied. Finally, an articulated self-propelled raise drill is designed for narrow tunnel in trackless mine. The drill realizes the walking and turning of the equipment through the way of track traction and tire drag and hang, the whole process of walking, positioning and construction without any disassembly, simple and convenient. Field application shows that compared with the the existing drilling rig, the paper design of articulated self-propelled patio drilling roadway through small size, fast drilling, hole of high precision, low construction cost, both in the efficiency of construction, or in the intelligent degree had the very big promotion, is very good to satisfy the development demand of intelligent mining about equipment replaces people, with high efficient and intelligent. [ABSTRACT FROM AUTHOR]

Lysine crotonylation (Kcr) is involved in plenty of activities in the human body. Various technologies have been developed for Kcr prediction. Sequence-based features are typically adopted in existing methods, in which only linearly neighboring amino acid composition was considered. However, modified Kcr sites are neighbored by not only the linear-neighboring amino acid but also those spatially surrounding residues around the target site. In this paper, we have used residue–residue contact as a new feature for Kcr prediction, in which features encoded with not only linearly surrounding residues but also those spatially nearby the target site. Then, the spatial-surrounding residue was used as a new scheme for feature encoding for the first time, named residue–residue composition (RRC) and residue–residue pair composition (RRPC), which were used in supervised learning classification for Kcr prediction. As the result suggests, RRC and RRPC have achieved the best performance of RRC at an accuracy of 0.77 and an area under curve (AUC) value of 0.78, RRPC at an accuracy of 0.74, and an AUC value of 0.80. In order to show that the spatial feature is of a competitively high significance as other sequence-based features, feature selection was carried on those sequence-based features together with feature RRPC. In addition, different ranges of the surrounding amino acid compositions' radii were used for comparison of the performance. After result assessment, RRC and RRPC features have shown competitively outstanding performance as others or in some cases even around 0.20 higher in accuracy or 0.3 higher in AUC values compared with sequence-based features. [ABSTRACT FROM AUTHOR]

Ubiquitination is an important post-translational modification, which controls protein turnover by labeling malfunctional and redundant proteins for proteasomal degradation, and also serves intriguing non-proteolytic regulatory functions. E3 ubiquitin ligases, whose substrate specificity determines the recognition of target proteins of ubiquitination, play crucial roles in ubiquitin–proteasome system. UbiNet 2.0 is an updated version of the database UbiNet. It contains 3332 experimentally verified E3–substrate interactions (ESIs) in 54 organisms and rich annotations useful for investigating the regulation of ubiquitination and the substrate specificity of E3 ligases. Based on the accumulated ESIs data, the recognition motifs in substrates for each E3 were also identified and a functional enrichment analysis was conducted on the collected substrates. To facilitate the research on ESIs with different categories of E3 ligases, UbiNet 2.0 performed strictly evidence-based classification of the E3 ligases in the database based on their mechanisms of ubiquitin transfer and substrate specificity. The platform also provides users with an interactive tool that can visualize the ubiquitination network of a group of self-defined proteins, displaying ESIs and protein–protein interactions in a graphical manner. The tool can facilitate the exploration of inner regulatory relationships mediated by ubiquitination among proteins of interest. In summary, UbiNet 2.0 is a user-friendly web-based platform that provides comprehensive as well as updated information about experimentally validated ESIs and a visualized tool for the construction of ubiquitination regulatory networks available at http://awi.cuhk.edu.cn/~ubinet/index.php. [ABSTRACT FROM AUTHOR]

We report here that macrocyclic H‐bonded pyridone pentamers, containing five properly and convergently spaced electron‐rich O‐atoms that decorate a rigid cavity of 2.85 Å across, exhibit an extraordinarily high yet pH‐independent capacity and selectivity in Cs+ removal. In particular, with [host]=240 μM and [Cs+]=15 μM, a single extraction efficiently removes more than 91% of Cs+ ions from artificial sea water, containing various competitive metal ions at a total concentration of 0.68 M ([total Mn+]/[Cs+]=4.5×104]). To our best knowledge, these pyridone pentamers represent the best small organic molecule‐based extractants that target Cs+ ions. [ABSTRACT FROM AUTHOR]

Antibiotic resistance/tolerance has become a severe threat to human and animal health. To combat antibiotic-resistant/tolerant bacteria, it is of significance to improve the efficacy of traditional antibiotics. Here we show that indole potentiates tobramycin to kill stationary-phase Staphylococcus aureus cells after a short, combined treatment, with its derivative 5-methylindole being the most potent compound tested and with the absence of ions as a prerequisite. Consistently, this combined treatment also kills various types of S. aureus persister cells as induced by the protonophore CCCP, nutrient shift, or starvation, as well as methicillin-resistant S. aureus (MRSA) cells. Importantly, 5-methylindole potentiates tobramycin killing of S. aureus persisters in a mouse acute skin wound model. Furthermore, 5-methylindole facilitates killing of many strains of gram-positive pathogens such as Staphylococcus epidermidis, Enterococcus faecalis , and Streptococcus pyogenes by aminoglycoside antibiotics, whereas it suppresses the action of aminoglycoside against the gram-negative pathogens Escherichia coli and Shigella flexneri. In conclusion, our work may pave the way for the development of indole derivatives as adjuvants to potentiate aminoglycosides against gram-positive pathogens. [ABSTRACT FROM AUTHOR]