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The quantification of 3D particle field is of interest for a vast range of fields. While in‐line particle holography (PH) can provide high‐resolution measurements of particles, it suffers from speckle noise. Plenoptic imaging (PI) is less susceptible to speckle noises, but it involves a trade‐off between spatial and angular resolution, rendering images with low resolution. Here, we report a simple microscopy setup with the goals of getting the strengths of both techniques. It is built with off‐the‐shelf and cost‐effective components including a photographic lens, a diaphragm, and a CCD camera. The cost of the microscopy setup is affordable to small labs and individual researchers. The pupil plane of the proposed setup can be mechanically accessible, allowing us to implement pupil plane modulation and increase the depth of field (DOF) without requiring any additional relay lenses. It also allows us to understand the working principle of pupil plane modulation clearly, benefiting microscopy education. It illuminates the sample (particles) using diffuse white light, and thus avoids the problem of speckle noise. It captures multiple perspective images via pupil plane modulation, without requiring trading off angular and spatial resolution. We validate the setup with 2D and 3D particle samples. Research Highlights: We report a simple and cost‐effective microscopy setup with the goals of getting the strengths of plenoptic imaging and in‐line particle holography. It is built with off‐the‐shelf and cost‐effective components. The cost of the microscopy setup is affordable to small labs and individual researchers. The pupil plane of the proposed setup can be mechanically accessible, allowing us to implement pupil plane modulation and increase the DOF without requiring any additional relay lenses. It also allows us to understand the working principle of pupil plane modulation clearly, benefiting microscopy education. It illuminates the sample (particles) using diffuse white light, and thus avoids the problem of speckle noise. It captures multiple perspective images via pupil plane modulation, without requiring trading off angular and spatial resolution. We validate the setup with 2D and 3D particle samples. [ABSTRACT FROM AUTHOR]

Landslides recurrently cause severe damage and, in some cases, the full disruption of many highways in mountainous areas, which can last from a few days to even months. Thus, there is a high demand for monitoring tools and precipitation data to support highway alignment selections before construction. In this study, we proposed a new system highway alignment selection method based on coherent scatter InSAR (CSI) and ~1 km high-spatial-resolution precipitation (HSRP) analysis. Prior to the CSI, we calculated and analyzed the feasibility of Sentinel-1A ascending and descending data. To illustrate the performance of the CSI, CSI and SBAS–InSAR were both utilized to monitor 80 slow-moving landslides, which were identified by optical remote-sensing interpretation and field investigation, along the Barkam–Kangting Highway Corridor (BKHC) in southwestern China, relying on 56 Sentinel-1A descending images from September 2019 to September 2021. The results reveal that CSI has clearer deformation signals and more measurement points (MPs) than SBAS-InSAR. And the maximum cumulative displacements and rates of the landslides reach −75 mm and −64 mm/year within the monitoring period (CSI results), respectively. Furthermore, the rates of the landslides near the Jinchuan River are higher than those of the landslides far from the river. Subsequently, to optimize the highway alignment selection, we analyzed the spatiotemporal evolution characteristics of feature points on a typical landslide by combining the −1 km HSRP, which was calculated from the 30′ Climatic Research Unit (CRU) time-series datasets, with the climatology datasets of WorldClim using delta spatial downscaling. The analysis shows that the sliding rates of landslides augment from the back edge to the tongue because of fluvial erosion and that accelerated sliding is highly related to the intense precipitation between April and September each year (ASP). Consequently, three solution types were established in our method by setting thresholds for the deformation rates and ASPs of every landslide. Afterward, the risk-optimal alignment selection of the BKHC was finalized according to the solution types and consideration of the construction's possible impacts. Ultimately, the major problems and challenges for our method were discussed, and conclusions were given. [ABSTRACT FROM AUTHOR]

Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in Western countries and has become the major cause of liver cirrhosis or hepatocellular carcinoma (HCC) in addition to viral hepatitis in recent decades. Furthermore, studies have shown that NAFLD is inextricably linked to the development of extrahepatic diseases. However, there is currently no effective treatment to cure NAFLD. In addition, in 2020, NAFLD was renamed metabolic dysfunction fatty liver disease (MAFLD) to show that its pathogenesis is closely related to metabolic disorders. Recent studies have reported that the development of MAFLD is inextricably associated with mitochondrial dysfunction in hepatocytes and hepatic stellate cells (HSCs). Simultaneously, mitochondrial stress caused by structural and functional disorders stimulates the occurrence and accumulation of fat and lipo-toxicity in hepatocytes and HSCs. In addition, the interaction between mitochondrial dysfunction and the liver–gut axis has also become a new point during the development of MAFLD. In this review, we summarize the effects of several potential treatment strategies for MAFLD, including antioxidants, reagents, and intestinal microorganisms and metabolites. [ABSTRACT FROM AUTHOR]

We describe a simple and robust calibration approach for axial‐scanning microscopy that realizes axial focus shifts with an electrically tunable lens (ETL). We demonstrate the calibration approach based on a microscope with an ETL placed close to the rear stop of the objective lens. By introducing a target—consisted of repeating lines at one known frequency and placed at a ~45° angle to the imaging path, the calibration method captures multiple images at different ETL currents and calibrates the dependence of the axial focus shift on the ETL current by evaluating the sharpness of the captured images. It calibrates the dependence of the magnification of the microscope on the ETL current by measuring the period of the repeating lines in the captured images. The experimental results show that different from the conventional calibration procedure, the proposed scheme does not involve any mechanical scanning and can simultaneously calibrate the dependence of the axial focus shift and the magnification on the ETL current. This might facilitate imaging studies that require the measurement of fine structures in a 3D volume. We also show the calibration procedure can be used to estimate the radius of a conner‐arc sample, fabricated using laser micromachining. We believe that this easy‐to‐use calibration approach may facilitate use of ETLs for a variety of imaging platforms. It may also provide new insights for the development of novel 3D surface measurement methods. Research Highlights: The proposed calibration scheme does not involve any mechanical scanning and can simultaneously calibrate the dependence of the axial focus shift and the magnification on the electrically tunable lens (ETL) current. It might facilitate imaging studies that require the measurement of fine structures in a 3D volume, and the use of ETLs for a variety of imaging platforms. It may also provide new insights for the development of novel 3D surface measurement methods. [ABSTRACT FROM AUTHOR]

In this study, the crystal appearance of industrial grade 2,6-diamino-3,5-dinitropyridine (PYX) was mostly needle-shaped or rod-shaped with an average aspect ratio of 3.47 and roundness of 0.47. According to national military standards, the explosion percentage of impact sensitivity s about 40% and friction sensitivity is about 60%. To improve loading density and pressing safety, the solvent–antisolvent method was used to optimize the crystal morphology, i.e., to reduce the aspect ratio and increase the roundness value. Firstly, the solubility of PYX in DMSO, DMF, and NMP was measured by the static differential weight method, and the solubility model was established. The results showed that the Apelblat equation and Van't Hoff equation could be used to clarify the temperature dependence of PYX solubility in a single solvent. Scanning electron microscopy (SEM) was used to characterize the morphology of the recrystallized samples. After recrystallization, the aspect ratio of the samples decreased from 3.47 to 1.19, and roundness increased from 0.47 to 0.86. The morphology was greatly improved, and the particle size decreased. The structures before and after recrystallization were characterized by infrared spectroscopy (IR). The results showed that no chemical structure changes occurred during recrystallization, and the chemical purity was improved by 0.7%. According to the GJB-772A-97 explosion probability method, the mechanical sensitivity of explosives was characterized. After recrystallization, the impact sensitivity of explosives was significantly reduced from 40% to 12%. A differential scanning calorimeter (DSC) was used to study the thermal decomposition. The thermal decomposition temperature peak of the sample after recrystallization was 5 °C higher than that of the raw PYX. The thermal decomposition kinetic parameters of the samples were calculated by AKTS software, and the thermal decomposition process under isothermal conditions was predicted. The results showed that the activation energy (E) of the samples after recrystallization was higher by 37.9~527.6 kJ/mol than raw PYX, so the thermal stability and safety of the recrystallized samples were improved. [ABSTRACT FROM AUTHOR]

We report a Gamma-corrected, SNR-enhanced and sharpness-projection-based reconstruction approach for digital particle holography. In this approach, we mitigate the artefacts from off-focal planes by capturing three holograms with various illumination angles, and extract particle information by applying image processing to a high-quality maximum – sharpness-projection (MSP) image. This approach reinforces weak edges using a Gamma correction procedure, and segments particles from the MSP image by using a new hybrid threshold, which comprises both local and global features. Experimental results for nonspherical particles show that the reported approach can provide a high-quality MSP image, being less likely than the conventional method to be fooled by noise and more likely to retain particle features. The hybrid threshold helps in retaining fine features, separating neighbouring particles and differentiating particles from the background. For the large particles (>20 pixels), the diameter error is generally less than 10% while using the proposed automatic hybrid thresholding technique. [ABSTRACT FROM AUTHOR]