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6. A study of the effect of changes in nasal tip prominence on the sense of anterior prominence of the upper lip

Author

ZHUANG Ziting, BAO Rui, LI Menghuan, WANG Weicai, and BAO Baicheng

Subjects
orthodontics, dental, facial aesthetics, visual illusion, 3dmd, 3d image, nasal tip prominence, lip protrusion, Medicine
Abstract

Objective The aim of this study was to investigate the effect of changes in nasal tip protrusion on the sense of upper lip protrusion in different populations and to provide a reference for the improvement of soft tissue beauty. Methods Informed consent and portrait authorization were obtained from the model. A female model whose face met the criteria was selected, and a 3D model of her was obtained using a 3D stereo camera. Based on the original model, ZBRUSH2019 software was used to simulate changes in nose tip protrusion. Then, 9 segments of facial dynamic rotation videos were produced, and an electronic questionnaire was created through a questionnaire website to evaluate the effect of different nose tip protrusions on perceived upper lip protrusion. Randomly selected orthodontic patients, orthodontics professionals and general adults completed the electronic questionnaire. In the questionnaire, a Visual Analog Scale was used to evaluate the perceived degree of protrusion of the upper lip. The higher the score, the more prominent the upper lip of the model in the image. The questionnaire data were statistically analyzed using a generalized linear mixed model. Results As the nasal tip position became progressively more retracted, the subjects' upper lip protrusion scores increased. Among male subjects, the results showed that the general population thought that the upper lip protrusion was higher than the patients did when the nasal tip protrusion was +6 mm and +4.5 mm (P = 0.023, P = 0.047). When the nasal tip protrusion was +6 mm, the scores of the general population were higher than those of the orthodontics professionals (P = 0.023). However, when the nasal tip variable was -6 mm, their score was lower than that of the patients (P = 0.003), and there was no significant difference in other retest distances between groups (P>0.05). Conclusion When the protrusion of the nasal tip decreased, the three groups experienced a visual illusion of upper lip protrusion. When the nasal tip protrusion is too large, the general population perceived the visual illusion of the upper lip protrusion as being more obvious.

Published
2023
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14. Idiopathic inflammatory myopathy and non-coding RNA

Author

Yang Yang, Hu GuangXuan, Wan GenMeng, Li MengHuan, Chang Bo, and Yi XueJie

Subjects
idiopathic inflammatory myopathies, autoimmune disease, non-coding RNAs, biomarker, clinical diagnosis, Immunologic diseases. Allergy, RC581-607
Abstract

Idiopathic inflammatory myopathies (IIMs) are common autoimmune diseases that affect skeletal muscle quality and function. The lack of an early diagnosis and treatment can lead to irreversible muscle damage. Non-coding RNAs (ncRNAs) play an important role in inflammatory transfer, muscle regeneration, differentiation, and regulation of specific antibody levels and pain in IIMs. ncRNAs can be detected in blood and hair; therefore, ncRNAs detection has great potential for diagnosing, preventing, and treating IIMs in conjunction with other methods. However, the specific roles and mechanisms underlying the regulation of IIMs and their subtypes remain unclear. Here, we review the mechanisms by which micro RNAs and long non-coding RNA-messenger RNA networks regulate IIMs to provide a basis for ncRNAs use as diagnostic tools and therapeutic targets for IIMs.

Published
2023
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27. Anti-Tuberculosis Drug Induced Regression of Psoriasis and Occurrence of Alopecia Areata: A Case Report.

Author

LI Menghuan, WU Wei, MA Hong, ZHANG Hanlin, ZHANG Ye, LI Yumei, and LIU Liping

Abstract

A 64-year-old man presented with diffuse patchy alopecia for one month. He had a 17-year history of moderate to severe plaque psoriasis. Significant resolution of psoriasis lesions occurred during preventive anti-tuberculosis therapy using isoniazid and rifampicin. However, diffuse patchy alopecia areata developed. After withdrawal of anti-tuberculosis drugs and administration of glucocorticoids, alopecia areata was in remission gradually. However, psoriatic lesions returned. Anti-tuberculosis drugs may exert anti-inflammatory and immunomodulatory effects through multiple key factors. [ABSTRACT FROM AUTHOR]

Published
2024
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