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1. Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt Object

Author

Stern, S. A., Weaver, H. A., Spencer, J. R., Olkin, C. B., Gladstone, G. R., Grundy, W. M., Moore, J. M., Cruikshank, D. P., Elliott, H. A., McKinnon, W. B., Parker, J. Wm., Verbiscer, A. J., Young, L. A., Aguilar, D. A., Albers, J. M., Andert, T., Andrews, J. P., Bagenal, F., Banks, M. E., Bauer, B. A., Bauman, J. A., Bechtold, K. E., Beddingfield, C. B., Behrooz, N., Beisser, K. B., Benecchi, S. D., Bernardoni, E., Beyer, R. A., Bhaskaran, S., Bierson, C. J., Binzel, R. P., Birath, E. M., Bird, M. K., Boone, D. R., Bowman, A. F., Bray, V. J., Britt, D. T., Brown, L. E., Buckley, M. R., Buie, M. W., Buratti, B. J., Burke, L. M., Bushman, S. S., Carcich, B., Chaikin, A. L., Chavez, C. L., Cheng, A. F., Colwell, E. J., Conard, S. J., Conner, M. P., Conrad, C. A., Cook, J. C., Cooper, S. B., Custodio, O. S., Ore, C. M. Dalle, Deboy, C. C., Dharmavaram, P., Dhingra, R. D., Dunn, G. F., Earle, A. M., Egan, A. F., Eisig, J., El-Maarry, M. R., Engelbrecht, C., Enke, B. L., Ercol, C. J., Fattig, E. D., Ferrell, C. L., Finley, T. J., Firer, J., Fischetti, J., Folkner, W. M., Fosbury, M. N., Fountain, G. H., Freeze, J. M., Gabasova, L., Glaze, L. S., Green, J. L., Griffith, G. A., Guo, Y., Hahn, M., Hals, D. W., Hamilton, D. P., Hamilton, S. A., Hanley, J. J., Harch, A., Harmon, K. A., Hart, H. M., Hayes, J., Hersman, C. B., Hill, M. E., Hill, T. A., Hofgartner, J. D., Holdridge, M. E., Horányi, M., Hosadurga, A., Howard, A. D., Howett, C. J. A., Jaskulek, S. E., Jennings, D. E., Jensen, J. R., Jones, M. R., Kang, H. K., Katz, D. J., Kaufmann, D. E., Kavelaars, J. J., Keane, J. T., Keleher, G. P., Kinczyk, M., Kochte, M. C., Kollmann, P., Krimigis, S. M., Kruizinga, G. L., Kusnierkiewicz, D. Y., Lahr, M. S., Lauer, T. R., Lawrence, G. B., Lee, J. E., Lessac-Chenen, E. J., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mages, D. M., Mallder, V. A., Martin, N. P., May, B. H., McComas, D. J., McNutt, R. L., Mehoke, Jr. D. S., Mehoke, T. S., Nelson, D. S., Nguyen, H. D., Núñez, J. I., Ocampo, A. C., Owen, W. M., Oxton, G. K., Parker, A. H., Pätzold, M., Pelgrift, J. Y., Pelletier, F. J., Pineau, J. P., Piquette, M. R., Porter, S. B., Protopapa, S., Quirico, E., Redfern, J. A., Regiec, A. L., Reitsema, H. J., Reuter, D. C., Richardson, D. C., Riedel, J. E., Ritterbush, M. A., Robbins, S. J., Rodgers, D. J., Rogers, G. D., Rose, D. M., Rosendall, P. E., Runyon, K. D., Ryschkewitsch, M. G., Saina, M. M., Salinas, M. J., Schenk, P. M., Scherrer, J. R., Schlei, W. R., Schmitt, B., Schultz, D. J., Schurr, D. C., Scipioni, F., Sepan, R. L., Shelton, R. G., Showalter, M. R., Simon, M., Singer, K. N., Stahlheber, E. W., Stanbridge, D. R., Stansberry, J. A., Steffl, A. J., Strobel, D. F., Stothoff, M. M., Stryk, T., Stuart, J. R., Summers, M. E., Tapley, M. B., Taylor, A., Taylor, H. W., Tedford, R. M., Throop, H. B., Turner, L. S., Umurhan, O. M., Van Eck, J., Velez, D., Versteeg, M. H., Vincent, M. A., Webbert, R. W., Weidner, S. E., Weigle II, G. E., Wendel, J. R., White, O. L., Whittenburg, K. E., Williams, B. G., Williams, K. E., Williams, S. P., Winters, H. L., Zangari, A. M., and Zurbuchen, T. H.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The Kuiper Belt is a distant region of the Solar System. On 1 January 2019, the New Horizons spacecraft flew close to (486958) 2014 MU69, a Cold Classical Kuiper Belt Object, a class of objects that have never been heated by the Sun and are therefore well preserved since their formation. Here we describe initial results from these encounter observations. MU69 is a bi-lobed contact binary with a flattened shape, discrete geological units, and noticeable albedo heterogeneity. However, there is little surface color and compositional heterogeneity. No evidence for satellites, ring or dust structures, gas coma, or solar wind interactions was detected. By origin MU69 appears consistent with pebble cloud collapse followed by a low velocity merger of its two lobes., Comment: 43 pages, 8 figure

Published
2020
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2. Structure-specific amyloid precipitation in biofluids

Author

Rodrigues, M., Bhattacharjee, P., Brinkmalm, A., Do, D. T., Pearson, C. M., De, S., Ponjavic, A., Varela, J. A., Kulenkampff, K., Baudrexel, I., Emin, D., Ruggeri, F. S., Lee, J. E., Carr, A. R., Knowles, T. P. J., Zetterberg, H., Snaddon, T. N., Gandhi, S., Lee, S. F., and Klenerman, D.

Published
2022
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3. The Pluto system: Initial results from its exploration by New Horizons

Author

Stern, S. A., Bagenal, F., Ennico, K., Gladstone, G. R., Grundy, W. M., McKinnon, W. B., Moore, J. M., Olkin, C. B., Spencer, J. R., Weaver, H. A., Young, L. A., Andert, T., Andrews, J., Banks, M., Bauer, B., Bauman, J., Barnouin, O. S., Bedini, P., Beisser, K., Beyer, R. A., Bhaskaran, S., Binzel, R. P., Birath, E., Bird, M., Bogan, D. J., Bowman, A., Bray, V. J., Brozovic, M., Bryan, C., Buckley, M. R., Buie, M. W., Buratti, B. J., Bushman, S. S., Calloway, A., Carcich, B., Cheng, A. F., Conard, S., Conrad, C. A., Cook, J. C., Cruikshank, D. P., Custodio, O. S., Ore, C. M. Dalle, Deboy, C., Dischner, Z. J. B., Dumont, P., Earle, A. M., Elliott, H. A., Ercol, J., Ernst, C. M., Finley, T., Flanigan, S. H., Fountain, G., Freeze, M. J., Greathouse, T., Green, J. L., Guo, Y., Hahn, M., Hamilton, D. P., Hamilton, S. A., Hanley, J., Harch, A., Hart, H. M., Hersman, C. B., Hill, A., Hill, M. E., Hinson, D. P., Holdridge, M. E., Horanyi, M., Howard, A. D., Howett, C. J. A., Jackman, C., Jacobson, R. A., Jennings, D. E., Kammer, J. A., Kang, H. K., Kaufmann, D. E., Kollmann, P., Krimigis, S. M., Kusnierkiewicz, D., Lauer, T. R., Lee, J. E., Lindstrom, K. L., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mallder, V. A., Martin, N., McComas, D. J., McNutt Jr., R. L., Mehoke, D., Mehoke, T., Melin, E. D., Mutchler, M., Nelson, D., Nimmo, F., Nunez, J. I., Ocampo, A., Owen, W. M., Paetzold, M., Page, B., Parker, A. H., Parker, J. W., Pelletier, F., Peterson, J., Pinkine, N., Piquette, M., Porter, S. B., Protopapa, S., Redfern, J., Reitsema, H. J., Reuter, D. C., Roberts, J. H., Robbins, S. J., Rogers, G., Rose, D., Runyon, K., Retherford, K. D., Ryschkewitsch, M. G., Schenk, P., Schindhelm, R., Sepan, B., Showalter, M. R., Singer, K. N., Soluri, M., Stanbridge, D., Steffl, A. J., Strobel, D. F., Stryk, T., Summers, M. E., Szalay, J. R., Tapley, M., Taylor, A., Taylor, H., Throop, H. B., Tsang, C. C. C., Tyler, G. L., Umurhan, O. M., Verbiscer, A. J., Versteeg, M. H., Vincent, M., Webbert, R., Weidner, S., Weigle II, G. E., White, O. L., Whittenburg, K., Williams, B. G., Williams, K., Williams, S., Woods, W. W., Zangari, A. M., and Zirnstein, E.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The Pluto system was recently explored by NASA's New Horizons spacecraft, making closest approach on 14 July 2015. Pluto's surface displays diverse landforms, terrain ages, albedos, colors, and composition gradients. Evidence is found for a water-ice crust, geologically young surface units, surface ice convection, wind streaks, volatile transport, and glacial flow. Pluto's atmosphere is highly extended, with trace hydrocarbons, a global haze layer, and a surface pressure near 10 microbars. Pluto's diverse surface geology and long-term activity raise fundamental questions about how small planets remain active many billions of years after formation. Pluto's large moon Charon displays tectonics and evidence for a heterogeneous crustal composition, its north pole displays puzzling dark terrain. Small satellites Hydra and Nix have higher albedos than expected., Comment: 8 pages - Initial Science paper from NASA's New Horizons Pluto Encounter

Published
2015
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10. Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

Author

Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., Cogdill, A. P., Zhao, L., Hudgens, C. W., Hutchinson, D. S., Manzo, T., Petaccia de Macedo, M., Cotechini, T., Kumar, T., Chen, W. S., Reddy, S. M., Szczepaniak Sloane, R., Galloway-Pena, J., Jiang, H., Chen, P. L., Shpall, E. J., Rezvani, K., Alousi, A. M., Chemaly, R. F., Shelburne, S., Vence, L. M., Okhuysen, P. C., Jensen, V. B., Swennes, A. G., McAllister, F., Marcelo Riquelme Sanchez, E., Zhang, Y., Le Chatelier, E., Zitvogel, L., Pons, N., Austin-Breneman, J. L., Haydu, L. E., Burton, E. M., Gardner, J. M., Sirmans, E., Hu, J., Lazar, A. J., Tsujikawa, T., Diab, A., Tawbi, H., Glitza, I. C., Hwu, W. J., Patel, S. P., Woodman, S. E., Amaria, R. N., Davies, M. A., Gershenwald, J. E., Hwu, P., Lee, J. E., Zhang, J., Coussens, L. M., Cooper, Z. A., Futreal, P. A., Daniel, C. R., Ajami, N. J., Petrosino, J. F., Tetzlaff, M. T., Sharma, P., Allison, J. P., Jenq, R. R., and Wargo, J. A.

Published
2018
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20. Challenges to the Future Conservation of the Antarctic

Author

Chown, S. L., Lee, J. E., Hughes, K. A., Barnes, J., Barrett, P. J., Bergstrom, D. M., Convey, P., Cowan, D. A., Crosbie, K., Dyer, G., Frenot, Y., Grant, S. M., Herr, D., Kennicutt, M. C., Lamers, M., Murray, A., Possingham, H. P., Reid, K., Riddle, M. J., Ryan, P. G., Sanson, L., Shaw, J. D., Sparrow, M. D., Summerhayes, C., Terauds, A., and Wall, D. H.

Published
2012
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25. PLANETARY SCIENCE: The Pluto system: Initial results from its exploration by New Horizons

Author

Stern, S. A., Bagenal, F., Ennico, K., Gladstone, G. R., Grundy, W. M., McKinnon, W. B., Moore, J. M., Olkin, C. B., Spencer, J. R., Weaver, H. A., Young, L. A., Andert, T., Andrews, J., Banks, M., Bauer, B., Bauman, J., Barnouin, O. S., Bedini, P., Beisser, K., Beyer, R. A., Bhaskaran, S., Binzel, R. P., Birath, E., Bird, M., Bogan, D. J., Bowman, A., Bray, V. J., Brozovic, M., Bryan, C., Buckley, M. R., Buie, M. W., Buratti, B. J., Bushman, S. S., Calloway, A., Carcich, B., Cheng, A. F., Conard, S., Conrad, C. A., Cook, J. C., Cruikshank, D. P., Custodio, O. S., Ore, Dalle C. M., Deboy, C., Dischner, Z. J. B., Dumont, P., Earle, A M., Elliott, H. A, Ercol, J., Ernst, C. M., Finley, T., Flanigan, S. H., Fountain, G., Freeze, M. J., Greathouse, T., Green, J. L., Guo, Y., Hahn, M., Hamilton, D. P., Hamilton, S. A., Hanley, J., Harch, A., Hart, H. M., Hersman, C. B., Hill, A., Hill, M. E., Hinson, D. P., Holdridge, M. E., Horanyi, M., Howard, A. D., Howett, C. J. A., Jackman, C., Jacobson, R. A., Jennings, D. E., Kammer, J. A., Kang, H. K., Kaufmann, D. E., Kollmann, P., Krimigis, S. M., Kusnierkiewicz, D., Lauer, T. R., Lee, J. E., Lindstrom, K. L., Linscott, I. R., Lisse, C. M., Lunsford, A. W., Mallder, V. A., Martin, N., McComas, D. J., McNutt, R. L., Jr., Mehoke, D., Mehoke, T., Melin, E. D., Mutchler, M., Nelson, D., Nimmo, F., Nunez, J. I., Ocampo, A., Owen, W. M., Paetzold, M., Page, B., Parker, A. H., Parker, J. W., Pelletier, F., Peterson, J., Pinkine, N., Piquette, M., Porter, S. B., Protopapa, S., Redfern, J., Reitsema, H. J., Reuter, D. C., Roberts, J. H., Bobbins, S. J., Rogers, G., Rose, D., Runyon, K., Retherford, K. D., Ryschkewitsch, M. G., Schenk, P., Schindhelm, E., Sepan, B., Showalter, M. R., Singer, K. N., Soluri, M., Stanbridge, D., Steffl, A. J., Strobel, D. F., Stryk, T., Summers, M. E., Szalay, J. R., Tapley, M., Taylor, A., Taylor, H., Throop, H. B., Tsang, C. C. C., Tyler, G. L., Umurhan, O. M., Verbiscer, A. J., Versteeg, M. H., Vincent, M., Webbert, R., Weidner, S., Weigle, G. E., II, White, O. L., Whittenburg, K., Williams, B. G., Williams, K., Williams, S., Woods, W. W., Zangari, A. M., and Zirnstein, E.

Published
2015
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30. Characteristics and anti-inflammatory effects of the enzymatically extracted polysaccharides of Sargassum fulvellum using crude enzyme from Shewanella oneidensis PKA 1008.

Author

Xu, X. T., Jeong, S. M., Lee, J. E., Kang, W. S., Ryu, S. H., Kim, K., Byun, E. H., Cho, Y. J., and Ahn, D. H.

Subjects
SHEWANELLA oneidensis, ALGINIC acid, SARGASSUM, ENZYMES, BROWN algae
Abstract

Alginic acid is a polysaccharide obtained from brown algae, and its oligosaccharide has various functions such as antiviral, antitumor, immunoregulation, and antioxidant. However, because of its high viscosity, numerous studies have degraded the alginic acid by enzymes to improve its utilisation. In the present work, we characterised Sargassum fulvellum enzymatic extract (SFEE) using polysaccharide-degrading enzyme obtained from Shewanella oneidensis PKA 1008, and investigated its anti-inflammatory potential. S. fulvellum powder and crude enzyme were mixed at a ratio of 1:1 (v/v), and reacted at 30°C for 0 - 48 h to obtain the optimum degrading time. The changes in pH, colour, reducing sugar, and viscosity of SFEE were determined. The anti-inflammatory activity of SFEE was confirmed by measuring the expression level of nitric oxide (NO) and proinflammatory cytokines (IL-6, TNF-a, and L-1ß) in RAW 264.7 macrophage cell line. The reducing sugar content was found to increase 2.75-fold at 24 h as compared to that at the initial reaction point, but pH and viscosity decreased significantly with increasing reaction time. SFEE showed a high inhibitory effect on the levels of NO and pro-inflammatory cytokines. SFEE thus has great potential for development as a functional food and therapeutic material owing to its anti-inflammatory effect. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Formation of embedded plasmonic Ga nanoparticle arrays and their influence on GaAs photoluminescence.

Author

Kang, M., Jeon, S., Jen, T., Lee, J.-E., Sih, V., and Goldman, R. S.

Subjects
GALLIUM, NANOPARTICLES, PHOTOLUMINESCENCE, GALLIUM arsenide, HETEROSTRUCTURES
Abstract

We introduce a novel approach to the seamless integration of plasmonic nanoparticle (NP) arrays into semiconductor layers and demonstrate their enhanced photoluminescence (PL) efficiency. Our approach utilizes focused ion beam-induced self-assembly of close-packed arrays of Ga NPs with tailorable NP diameters, followed by overgrowth of GaAs layers using molecular beam epitaxy. Using a combination of PL spectroscopy and electromagnetic computations, we identify a regime of Ga NP diameter and overgrown GaAs layer thickness where NP-array-enhanced absorption in GaAs leads to enhanced GaAs near-band-edge (NBE) PL efficiency, surpassing that of high-quality epitaxial GaAs layers. As the NP array depth and size are increased, the reduction in spontaneous emission rate overwhelms the NP-array-enhanced absorption, leading to a reduced NBE PL efficiency. This approach provides an opportunity to enhance the PL efficiency of a wide variety of semiconductor heterostructures. [ABSTRACT FROM AUTHOR]

Published
2017
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