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10,995 results on '"Lauro, A."'

1. Dianoga SIDM: galaxy cluster self-interacting dark matter simulations

Author

Ragagnin, Antonio, Meneghetti, Massimo, Calura, Francesco, Despali, Giulia, Dolag, Klaus, Fischer, Moritz S., Giocoli, Carlo, and Moscardini, Lauro

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Phenomenology
Abstract

This work aims at assessing the impact of DM self-interactions on the properties of galaxy clusters. In particular, the goal is to study the angular dependence of the cross section by testing rare (large angle scattering) and frequent (small angle scattering) SIDM models with velocity-dependent cross sections. We re-simulate six galaxy cluster zoom-in initial conditions with a dark matter only run and with a full-physics setup simulations that includes a self-consistent treatment of baryon physics. We test the dark matter only setup and the full physics setup with either collisionless cold dark matter, rare self-interacting dark matter, and frequent self-interacting dark matter models. We then study their matter density profiles as well as their subhalo population. Our dark matter only SIDM simlations agree with theoretical models, and when baryons are included in simulations, our SIDM models substantially increase the central density of galaxy cluster cores compared to full-physics simulations using collisionless dark matter. SIDM subhalo suppression in full-physics simulations is milder compared to the one found in dark matter only simulations, because of the cuspier baryionic potential that prevent subhalo disruption. Moreover SIDM with small-angle scattering significantly suppress a larger number of subhaloes compared to large angle scattering SIDM models. Additionally, SIDM models generate a broader range of subhalo concentration values, including a tail of more diffuse subhaloes in the outskirts of galaxy clusters and a population of more compact subhaloes in the cluster cores., Comment: 14 pages, 15 figures, abstract abridged to fit arXiv character limit, submitted to Astronomy and Astrophysics

Published
2024
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2. AMICO galaxy clusters in KiDS-DR3: measuring the splashback radius from weak gravitational lensing

Author

Giocoli, Carlo, Palmucci, Lorenzo, Lesci, Giorgio F., Moscardini, Lauro, Despali, Giulia, Marulli, Federico, Maturi, Matteo, Radovich, Mario, Sereno, Mauro, Bardelli, Sandro, Castignani, Gianluca, Covone, Giovanni, Ingoglia, Lorenzo, Romanello, Massimiliano, Roncarelli, Mauro, and Puddu, Emanuella

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Context. Weak gravitational lensing offers a powerful method to investigate the projected matter density distribution within galaxy clusters, granting crucial insights into the broader landscape of dark matter on cluster scales. Aims. In this study, we make use of the large photometric galaxy cluster data set derived from the publicly available Third Data Release of the Kilo-Degree Survey, along with the associated shear signal. Our primary objective is to model the peculiar sharp transition in the cluster profile slope, that is what is commonly referred to as the splashback radius. The data set under scrutiny includes 6962 galaxy clusters, selected by AMICO - an optimised detection algorithm of galaxy clusters - on the KiDS-DR3 data, in the redshift range of 0.1 < z < 0.6, all observed at a signal-to-noise ratio greater than 3.5. Methods. Employing a comprehensive Bayesian analysis, we model the stacked excess surface mass density distribution of the clusters. We adopt a model from recent results on numerical simulations that capture the dynamics of both orbiting and infalling materials, separated by the region where the density profile slope undergoes a pronounced deepening. Results. We find that the adopted profile successfully characterizes the cluster masses, consistent with previous works, and models the deepening of the slope of the density profiles measured with weak-lensing data up to the outskirts. Moreover, we measure the splashback radius of galaxy clusters and show that its value is close to the radius within which the enclosed overdensity is 200 times the mean matter density of the Universe, while theoretical models predict a larger value consistent with a low accretion rate. This points to a potential bias of optically selected clusters preferentially characterized by a high density at small scales compared to a pure mass-selected cluster sample., Comment: Accepted for publication in A&A. Added a discussion about prior parameters, as suggested by the reviewer. arXiv admin note: text overlap with arXiv:2103.05653

Published
2024
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6. Budget impact analysis of introducing digital breast tomosynthesis in breast cancer screening in Italy

Author

Djuric, Olivera, Deandrea, Silvia, Mantellini, Paola, Sardanelli, Francesco, Venturelli, Francesco, Montemezzi, Stefania, Vecchio, Riccardo, Bucchi, Lauro, Senore, Carlo, Giordano, Livia, Paci, Eugenio, Bonifacino, Adriana, Calabrese, Massimo, Caumo, Francesca, Degrassi, Flori, Sassoli de’ Bianchi, Priscilla, Battisti, Francesca, Zappa, Marco, Pattacini, Pierpaolo, Campari, Cinzia, Nitrosi, Andrea, Di Leo, Giovanni, Frigerio, Alfonso, Magni, Veronica, Fornasa, Francesca, Romanucci, Giovanna, Falini, Patrizia, Auzzi, Noemi, Armaroli, Paola, and Giorgi Rossi, Paolo

Published
2024
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8. Understanding factors limiting hematopoietic cell transplantation for acute myeloid leukemia patients in Mexico: a comprehensive analysis

Author

Solís-Armenta, Rubén, Rodríguez-Rodríguez, Sergio, Hernández-Pérez, Andrea Priscila, Paulina-Zapata, Nidia, Delgado, Nancy, Montano-Figueroa, Efreen H., Leyto, Faustino, Solís-Poblano, Juan Carlos, Gómez-De León, Andrés, Amador, Lauro Fabian, García-Castillo, Carolina, Martínez-Hernández, Ramon, Saldaña-Velazquez, Hugo Alexis, Valero-Saldaña, Luis Manuel, Terreros, Eduardo, Jimenez-Ochoa, Marco Alejandro, Milán-Salvatierra, Andrea, Colunga-Pedraza, Perla Rocío, Gómez-Almaguer, David, Alcivar, Luisa M., Apodaca-Chávez, Elia, Meza, Mario, Yocupicio, Fabiola, Sánchez-Díaz, Susana, and Demichelis-Gómez, Roberta

Published
2024
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9. Organizational impact of systemic implementation of digital breast tomosynthesis as a primary test for breast cancer screening in Italy

Author

Djuric, Olivera, Deandrea, Silvia, Mantellini, Paola, Sardanelli, Francesco, Venturelli, Francesco, Montemezzi, Stefania, Vecchio, Riccardo, Bucchi, Lauro, Senore, Carlo, Giordano, Livia, Paci, Eugenio, Bonifacino, Adriana, Calabrese, Massimo, Caumo, Francesca, Degrassi, Flori, Sassoli de’ Bianchi, Priscilla, Battisti, Francesca, Zappa, Marco, Pattacini, Pierpaolo, Campari, Cinzia, Nitrosi, Andrea, Di Leo, Giovanni, Frigerio, Alfonso, Magni, Veronica, Fornasa, Francesca, Romanucci, Giovanna, Falini, Patrizia, Auzzi, Noemi, Armaroli, Paola, and Giorgi Rossi, Paolo

Published
2024
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10. AMICO-COSMOS galaxy cluster and group catalogue up to $z = 2$: Sample properties and X-ray counterparts

Author

Toni, Greta, Maturi, Matteo, Finoguenov, Alexis, Moscardini, Lauro, and Castignani, Gianluca

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

We present a new galaxy cluster search in the COSMOS field through the use of the Adaptive Matched Identifier of Clustered Objects (AMICO). We produced a new cluster and group catalogue up to $z=2$, by performing an innovative application of AMICO with respect to previous successful applications to wide-field surveys, in terms of depth (down to $r < 26.7$), small area covered ($1.69 deg^2$ of unmasked area) and redshift extent. This sample, and the comparative analysis we performed with the X-rays, allowed for the calibration of mass-proxy scaling relations up to $z=2$ and down to less than $10^{13} M_{sun}$ and constitutes the base for the refinement of the cluster model for future applications of AMICO, like the analysis of upcoming Euclid data. AMICO is based on an optimal linear matched filter and detects clusters in photometric galaxy catalogues using galaxy location, photometric redshift and, in the simplest case, one galaxy property. We used one magnitude as galaxy property, avoiding explicit use of galaxy colour, and performed 3 independent runs in the r, Y and H bands using both COSMOS2020 and COSMOS2015 galaxy catalogues. The final catalogue resulting from matching the results of the three runs contains 1269 and 666 candidate clusters with $S/N >3.0$ and $>3.5$, respectively. Most of the unmatched ones have $S/N <3.5$ which can be chosen as cut for a more robust sample. We assigned X-ray properties to our detections via matching with a public X-ray group sample and by estimating, for unmatched detections, X-ray properties at the location of AMICO candidates based on Chandra+XMM-Newton data. 622 are the candidates with X-ray flux estimate. This large sample allowed for the calibration of the scaling relations between AMICO mass-proxies and X-ray mass and the study of their redshift dependence for the selection of the most stable photometric bands., Comment: 16 pages, 15 figures, 3 tables, submitted to Astronomy & Astrophysics (A&A)

Published
2023
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11. Intersectionalities in Internationalization Studies: An Overview of Brazilian Research

Author

Simone M. Costa, Lauro Sérgio M. Pereira, and Kléber A. Silva

Abstract

This systematic review explores the intersection of race, gender, and social class in the context of internationalization of higher education (IHE) research in Brazil. Historically, the development of the Brazilian educational system has responded to the elite's demands and reproduced Western-European values and knowledge. The exponential growth of IHE has led to increased scholarly interest in various interdisciplinary research areas, with a possible move in studies and practices from a neoliberal to a more critical, decolonial, and diverse perspective. This article aims to investigate to what extent Brazilian researchers have investigated the intersectionality of gender, race, and class in IHE. Using two scientific databases, the published between 2015 and 2022. The theoretical framework of intersectionality (Crenshaw, 2002; Collins & Bilge, 2021; Akotirene, 2019) is presented to help recognize the interaction of different social markers of inequalities in IHE. The results pointed to a small number of publications related to this theme and continuous interest in the Science without Borders (SwB) mobility program. A particularly privileged profile of participants in academic mobility programs across various higher education institutions (HEI) in Brazil demonstrated the need for planning and actions to understand the social, historical, and political aspects that perpetuate exclusions. Moreover, this review indicates the importance of addressing colonialism in social dynamics and recognizing the coloniality of power in language policies in IHE. It calls for further investigations that explore the intersections of social markers in IHE processes from a more politically engaged perspective.

Published
2023

13. Ancient Plasmodium genomes shed light on the history of human malaria

Author

Michel, Megan, Skourtanioti, Eirini, Pierini, Federica, Guevara, Evelyn K., Mötsch, Angela, Kocher, Arthur, Barquera, Rodrigo, Bianco, Raffaela A., Carlhoff, Selina, Coppola Bove, Lorenza, Freilich, Suzanne, Giffin, Karen, Hermes, Taylor, Hiß, Alina, Knolle, Florian, Nelson, Elizabeth A., Neumann, Gunnar U., Papac, Luka, Penske, Sandra, Rohrlach, Adam B., Salem, Nada, Semerau, Lena, Villalba-Mouco, Vanessa, Abadie, Isabelle, Aldenderfer, Mark, Beckett, Jessica F., Brown, Matthew, Campus, Franco G. R., Chenghwa, Tsang, Cruz Berrocal, María, Damašek, Ladislav, Duffett Carlson, Kellie Sara, Durand, Raphaël, Ernée, Michal, Fântăneanu, Cristinel, Frenzel, Hannah, García Atiénzar, Gabriel, Guillén, Sonia, Hsieh, Ellen, Karwowski, Maciej, Kelvin, David, Kelvin, Nikki, Khokhlov, Alexander, Kinaston, Rebecca L., Korolev, Arkadii, Krettek, Kim-Louise, Küßner, Mario, Lai, Luca, Look, Cory, Majander, Kerttu, Mandl, Kirsten, Mazzarello, Vittorio, McCormick, Michael, de Miguel Ibáñez, Patxuka, Murphy, Reg, Németh, Rita E., Nordqvist, Kerkko, Novotny, Friederike, Obenaus, Martin, Olmo-Enciso, Lauro, Onkamo, Päivi, Orschiedt, Jörg, Patrushev, Valerii, Peltola, Sanni, Romero, Alejandro, Rubino, Salvatore, Sajantila, Antti, Salazar-García, Domingo C., Serrano, Elena, Shaydullaev, Shapulat, Sias, Emanuela, Šlaus, Mario, Stančo, Ladislav, Swanston, Treena, Teschler-Nicola, Maria, Valentin, Frederique, Van de Vijver, Katrien, Varney, Tamara L., Vigil-Escalera Guirado, Alfonso, Waters, Christopher K., Weiss-Krejci, Estella, Winter, Eduard, Lamnidis, Thiseas C., Prüfer, Kay, Nägele, Kathrin, Spyrou, Maria, Schiffels, Stephan, Stockhammer, Philipp W., Haak, Wolfgang, Posth, Cosimo, Warinner, Christina, Bos, Kirsten I., Herbig, Alexander, and Krause, Johannes

Published
2024
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14. ChatGPT vs. neurologists: a cross-sectional study investigating preference, satisfaction ratings and perceived empathy in responses among people living with multiple sclerosis

Author

Maida, Elisabetta, Moccia, Marcello, Palladino, Raffaele, Borriello, Giovanna, Affinito, Giuseppina, Clerico, Marinella, Repice, Anna Maria, Di Sapio, Alessia, Iodice, Rosa, Spiezia, Antonio Luca, Sparaco, Maddalena, Miele, Giuseppina, Bile, Floriana, Scandurra, Cristiano, Ferraro, Diana, Stromillo, Maria Laura, Docimo, Renato, De Martino, Antonio, Mancinelli, Luca, Abbadessa, Gianmarco, Smolik, Krzysztof, Lorusso, Lorenzo, Leone, Maurizio, Leveraro, Elisa, Lauro, Francesca, Trojsi, Francesca, Streito, Lidia Mislin, Gabriele, Francesca, Marinelli, Fabiana, Ianniello, Antonio, De Santis, Federica, Foschi, Matteo, De Stefano, Nicola, Morra, Vincenzo Brescia, Bisecco, Alvino, Coghe, Giancarlo, Cocco, Eleonora, Romoli, Michele, Corea, Francesco, Leocani, Letizia, Frau, Jessica, Sacco, Simona, Inglese, Matilde, Carotenuto, Antonio, Lanzillo, Roberta, Padovani, Alessandro, Triassi, Maria, Bonavita, Simona, and Lavorgna, Luigi

Published
2024
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22. Supporting Better Insights of Data Science Pipelines with Fine-grained Provenance

Author

Chapman, Adriane, Lauro, Luca, Missier, Paolo, and Torlone, Riccardo

Subjects
Computer Science - Databases, 68, H.1, H.2
Abstract

Successful data-driven science requires complex data engineering pipelines to clean, transform, and alter data in preparation for machine learning, and robust results can only be achieved when each step in the pipeline can be justified, and its effect on the data explained. In this framework, our aim is to provide data scientists with facilities to gain an in-depth understanding of how each step in the pipeline affects the data, from the raw input to training sets ready to be used for learning. Starting from an extensible set of data preparation operators commonly used within a data science setting, in this work we present a provenance management infrastructure for generating, storing, and querying very granular accounts of data transformations, at the level of individual elements within datasets whenever possible. Then, from the formal definition of a core set of data science preprocessing operators, we derive a provenance semantics embodied by a collection of templates expressed in PROV, a standard model for data provenance. Using those templates as a reference, our provenance generation algorithm generalises to any operator with observable input/output pairs. We provide a prototype implementation of an application-level provenance capture library to produce, in a semi-automatic way, complete provenance documents that account for the entire pipeline. We report on the ability of our implementations to capture provenance in real ML benchmark pipelines and over TCP-DI synthetic data. We finally show how the collected provenance can be used to answer a suite of provenance benchmark queries that underpin some common pipeline inspection questions, as expressed on the Data Science Stack Exchange., Comment: 37 pages, 27 figures, submitted to a journal

Published
2023
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24. MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features

Author

Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto-Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, and David R. Raleigh

Subjects
Science
Abstract

Abstract Meningiomas are associated with inactivation of NF2/Merlin, but approximately one-third of meningiomas with favorable clinical outcomes retain Merlin expression. Biochemical mechanisms underlying Merlin-intact meningioma growth are incompletely understood, and non-invasive biomarkers that may be used to guide treatment de-escalation or imaging surveillance are lacking. Here, we use single-cell RNA sequencing, proximity-labeling proteomic mass spectrometry, mechanistic and functional approaches, and magnetic resonance imaging (MRI) across meningioma xenografts and patients to define biochemical mechanisms and an imaging biomarker that underlie Merlin-intact meningiomas. We find Merlin serine 13 (S13) dephosphorylation drives meningioma Wnt signaling and tumor growth by attenuating inhibitory interactions with β-catenin and activating the Wnt pathway. MRI analyses show Merlin-intact meningiomas with S13 phosphorylation and favorable clinical outcomes are associated with high apparent diffusion coefficient (ADC). These results define mechanisms underlying a potential imaging biomarker that could be used to guide treatment de-escalation or imaging surveillance for patients with Merlin-intact meningiomas.

Published
2024
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25. Uno sguardo gestaltico sulla psicoterapia di coppia: dalla teoria dell’attaccamento alla terapia focalizzata sulle emozioni (EFT)

Author

Francesco Marino 1, Arianna Glorioso 1, Rita Zampi, Gabriele Gautiero, Giusy Lauro, and Maura Perrone

Subjects
psicoterapia di coppia, attaccamento, emozioni, Pathology, RB1-214, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

La formazione della coppia è un processo in continua evoluzione, negli ultimi anni le richieste d’aiuto per la psicoterapia di coppia sono sempre più in aumento. I motivi sembrano riguardare il presente, ma spesso sono legati ad un malessere radicato nel tempo. Attraverso la lente dello psicoterapeuta della Gestalt abbiamo analizzato prevalentemente gli studi della teoria dell’attaccamento riferiti al lavoro con le coppie attraverso un’integrazione di approcci, teorie e pratiche, in particolare la terapia di coppia focalizzata sulle emozioni. Secondo la teoria dell’attaccamento gli stili relazionali degli adulti con i propri partner sono paralleli alle relazioni bambino-caregiver, caratterizzandosi perciò per la ricerca di determinate caratteristiche nell’altra persona. Il lavoro psicoterapeutico con le coppie ha tra i propri obiettivi quello di modificare i modelli operativi interni di attaccamento dei pazienti. La terapia di coppia focalizzata sulle emozioni si basa sulla risposta emotiva e su quello che i partner sentono all’interno di una relazione supportante. Consente un’esperienza emotiva risanatrice, trasformando i cicli di interazione negativa presenti nella relazione e sperimentati con i caregiver primari. La psicoterapia della Gestalt ci aiuta a osservare come i partner della coppia realizzano o bloccano la loro intenzionalità di raggiungere e farsi raggiungere dall'altro. Lo scopo della ricerca è stato esaminare i correlati tra teoria dell’attaccamento, terapia focalizzata sulle emozioni e terapia della Gestalt, in vista di ulteriori studi che permettano un maggior approfondimento delle dinamiche di coppia in terapia.

Published
2024
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26. Non-Uniform Drying Shrinkage in Robocasted Green Body Ceramic Products

Author

Nicolas Lauro, Arnaud Alzina, Benoit Nait-Ali, and David S. Smith

Subjects
drying, shrinkage, robocasting, image analysis, Technology, Chemical technology, TP1-1185
Abstract

The formation of defects, due to drying, in robocasted ceramic objects is an important issue arising from non-uniform shrinkage of the material during this step in the process. Common methods for shrinkage measurement are not well suited to the small size of robocasted cords or the complexity of robocasted objects. Innovative methods for shrinkage measurement were developed using non-destructive optical vision techniques with computer-controlled data acquisition, allowing measurement on millimetric cords and on specific zones of a product. The study of a single porcelain cord revealed an anisometric shrinkage related to the orientation of grains during extrusion. A differential shrinkage at the macroscopic scale was also measured on a robocasted object, indicating a moisture content gradient in the material. The methods presented in this paper are of particular relevance to real-time control of the drying process for robocasted objects.

Published
2024
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27. Robot-assisted knee arthroplasty: Analyzing the learning curve and initial institutional experience

Author

Leandro Ejnisman, Eliane Antonioli, Luciana Cintra, Pamela Gabriela de Oliveira Souza, Lauro Augusto Veloso Costa, and Mario Lenza

Subjects
Robotic surgical procedures, Total knee arthroplasty, Learning curve, Functional outcomes, Biotechnology, TP248.13-248.65
Abstract

Robot-assisted total knee arthroplasty (rTKA) involves a learning curve for orthopedic surgeons. The aim of the present study was to assess the surgical times of rTKA procedures performed by initial stage and proficiency stage surgeons in comparison with times of conventional total knee arthroplasty (cTKA). The results reveal that the learning curve for rTKA varies considerable between surgeons, suggesting that the skill and aptitude of the individual to adapt to the robotic system play key roles in the learning process. Proficiency stage surgeons were able to reduce rTKA surgical times to levels comparable with those of conventional surgeries after performing approximately 30 to 40 robotic procedures. Ongoing research has shown promising outcomes in terms of improved clinical results and reduced complications following the application of advanced robotic technology to total knee arthroplasty.

Published
2024
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29. Preovulatory follicular fluid secretome added to in vitro maturation medium influences the metabolism of equine cumulus-oocyte complexes

Author

Luis-Calero, Marcos, Ortiz-Rodríguez, José Manuel, Fernández-Hernández, Pablo, Muñoz-García, Carmen Cristina, Pericuesta, Eva, Gutiérrez-Adán, Alfonso, Marinaro, Federica, Embade, Nieves, Conde, Ricardo, Bizkarguenaga, Maider, Millet, Óscar, González-Fernández, Lauro, and Macías-García, Beatriz

Published
2024
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30. Association of institutional masking policies with healthcare-associated SARS-CoV-2 infections in Swiss acute care hospitals during the BA.4/5 wave (CH-SUR study): a retrospective observational study

Author

Dörr, Tamara, Güsewell, Sabine, Flury, Domenica, Süveges, Maria, Gaza Valera, Camille Beatrice, Botero-Mesa, Sara, Zanella, Marie-Céline, Iten, Anne, Balmelli, Carlo, Troillet, Nicolas, Tschudin-Sutter, Sarah, W Schreiber, Peter, Jent, Philipp, Damonti, Lauro, Sommerstein, Rami, Portmann, Lea, Vuichard-Gysin, Danielle, Cusini, Alexia, Nussbaumer-Ochsner, Yvonne, Heininger, Ulrich, Berger, Christoph, Zimmermann, Petra, Gardiol, Céline, Keiser, Olivia, Schlegel, Matthias, Kohler, Philipp, and P Kuster, Stefan

Published
2024
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31. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats

Author

de Noronha, Sylvana I. S. Rendeiro, de Moraes, Lauro Angelo Gonçalves, Hassell, Jr., James E., Stamper, Christopher E., Arnold, Mathew R., Heinze, Jared D., Foxx, Christine L., Lieb, Margaret M., Cler, Kristin E., Karns, Bree L., Jaekel, Sophia, Loupy, Kelsey M., Silva, Fernanda C. S., Chianca-Jr., Deoclécio Alves, Lowry, Christopher A., and de Menezes, Rodrigo Cunha

Published
2024
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36. Translation and cross-cultural adaptation of seventeen widely-used assessment instruments for child and adolescent mental health in Greece

Author

Karagiorga, Vasiliki Eirini, Schafer, Julia Luiza, Marchionatti, Lauro Estivalete, Caye, Arthur, Serdari, Aspasia, Kotsis, Konstantinos, Basta, Maria, Balikou, Panagiota, Kapsimalli, Efstathia, Mitropoulou, Andromachi, Klavdianou, Nikanthi, Zeleni, Domna, Mitroulaki, Sotiria, Botzaki, Anna, Gerostergios, Giorgos, Samiotakis, Giorgos, Simioni, André, Georgiades, Katholiki, Salum, Giovanni Abrahão, and Koumoula, Anastasia

Published
2024
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40. Understanding priorities and needs for child and adolescent mental health in Greece from multiple informants: an open resource dataset

Author

Koumoula, Anastasia, Marchionatti, Lauro Estivalete, Karagiorga, Vasiliki Eirini, Schafer, Julia Luiza, Simioni, André, Caye, Arthur, Serdari, Aspasia, Kotsis, Konstantinos, Basta, Maria, Athanasopoulou, Lilian, Dafoulis, Vaios, Tatsiopoulou, Paraskevi, Zilikis, Nikos, Vergouli, Evangelia, Balikou, Panagiota, Kapsimalli, Efstathia, Mitropoulou, Andromachi, Tzotzi, Alexandra, Klavdianou, Nikanthi, Zeleni, Domna, Mitroulaki, Sotiria, Botzaki, Anna, Gerostergios, Giorgos, Samiotakis, Giorgos, Moschos, Giorgos, Giannopoulou, Ioanna, Papanikolaou, Katerina, Angeli, Katerina, Scarmeas, Nikolaos, Emanuele, Jill, Schuster, Kenneth, Karyotaki, Eirini, Kalikow, Lily, Pronoiti, Katerina, Merikangas, Kathleen R., Szatmari, Peter, Cuijpers, Pim, Georgiades, Katholiki, Milham, Michael P., Corcoran, Mimi, Burke, Sarah, Koplewicz, Harold, and Salum, Giovanni Abrahão

Published
2024
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44. Role of targeted biopsy, perilesional biopsy, random biopsy, and their combination in the detection of clinically significant prostate cancer by mpMRI/transrectal ultrasonography fusion biopsy in confirmatory biopsy during active surveillance program

Author

Novara, Giacomo, Zattoni, Fabio, Zecchini, Giovanni, Aceti, Alberto, Pellizzari, Anna, Ferraioli, Giordana, Cobacchini, Claudia, Taverna, Alessandra, Sattin, Francesca, Carletti, Filippo, La Bombarda, Giulia, Lacognata, Carmelo Salvino, Lauro, Alberto, Gardiman, Marina, Morlacco, Alessandro, Betto, Giovanni, and Dal Moro, Fabrizio

Published
2024
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49. Estudo do processo de produção de biochar via pirólise da semente de açaí visando à remediação do solo

Author

Wagner Monteiro Lucena, Fernanda Paula da Costa Assunção, Douglas Alberto Rocha de Castro, Lauro Henrique Hamoy Guerreiro, and Nélio Teixeira Machado

Subjects
caroço de açaí, adsorção. biochar, pirólise., remediação., Environmental technology. Sanitary engineering, TD1-1066, Environmental engineering, TA170-171, Environmental sciences, GE1-350
Abstract

Neste trabalho se investigou a produção de biochar (biocarvão) oriundo do processo de pirólise dos caroços de açaí (Euterpe oleracea), utilizando as temperaturas de 400°C e 450°C. Observou-se que a temperatura do processo influencia o rendimento de biochar. Os resultados mostraram que, com o aumento de temperatura o rendimento do biochar diminui, enquanto o do bio-óleo aumenta. A temperatura de pirólise alterou a morfologia do biochar, sendo reduzido a pó depois dela. Assim, foram realizados testes de adsorção nas amostras de 400°C e 450°C e em amostras impregnadas com uma solução de 2 mol.L-1 de ácido clorídrico (HCl). Os dados de equilíbrio foram analisados com base nas isotermas de Langmuir e Freundlich. A cinética foi avaliada de acordo com a variação de tempo para a concentração de 1% v/v de ácido acético (CH3COOH), conforme os modelos cinéticos obtidos. Desse modo, conclui-se que o biochar dos caroços de açaí é um adsorvente de baixo custo com capacidade satisfatória para remediação do solo. A partir dos resultados dos ensaios de adsorção foi constatado que a ativação com ácido clorídrico não foi eficaz devido à redução da capacidade de adsorção em relação aos adsorventes não impregnados.

Published
2024
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50. Exploring a Novel Approach to Spare Classic Chemotherapy in HER2-Low, ER-Positive Breast Cancer Based on Trastuzumab Deruxtecan Combined with Endocrine Therapy

Author

Luca Scafuri, Carlo Buonerba, Vincenzo Di Lauro, Vincenzo Tortora, Marco Cascella, Luigi Liguori, Antonella Sciarra, Francesco Sabbatino, Anna Diana, Antonio Marra, Paolo Tarantino, Dario Trapani, Mario Giuliano, Grazia Arpino, Giuseppe Curigliano, and Giuseppe Di Lorenzo

Subjects
Breast cancer, HER2-low, Estrogen receptor-positive, Neoadjuvant therapy, Trastuzumab deruxtecan, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Breast cancer presents diverse molecular subtypes affecting treatment strategies. Human epidermal growth factor receptor 2 (HER2)-low, hormone receptor-positive (HR+) breast cancer poses a challenge due to limited targeted therapies. Current neoadjuvant treatment primarily utilizes chemotherapy, with conflicting results regarding efficacy in patients with HER2-low breast cancer. Trastuzumab deruxtecan (T-DXd) shows promise in HER2-low metastatic disease, and preliminary evidence suggests synergy with endocrine therapy. Objective This editorial explores the hypothesis that neoadjuvant T-DXd with or without endocrine therapy offers efficacy in the clinical management of HR+/HER2-low breast cancer. Methods We propose a phase II study with two treatment arms: T-DXd + letrozole and T-DXd alone. The primary endpoint is the radiological complete response rate. Secondary endpoints include pathological complete response rate, safety, event-free survival, and overall survival. Exploratory analyses will compare the arms to identify potential for optimizing treatment efficacy and minimizing side effects. Conclusions This study design allows for initial assessment of T-DXd with or without endocrine therapy in the treatment of HER2-low breast cancer. The findings may pave the way for personalized treatment strategies and inform future research, potentially leading to a chemotherapy-sparing approach.

Published
2024
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