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Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within‐individual basis is incorrect and greatly variable between individuals. Indeed, each data point on the autoregulatory curve originated from independent samples of participants and patients and represented interindividual relationships between cerebral blood flow and mean arterial pressure. Nonetheless, this influential concept remains commonly cited and illustrated in various high‐impact publications and medical textbooks, and is frequently taught in medical and science education without appropriate nuances and caveats. Herein, we provide the rationale and additional experimental data supporting the notion we need to lose this dogmatic view of cerebral autoregulation.

In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept suggested a relatively broad mean arterial pressure range (~60–150 mmHg) wherein cerebral blood flow remains constant. However, the assumption that this wide cerebral autoregulation plateau could be applied on a within‐individual basis is incorrect and greatly variable between individuals. Indeed, each data point on the autoregulatory curve originated from independent samples of participants and patients and represented interindividual relationships between cerebral blood flow and mean arterial pressure. Nonetheless, this influential concept remains commonly cited and illustrated in various high‐impact publications and medical textbooks, and is frequently taught in medical and science education without appropriate nuances and caveats. Herein, we provide the rationale and additional experimental data supporting the notion we need to lose this dogmatic view of cerebral autoregulation. [ABSTRACT FROM AUTHOR]

Researchers have documented precipitous declines in Cascades Frog (Rana cascadae) populations in the southern portion of the species' range, in the Lassen region of California. Reasons for the declines, however, have not been elucidated. In addition to common, widespread causes, an understanding of local community interactions may be necessary to fully understand proximal causes of the declines. Based on existing literature and observations made during extensive aquatic surveys throughout the range of R. cascadae in California, we propose that a proliferation of freshwater leeches (subclass Hirudinida) in the Lassen region may be adversely affecting R. cascadae populations. Leeches may affect R. cascadae survival or fecundity directly by preying on egg and hatchling life stages, and indirectly by contributing to the spread of pathogens and secondary parasites. In 2007, we conducted focused surveys at known or historic R. cascadae breeding sites to document co-occurrences of R. cascadae and leeches, determine if leeches were preying on or parasitizing eggs or hatchlings of R. cascadae, and identify the leech species to establish whether or not they were native to the region. We found R. cascade at 4 of 21 sites surveyed and freshwater leeches at 9 sites, Including all sites with R. cascadae. In 2007 and 2008, the predatory leech Haemopis marmorata frequented R. cascadae egg masses, was observed probing or tearing at eggs on 24 occasions, and was 10 times more common in 1-m2 plots centered on egg masses than in similar plots without egg masses. Six species of leech were identified from the Lassen region, only 3 of which have been documented from the region prior to this study. Given our documentation of a diverse freshwater leech fauna in direct association with a precipitously declining species, we believe a better understanding of the biology and ecology of this poorly studied taxon is needed, in addition to studies of the effects of freshwater leeches on survival and recruitment of co-occurring amphibians. [ABSTRACT FROM AUTHOR]

Abstract: Variations in spatial abundances, compositions, and textures of undercooled magmatic inclusions were determined in a glaciated Pleistocene lava dome (Mt. Helen; ~0.6 km3) at the Lassen volcanic center (LVC), southernmost Cascades. Spatial variations were determined by point-counting at 86 locations separated by ~100 m on the dome. Major and trace element compositions of host rocks and inclusions at 12 locations along the flow length of the dome were obtained. Important results include the following. (1) Inclusion abundances range from 3–19 vol.%, with the highest values generally located along the little eroded northwestern margin and flow front of the dome. (2) Host rock compositions are markedly uniform across the dome (65.4+/−0.4 wt.% SiO2) indicating that the degree of inclusion disaggregation was uniform, despite large spatial variations in inclusion abundances. (3) Inclusion sizes range from a maximum of ~1 m across to mm-sized crystal clots of phenocrysts plus adhering Ca-rich plagioclase microphenocrysts. (4) Inclusions have variable macroscopic textures indicating that partial undercooling both prior to and following entrapment in cooler dacitic host magma were important processes. (5) Inclusions are variably fractionated magmas with large variations in Ni (79–11 ppm) and Cr (87–7 ppm) contents that are lower than presumed mantle-derived melts. Furthermore, large ranges in incompatible trace elements indicate that inclusion compositions also reflect deep processes involving either melting of variable mantle source rocks or assimilation–fractional crystallization. (6) Inclusions are variably mixed magmas (56–61 wt.% SiO2) that contain up to 50% host dacitic magma. (7) Correlations between Ni and Cr contents in hosts and inclusions from individual outcrops indicate that the effect of inclusion disaggregation and magma mingling on host dacitic magma was local (e.g., <50 m). These features are interpreted to reflect protracted recharge of diverse composition mafic magmas into the base of a shallow magma reservoir containing a lower layer of compositionally evolving hybrid mafic magma and an upper layer of rhyodacitic magma. Complex interactions among magmas in the upper and lower layers resulted in formation of mafic inclusions by both pre- and post-entrapment undercooling mechanisms, followed by buoyant rise and accumulation near the roof of the reservoir. The main stage of inclusion disaggregation probably occurred in the conduit during eruptive ascent and largely ceased upon surface eruption. We infer that endogenous growth concentrated inclusions along the margins and top of the dome as more inclusion-poor dacite was progressively tapped from deeper regions of the reservoir. [Copyright &y& Elsevier]

Abstract: 40Ar/39Ar ages on the Hat Creek Basalt (HCB) and stratigraphically related lava flows show that latest Pleistocene tholeiitic basalt with very low K2O can be dated reliably. The HCB underlies ∼15 ka glacial gravel and overlies four andesite and basaltic andesite lava flows that yield 40Ar/39Ar ages of 38±7 ka (Cinder Butte; 1.65% K2O), 46±7 ka (Sugarloaf Peak; 1.85% K2O), 67±4 ka (Little Potato Butte; 1.42% K2O) and 77±11 ka (Potato Butte; 1.62% K2O). Given these firm age brackets, we then dated the HCB directly. One sample (0.19% K2O) clearly failed the criteria for plateau-age interpretation, but the inverse isochron age of 26±6 ka is seductively appealing. A second sample (0.17% K2O) yielded concordant plateau, integrated (total fusion), and inverse isochron ages of 26±18, 30±20 and 24±6 ka, all within the time bracket determined by stratigraphic relations; the inverse isochron age of 24±6 ka is preferred. As with all isotopically determined ages, confidence in the results is significantly enhanced when additional constraints imposed by other isotopic ages within a stratigraphic context are taken into account. [Copyright &y& Elsevier]

Carbon dioxide emissions from active subaerial volcanoes represent 20–50% of the annual global volcanic CO 2 flux (Barry et al., 2014). Passive degassing of carbon from the flanks of volcanoes, and the associated accumulation of dissolved inorganic carbon (DIC) within nearby groundwater, also represents a potentially important, yet poorly constrained flux of carbon to the surface (Werner et al., 2019). Here we investigate sources and sinks of DIC in groundwaters in the Lassen Peak region of California. Specifically, we report and interpret the relative abundance and isotopic composition of helium (3He, 4He) and carbon (12C, 13C, 14C) in 37 groundwater samples, from 24 distinct wells, collected between 20 and 60 km from Lassen Peak. Measured groundwater samples have air-corrected 3He/4He values between 0.19 and 7.44 R A (where R A = air 3He/4He = 1.39 × 10−6), all in excess of the radiogenic production value (~0.05 R A), indicating pervasive mantle-derived helium additions to the groundwater system in the Lassen Peak region. Stable carbon isotope ratios of DIC (δ13C) vary between −12.6 and − 27.7‰ (vs. VPDB). Measured groundwater DIC/3He values fall in the range of 2.2 × 1010 to 1.1 × 1012. Using helium and carbon isotope data, we explore several conceptual models to estimate surface carbon contributions and to differentiate between DIC derived from soil CO 2 versus DIC derived from external (slab and mantle) carbon sources. Specifically, if we use 14C to identify soil-derived DIC (assuming decadal-to-centennial groundwater ages and a soil CO 2 14C activity equal to that of the atmosphere), we calculate that a hypothetical external carbon source would have an apparent δ13C signature between −10.3 and − 59.3‰ (vs. Vienna Pee Dee Belemnite (VPDB)) and an apparent C/3He between 7.0 × 109 and 1.0 × 1012. These apparent δ13C and C/3He values are substantially isotopically lighter than and greater than canonical MORB values, respectively. We suggest that >95% of any external (non-soil-derived) DIC in groundwater must thus be non-mantle in origin (i.e., slab derived or assimilated organic carbon). We further investigate possible sources of external DIC to groundwater using two idealized conceptual approaches: a pure (unfractionated) source mixing model (after Sano and Marty, 1995) and a scenario that invokes fractionation due to calcite precipitation. Because the former model requires carbon contributions from an organic source component with unrealistically low δ13C (~ − 60‰), we suggest that the second scenario is more plausible. Importantly, however, we caution that all conceptual models are dependent on assumptions about initial 14C activity. Thus, we cannot rule out the possibility that the true fraction of non-surface-derived DIC in these samples is lower or negligible, despite the pervasive mantle-derived He isotope signatures throughout the region. Following the 14C approach to deconvolving sources of DIC, we determine that the maximum passive carbon flux could be up to ~2.2 × 106 kg/yr, which is lower than previous magmatic carbon flux estimates from the Lassen region (Rose and Davisson, 1996). We find that the passive dissolved carbon flux could represent a maximum of ~4–18% of the total Lassen geothermal CO 2 degassing flux (estimated to be ~3.5 × 107 kg/yr Rose and Davisson, 1996 ; Gerlach et al., 2008), which is still more than an order of magnitude smaller than soil gas CO 2 flux estimates (7.3–11 × 107 kg/yr) for nearby volcanoes (Sorey et al., 1998 ; Gerlach et al., 1999 ; Evans et al., 2002 ; Werner et al., 2014). We conclude that passive dissolved carbon fluxes should be combined with geothermal fluxes and soil gas fluxes to obtain a complete picture of volcanic carbon emissions globally. Our approach highlights the utility of measuring helium isotopes in concert with the full suite of noble gas abundances, tritium, δ13C and 14C, which when interpreted together can be used to better elucidate the various sources of DIC in groundwater. [ABSTRACT FROM AUTHOR]

The eruption of Lassen Peak in May 1915 produced four volcanic rock types within 3 days, and in the following order: (1) hybrid black dacite lava containing (2) undercooled andesitic inclusions, (3) compositionally banded pumice with dark andesite and light dacite bands, and (4) unbanded light dacite. All types represent stages of a complex mixing process between basaltic andesite and dacite that was interrupted by the eruption. They contain disequilibrium phenocryst assemblages characterized by the coexistence of magnesian olivine and quartz and by reacted and unreacted phenocrysts derived from the dacite. The petrography and crystal chemistry of the phenocrysts and the variation in rock compositions indicate that basaltic andesite intruded dacite magma and partially hybridized with it. Phenocrysts from the dacite magma were reacted. Cooling, crystallization, and vesiculation of the hybrid andesite magma converted it to a layer of mafic foam. The decreased density of the andesite magma destabilized and disrupted the foam. Blobs of foam rose into and were further cooled by the overlying dacite magma, forming the andesitic inclusions. Disaggregation of andesitic inclusions in the host dacite produced the black dacite and light dacite magmas. Formation of foam was a dynamic process. Removal of foam propagated the foam layer downward into the hybrid andesite magma. Eventually the thermal and compositional contrasts between the hybrid andesite and black dacite magmas were reduced. Then, they mixed directly, forming the dark andesite magma. About 40–50% andesitic inclusions were disaggregated into the host dacite to produce the hybrid black dacite. Thus, disaggregation of inclusions into small fragments and individual crystals can be an efficient magma-mixing process. Disaggregation of undercooled inclusions carrying reacted host-magma phenocrysts produces coexisting reacted and unreacted phenocryst populations. [ABSTRACT FROM AUTHOR]

Cinder Cone is the youngest scoria cone volcano in the continental United States. Erupted in 1666 C.E. within what is now Lassen Volcanic National Park, Cinder Cone is an un-vegetated scoria cone with well-preserved lava flows and tephra deposits that display complex geochemical variability. In this study, we utilize the volatile (H 2 O, CO 2, Cl), major, and trace element chemistry of olivine-hosted melt inclusions from the tephra deposit of Cinder Cone to better understand the sub-surface evolution of magmas that erupt to produce scoria cones. High-Fo olivine phenocrysts from all erupted units contain melt inclusions that are more primitive in composition than the erupted material. The evolved compositions of the lava and bulk tephra and the abundance of quartz xenocrysts within the deposits suggest the basaltic parental magmas were rapidly contaminated by granitic material in the middle to upper crust, after melt inclusion entrapment. Distinct compositional variability between early and late erupted units suggests two different mantle-derived basaltic magmas were tapped and erupted sequentially as two distinct eruptive phases. The CO 2 concentrations in the melt inclusions, after correction for the presence of vapor bubbles, suggest minimum entrapment depths of ~9.5–20 km and show no resolvable differences between early and late erupted units at the time of olivine crystallization. Diffusion modeling of Ni and Fo gradients in olivine rims indicates that olivine residence times in an evolving magma were on the order of weeks to years, similar to those calculated for longer-lived scoria cone eruptions, such as Jorullo, in Mexico. Additionally, geochemical evidence suggests that the evolution of parental magmas was likely driven by the partial melting, disaggregation, and assimilation of granitic material in the upper crust. Our combined results provide new insight into the complexities of short-lived monogenetic eruptions. • Cinder Cone erupted in 1666 C.E. and displays complex geochemical variability. • Olivine-hosted melt inclusions are more primitive in composition than the erupted material. • Two different mantle-derived basaltic magmas erupted sequentially as two distinct phases. • Changes in explosivity were related to driving pressure changes, not vesiculation kinetics. • Primitive parent magmas were contaminated by an evolved magma or a granitic mush. [ABSTRACT FROM AUTHOR]