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The AIAG established the MSA, 4th Edition, as an international guideline to determine if the selected measurement system is capable and can be used for the intended purpose. The MSA guideline provides a practical basis for decision-making and is applied in both scientific and industrial contexts. In addition to the MSA, the Guide to the Expression of Uncertainty in Measurement (GUM) has standardized the determination of measurement uncertainties at an international level. This paper provides a practical example of using a surface comparator to demonstrate the limitations of the MSA for roughness parameters. Additionally, it presents a new method for assessing the capability of a measuring system for roughness measurements by considering the aspects from MSA and GUM. This work considers all information, distinguishing between existing and experimentally generated data. The experimental investigations for the application of the new method were carried out using a confocal laser scanning measuring microscope. The approach presents a new practical opportunity for both science and industry.

Objective Methods Results Conclusion To evaluate the available literature on ureteric stent‐related infections, the use of antibiotics and bacterial colonisation to identify the current incidence of stent‐related infections, unveil knowledge gaps and generate potential hypotheses for future research.A literature review was conducted using PubMed, Cochrane and urological association websites identifying relevant English literature published between 1983 and January 2024.There is a worldwide lack of guidelines for antibiotic prophylaxis for stent placement, exchange or extraction. In patients with a negative preoperative urine culture undergoing ureteroscopy and stent placement, it may be considered to only provide prophylaxis in presence of risk factors. However, in pre‐stented patients a preoperative urine culture is important to guide prophylaxis during endourological surgery. During stent indwell time, antibiotic prophylaxis does not show any advantage in preventing urinary tract infections (UTIs). There is no strong evidence to support the use of antibiotics at time of stent removal. In the absence of any clear evidence, management strategies for treating UTIs in patients with ureteric stents vary widely. Stent exchange could be considered to remove the biofilm as a potential source of bacteria. Stent culture can help to guide treatment during infection as urine culture and stent culture can differ.In terms of good antibiotic stewardship, urologists should be aware that unnecessary use of antibiotics provokes bacterial resistance. There is a great need for further research in the field of antibiotic prophylaxis and stent‐related infections to develop evidence that can help shape clear guidelines for this very common urological practice. [ABSTRACT FROM AUTHOR]

Full-scale axial load tests were performed on five screw injection piles founded in medium-dense to dense sand at a site in Delft, the Netherlands. Each pile was instrumented with distributed fiber-optic sensors along its full length, giving detailed insights into the shaft and base response under compression loading. The paper focuses on the pile base response and combines the test results with a newly compiled database of instrumented load tests on screw displacement piles in sand. Given the range of screw displacement piles on the market, the influence of different installation methods and pile geometries on the base resistance can be assessed through the database. In summary, the analysis showed that all screw displacement pile types tended to mobilize base capacities similar to bored or nondisplacement piles. Despite high variability in the database, no significant trend with pile geometry, such as length or diameter, was evident. [ABSTRACT FROM AUTHOR]

Due to social and political change the process of young citizens' political socialization was put on a new basis in West European democracies over the last decades. In this article we discuss some aspects of this development and show their consequences. We analyse empirical findings from Germany, focussing on the relevant social factors which influence the individual propensity to participate in politics. The impact of the financial and economic crisis in Europe on political attitudes will also be considered, taking in account sociological aspects. Based on the empirical findings we discuss implications for civic education. In contrast to many discussions in literature about this issue, in which the focus is on the need to put the various influences of political socialization into a broader context, we argue that the parental social background is the crucial upstream factor, prior to e.g. civic education. The conclusion indicates that a group-specific educational approach, taking into account the social background, is the most promising one for reaching the normative goal of civic education: Politically self-determined citizens.

The investigation is about which ideas ninth form students at grammar schools and secondary modern schools have about globalisation. It shall be investigated if the perception of and judgement on globalisation-connected contexts happens along social structure-specific patterns. At first, by way of a questionnaire, the field of ideas is supposed to be broadly recorded, a selection of interview partners based on the results of the questionnaire aims at a deeper analysis of the students´ ideas. Knowledge of these subjective preconditions for learning, as far as the topic of globalisation is concerned, is supposed to provide empirically-grounded hints for what curricula in the political-economic field of learning might look like. Apart from the education-political background, also the methodical outline of the investigation is described. This is followed by a presentation of the results of the analysis of the questionnaire.

Three driven precast, four driven cast-in-situ, and four screw injection piles were installed and tested in dense to very dense sand at a site in the Netherlands. Each pile was instrumented with two types of fiber optic sensors and tested under axial compression. Through these tests, a comparison could be made of how different installation methods influence the pile base and shaft response. For example, large residual base stresses were measured in the driven precast piles after installation. Of the three pile types tested, the driven precast piles also reached the highest base stresses, mobilizing their full base resistance at comparatively low displacements. The base response of the driven cast-in-situ piles was also like that of a driven precast pile with residual stresses excluded. In contrast, the screw injection piles mobilized much lower ultimate base resistances and with a much lower stiffness. In terms of shaft resistance, the precast piles showed friction fatigue effects in line with existing models, but this effect was not evident for the driven cast-in-situ or screw injection piles. Finally, shaft and base resistances measured in the dense to very dense sand layers were greater than limiting resistances prescribed in several design standards. By taking this into consideration in design standards, the results would help reduce some of the overconservatism present in design and consequently reduce the financial and environmental cost of pile manufacturing and installation. [ABSTRACT FROM AUTHOR]

Politics without history has no roots; history without politics bears no fruits. If one inquires into the content of the relation between politics and history, then one discovers it is defined by symbiotic dependence. Those who are trained in history also take into account the political dimensions of history, and those educated in political science cannot neglect the historical factors inhering in current issues and problems. The fact that politics is part of history and vice versa has always been significant on both a theoretical level and in the practice of teaching history and politics. Currently, the relation between the teaching methodology applied to history and politics receives significant attention from the historical side, but is only seldom referred to from the political perspective. Nevertheless, at the present time there is no explicitly delineated educational approach that integrates the teaching of both of these disciplines. This article attempts to advance an approach that places historical and political learning in the field of tension spanning political history and historical politics. (Contains 44 notes.)

Introduction: Recent retrospective literature suggests that the quick sequential organ failure assessment (qSOFA) scoring tool is a potentially superior tool over use of the systemic inflammatory response syndrome (SIRS) criteria to predict septic shock after percutaneous nephrolithotomy (PCNL) surgery. Here we examine use of qSOFA and SIRS to predict septic shock within data series collected prospectively on PCNL patients as part of a greater study of infectious complications. Materials and Methods: We performed a secondary analysis of two prospective multicenter studies including PCNL patients across nine institutions. Clinical signs informing SIRS and qSOFA scores were collected no later than postoperative day 1. The primary outcome was sensitivity and specificity of SIRS and qSOFA (high-risk score of greater-or-equal to two points) in predicting admission to the intensive care unit (ICU) for vasopressor support. Results: A total of 218 cases at 9 institutions were analyzed. One patient required vasopressor support in the ICU. The sensitivity/specificity was 100%/72.4% (McNemar's test p < 0.001) for SIRS and was 100%/90.8% (McNemar's test p < 0.001) for qSOFA. Conclusion: Although positive predictive value for both qSOFA and SIRS in prediction of post-PCNL septic shock is low, prospectively collected data demonstrate use of qSOFA may offer greater specificity than SIRS criteria when predicting post-PCNL septic shock. [ABSTRACT FROM AUTHOR]

Bacterial infection and poor cell recruitment are among the main factors that prolong wound healing. To address this, a strategy is required that can prevent infection while promoting tissue repair. Here, we have created a silver nanoparticle-based hydrogel composite that is antibacterial and provides nutrients for cell growth, while filling cavities of various geometries in wounds that are difficult to reach with other dressings. Silver nanoparticles (AgNPs) were synthesized by chemical reduction and characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS), and inductively coupled plasma-mass spectroscopy (ICP-MS). Using varying concentrations of AgNPs (200, 400, and 600 ppm), several collagen-based silver–hydrogel nanocomposite candidates were generated. The impact of these candidates on wound healing was assessed in a rat splinted wound model, while their ability to prevent wound infection from a contaminated surface was assessed using a rat subcutaneous infection model. Biocompatibility was assessed using the standard MTT assay and in vivo histological analyses. Synthesized AgNPs were spherical and stable, and while hydrogel alone did not have any antibacterial effect, AgNP–hydrogel composites showed significant antibacterial activity both in vitro and in vivo. Wound healing was found to be accelerated with AgNP–hydrogel composite treatment, and no negative effects were observed compared to the control group. The formulations were non-cytotoxic and did not differ significantly in hematological and biochemical factors from the control group in the in vivo study. By presenting promising antibacterial and wound healing activities, silver–hydrogel nanocomposite offers a safe therapeutic option that can be used as a functional scaffold for an acceleration of wound healing. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study is to evaluate the current availability of technology for urolithiasis treatment and ureteroscopy (URS). Perioperative practice patterns, availability of ureteroscopic technologies, pre- and poststenting practices, and methods to alleviate stent-related symptoms (SRS) were assessed via a survey of members of the Endourological Society. Methods: We distributed a 43-question survey online via the Qualtrics platform to members of the Endourological Society. The survey consisted of questions pertaining to the following topics: general (6), equipment (17), preoperative URS (9), intraoperative URS (2), and postoperative URS (9). Results: A total of 191 urologists responded to the survey and 126 completed all questions of the survey (66%). Fifty-one percent (65/127) of urologists were fellowship trained and dedicated an average of 58% of their practice to stone management. In terms of procedures, most urologists performed URS most commonly (68%), followed by percutaneous nephrolithotomy (23%) and extracorporeal shockwave lithotripsy (11%). Ninety percent (120/133) of respondent urologists purchased a new ureteroscope within the last 5 years (16% single-use scopes, 53% reusable, and 31% purchased both). Fifty-three percent (70/132) of the respondents stated that they would be interested in a ureteroscope that can sense intrarenal pressure, with an additional 28% (37/132) stating they would be interested depending on the cost. Seventy-four percent (98/133) of responders purchased a new laser within the last 5 years, and 59% (57/97) changed their lasering technique due to the new laser. Urologists are performing primary ureteroscopy for obstructing stones in 70% of cases, and prefer prestenting patients for subsequent URS in 30% (on average after 21 days). Seventy-one percent (90/126) of responders insert a ureteral stent after uncomplicated URS, which is removed, on average, after 8 days in uncomplicated cases and 21 days after complicated URS. Most urologists give analgesics, alpha-blockers, and anticholinergics for SRS and <10% prescribe opioids. Conclusion: Our survey revealed urologists' eagerness for the early adoption of novel technologies and adherence to conservative practice patterns focused on patient safety. [ABSTRACT FROM AUTHOR]

Despite the risk of developing catheter-associated urinary tract infections (CAUTI), catheter reuse is common among people with spinal cord injury (SCI). This study examined the microbiological burden and catheter surface changes associated with short-term reuse. Ten individuals with chronic SCI reused their catheters over 3 days. Urine and catheter swab cultures were collected daily for analysis. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) analyses were used to assess catheter surface changes. Catheter swab cultures showed no growth after 48 h (47.8%), skin flora (28.9%), mixed flora (17.8%), or bacterial growth (5.5%). Asymptomatic bacteriuria was found for most participants at baseline (n = 9) and all at follow-up (n = 10). Urine samples contained Escherichia coli (58%), Klebsiella pneumoniae (30%), Enterococcus faecalis (26%), Acinetobacter calcoaceticus–baumannii (10%), Pseudomonas aeruginosa (6%) or Proteus vulgaris (2%). Most urine cultures showed resistance to one or more antibiotics (62%). SEM images demonstrated structural damage, biofilm and/or bacteria on all reused catheter surfaces. XPS analyses also confirmed the deposition of bacterial biofilm on reused catheters. Catheter surface changes and the presence of antibiotic-resistant bacteria were evident following short-term reuse, which may increase susceptibility to CAUTI in individuals with SCI despite asymptomatic bacteriuria. [ABSTRACT FROM AUTHOR]

Background: Residual fragments (RFs) after percutaneous nephrolithotomy (PCNL) have a significant impact on patients' quality of life and clinical course. There is a paucity of studies that evaluate the natural history of RFs after PCNL. The objective of this study is to compare rates of reintervention, complications, stone growth, and passage in patients with RFs >4, ≤4, and ≤2 mm after PCNL. Methods: Sites from the Endourologic Disease Group for Excellence (EDGE) research consortium examined data of PCNL patients from 2015 to 2019 with at least 1-year follow-up. RF passage, regrowth, reintervention, and complications were recorded and RFs were stratified into >4 and ≤4 mm groups, as well as >2 and ≤2 mm groups. Potential predictors for stone-related events after PCNL were determined using multivariable logistic regression analysis. It was hypothesized that larger RF thresholds would result in lower passage rates, faster regrowth, and greater clinically significant events (complications and reinterventions) than smaller RF thresholds. Results: A total of 439 patients with RFs >1 mm on CT postoperative day 1 were included in this study. For RFs >4 mm, rates of reintervention were found to be significantly higher and Kaplan–Meier curve analysis showed significantly higher rates of stone-related events. Passage and RF regrowth were not found to be significantly different compared with RFs ≤4 mm. However, RFs ≤2 mm had significantly higher rates of passage, and significantly lower rates of fragment regrowth (>1 mm), complications, and reintervention compared with RFs >2 mm. On multivariable analysis, older age, body mass index, and RF size were found to be predictive of stone-related events. Conclusions: With the largest cohort to date, this study by the EDGE research consortium further confirms that clinically insignificant residual fragment is problematic for patients after PCNL, particularly in older more obese patients with larger RFs. Our study underscores the importance of complete stone clearance post-PCNL and challenges the use of Clinically insignificant residual fragment (CIFR). [ABSTRACT FROM AUTHOR]

Dieser Beitrag stellt die Ergebnisse einer qualitativen Studie mit Schülerinnen und Schülern zu ihren Vorstellungen, Emotionen und Meinungsbildungsprozessen mit Bezug auf den Ukraine-Krieg dar. Zusätzlich werden mit dem Krieg in Verbindung stehende und für die Politikdidaktik relevante Themenbereiche diskutiert und ein Ausblick auf mögliche didaktische Anknüpfungspunkte gegeben. [ABSTRACT FROM AUTHOR]

Murine sepsis models are typically polymicrobial, and are associated with high mortality. We aimed to develop a high-throughput murine model that mimics a slow-paced, monomicrobial sepsis originating from the urinary tract. A total of 23 male C57Bl/6 mice underwent percutaneous insertion of a 4 mm catheter into the bladder using an ultrasound-guided method, previously developed by our group. The following day, Proteus mirabilis (PM) was introduced percutaneously in the bladder in three groups: g1—50 µL 1 × 108 CFU/mL solution (n = 10); g2—50 µL 1 × 107 CFU/mL solution (n = 10); and g3 (sham mice)—50 µL sterile saline (n = 3). On day 4, mice were sacrificed. The number of planktonic bacteria in urine, adherent to catheters, and adherent to/invaded into the bladder and spleen was assessed. Cell-free DNA, D-dimer, thrombin–antithrombin complex (TAT), and 32 pro-/anti-inflammatory cytokines/chemokines were quantified in the blood. All mice survived the 4 day postinterventional period. Mean weight loss was 11% in g1, 9% in g2, and 3% in the control mice. Mean urine CFU counts were highest in group 1. All catheters showed high catheter-adhered bacterial counts. Of the infected mice, 17/20 had CFU counts in the splenic tissue, indicating septicemia. Plasma levels of cell-free DNA, D-dimer, and the proinflammatory cytokines IFN-γ, IL-6, IP-10, MIG, and G-CSF were significantly elevated in infected mice versus controls. We present a reproducible, monomicrobial murine model of urosepsis that does not lead to rapid deterioration and death, and is useful for studying prolonged urosepsis. [ABSTRACT FROM AUTHOR]

Proteus mirabilis (PM) is a Gram-negative, rod-shaped bacterium that causes catheter-associated urinary tract infections (CAUTIs). The specific roles of bacterial surface components (BSCs) in PM pathogenicity and CAUTIs remain unknown. To address this knowledge gap, we utilized relevant in vitro adhesion/invasion models and a well-established murine model of CAUTI to assess the ability of wildtype (WT) and seven mutant strains (MSs) of PM with deficiencies in various genes encoding BSCs to undergo the infectious process (including adhesion to catheters) in both model systems. Overall, MSs adhesion to catheters and the different cell types tested was significantly reduced compared to WT, while no invasion of cells was evident at 24 h. In vivo, WT showed a greater number of planktonic (urine) bacteria, bacteria adherent to catheters, and bacteria adherent to/invading bladder tissue when compared to the MSs. Bacterial counts in urine for PMI3191 and waaE mutants were lower than that for WT and other MSs. The complementation of mutated BSC genes resulting in the biggest defects restored the invasion phenotype both in vitro and in vivo. BSCs play a critical role at various steps in the pathogenicity of PM including adhesion to indwelling medical devices and adhesion/invasion of urinary tissue in vivo. [ABSTRACT FROM AUTHOR]