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8. Were cancer patients worse off than the general population during the COVID-19 pandemic? A population-based study from Norway, Denmark and Iceland during the pre-vaccination era

Author

Johansson, Anna L.V., Skog, Anna, Johannesen, Tom Børge, Myklebust, Tor Åge, Skovlund, Charlotte Wessel, Mørch, Lina Steinrud, Friis, Søren, Gamborg, Mads, Kristiansen, Marnar Fríðheim, Pettersson, David, Ólafsdóttir, Elínborg J., Birgisson, Helgi, Palsson, Runolfur, Eythorsson, Elias, Irenaeus, Sandra, Lambe, Mats, and Ursin, Giske

Published
2023
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9. Socioeconomic inequality in prostate cancer diagnostics, primary treatment, rehabilitation, and mortality in Sweden.

Author

Strömberg, Ulf, Berglund, Anders, Carlsson, Stefan, Thellenberg Karlsson, Camilla, Lambe, Mats, Lissbrant, Ingela Franck, Stattin, Pär, and Bratt, Ola

Subjects
PROSTATE cancer, HEALTH equity, PROSTATE cancer patients, MAGNETIC resonance imaging, NATIONAL health services, INCOME, ENDORECTAL ultrasonography
Abstract

We designed a nationwide study to investigate the association between socioeconomic factors (household income and education) and different aspects of prostate cancer care, considering both individual‐ and neighbourhood‐level variables. Data were obtained from Prostate Cancer data Base Sweden (PCBaSe), a research database with data from several national health care registers including clinical characteristics and treatments for nearly all men diagnosed with prostate cancer in Sweden. Four outcomes were analysed: use of pre‐biopsy magnetic resonance imaging (MRI) in 2018–2020 (n = 11,843), primary treatment of high‐risk non‐metastatic disease in 2016–2020 (n = 6633), rehabilitation (≥2 dispensed prescriptions for erectile dysfunction within 1 year from surgery in 2016–2020, n = 6505), and prostate cancer death in 7770 men with high‐risk non‐metastatic disease diagnosed in 2010–2016. Unadjusted and adjusted odds and hazard ratios (OR/HRs) with 95% confidence intervals (CIs) were calculated. Adjusted odds ratio (ORs) comparing low versus high individual education were 0.74 (95% CI 0.66–0.83) for pre‐biopsy MRI, 0.66 (0.54–0.81) for primary treatment, and 0.82 (0.69–0.97) for rehabilitation. HR gradients for prostate cancer death were significant on unadjusted analysis only (low vs. high individual education HR 1.41, 95% CI 1.17–1.70); co‐variate adjustments markedly attenuated the gradients (low vs. high individual education HR 1.10, 95% CI 0.90–1.35). Generally, neighbourhood‐level analyses showed weaker gradients over the socioeconomic strata, except for pre‐biopsy MRI. Socioeconomic factors influenced how men were diagnosed with prostate cancer in Sweden but had less influence on subsequent specialist care. Neighbourhood‐level socioeconomic data are more useful for evaluating inequality in diagnostics than in later specialist care. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Impact of variation in cancer registration practice on observed international cancer survival differences between International Cancer Benchmarking Partnership (ICBP) jurisdictions

Author

Eden, Michael, Harrison, Samantha, Griffin, Michelle, Lambe, Mats, Pettersson, David, Gavin, Anna, Brewster, David H., Lin, Yulan, Johannesen, Tom B., Milne, Roger L., Farrugia, Helen, Nishri, Diane, King, Mary-Jane, Huws, Dyfed W, Warlow, Janet, Turner, Donna, Earle, Craig C., Peake, Michael, and Rashbass, Jem

Published
2019
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37. Penile cancer: long-term infectious and thromboembolic complications following lymph node dissection – a population-based study (Sweden).

Author

Glombik, Dominik, Davidsson, Sabina, Sandin, Fredrik, Lambe, Mats, Carlsson, Jessica, Sundqvist, Pernilla, and Kirrander, Peter

Subjects
PENILE tumors, LYMPHADENECTOMY, CONFIDENCE intervals, LYMPH nodes, SURGICAL complications, ANTICOAGULANTS, RISK assessment, INFECTION, COMPARATIVE studies, INAPPROPRIATE prescribing (Medicine), THROMBOEMBOLISM, PROPORTIONAL hazards models, EVALUATION
Abstract

To assess the long-term risks of infectious and thromboembolic events following inguinal (ILND) and pelvic (PLND) lymph node dissection in men with penile cancer. A total of 364 men subjected to ILND with or without PLND for penile cancer between 2000 and 2012 were identified in the Swedish National Penile Cancer Register. Each patient was matched based on age and county of residence with six penile cancer-free men. The Swedish Cancer Register and other population-based registers were used to retrieve information on treatment and hospitalisation for selected infectious and thromboembolic events. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazard models with multiple imputation. The risk of infectious events remained increased for more than five years postoperatively in men with penile cancer compared with matched controls. The palpable nodal disease was the only predictor of these events, with risk increasing with the cN stage. The HR at one, three and five years and six months postoperatively was 8.60 (95% CI 5.16–14.34), 4.02 (95% CI 2.65–6.09) and 1.93 (95% CI 1.11–3.38), respectively. An increased risk of thromboembolic events persisted for three years postoperatively. The HR at one and three years postoperatively was 13.51 (95% CI 6.53–27.93) and 2.12 (95% CI 1.07–4.20). The results correspond well with the over-prescription of anticoagulants observed during this period. An association with bulky disease (cN3) was observed. Lymph node dissection for penile cancer is associated with an increased risk of infectious and thromboembolic events. The findings of this population-based study show that the risks of these events remain increased more than five years for infectious and three years for thromboembolic events. Improved awareness of long-term complications following ILND is of importance both among patients and care givers to ensure early detection and treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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38. A Quasi-Experimental Study of Maternal Smoking during Pregnancy and Offspring Academic Achievement

Author

D'Onofrio, Brian M., Singh, Amber L., Iliadou, Anastasia, Lambe, Mats, Hultman, Christina M., Neiderhiser, Jenae M., Langstrom, Niklas, and Lichtenstein, Paul

Abstract

The current study, based on all births in Sweden from 1983 to 1991 (N = 654,707), explored the processes underlying the association between smoking during pregnancy (SDP) and offspring school grades and mathematic proficiency at age 15. The analyses compared relatives who varied in their exposure to SDP and who varied in their genetic relatedness. Although SDP was statistically associated with academic achievement (AA) when comparing unrelated individuals, the results suggest that SDP does not cause poorer academic performance, as full siblings differentially exposed to SDP did not differ in their academic scores. The pattern of results suggests that genetic factors shared by parents and their offspring help explain why offspring exposed to SDP have lower levels of AA. (Contains 8 tables and 2 figures.)

Published
2010
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39. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer

Author

Lohr, Miriam, Edlund, Karolina, Botling, Johan, Hammad, Seddik, Hellwig, Birte, Othman, Amnah, Berglund, Anders, Lambe, Mats, Holmberg, Lars, Ekman, Simon, Bergqvist, Michael, Pontén, Fredrik, Cadenas, Cristina, Marchan, Rosemarie, Hengstler, Jan G., Rahnenführer, Jörg, and Micke, Patrick

Published
2013
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