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Copyright of Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi is the property of Balikesir Health Sciences Journal (BAUN Health Sci J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Paeoniflorin (Pae) is a monoterpene glycoside with immune‐regulatory effects. Several studies have already demonstrated the impact of Pae on periodontitis, but its effect on diabetic periodontitis is unclear. In this study, our aim was to test the hypothesis that Pae had a strong anti‐inflammatory effect that prevented bone loss in diabetic periodontitis. Methods: Thirty male Wistar albino rats were randomly divided into control (healthy, n = 10), periodontitis (PD) + diabetes (DM; n = 10), and PD + DM + Pae (n = 10) groups. Ligature‐induced periodontitis was created by placing 4–0 silk ligatures around the lower first molars on both sides of the mandibulae. Experimental DM was created via an injection of 50 mg/kg and streptozotocin (STZ). Hyperglycemia was confirmed by the blood glucose levels of rats (>300 mg/dL). The bone mineral density (BMD), trabecular number, trabecular thickness, and bone loss were measured by micro‐CT. The expression levels of IL‐1β, IL‐6, and TNF‐α were measured in tissue homogenates by ELISA. Results: The PD + DM + Pae group had significantly less alveolar crest resorption when compared to the PD + DM group. There was also a significant difference between the PD + DM + Pae group compared to PD + DM group in trabecular thickness, BMD, and the number of trabeculae. Pae application led to a statistically significant decrease in IL‐1β, IL‐6, and TNF‐α levels in diabetic periodontitis. Conclusion: Systemic application of Pae suppressed inflammation caused by PD and DM, leading to reduced bone loss and enhanced bone quality. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effects of photobiomodulation therapy (PBMT) at distinct energy levels on periimplant bone healing in extra-short implants in a experimental rabbit model. Background: The effect of PBMT on peri-implant bone healing in short implants remains unclear. This explored the effect of PBMT on extra-short implants in terms of bone-implant contact (BIC) length and rate, and implant stability quotient (ISQ). Methods: Fifteen white New Zealand rabbits were randomly divided into five groups. In all groups, extra-short implants (3.5 · 4mm; Nucleoss T6, _Izmir/Turkey) were placed in both tibias of the rabbits. PBMT was performed in four groups (group 1, 5 J/cm²; group 2, 10 J/cm²; group 3, 20 J/cm²; and group 4, 25 J/cm²); no PBMT was performed in the control group. On the 30th day, the rabbits were sacrificed and peri-implant tissue samples were obtained to determine the BIC length and BIC rate. Implant stability levels were measured by resonance frequency analysis using the Osstell penguin device and were determined as ISQ values on the 1st and 30th days of the study. Results: PBMT significantly increased the BIC length and BIC rate in groups 3 and 4 ( p < 0.001). For the ISQ values, there were significant differences between the 1st and 30th day ( p < 0.001). On the 30th day, the ISQ values were significantly higher in groups 3 and 4 compared with the remaining groups ( p < 0.001). Conclusions: In this study, PBMT improved peri-implant bone healing through increase in BIC length, BIC rate, and ISQ parameter values in extra-short implants. [ABSTRACT FROM AUTHOR]

Aim: The present study aims to investigate the healing of artificially created peri-implant osseous defects using Titanium-Platelet Rich Fibrin Material and Method: Bone defects (9-mm diameter, 4-mm depth) were created and implant beds (3-mm diameter, 6-mm depth) were prepared in the middle of them in rabbit tibias (24 rabbits) used as the experimental model. Afterwards, dental implants were installed into the left and right tibia (diameter 3.0 mm, length 8 mm). In the experimental groups, the peri-implant defect was filled with Autogenous grafts (AG), Titanium-Platelet Rich Fibrin (T-PRF), Biphasic Calcium Phosphate grafts (BCP). The control group did not receive any filling. The bone-to-implant contact (BIC) was obtained by histomorphometrically examining the sections taken from the study groups. Results: AG group was resulted in a high degree of BIC. No difference of statistical significance was found for the BIC as far as autogenous graft and PRF groups are concerned. Conclusion: Peri-implantal defects in regeneration of T-PRF were found to be nearly as affective as the autogenous bone graft. We, therefore, conclude that T-PRF can be used for guided bone regeneration in the function of autogenic matrix in the future. [ABSTRACT FROM AUTHOR]