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Minna Anttila,1 Tella Lantta,1 Milla Ylitalo,1,2 Marjo Kurki,1,3 Marko Kuuskorpi,4 Maritta Välimäki1,5 1Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland; 2Laurea University of Applied Sciences, Vantaa, Uusimaa Region, Finland; 3Itla Children’s Foundation, Helsinki, Uusimaa Region, Finland; 4Piikkiö comprehensive school, Kaarina, Southwest Finland, Finland; 5Xiangya School of Nursing, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Maritta VälimäkiXiangya Nursing School, Central South University, 172 Tongzipo Road, Changsha, Hunan 410013, China; Department of Nursing Science, University of Turku, Turku, Southwest Finland, FinlandTel +358 40 559 9235Fax +358 29 450 5040Email maritta.vaelimaeki@csu.edu.cnPurpose: Health-related behaviors that arise during adolescence can have important, sometimes lifelong, implications on a person’s health. Psychiatric and neurodevelopmental diagnoses among minors have increased, and the related depressive symptoms may negatively affect quality of life. There is great potential for information technology (IT) to benefit the area of mental health for adolescents, and schools can serve as a setting in which this can be done. We tested whether the IT-based program “DepisNet” could be used as a universal school-based program to support adolescents’ well-being and mental health.Patients and Methods: We used a quasi-experimental, pre-post design with two preference arms (intervention and control groups). The study setting comprised two lower secondary schools (N=151 adolescents) in one city in Finland. To analyze the impact of the program, we compared the changes in the outcome measures between the two groups using T-tests and Mann–Whitney U-tests. We analyzed the changes within the groups using T-tests and Wilcoxon tests.Results: Our analysis revealed no statistically significant differences between the groups in any of the outcomes (depression, quality of life, self-esteem, self-efficacy). Regarding adolescents’ quality of life, the observed change was more positive in the intervention group, compared to that of the control group (change mean 1.36 vs − 0.49), although statistical significance was not achieved (p=0.10). Our results indicated encouraging results related to the feasibility components: adherence and acceptance.Conclusion: Universal interventions and programs that relate to adolescent well-being and mental health can be integrated into school curricula to promote the awareness of adolescents’ general well-being and mental health issues.Keywords: teenaged, universal intervention, mental health support, IT-based program, pupils

Objective: Low-grade inflammation may raise serum C-reactive protein (CRP) concentrations. We studied whether serum CRP is altered in preterm premature rupture of membranes (PPROM), which is frequently associated with an asymptomatic intrauterine infection. Study design: CRP was quantitated with highly sensitive immunofluorometric (IFMA) and immunoenzymometric (IEMA) assays in 32 women with PPROM at 30.7±0.4 gestational weeks (mean±standard error of the mean) and in 27 gestational age-matched healthy women. The results were compared to those obtained by the conventional immunoturbidimetric method. Results: Twenty-three PPROM patients had a normal CRP value (≤12 mg/l) by immunoturbidimetry. Their highly sensitive CRP value was not different from that of controls. During the observation period of 11±3 days after PPROM, an increase in the highly sensitive CRP was observed in patients whose immunoturbidimetric CRP remained normal (n=10). Conclusion: The increase in the highly sensitive CRP in PPROM patients with constantly normal immunoturbidimetric CRP may reflect the presence of a subclinical inflammation. [Copyright &y& Elsevier]