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Your search keyword '"Kozuma, Shiro"' showing total 175 results
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175 results on '"Kozuma, Shiro"'

23. The Prevalence Of Cervical Regulatory T Cells in HPV-Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN

Author

Kojima, Satoko, Kawana, Kei, Tomio, Kensuke, Yamashita, Aki, Taguchi, Ayumi, Miura, Shiho, Adachi, Katsuyuki, Nagamatsu, Takeshi, Nagasaka, Kazunori, Matsumoto, Yoko, Arimoto, Takahide, Oda, Katsutoshi, Wada-Hiraike, Osamu, Yano, Tetsu, Taketani, Yuji, Fujii, Tomoyuki, Schust, Danny J., and Kozuma, Shiro

Published
2013
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47. Omega-3 Polyunsaturated Fatty Acids Suppress the Cystic Lesion Formation of Peritoneal Endometriosis in Transgenic Mouse Models.

Author

Tomio, Kensuke, Kawana, Kei, Taguchi, Ayumi, Isobe, Yosuke, Iwamoto, Ryo, Yamashita, Aki, Kojima, Satoko, Mori, Mayuyo, Nagamatsu, Takeshi, Arimoto, Takahide, Oda, Katsutoshi, Osuga, Yutaka, Taketani, Yuji, Kang, Jing X., Arai, Hiroyuki, Arita, Makoto, Kozuma, Shiro, and Fujii, Tomoyuki

Subjects
TREATMENT of endometriosis, OMEGA-3 fatty acids, INFLAMMATION, EICOSAPENTAENOIC acid, GENE expression, ANTI-inflammatory agents, LABORATORY mice
Abstract

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) play a role in controlling pathological inflammatory reactions. Endometriosis is characterized by the presence of endometrial tissue on the peritoneum and an exaggerated inflammatory environment around ectopic tissues. Here peritoneal endometriosis was reproduced using a mouse model in which murine endometrial fragments were inoculated into the peritoneal cavity of mice. Fat-1 mice, in which omega-6 can be converted to omega-3 PUFAs, or wild type mice, in which it cannot, were used for the endometriosis model to address the actions of omega-3 PUFAs on the development of endometriotic lesions. The number and weight of cystic endometriotic lesions in fat-1 mice two weeks after inoculation were significantly less than half to those of controls. Mediator lipidomics revealed that cystic endometriotic lesions and peritoneal fluids were abundant in 12/15-hydroxyeicosapentaenoic acid (12/15-HEPE), derived from eicosapentaenoic acid (EPA), and their amount in fat-1 mice was significantly larger than that in controls. 12/15-Lipoxygenase (12/15-LOX)-knockout (KO) and control mice with or without EPA administration were assessed for the endometriosis model. EPA administration decreased the number of lesions in controls but not in 12/15-LOX-KO mice. The peritoneal fluids in EPA-fed 12/15-LOX-KO mice contained reduced levels of EPA metabolites such as 12/15-HEPE and EPA-derived resolvin E3 even after EPA administration. cDNA microarrays of endometriotic lesions revealed that Interleukin-6 (IL-6) expression in fat-1 mice was significantly lower than that in controls. These results suggest that both endogenous and exogenous EPA-derived PUFAs protect against the development of endometriosis through their anti-inflammatory effects and, in particular, the 12/15-LOX-pathway products of EPA may be key mediators to suppress endometriosis. [ABSTRACT FROM AUTHOR]

Published
2013
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48. The Influence of Infertility Treatment on the Prognosis of Endometrial Cancer and Atypical Complex Endometrial Hyperplasia.

Author

Ichinose, Mari, Fujimoto, Akihisa, Osuga, Yutaka, Minaguchi, Takeo, Kawana, Kei, Yano, Tetsu, and Kozuma, Shiro

Abstract

Many patients with endometrial cancer have no children when diagnosed, and thus are reluctant to undergo hysterectomy, hoping to preserve their fertility. Their requirement is met, at least partially, with high-dose medroxyprogesterone acetate that brings good response rate in the treatment of endometrial cancer in the early stage and atypical complex endometrial hyperplasia (EC/ACEH). Actually, a number of successful pregnancies after the conservative treatment have been reported. To conceive, many of them need infertility treatment because of ovulation disorders which might have induced the cancer with unopposed estrogens. However, on the other side, hyperestrogenic status caused by ovulation induction or controlled ovarian stimulation might promote the progression and the recurrence of the disease.This study aimed to assess the effectiveness and safety of infertility treatment after conservative therapy for EC/ACEH, to confirm the significance of fertility-sparing therapy.The patients with EC/ACEH who achieved complete response after high-dose medroxyprogesterone acetate were eligible for this retrospective study. Characteristics of the patients, whether they underwent infertility treatment, conceived, or relapsed, and the interval from complete response to conception or recurrence were retrospectively analyzed.The clinical outcomes of 36 patients were investigated. Twenty-six of them desired to conceive soon after complete response. All of them underwent infertility treatment, and 16 women delivered healthy babies. Kaplan-Meyer curve and log-rank test analysis revealed that women who achieved live birth had a significantly lower risk of recurrence than those without live birth. There was not a significant difference between the patients with and without infertility treatment.Use of ovulation induction drugs after conservative treatment of endometrial cancer did not increase the recurrence of the disease. Moreover, resulting pregnancy seems to have an advantageous effect on the oncologic outcome. [ABSTRACT FROM AUTHOR]

Published
2013
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49. A Novel Interaction between hScrib and PP1γ Downregulates ERK Signaling and Suppresses Oncogene-Induced Cell Transformation.

Author

Nagasaka, Kazunori, Seiki, Takayuki, Yamashita, Aki, Massimi, Paola, Subbaiah, Vanitha Krishna, Thomas, Miranda, Kranjec, Christian, Kawana, Kei, Nakagawa, Shunsuke, Yano, Tetsu, Taketani, Yuji, Fujii, Tomoyuki, Kozuma, Shiro, and Banks, Lawrence

Subjects
CELLS, PHOSPHATASES, PHOSPHOPROTEIN phosphatases, PHOSPHORYLATION, ONCOGENES, CANCER
Abstract

Previous studies have shown that the cell polarity regulator hScrib interacts with, and consequently controls, the ERK signaling pathway. This interaction occurs through two well-conserved Kinase Interacting Motifs, which allow hScrib to bind ERK1 directly, resulting in a reduction in the levels of phospho-ERK. This suggests that hScrib might recruit a phosphatase to regulate this signaling pathway. Using a proteomic approach we now show that Protein Phosphatase 1γ (PP1γ) is a major interacting partner of hScrib. This interaction is direct and occurs through a conserved PP1γ interaction motif on the hScrib protein, and this interaction appears to be required for hScrib's ability to downregulate ERK phosphorylation. In addition, hScrib also controls the pattern of PP1γ localization, where loss of hScrib enhances the nuclear translocation of PP1γ. Furthermore, we also show that the ability of hScrib to interact with PP1γ is important for the ability of hScrib to suppress oncogene-induced transformation of primary rodent cells. Taken together, these results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1c and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Uterine arteriovenous fistula treated with repetitive transcatheter embolization: case report.

Author

Hasegawa A, Sasaki H, Wada-Hiraike O, Osuga Y, Yano T, Usman SM, Akahane M, Kozuma S, Taketani Y, Hasegawa, Akiko, Sasaki, Hiroki, Wada-Hiraike, Osamu, Osuga, Yutaka, Yano, Tetsu, Usman, Salmyah M, Akahane, Masaaki, Kozuma, Shiro, and Taketani, Yuji

Abstract

Uterine arteriovenous fistula (AVF) is a rare entity, but may lead to life-threatening hemorrhage. Although transcatheter embolization, surgical ligation, or hysterectomy would be considered for treatment of uterine AVF, there is poor knowledge as to how gynecologists can manage the uterine AVF with multiple large inflow arteries. Herein we report a uterine AVF successfully treated using multiple-step transcatheter embolization. The patient, a 58-year-old postmenopausal woman with a history of dilation and curettage, had intermittent massive uterine bleeding. Radiologic imaging revealed the presence of a large vasculature mass. The mass occupied the entire pelvis, and the source of hemorrhage was identified as an accompanying AVF. We thought that surgical intervention was contraindicated because of the potential risk of uncontrollable intraoperative bleeding. Multiple-step transcatheter embolization was performed, with complete resolution of the AVF. Thereafter, the patient had no further uterine bleeding. Multiple-step transcatheter embolization might be the most beneficial and efficient treatment option for a uterine AVF with multiple large inflow arteries. [ABSTRACT FROM AUTHOR]

Published
2012
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