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26. Klinische Praxis und Ergebnisse der neoadjuvanten Chemotherapie bei frühem Brustkrebs: Analyse der Daten von 94.638 Patienten*innen aus 55 zertifizierten Brustkrebszentren.

Author

Ortmann, Olaf, Blohmer, J.-U., Sibert, N. T., Brucker, S., Janni, W., Wöckel, A., Scharl, A., Dieng, S., Ferencz, J., Inwald, E. C., Wesselmann, S., Kowalski, C., DKG‑zertifizierte Brustkrebszentren in Deutschland, Denisjuk, E., Csorba, R., Rezek, D., Peschel, S., Denschlag, D., Schad, F., and Dieterle, D.

Published
2022
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36. Tolerance of Biopronil Spot on® after repeated single- or multiple-dose topical treatments in dogs

Author

H Turlewicz-Podbielska, Kowalski CJ, A Burmanczuk, A Vynjarska, J Wojciechowski, M Pomorska-Mol, and M Rybska

Subjects
adverse effects, biochemical indicators, fipronil, haematological indicators, substance-related disorders, Veterinary medicine, SF600-1100
Abstract

A variety of toxic effects of fipronil (FIP), the active substance of Biopronil Spot on®, on animals and humans has been reported and raises the need to investigate the FIP toxic effects. The objectives of the study were the evaluation of the local and systemic tolerance of Biopronil Spot on® and the assessment of its influence on haematological and biochemical blood parameters after single and multiple topical treatment in dogs. Thirty-two mixed breed dogs were included in the study assessing the local and general tolerance of Biopronil Spot on® following single, triple and fivefold dose after spot-on multiple applications in dogs (on days 0, +28 and +56) at a dosage 134 mg for a dog weighing 10-20 kg and 268 mg for a dog weighing 21-40 kg. A physical examination and biochemical and haematological analyses were performed on the days of the study as follows: -14, -5, +3, +31, +59, +70. No visible pathological changes on the skin were observed. The biochemical and haematological indicators rarely exceeded the reference values. No influence of Biopronil Spot on® administered in single, triple and fivefold repeated doses on the assessed clinical, haematological and biochemical parameters in dogs was found under the conditions described in the study.

Published
2022
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43. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets.

Author

Burmańczuk, A., Kowalski, C., Giorgi, M., Owen, H., and Grabowski, T.

Subjects
*PYRAZOLONES, *PYRAZOLES, *NONSTEROIDAL anti-inflammatory agents, *PHARMACOKINETICS, *METABOLITES
Abstract

Metamizole ( MT) is a pyrazolone nonsteroidal anti-inflammatory drug labelled for humans and animals. The aim of this study was to assess the pharmacokinetics of its active metabolites 4-methylamino-antipyrine ( MAA) and 4-amino-antipyrine ( AA) in male piglets after a single intramuscular injection of MT. Eight healthy male piglets were administered MT (100 mg/kg) intramuscularly. Blood was sampled at scheduled time intervals, and drug plasma concentrations evaluated by a validated HPLC method. MAA and AA plasma concentrations were quantitatively detectable from 0.25 to 48 h and 0.50 to 72 h, respectively, in 6 of 8 and 7 of 8 animals. The average maximum concentrations of MAA and AA were of 47.59 and 4.94 mg/ mL, respectively. The average half-lives were 8.57 and 13.3 h for MAA and AA, respectively. This study showed that the amount of MAA and AA produced in piglets is different to that in the animal species previously investigated. Further studies are necessary to understand whether these differences in MAA and AA plasma concentrations between animal species necessitate diverse therapeutic drug dosing. [ABSTRACT FROM AUTHOR]

Published
2016
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