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Your search keyword '"Korsen, Joshua A."' showing total 9 results
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9 results on '"Korsen, Joshua A."'

1. Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer

Author

Bakht, Martin K., Yamada, Yasutaka, Ku, Sheng-Yu, Venkadakrishnan, Varadha Balaji, Korsen, Joshua A., Kalidindi, Teja M., Mizuno, Kei, Ahn, Shin Hye, Seo, Ji-Heui, Garcia, Maria Mica, Khani, Francesca, Elemento, Olivier, Long, Henry W., Chaglassian, Alain, Pillarsetty, Nagavarakishore, Lewis, Jason S., Freedman, Matthew, Belanger, Anthony P., Nguyen, Quang-De, and Beltran, Himisha

Published
2023
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9. Synthetic molecular recognition nanosensor paint for microalbuminuria.

Author

Shah, Janki, Cohen, Joseph R., Jena, Prakrit V., Ramanathan, Lakshmi V., Budhathoki-Uprety, Januka, Korsen, Joshua A., Galassi, Thomas V., Harvey, Jackson D., Jaimes, Edgar A., Heller, Daniel A., and Wayne, Alysandria E.

Subjects
NANOSENSORS, MOLECULAR recognition, ALBUMINS, PHOTOLUMINESCENCE, FATTY acids
Abstract

Microalbuminuria is an important clinical marker of several cardiovascular, metabolic, and other diseases such as diabetes, hypertension, atherosclerosis, and cancer. The accurate detection of microalbuminuria relies on albumin quantification in the urine, usually via an immunoturbidity assay; however, like many antibody-based assessments, this method may not be robust enough to function in global health applications, point-of-care assays, or wearable devices. Here, we develop an antibody-free approach using synthetic molecular recognition by constructing a polymer to mimic fatty acid binding to the albumin, informed by the albumin crystal structure. A single-walled carbon nanotube, encapsulated by the polymer, as the transduction element produces a hypsochromic (blue) shift in photoluminescence upon the binding of albumin in clinical urine samples. This complex, incorporated into an acrylic material, results in a nanosensor paint that enables the detection of microalbuminuria in patient samples and comprises a rapid point-of-care sensor robust enough to be deployed in resource-limited settings. Microalbuminuria, a clinical marker associated with cancer and hypertension, defined by low albumin levels in the urine, is normally detected by immunoassay. Herein, a nanosensor paint was developed using a polymer to mimic fatty acid binding to albumin, transduced by carbon nanotube fluorescence. [ABSTRACT FROM AUTHOR]

Published
2019
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