1. The Structure of 2′ (R)-Mercapto-2′-deoxyneplanocin A (Nucleosides and Nucleotides 48.)
- Author
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Mitsuo Hayashi, Kazumi Nakatsu, Tohru Ueda, Kenji Kinoshita, Takao Hirano, and Kiyofumi Fukukawa
- Subjects
chemistry.chemical_classification ,Stereochemistry ,Structure (category theory) ,Atom (order theory) ,Crystal structure ,Dihedral angle ,Biochemistry ,Base (group theory) ,Crystallography ,chemistry ,Group (periodic table) ,Alkane stereochemistry ,Genetics ,Nucleotide - Abstract
The molecular and crystal structure of 2′(R)-mercapto-2′-deoxyneplanocin A, C11H13N5O2S M.W.=279.32, has been determined by X-ray analysis. The space group is P212121 with a=10.322(1), b=22.870(2), c=5.273(1)A and z=4. The structure was solved by direct method, and least-squares refinement using 1806 reflections with |Fo| > 30(F) led to the final R value of 0.045. The sugar C(2′) atom is displaced by 0.35A opposite to the base N(9), i.e., C(2′)-exo conformation and the torsion angle about the N(9)-C(1) bond is 26.3(4)° (anti conformation).
- Published
- 1983
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