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1. Association of Cough Severity with Asthma Control and Quality of Life in Patients with Severe Asthma

Author

Lee, Hwa Young, Lee, Youngsoo, Lee, Ji-Hyang, Lee, Seung-Eun, Sim, Da Woon, Kang, Noeul, Kim, Joo-Hee, Kang, Sung-Yoon, Sohn, Kyoung-Hee, Nam, Young Hee, Kim, Sujeong, Park, Chan Sun, Kim, So Ri, An, Jin, Kim, Byung-Keun, Jin, Hyun Jung, Park, So-Young, Lee, Byung-Jae, Lee, Sook Young, Park, Hae-Sim, Cho, You Sook, Kim, Sang-Heon, and Song, Woo-Jung

Published
2024
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2. Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study

Author

Pham, Duong Duc, Lee, Ji-Hyang, Kwon, Hyouk-Soo, Song, Woo-Jung, Cho, You Sook, Kim, Hyunkyoung, Kwon, Jae-Woo, Park, So-Young, Kim, Sujeong, Hur, Gyu Young, Kim, Byung Keun, Nam, Young-Hee, Yang, Min-Suk, Kim, Mi-Yeong, Kim, Sae-Hoon, Lee, Byung-Jae, Lee, Taehoon, Park, So-Young, Kim, Min-Hye, Cho, Young-Joo, Park, ChanSun, Jung, Jae-Woo, Park, Han Ki, Kim, Joo-Hee, Moon, Ji-Yong, Bhavsar, Pankaj, Adcock, Ian, Chung, Kian Fan, and Kim, Tae-Bum

Published
2024
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3. Effect of biologic therapies on quality of life in severe asthma: Findings from the PRISM study

Author

Rhyou, Hyo-In, Kim, Hyun-Kyoung, Song, Woo-Jung, Lee, Sang Min, Kim, Sang-Ha, Kwon, Jae-Woo, Park, Han-Ki, Park, Hye-Kyung, Kim, Sang Hoon, Choi, Jeong-Hee, Kim, Sujeong, Park, So-Young, Kim, Sae-Hoon, Moon, Ji-Yong, Jung, Jae-Woo, Cho, Young-Joo, Park, Chan Sun, Kim, Byung Keun, Kim, Joo-Hee, Yang, Min-Suk, Kim, Min-Hye, Nam, Young-Hee, Lee, Taehoon, Lee, Byung-Jae, Bhavsar, Pankaj, Adcock, Ian M., Chung, Kian Fan, and Kim, Tae-Bum

Published
2024
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11. Prospective direct comparison of biologic treatments for severe eosinophilic asthma: Findings from the PRISM study

Author

Pham, Duong Duc, Lee, Ji-Hyang, Kwon, Hyouk-Soo, Song, Woo-Jung, Cho, You Sook, Kim, Hyunkyoung, Kwon, Jae-Woo, Park, So-Young, Kim, Sujeong, Hur, Gyu Young, Kim, Byung Keun, Nam, Young-Hee, Yang, Min-Suk, Kim, Mi-Yeong, Kim, Sae-Hoon, Lee, Byung-Jae, Lee, Taehoon, Park, So Young, Kim, Min-Hye, Cho, Young-Joo, Park, ChanSun, Jung, Jae-Woo, Park, Han Ki, Kim, Joo-Hee, Moon, Ji-Yong, Adcock, Ian, Bhavsar, Pankaj, Chung, Kian Fan, and Kim, Tae-Bum

Published
2024
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13. A comparison of treatment response to biologics in asthma-COPD overlap and pure asthma: Findings from the PRISM study

Author

Shim, Ji-Su, Kim, Hyunkyoung, Kwon, Jae-Woo, Park, So-Young, Kim, Sujeong, Kim, Byung-Keun, Nam, Young-Hee, Yang, Min-Suk, Kim, Mi-Yeong, Kim, Sae-Hoon, Lee, Byung-Jae, Lee, Taehoon, Kim, Sang-Ha, Park, So Young, Cho, Young-Joo, Park, Chan Sun, Jung, Jae-Woo, Park, Han-Ki, Kim, Joo-Hee, Choi, Jeong-Hee, Moon, Ji-Yong, Adcock, Ian, Chung, Kian Fan, Kim, Min-Hye, and Kim, Tae-Bum

Published
2023
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17. Clinical predictors of treatment response to tiotropium add-on therapy in adult asthmatic patients: From multicenter real-world cohort data in Korea

Author

Shim, Ji-Su, Jin, Juhae, Kim, Sae-Hoon, Lee, Taehoon, Jang, An-Soo, Park, Chan Sun, Jung, Jae-Woo, Kwon, Jae-Woo, Moon, Ji-Yong, Yang, Min-Suk, Lee, Jaechun, Choi, Jeong-Hee, Shin, Yoo Seob, Kim, Hee-Kyoo, Kim, Sujeong, Kim, Joo-Hee, Cho, Sang-Heon, Nam, Young-Hee, Kim, Sang-Hoon, Park, So Young, Hur, Gyu Young, Kim, Sang-Ha, Park, Hye-Kyung, Jin, Hyun Jung, Lee, Jae-Hyun, Park, Jung-Won, Yoon, Ho Joo, Choi, Byoung Whui, Cho, Young-Joo, Kim, Min-Hye, and Kim, Tae-Bum

Published
2022
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23. Epidemiological Evidence for Upper Respiratory Infections as a Potential Risk Factor for Meniere's Disease: A Korean National Health Sample Cohort Study.

Author

Kwon, Mi Jung, Kang, Ho Suk, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Yoo, Dae Myoung, Lee, Na-Eun, Han, Kyeong Min, Kim, Nan Young, Choi, Hyo Geun, Kim, Min-Jeong, and Kim, Eun Soo

Subjects
RESPIRATORY infections, MENIERE'S disease, NATIONAL health insurance, PROPENSITY score matching, HEARING disorders, INNER ear
Abstract

Meniere's disease (MD) is a chronic inner ear disorder characterized by tinnitus, ear fullness, episodic vertigo, and fluctuating hearing loss, which significantly impacts quality of life and poses management challenges. Recent evidence suggests that upper respiratory infections (URIs) may contribute to MD's onset. This study examines the potential link between URIs and MD using data from the Korean National Health Insurance Service-National Sample Cohort (2002–2019). We analyzed 19,721 individuals with MD and 78,884 matched controls, adjusting for demographic factors and comorbidities using propensity score matching. Our results showed that individuals with a URI within one year prior to the index date exhibited a 2.01-fold greater likelihood of developing MD (95% confidence interval [CI] = 1.91–2.11, p < 0.001), while those with URIs within two years demonstrated a 1.54-fold higher probability (95% CI = 1.50–1.59, p < 0.001). Furthermore, we found that even remote URIs occurring up to two years before the index date significantly increased the risk of developing MD, underscoring the need for long-term patient follow-up. Overall, our study suggests that individuals with a history of URI may have an elevated risk of developing MD over multiple time frames, regardless of demographic or health profiles. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Regulatory Framework for Drug-Device Combination Products in the United States, Europe, and Korea.

Author

Kim, Joo Hee, Kwon, Sera, Seol, Ju Eun, Kim, Mi Hye, and Kim, Su Dong

Subjects
MEDICAL equipment laws, MEDICAL protocols, PRODUCT safety, PATIENT safety, DRUG delivery systems, BIOLOGICAL products, DRUG approval, NEW product development laws, GOVERNMENT regulation
Abstract

Combination products (CPs) combine two or more product types such as drugs, devices, and/or biological products for increased safety and clinical effectiveness. The emergence of innovative CPs poses new challenges for regulatory agencies in assigning jurisdiction for premarket review and oversight. In US, the 1990 Safe Medical Devices Act defines and provides classification criteria for CPs, and the US government has developed a regulatory process through multiple acts, including the 21st Century Cures Act of 2016. Meanwhile, regulators in the European Union (EU) and the Republic of Korea have recently recognized the importance of premarket pathways for CPs. The European Medicines Agency (EMA) has issued guidelines and explanations on compliance issues related to drug–device CPs under MDR. EMA doesn't have the definitions of CPs, but uses the term drug–device combination products (drug-device CPs). CPs are categorized as drugs or medical devices, which follow their relevant regulatory framework. The Ministry of Food and Drug Safety (MFDS) in Korea has legal definitions of CPs under the Notice of the MFDS. CPs are designated as drugs or medical devices according to their primary mode of actions (PMOA) and follow regulatory processes through the framework of drugs or medical devices. This study aims to comprehensively summarize the regulatory oversight of CPs by analyzing the regulatory policies and legal frameworks in the US, the EU, and Korea. The regulatory challenges encountered when developing CPs are also discussed. With specific emphasis on the combination of drugs and devices, this study provides in-depth insights into the regulatory landscape, shedding light on the unique challenges associated with the development of CPs for this particular intersection of drugs and devices. [ABSTRACT FROM AUTHOR]

Published
2024
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25. The Effectiveness and Safety of Wu Tou Decoction on Rheumatoid Arthritis—A Systematic Review and Meta-Analysis.

Author

Moon, Jeong-Hyun, Park, Gyoungeun, Kwon, Chan-Young, Kim, Joo-Hee, Kim, Eun-Jung, Seo, Byung-Kwan, Lee, Seung-Deok, Hong, Seung-Ug, and Sung, Won-Suk

Subjects
CHINESE medicine, MEDICAL information storage & retrieval systems, MITOGEN-activated protein kinases, COMBINATION drug therapy, ALKALOIDS, PATIENT safety, RESEARCH funding, RHEUMATOID arthritis, HERBAL medicine, ANTIRHEUMATIC agents, TREATMENT effectiveness, META-analysis, DESCRIPTIVE statistics, BLOOD sedimentation, SYSTEMATIC reviews, MEDLINE, GENE expression, DRUG efficacy, MEDICAL databases, CONFIDENCE intervals, INTERLEUKINS, C-reactive protein, DISEASE progression, THERAPEUTICS, PHARMACODYNAMICS
Abstract

Rheumatoid arthritis (RA) is an autoimmune disease primarily affecting the joints and requires various treatments, including medication, injection, and physiotherapy. Wu tou decoction (WTD) is a traditional Chinese medicine prescribed for RA, with several articles documenting its effectiveness in RA treatment. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of WTD for RA. We searched for randomized controlled trials (RCTs) comparing WTD with conventional treatments (including medication, injection, and physiotherapy) from its inception to May 2024. Primary outcomes were disease activity scores, including effective rate, tender joint count, and morning stiffness. Secondary outcomes comprised blood test results (erythrocyte sedimentation rate, C-reactive protein, and rheumatoid factor) and adverse events. Nineteen RCTs involving 1794 patients were included. Statistically, WTD demonstrated better improvement than conventional treatments (18 medications and 1 injection) across the effective rate, joint scale, and blood tests, regardless of the treatment type (monotherapy or combination therapy). Adverse events were reported in 11 studies, with no statistical differences observed between them. The numerical results showed that WTD may offer potential benefits for managing RA. However, the significant discrepancy between clinical practice and the low quality of the RCTs remains a limitation. Therefore, further well-designed studies with larger patient cohorts are needed to draw definitive conclusions. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Pragmatic Randomized Controlled Trial for Stepping Down Asthma Controller Treatment in Patients Controlled with Low-Dose Inhaled Corticosteroid and Long-Acting β2-Agonist: Step-Down of Intervention and Grade in Moderate Asthma Study

Author

Song, Woo-Jung, Kwon, Hyouk-Soo, Sook, You, Seo, Bomi, Kim, Jung-Hyun, Choi, Byoung-Whui, Cho, Young-Joo, Park, So Young, Yoon, Sun-Young, Jin, Hyun Jung, Park, So-Young, Park, Hye-Kyung, Hur, Gyu Young, Kim, Sang Ha, Kim, Sae-Hoon, Lee, Taehoon, Jang, An-Soo, Park, Chan Sun, Jung, Jae-Woo, Kim, Min-Hye, Kwon, Jae-Woo, Moon, Ji-Yong, Yang, Min-Suk, Lee, Jaechun, Choi, Jeong-Hee, Shin, Yoo Seob, Kim, Hee-Kyoo, Kim, Sujeong, Kim, Joo-Hee, Lee, Suh-Young, Nam, Young-Hee, Kim, Sang-Hoon, and Kim, Tae-Bum

Published
2021
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32. A Randomized, Noninferiority Trial Comparing ICS + LABA with ICS + LABA + LAMA in Asthma-COPD Overlap (ACO) Treatment: The ACO Treatment with Optimal Medications (ATOMIC) Study

Author

Song, Woo-Jung, Kwon, Hyouk-Soo, Cho, You Sook, Moon, Hee-Bom, Ki, Tae-Bum, Kim, Sae-Hoon, Seo, Bomi, Choi, Byoung-Whui, Jung, Jae-Woo, Cho, Young-Joo, Kim, Min-Hye, Jang, An-Soo, Shin, Yoo Seob, Moon, Ji-Yong, Kwon, Jae-Woo, Kim, Sang-Hoon, Park, So Young, Lee, Taehoon, Kim, Sujeong, Park, Chan Sun, Kim, Joo-Hee, Choi, Jeong-Hee, Nam, Young-Hee, Yoon, Sun-Young, Jin, Hyun Jung, Yang, Min-Suk, Lee, Jaechun, Park, Hye-Kyung, Hur, Gyu Young, Kim, Hee-Kyoo, Kim, Sang-Ha, Park, So-Young, Lee, Sang Min, Kang, Sung-Yoon, Ban, Ga-Young, Kim, Solmi, Kim, Jung-Hyun, Park, Seo Young, and Kim, Tae-Bum

Published
2021
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33. A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea

Author

Kang, Dong Yoon, Yun, James, Lee, Suh-Young, Koh, Young-Il, Sim, Da Woon, Kim, Sujeong, Nam, Young Hee, Park, Jung-Won, Kim, Sae Hoon, Ye, Young-Min, Park, Hye-Kyung, Kim, Min-Hye, Jee, Young-Koo, Jung, Jae-Woo, Yang, Min-Suk, Kim, Sang-Heon, Lee, Jun Kyu, Kim, Cheol-Woo, Hur, Gyu Young, Kim, Mi-Yeong, Park, Seoung Ju, Kwon, Yong Eun, Choi, Jeong-Hee, Kim, Joo-Hee, Kim, Sang Hyon, La, Hyen O., Kang, Min-Gyu, Park, Chan Sun, Lee, Sang Min, Jeong, Yi Yeong, Kim, Hee-Kyoo, Jin, Hyun Jung, Jeong, Jae-Won, Lee, Jaechun, Lee, Yong Won, Lee, Seung Eun, Kim, Myoung Shin, and Kang, Hye-Ryun

Published
2021
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34. The Association between Statin Use and Reduced Migraine Likelihood: A Comprehensive Analysis of Migraine Subtypes and Statin Types in a Nationwide Korean Cohort.

Author

Kang, Ho Suk, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Yoo, Dae Myoung, Lee, Na-Eun, Han, Kyeong Min, Kim, Nan Young, Choi, Hyo Geun, Min, Kyueng-Whan, and Kwon, Mi Jung

Subjects
*MIGRAINE aura, *NATIONAL health insurance, *PROPENSITY score matching, *KOREANS, *STATINS (Cardiovascular agents)
Abstract

Despite growing interest in the preventive effects of statins, as lipid-lowering agents, on migraine attacks, comprehensive nationwide studies comparing migraine likelihood between statin users and controls are lacking. Our nested case–control study within the Korean National Health Insurance Service-Health Screening Cohort (2002–2019) investigated this association using 38,957 migraine patients and 155,828 controls, considering migraine subtypes (with/without aura) and statin types (lipophilic vs. hydrophilic). Using propensity score matching and adjusting for confounders, statin use was linked to reduced migraine likelihood overall (odds ratio (OR) 0.93), particularly for migraines with aura (OR 0.75) and without aura (OR 0.94). Lipophilic statins were effective for both subtypes, while hydrophilic statins mainly reduced the likelihood of migraines without aura. Subgroup analyses showed consistent benefits across demographics, but varied effectiveness based on weight, smoking, alcohol use, hemoglobin levels, and dyslipidemia history. In summary, this nationwide cohort study suggests that statin use may reduce migraine likelihood among Korean adults across diverse demographics and clinical profiles, but varied effectiveness based on certain lifestyle and comorbidity factors underscores the importance of considering individual patient profiles when assessing the potential benefits of statin therapy for migraine prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Development of a Risk Prediction Model for Adverse Skin Events Associated with TNF-α Inhibitors in Rheumatoid Arthritis Patients.

Author

Kim, Woorim, Oh, Soo-Jin, Kim, Hyun-Jeong, Kim, Jun-Hyeob, Gil, Jin-Yeon, Ku, Young-Sook, Kim, Joo-Hee, Kim, Hyoun-Ah, Jung, Ju-Yang, Choi, In-Ah, Kim, Ji-Hyoun, Kim, Jinhyun, Han, Ji-Min, and Lee, Kyung-Eun

Subjects
MACHINE learning, DISEASE risk factors, TUMOR necrosis factors, GENOME-wide association studies, LOGISTIC regression analysis, RHEUMATOID arthritis
Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder primarily targeting joints, significantly impacting patients' quality of life. The introduction of tumor necrosis factor-alpha (TNF-α) inhibitors has markedly improved RA management by reducing inflammation. However, these medications are associated with adverse skin reactions, which can vary greatly among patients due to genetic differences. Objectives: This study aimed to identify risk factors associated with skin adverse events by TNF-α in RA patients. Methods: A cohort study was conducted, encompassing patients with RA who were prescribed TNF-α inhibitors. This study utilized machine learning algorithms to analyze genetic data and identify markers associated with skin-related adverse events. Various machine learning algorithms were employed to predict skin and subcutaneous tissue-related outcomes, leading to the development of a risk-scoring system. Multivariable logistic regression analysis identified independent risk factors for skin and subcutaneous tissue-related complications. Results: After adjusting for covariates, individuals with the TT genotype of rs12551103, A allele carriers of rs13265933, and C allele carriers of rs73210737 exhibited approximately 20-, 14-, and 10-fold higher incidences of skin adverse events, respectively, compared to those with the C allele, GG genotype, and TT genotype. The machine learning algorithms used for risk prediction showed excellent performance. The risk of skin adverse events among patients receiving TNF-α inhibitors varied based on the risk score: 0 points, 0.6%; 2 points, 3.6%; 3 points, 8.5%; 4 points, 18.9%; 5 points, 36.7%; 6 points, 59.2%; 8 points, 90.0%; 9 points, 95.7%; and 10 points, 98.2%. Conclusions: These findings, emerging from this preliminary study, lay the groundwork for personalized intervention strategies to prevent TNF-α inhibitor-associated skin adverse events. This approach has the potential to improve patient outcomes by minimizing the risk of adverse effects while optimizing therapeutic efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Association between Gastric Cancer and Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Sample Cohort.

Author

Han, Kyeong Min, Kwon, Mi Jung, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Choi, Hyo Geun, Yoo, Dae Myoung, Lee, Na-Eun, Kim, Nan Young, and Kang, Ho Suk

Subjects
RISK assessment, STOMACH tumors, RESEARCH funding, LONGITUDINAL method, KAPLAN-Meier estimator, OSTEOPOROSIS, COMPARATIVE studies, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Using data from the Korean National Health Insurance Service—National Sample Cohort database, we evaluated whether patient-specific factors such as age, sex, income, residence, and the presence of comorbidities influence the relationship between gastric cancer (GC) and the likelihood of developing osteoporosis. Our study, with 1:4 propensity score matching and a stratified Cox proportional hazards model, showed that the hazard ratio of osteoporosis for the GC group was 1.13 (95%CI, 1.03–1.24) compared to that for the control group. In addition, subgroup analysis showed that age < 65 years, male sex, and a Charlson Comorbidity Index of 0 were risk factors for osteoporosis. Gastric cancer (GC) survivors may be more likely to develop osteoporosis. However, few studies on the relationship between GC and osteoporosis have been conducted on large patient populations. We aimed to determine the incidence of osteoporosis and identify related factors by comparing patients with GC and matched controls using the Korean National Health Insurance Service—National Sample Cohort (KNHIS-NSC). This study included 9078 patients with GC and 36,312 controls (1:4 propensity score-matched for sex, age, residence, and income). The hazard ratio (HR) for osteoporosis was significantly greater for GC patients than for controls according to Charlson Comorbidity Index (CCI) score-adjusted models (adjusted HR = 1.13). Kaplan–Meier analysis revealed that the cumulative incidence of osteoporosis during the follow-up period commencing from the index date was significantly greater in GC patients than in the controls (p = 0.0087). A positive correlation of osteoporosis with GC was detected for those aged < 65 years, males, and those with CCI scores = 0. In conclusion, the study findings suggest that men with GC aged < 65 years may be at an increased risk for osteoporosis. Research into additional risk factors and the optimal timing of interventions are needed to prevent fractures and minimize bone loss in GC survivors. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Association of Gout with Head and Neck Cancer: Longitudinal Follow-Up Studies Using a National Health Insurance Database in South Korea.

Author

Kim, So Young, Park, Il Hwan, Byun, Chun Sung, Choi, Hyo Geun, Kwon, Mi Jung, Kim, Ji Hee, Kim, Joo-Hee, and Kim, Chang Wan

Subjects
HEAD & neck cancer, NATIONAL health insurance, SALIVARY gland cancer, GOUT, NASOPHARYNX cancer
Abstract

Objective: Previous studies have reported controversial results on the association between gout and the risk of cancer. This study aimed to investigate the relationship between gout and the incidence of head and neck cancer (HNC). Methods: The data of participants who underwent health checkups in 2009 were analyzed using the National Health Insurance Database in South Korea. A total of 14,348 HNC patients and 57,392 control participants were analyzed for a prior history of gout. Overlap weighting was applied, and odds ratios (ORs) of gout for HNC patients were analyzed. The overlap-weighted model adjusted for demographic, socioeconomic, and lifestyle factors and comorbidities. HNC sites were classified as oral cavity cancer, oropharyngeal cancer, nasopharyngeal cancer, hypopharyngeal cancer, nasal cavity/sinus cancer, larynx cancer, or salivary gland cancer, and the ORs of gout were estimated for each site. Results: Overall, patients with HNC had 1.12-fold greater odds of having gout (95% confidence intervals [CIs] = 1.04–1.20). According to the site of HNC, oral cavity cancer, oropharynx cancer, and larynx cancer demonstrated high odds of having gout (OR = 1.25, 95% CI = 1.16–1.34 for oral cavity cancer; OR = 1.08, 95% CI = 1.01–1.15 for oropharynx cancer; and OR = 1.12, 95% CI = 1.06–1.20 for larynx cancer). On the other hand, nasal cavity/sinus cancer, nasopharynx cancer, and salivary gland cancer presented low odds of having gout (OR = 0.78, 95% CI = 0.72–0.84 for nasal cavity/sinus cancer; OR = 0.89, 95% CI = 0.83–0.96 for nasopharynx cancer; and OR = 0.88, 95% CI = 0.81–0.96 for salivary gland cancer). Conclusions: A prior history of gout was associated with a high overall incidence of HNC. Oral cavity cancer, oropharynx cancer, and larynx cancer have a high incidence in gout patients. However, nasal cavity/sinus cancer, nasopharyngeal cancer, and salivary gland cancer have low incidences in gout patients. The impact of gout on HNC risk should be specifically considered according to the site of the HNC. [ABSTRACT FROM AUTHOR]

Published
2024
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38. A multicenter anaphylaxis registry in Korea: Clinical characteristics and acute treatment details from infants to older adults

Author

Jeong, Kyunguk, Ye, Young-Min, Kim, Sang-Ha, Kim, Kyung Won, Kim, Jeong Hee, Kwon, Ji-Won, Yang, Song-I., Lee, So-Yeon, Chung, Eun Hee, Kim, Mi-Ae, Kim, Yoon Hee, Kim, Hye-Young, Jang, Gwang Cheon, Kim, Joo-Hee, Lee, Eunjoo, Kim, Jihyun, Ahn, Kangmo, Chang, Yoon-Seok, Hur, Gyu-Young, Lee, Jeongmin, Min, Taek Ki, Pyun, Bok-Yang, Park, Kyung Hee, Lee, Jaechun, Song, Tae Won, Jee, Hye Mi, Shin, Yoo Seob, Yoon, Dankyu, Lee, Jeom-Kyu, and Lee, Sooyoung

Published
2020
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40. Letter from Korea—Oral corticosteroid stewardship in Korea: Insights from the Korean Severe Asthma Registry (KoSAR).

Author

Kang, Noeul, Kim, Joo‐Hee, and Kim, So Ri

Subjects
*EMERGENCY room visits, *PULMONARY aspergillosis, *CHURG-Strauss syndrome, *MEDICAL personnel, *ASTHMATICS, *ADRENAL insufficiency
Abstract

The article discusses the prevalence of severe asthma in South Korea and the challenges associated with oral corticosteroid (OCS) use for managing severe asthma. The Korean Severe Asthma Registry (KoSAR) provides valuable insights into patients with severe asthma in Korea, highlighting the need for OCS stewardship to minimize risks associated with long-term OCS use. The implementation of OCS stewardship involves strategies such as biologics as alternatives to OCS, stepwise OCS tapering protocols, and multidisciplinary collaboration among healthcare providers. By adopting these approaches, the management of severe asthma in South Korea can be improved, leading to better patient outcomes and quality of life. [Extracted from the article]

Published
2024
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44. Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA

Author

Kim, Tae-Bum, Song, Woo-Jung, Kwon, Hyouk-Soo, Cho, You Sook, Kim, Sae-Hoon, Choi, Byoung Whui, Jung, Jae-Woo, Cho, Young-Joo, Kim, Min-Hye, Jang, An-Soo, Shin, Yoo Seob, Moon, Ji-Yong, Kwon, Jae-Woo, Kim, Sang-Hoon, Park, So Young, Lee, Taehoon, Kim, Sujeong, Park, Chan Sun, Kim, Joo-Hee, Choi, Jeong-Hee, Nam, Young-Hee, Yoon, Sun-Young, Jin, Hyun Jung, Yang, Min-Suk, Lee, Jaechun, Park, Hye-Kyung, Hur, Gyu Young, Kim, Hee-Kyoo, Kim, Sang Ha, Jung, Hee Won, Lee, Jae Moon, Shin, Bomi, Kim, Hyo Jung, Park, Heung-Woo, Chang, Yoon-Seok, Cho, Sang-Heon, Won, Sungho, Park, Taesung, Moon, Hee-Bom, and Kim, Changsoo

Published
2019
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48. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, 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Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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49. The Association of Chronic Periodontitis as a Potential Risk Factor with Rheumatoid Arthritis: A Nested Case-Control Study Using a Korean National Health Screening Cohort.

Author

Kang, Ho Suk, Kim, Joo-Hee, Kim, Ji Hee, Bang, Woo Jin, Choi, Hyo Geun, Yoo, Dae Myoung, Lee, Na-Eun, Han, Kyeong Min, Kim, Nan Young, Park, Ha Young, Min, Kyueng-Whan, and Kwon, Mi Jung

Subjects
MEDICAL screening, RHEUMATOID arthritis, PERIODONTITIS, CASE-control method, PROPENSITY score matching, KOREANS
Abstract

Growing research has proposed that rheumatoid arthritis (RA) and chronic periodontitis (CP) share similar pathophysiological mechanisms involving inflammation and tissue destruction. However, the potential correlation of CP as a contributing factor for the occurrence of RA warrants validation in the Korean population, where both diseases are prevalent, especially considering the increasingly aging demographic in Korea. This study examined 5139 RA cases and 509,727 matched controls from a Korean national cohort dataset (2002–2019) by carefully employing propensity score matching to ensure comparability between groups. Baseline characteristics were compared using standardized differences, and logistic regression was employed to estimate the impact of CP history on RA likelihood while controlling for covariates. We fully examined medical records documenting CP occurrences within the two-year period leading up to the index date, conducting comprehensive subgroup analyses. While a 1-year history of CP did not show a significant association with likelihood of RA, a 2-year history of CP increased RA likelihood by 12%, particularly among older adults, females, rural residents, and those with certain comorbidities such as hypercholesterolemia. Interestingly, this association persisted even among individuals with non-smoking habits, normal weight, and infrequent alcohol consumption. These findings suggest that chronic CP exposure for at least 2 years may independently elevate RA risk in Korean adults. The association in certain subgroups appears to suggest a predisposition toward genetic susceptibilities over lifestyle and environmental factors. Predicting RA in CP patients may be challenging, emphasizing the importance of regular RA screening, especially in high-risk subgroups. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Associations between Peritonsillar Abscess and Deep Neck Infection in Chronic Periodontitis Patients: Two Nested Case—Control Studies Using a National Health Screening Cohort.

Author

Kim, So Young, Park, Il Hwan, Byun, Chun Sung, Choi, Hyo Geun, Kwon, Mi Jung, Kim, Ji Hee, Kim, Joo-Hee, and Kim, Chang Wan

Subjects
MEDICAL screening, PERIODONTITIS, NATIONAL health insurance, ABSCESSES, NECK, LOGISTIC regression analysis
Abstract

Background/Introduction: Odontogenic infection is one of the main etiologies of deep neck infection (DNI). However, the relationship between chronic periodontitis (CP) and the incidence of DNI has not been examined. This study aimed to evaluate the incidence of DNI and peritonsillar abscess (PTA) after CP. Methods: The Korean National Health Insurance Service-National Sample Cohort 2002–2019 was used. In Study I, 4585 PTA patients were matched with 19,340 control I participants. A previous history of CP for 1 year was collected, and the odds ratios (ORs) of CP for PTA were analyzed using conditional logistic regression. In Study II, 46,293 DNI patients and 185,172 control II participants were matched. A previous history of CP for 1 year was collected, and conditional logistic regression was conducted for the ORs of CP for DNI. Secondary analyses were conducted in demographic, socioeconomic, and comorbidity subgroups. Results: In Study I, a history of CP was not related to the incidence of PTA (adjusted OR = 1.28, 95% confidence interval [CI] = 0.91–1.81). In Study II, the incidence of DNI was greater in participants with a history of CP (adjusted OR = 1.55, 95% CI = 1.41–1.71). The relationship between CP history and DNI was greater in groups with young, male, low-income, and rural residents. Conclusions: A prior history of CP was associated with a high incidence of DNI in the general population of Korea. Patients with CP need to be managed for the potential risk of DNI. [ABSTRACT FROM AUTHOR]

Published
2024
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