Search

Breast cancer is the biggest cause of death among women worldwide. Natural chemicals from medicinal plants offer promise for cancer therapy. This research screens 29 Dryopteris species plant-derived chemicals, mostly phloroglucinols, for breast cancer therapy potential. First, we used Gaussian09 and DFT/B3LYP/6-311+G(d, p) calculations to evaluate compound stability and reactivity. We conducted molecular docking experiments to identify drugs with high binding affinity for the PI3Kα protein’s active pocket. DJ1–DJ22 were found to be the most effective PI3Kα inhibitors, with energies ranging from −8.0 to −9.2 kJ/mol. From in silico pharmacokinetic and bioactivity screening, DJ3, DJ7, and DJ18 were identified as promising PI3Kα inhibitors. PI3Kα backbone stability was tested in a water model using molecular dynamics simulations employing DJ3, DJ7, DJ18, and Trastuzumab as a pharmacological reference. Synthesis of target-hit DJ3, DJ7, and DJ18 derivatives may lead to breast cancer drug-like molecules for related cancers. The work uses in silico methods to find natural phloroglucinols for breast cancer therapy, enabling new chemotherapeutic drugs.

The paper examines the adequacy and deficiency of transport planning in Lahore to recommend some measures for developing a sustainable urban transport system in the city. Urban transport is one of the most important sectors having a direct impact on sustainable development. The pattern of land use and the available transportation systems in urban areas play a critical role in determining the livability and sustainability of those urban areas. Land use planning and its integration with the transport planning is most ignored issue. Traffic management and roadway construction has not kept pace with the increased mobility needs of the society. Lahore city is being the cultural, intellectual, political and economic hub of the Punjab province, has experienced adverse impacts of traffic congestion and mismanagement. [ABSTRACT FROM AUTHOR]

Spatiao-Temporal residential growth indicates the spatial and temporal proportions of land cover/land use change at the level of the urban landscape.Lahore has undergone various changes over the years. The largest perhaps being the scale in its crowding and the urban growth. Its rural landscape is being swallowed with a great pace due to invasion of urban areas causing urban growth of unprecedented nature and this insertion into the urban arena is without any urban policy both at the provincial and local level. In order to understand the spatial and temporal pattern of residential growth of Lahore, which is necessary for future urban planning and policy management, current study of Lahore is done. [ABSTRACT FROM AUTHOR]