Search

Your search keyword '"Kardono, Leonardus B.S."' showing total 21 results
Start Over Author "Kardono, Leonardus B.S." Search Limiters Peer Reviewed
21 results on '"Kardono, Leonardus B.S."'

13. Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinata.

Author

Deng, Ye, Chin, Young-Won, Chai, Hee-Byung, de Blanco, Esperanza Carcache, Kardono, Leonardus B.S., Riswan, Soedarsano, Soejarto, Djaja D., Farnsworth, Norman R., and Kinghorn, A. Douglas

Subjects
BREAST cancer treatment, VITEX, MEDICAL botany, PHYTOCHEMICALS, LEAVES, CELL-mediated cytotoxicity, CELL lines, CANCER cells, ENZYME-linked immunosorbent assay
Abstract

Abstract: A phytochemical investigation of the leaves of Vitex quinata (Lour.) F.N. Williams (Verbenaceae), guided by a cytotoxicity assay against the MCF-7 human breast cancer cell line, led to the isolation of a new δ-truxinate derivative (1) and a new phytonoic acid derivative (2), together with 12 known compounds. The structures of the new compounds were determined by spectroscopic methods as dimethyl 3,4,3′,4′-tetrahydroxy-δ-truxinate (1) and methyl 10R-methoxy-12-oxo-9(13),16E-phytodienoate (2), respectively. In a cytotoxicity assay, (S)-5-hydroxy-7,4′-dimethoxyflavanone (3) was found to be the sole active principle, with ED50 values of 1.1–6.7μM, respectively, when tested against a panel of three human cancer cells. Methyl 3,4,5-O-tricaffeoyl quinate (4) showed activity in an enzyme-based ELISA NF-κB p65 assay, with an ED50 value of 10.3μM. [Copyright &y& Elsevier]

Published
2011
Full Text
View/download PDF

14. A novel polyisoprenyl benzophenone derivative from Garcinia eugeniaefolia.

Author

Hartati, Sri, Soemiati, Atiek, Wang, Hong-Bing, Kardono, Leonardus B.S., Hanafi, Muhammad, Kosela, Soleh, and Qin, Guo-Wei

Subjects
GARCINIA, SPECTRUM analysis, X-ray diffraction, CRYSTALS, BUTANE
Abstract

A novel polyisoprenyl benzophenone derivative named eugeniaphenone (1) was isolated from the stem bark of Garcinia eugeniaefolia Wall. Its structure was elucidated by spectroscopic methods, including 1D and 2D NMR techniques, and confirmed by single-crystal X-ray diffraction analysis. It is the first example in which an isoprenyl unit formed a cyclobutane-containing side chain in the polyisoprenyl benzophenone derivatives. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

15. Silvestrol and Episilvestrol, Potential Anticancer Rocaglate Derivatives from Aglaia silvestris.

Author

Bang Yeon Hwang, Bao-Ning Su, Chai, Heebyung, Mi, Qiuwen, Kardono, Leonardus B.S., Afriastini, Johar J., Riswan, Soedarsonio, Santarsiero, Bernard D., Mesecar, Andrew D., Wild, Robert, Fairchild, Craig R., Vite, Gregory D., Rose, William C., Farnsworth, Norman R., Cordell, Geoffrey A., Pezzuto, John M., Swanson, Steven M., and Kinghorn, A. Douglas

Published
2004
Full Text
View/download PDF

19. Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa

Author

Pan, Li, Lantvit, Daniel D., Riswan, Soedarsono, Kardono, Leonardus B.S., Chai, Hee-Byung, Carcache de Blanco, Esperanza J., Farnsworth, Norman R., Soejarto, Djaja Doel, Swanson, Steven M., and Kinghorn, A. Douglas

Subjects
*ASTERACEAE, *SESQUITERPENES, *ANTINEOPLASTIC agents, *CANCER cells, *CELL lines, *COLON cancer, *MOLECULAR structure, *SPECTRUM analysis
Abstract

Abstract: Cytotoxicity-guided fractionation of a methanol extract of the leaves and twigs of Rolandra fruticosa using the HT-29 human colon cancer cell line led to the isolation of seven sesquiterpene lactones, including the hitherto unknown isorolandrolide, 13-methoxyisorolandrolide (1), and bourbonenolide, 2α,13-diacetoxy-4α-hydroxy-8α-isobutyroyloxybourbonen-12,6α-olide (2), as well as five known compounds, 13-acetoxyrolandrolide (3), 8-desacyl-13-acetoxyrolandrolide-8-O-tiglate (4), 2-epi-glaucolide E (5), 2α,13-diacetoxy-4α-hydroxy-8α-methacryloyloxybourbonen-12,6α-olide (6), and 2α,13-diacetoxy-4α-hydroxy-8α-tigloyloxybourbonen-12,6α-olide (7). The structures of the two sesquiterpenes were elucidated on the basis of spectroscopic methods. All isolates were evaluated for their cytotoxicity using the HT-29 cell line, and only 13-acetoxyrolandrolide (3) was found to possess a potent inhibitory effect against this cell line. Compounds 3, 5 and 6 were also tested in a NF-κB (p65) inhibition assay, and 3 was assessed in an in vivo hollow fiber assay. [Copyright &y& Elsevier]

Published
2010
Full Text
View/download PDF

20. Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum

Author

Salim, Angela A., Su, Bao-Ning, Chai, Hee-Byung, Riswan, Soedarsono, Kardono, Leonardus B.S., Ruskandi, Agus, Farnsworth, Norman R., Swanson, Steven M., and Douglas Kinghorn, A.

Subjects
*ORGANIC cyclic compounds, *ZINGIBERACEAE, *ORGANIC oxides, *ORGANIC chemistry
Abstract

Abstract: Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1–4), their potential precursor, 5R-hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1–4, 6, and 7 showed cytotoxic activity against several human cancer cell lines. [Copyright &y& Elsevier]

Published
2007
Full Text
View/download PDF

21. Edulisones A and B, two epimeric benzo[b]oxepine derivatives from the bark of Aglaia edulis

Author

Kim, Soyoung, Su, Bao-Ning, Riswan, Soedarsono, Kardono, Leonardus B.S., Afriastini, Johar J., Gallucci, Judith C., Chai, Heebyung, Farnsworth, Norman R., Cordell, Geoffrey A., Swanson, Steven M., and Kinghorn, A. Douglas

Subjects
*OPTICAL polarization, *PYRROLIDINE, *CHEMISTRY, *OPTICAL diffraction, *HYDROLYSIS
Abstract

Abstract: Two benzo[b]oxepine derivatives, edulisones A ( 1 ) and B ( 2 ), were isolated from the bark of Aglaia edulis, collected in Indonesia. The relative stereochemistry of 1 was determined by single-crystal X-ray diffraction analysis. Treatment of compounds 1 and 2 with lithium hydroxide produced the same hydrolysis products, 1a and 1b , as a result of cleavage of the pyrrolidine ring to an alkylated amide mixture in each case, which demonstrated that these substances are epimeric at their 2-aminopyrrolidine moiety. [Copyright &y& Elsevier]

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results