982 results on '"Kang, C."'
Search Results
2. Gut microbiome predicts cognitive function and depressive symptoms in late life
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Kolobaric, A., Andreescu, C., Jašarević, E., Hong, C. H., Roh, H. W., Cheong, J. Y., Kim, Y. K., Shin, T. S., Kang, C. S., Kwon, C. O., Yoon, S. Y., Hong, S. W., Aizenstein, H. J., Karim, H. T., and Son, S. J.
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- 2024
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3. Insight of heavy metal contamination of soil in high background area: field investigation and laboratory test
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Xie, N., Kang, C., Feng, B. Z., and Zhang, B.
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- 2024
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4. The effects of urban green space and road proximity to indoor traffic-related PM2.5, NO2, and BC exposure in inner-city schools
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Matthaios, V. N., Holland, I., Kang, C. M., Hart, J. E., Hauptman, M., Wolfson, J. M., Gaffin, J. M., Phipatanakul, W., Gold, D. R., and Koutrakis, P.
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- 2024
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5. Projected background and sensitivity of AMoRE-II
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Agrawal, A., Alenkov, V. V., Aryal, P., Beyer, J., Bhandari, B., Boiko, R. S., Boonin, K., Buzanov, O., Byeon, C. R., Chanthima, N., Cheoun, M. K., Choe, J. S., Choi, Seonho, Choudhury, S., Chung, J. S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavrilyuk, Y. M., Gezhaev, A. M., Gileva, O., Grigorieva, V. D., Gurentsov, V. I., Ha, C., Ha, D. H., Ha, E. J., Hwnag, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, Ho-Jong, Kim, H. J., Kim, H. L., Kim, H. S., Kim, M. B., Kim, S. C., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C. H., Lee, DongYeup, Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Makarov, E. P., Nyanda, P., Oh, Y., Olsen, S. L., Panasenko, S. I., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S., Ratkevich, S. S., Rooh, G., Sala, E., Sari, M. B., Seo, J., Seo, K. M., Sharma, B., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J., Sokur, N. V., Son, J. K., Song, J. W., Srisittipokakun, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yeon, H. J., Yoon, Y. S., and Yue, Q.
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- 2025
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6. Effect of a latent tuberculosis infection programme for healthcare workers in a country with an intermediate tuberculosis burden
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Cho, S.Y., Nham, E., Chung, D.R., Kim, J., Jeong, J., Ko, J.-H., Huh, K., Kang, C.-I., and Peck, K.R.
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- 2024
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7. Strategies and Progress of Raman Technologies for Cellular Uptake Analysis of the Drug Delivery Systems
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Liu Y, Li M, Liu H, Kang C, and Yu X
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nanoparticle ,spontaneous raman scattering ,coherence raman scattering ,surface-enhanced raman scattering ,drug delivery systems. ,Medicine (General) ,R5-920 - Abstract
Yajuan Liu,1 Mei Li,2 Haisha Liu,2 Chao Kang,2 Xiyong Yu1 1Key Laboratory of Molecular Target & Clinical Pharmacology, and the NMPA & State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People’s Republic of China; 2School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025, People’s Republic of ChinaCorrespondence: Chao Kang, Guizhou University, Guiyang, 550025, People’s Republic of China, Tel +008615285040313, Email ckang@gzu.edu.cn Xiyong Yu, Guangzhou Medical University (Panyu), Guangzhou, 511436, People’s Republic of China, Tel +008602037103261, Fax +008602037103261, Email yuxycn@gzhmu.edu.cnAbstract: Nanoparticle (NP)-based drug delivery systems have the potential to significantly enhance the pharmacological and therapeutic properties of drugs. These systems enhance the bioavailability and biocompatibility of pharmaceutical agents via enabling targeted delivery to specific tissues or organs. However, the efficacy and safety of these systems are largely dependent on the cellular uptake and intracellular transport of NPs. Thus, it is crucial to monitor the intracellular behavior of NPs within a single cell. Yet, it is challenging due to the complexity and size of the cell. Recently, the development of the Raman instrumentation offers a versatile tool to allow noninvasive cellular measurements. The primary objective of this review is to highlight the most recent advancements in Raman techniques (spontaneous Raman scattering, bioorthogonal Raman scattering, coherence Raman scattering, and surface-enhanced Raman scattering) when it comes to assessing the internalization of NP-based drug delivery systems and their subsequent movement within cells.Keywords: nanoparticle, spontaneous Raman scattering, coherence Raman scattering, surface-enhanced Raman scattering, drug delivery systems
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- 2023
8. A soluble and recyclable polymeric adsorbent of intrinsic microporosity for CO2 capture
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Wang, X., Ma, P., Jing, Y.J., Yu, C., Qiu, H., Kang, C., Cui, Z., Hou, K., Yip, A.C.K., and Yin, B.H.
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- 2023
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9. Status and Performance of the AMoRE-I Experiment on Neutrinoless Double Beta Decay
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Kim, H. B., Ha, D. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kang, C. S., Kang, W. G., Kim, H. S., Kim, S. C., Kim, S. G., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kwon, D. H., Lee, E. S., Lee, H. J., Lee, H. S., Lee, J. S., Lee, M. H., Lee, S. W., Lee, Y. C., Leonard, D. S., Lim, H. S., Mailyan, B., Nyanda, P. B., Oh, Y. M., Sari, M. B., Seo, J. W., Seo, K. M., Seo, S. H., So, J. H., Woo, K. R., and Yoon, Y. S.
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- 2022
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10. Monovalent and trivalent VSV-based COVID-19 vaccines elicit neutralizing antibodies and CD8+ T cells against SARS-CoV-2 variants
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Parham, Kate A., Kim, Gyoung Nyoun, Richer, Connor G., Ninkov, Marina, Wu, Kunyu, Saeedian, Nasrin, Li, Yue, Rashu, Rasheduzzaman, Barr, Stephen D., Arts, Eric J., Haeryfar, S.M. Mansour, Kang, C. Yong, and Troyer, Ryan M.
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- 2023
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11. Motorcycle-Associated Ocular Injuries: A Narrative Review
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Kim EJ, Ganga A, Kang C, Elnemer W, Lee JY, Ronquillo YC, Hoopes PC, and Moshirfar M
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motorcycle ,ocular injury ,eye ,trauma ,orbital fracture ,Ophthalmology ,RE1-994 - Abstract
Eric J Kim,1 Arjun Ganga,1 Chaerim Kang,2 William Elnemer,3 James Y Lee,4 Yasmyne C Ronquillo,5 Phillip C Hoopes,5 Majid Moshirfar5– 7 1Division of Ophthalmology, Warren Alpert Medical School at Brown University, Providence, RI, USA; 2Program in Liberal Medical Education, Brown University, Providence, RI, USA; 3Johns Hopkins School of Medicine, Baltimore, MD, USA; 4Brown University, Providence, RI, USA; 5Hoopes Vision Research Center, Draper, UT, USA; 6John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA; 7Utah Lions Eye Bank, Murray, UT, USACorrespondence: Eric J Kim, Division of Ophthalmology, Warren Alpert Medical School at Brown University, Providence, RI, USA, Tel +1 978-289-0659, Email eric_kim2@brown.eduPurpose: Motorcycle-related injuries involving the eye and orbit are not well characterized, with a paucity of prospective studies focusing specifically on motorcycle-associated eye injuries nor literature reviews having been conducted on the subject. To better understand the injury types and descriptive characteristics of patients experiencing motorcycle-associated eye injuries, we sought to conduct a narrative review.Methods: The research team utilized the following databases: PubMed, EMBASE, and Web of Science to query for English articles from peer-reviewed journals that provided some patient data regarding eye injury due to motorcycle or moped accidents or usage.Results: A total of 65 studies were included in our qualitative synthesis. Of these studies, 40 (61.5%) were case reports, 20 retrospective case series (30.8%), and five (7.69%) were observational prospective studies. Among the 25 retrospective and prospective studies, 12 (48.0%) of these studies primarily focused on motorcycle-associated injuries. These 65 studies described a wide variety of motorcycle-associated eye injuries, including but not limited to orbital fractures and associated sequelae, foreign bodies, vitreoretinal trauma, neuro-ophthalmic trauma, corneal injuries, open globe injuries, lacerations, and globe avulsions.Conclusion: The current state of the literature indicates that knowledge regarding the ocular manifestations of motorcycle accidents is limited to mostly case reports and few retrospective cohort studies focused specifically on motorcycle-associated eye injuries. However, it is evident that the types of motorcycle-associated eye injuries are legion and predominantly seen in adult males, potentially leading to severe injuries and loss of vision and blindness.Keywords: motorcycle, ocular injury, eye, trauma, orbital fracture, ruptured globe, corneal injury, vitreoretinal damage, vehicular accidents
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- 2022
12. Research Advances in the Treatment of Allergic Rhinitis by Probiotics
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Liu P, Hu T, Kang C, Liu J, Zhang J, Ran H, Zeng X, and Qiu S
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allergy rhinitis;probiotics;immune tolerance;th1/th2 balance;treg/th17 balance;mucosal barrier ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Peng Liu,1 Tianyong Hu,2 Chenglin Kang,1 Jiangqi Liu,2 Jin Zhang,1 Hong Ran,1 Xianhai Zeng,2 Shuqi Qiu2 1Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai Campus, Zunyi, People’s Republic of China; 2Department of Otolaryngology, Longgang E.N.T Hospital & Shenzhen Key Laboratory of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, People’s Republic of ChinaCorrespondence: Shuqi Qiu; Xianhai Zeng, Email qiushuqi66858@163.com; zxhklwx@163.comAbstract: Allergic rhinitis (AR) impairs the quality of life of patients and reduces the efficiency of social work, it is an increasingly serious public medical and economic problem in the world. Conventional anti-allergic drugs for the treatment of allergic rhinitis (AR) can cause certain side effects, which limit the quality of life of patients. Therefore, it makes sense to look for other forms of treatment. Several studies in recent years have shown that probiotics have shown anti-allergic effects in various mouse and human studies. For example, the application of certain probiotic strains can effectively relieve the typical nasal and ocular symptoms of allergic rhinitis in children and adults, thereby improving the quality of life and work efficiency. At the same time, previous studies in humans and mice have found that probiotics can produce multiple effects, such as reduction of Th2 cell inflammatory factors and/or increase of Th1 cell inflammatory factors, changes in allergy-related immunoglobulins and cell migration, regulate Th1/Th2 balance or restore intestinal microbiota disturbance. For patients with limited activity or allergic rhinitis with more attacks and longer attack duration, oral probiotics have positive effects. The efficacy of probiotics in the prevention and treatment of allergic rhinitis is remarkable, but its specific mechanism needs further study. This review summarizes the research progress of probiotics in the treatment of allergic rhinitis in recent years.Keywords: allergy rhinitis, probiotics, immune tolerance, Th1/Th2 balance, Treg/Th17 balance, mucosal barrier
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- 2022
13. The Efficacy of Percutaneous Transhepatic Gallbladder Drainage Combined with Gallbladder-Preserving Cholecystolithotomy in High-Risk Patients with Acute Calculous Cholecystitis
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Kang C, Zhang J, Hou S, Wang J, Li X, Chi X, Shan H, Zhang Q, and Liu T
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percutaneous transhepatic gallbladder drainage ,ptgd ,gallbladder-preserving cholecystolithotomy ,gpc ,high-risk acute calculous cholecystitis. ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Chunbo Kang, Jie Zhang, Shiyang Hou, Jinlei Wang, Xubin Li, Xiaowei Li, Xiaoqian Chi, Haifeng Shan, Qijun Zhang, Tiejun Liu General Surgery Department, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, 100144, People’s Republic of ChinaCorrespondence: Tiejun Liu, General Surgery Department, Beijing Rehabilitation Hospital of Capital Medical University, Xixiazhuang, Badachu Road, Shijingshan District, Beijing, 100144, People’s Republic of China, Tel/Fax +86 10 5698 1152, Email liutjdoc@163.comObjective: This study aimed to investigate the value of combining percutaneous transhepatic gallbladder drainage (PTGD) with gallbladder-preserving cholecystolithotomy (GPC) in high-risk patients with acute calculous cholecystitis.Methods: Clinical data from 74 high-risk patients with acute calculous cholecystitis, admitted to our hospital between October 2018 and September 2021, were analyzed retrospectively. All the patients underwent PTGD, and 59 of them underwent delayed cholecystectomy, while 14 patients were subjected to GPC 8– 12 weeks after the PTGD; one patient, whose life expectancy was fewer than 6 months, was not treated for gallstones after PTGD.Results: In all 74 patients, symptom remission was achieved after the PTGD therapy, and the incidence of catheter-related complications was 10.8%. Among the 59 patients who underwent delayed cholecystectomy (DC) after PTGD, there was a complication incidence of 6.8%. Of the 14 patients who underwent GPC after the PTGD, 13 patients were subjected to the removal of drainage tubes, 1 patient received cholecystostomy catheter draining externally, and two patients (14.3%) had complications. There were no perioperative deaths.Conclusion: Percutaneous transhepatic gallbladder drainage, combined with GPC, is a safe and effective treatment that is suitable for high-risk patients with acute calculous cholecystitis who cannot receive DC. This combined method allows for early acute cholecystitis to settle, helps to remove gallstones at a later stage, and solves the problem of long-term tube drainage after PTGD.Keywords: percutaneous transhepatic gallbladder drainage, PTGD, gallbladder-preserving cholecystolithotomy, GPC, high-risk acute calculous cholecystitis
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- 2022
14. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis
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Dell, K., Sedor, J., Schachere, M., Negrey, J., Lemley, K., Silesky, B., Srivastava, T., Garrett, A., Sethna, C., Laurent, K., Canetta, P., Pradhan, A., Greenbaum, L., Wang, C., Kang, C., Adler, S., LaPage, J., Athavale, A., Itteera, M., Atkinson, M., Dell, T., Fervenza, F., Hogan, M., Lieske, J., Chernitskiy, V., Kaskel, F., Ross, M., Flynn, P., Kopp, J., Blake, J., Trachtman, H., Zhdanova, O., Modersitzki, F., Vento, S., Lafayette, R., Mehta, K., Gadegbeku, C., Quinn-Boyle, S., Hladunewich, M., Reich, H., Ling, P., Romano, M., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., Klida, C., Derebail, V., Gibson, K., Cole, E., Ormond-Foster, J., Holzman, L., Meyers, K., Kallem, K., Swenson, A., Sambandam, K., Wang, Z., Rogers, M., Jefferson, A., Hingorani, S., Tuttle, K., Bray, M., Pao, E., Cooper, A., Lin, J.J., Baker, Stefanie, Barisoni, L., Bixler, J., Desmond, H., Eddy, S., Fermin, D., Gillespie, B., Kurtz, V., Larkina, M., Li, S., Lienczewski, C.C., Liu, J., Mainieri, T., Mariani, L., Sampson, M., Smith, A., Zee, J., Avila-Casado, Carmen, Bagnasco, Serena, Gaut, Joseph, Hewitt, Stephen, Hodgin, Jeff, Lemley, Kevin, Mariani, Laura, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Thomas, David, Zee, Jarcy, Barisoni, Laura, Nast, Cynthia, McNulty, Michelle T., Fermin, Damian, Eichinger, Felix, Jang, Dongkeun, Kretzler, Matthias, Burtt, Noël P., Pollak, Martin R., Flannick, Jason, Weins, Astrid, Friedman, David J., and Sampson, Matthew G.
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- 2022
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15. Midline versus paramedian mandibulotomy for tongue cancer surgery: analysis of complications
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Chiu, T.-H., Marchi, F., Huang, S.-F., Kang, C.-J., Liao, C.-T., Hung, S.-Y., Cheong, D.C.-F., and Tsao, C.-K.
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- 2022
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16. Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome
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Dell, K., Sedor, J., Schachere, M., Negrey, J., Lemley, K., Lim, E., Srivastava, T., Garrett, A., Sethna, C., Laurent, K., Canetta, P., Pradhan, A., Greenbaum, L., Wang, C., Kang, C., Adler, S., LaPage, J., Athavale, A., Itteera, M., Atkinson, M., Boynton, S., Fervenza, F., Hogan, M., Lieske, J., Chernitskiy, V., Kaskel, F., Ross, M., Flynn, P., Kopp, J., Blake, J., Trachtman, H., Zhdanova, O., Modersitzki, F., Vento, S., Bray, M., Kelton, M., Cooper, A., Lafayette, R., Mehta, K., Gadegbeku, C., Quinn-Boyle, S., Hladunewich, M., Reich, H., Ling, P., Romano, M., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., LaVigne, J., Derebail, V., Gibson, K., Cole, E., Ormond-Foster, J., Holzman, L., Meyers, K., Kallem, K., Swenson, A., Sambandam, K., Wang, Z., Rogers, M., Jefferson, A., Hingorani, S., Tuttle, K., Lin, J.J., Barisoni, L., Bixler, J., Desmond, H., Eddy, S., Fermin, D., Gillespie, B., Kurtz, V., Larkina, M., Lavigne, J., Li, S., Lienczewski, C.C., Liu, J., Mainieri, T., Mariani, L., Sampson, M., Smith, A., Zee, J., Avila-Casado, Carmen, Bagnasco, Serena, Gaut, Joseph, Hewitt, Stephen, Hodgin, Jeff, Lemley, Kevin, Mariani, Laura, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Thomas, David, Zee, Jarcy, Barisoni, Laura, Nast, Cynthia, Hodgin, Jeffrey B., Mariani, Laura H., Liu, Qian, Smith, Abigail R., Eddy, Sean, Hartman, John, Hamidi, Habib, Gaut, Joseph P., Palmer, Matthew B., Nast, Cynthia C., Chang, Anthony, Gillespie, Brenda W., Kretzler, Matthias, and Holzman, Lawrence B.
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- 2022
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17. Alpha backgrounds in the AMoRE-Pilot experiment
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Alenkov, V., Bae, H. W., Beyer, J., Boiko, R. S., Boonin, K., Buzanov, O., Chanthima, N., Cheoun, M. K., Choi, S. H., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A., Gastaldo, L., Gavriljuk, Yu. M., Gezhaev, A., Grigoryeva, V. D., Gurentsov, V., Ha, D. H., Ha, C., Ha, E. J., Hahn, I., Jeon, E. J., Jeon, J., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, S. J., Kang, W. G., Karki, S., Kazalov, V., Khan, A., Khan, S., Kim, D.-Y., Kim, G. W., Kim, H. B., Kim, H. J., Kim, H. L., Kim, H. S., Kim, I., Kim, W. T., Kim, S. R., Kim, S. C., Kim, S. K., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuz’minov, V., Kwon, D. H., Lee, C., Lee, E. K., Lee, H. J., Lee, H. S., Lee, J., Lee, J. S., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. H., Lee, S. W., Lee, S. W., Leonard, D. S., Li, J., Li, Y., Limkitjaroenporn, P., Mailyan, B., Makarov, E. P., Oh, S. Y., Oh, Y. M., Gileva, O., Olsen, S., Pabitra, A., Panasenko, S., Pandey, I., Park, C. W., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Polischuk, O. G., Prihtiadi, H., Ra, S. J., Ratkevich, S., Rooh, G., Sari, M. B., Seo, J., Seo, K. M., Shin, J. W., Shin, K. A., Shlegel, V. N., Siyeon, K., Sokur, N. V., Son, J.-K., Srisittipokakun, N., Toibaev, N., Tretyak, V. I., Wirawan, R., Woo, K. R., Yoon, Y. S., and Yue, Q.
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- 2022
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18. Predictors of revisit and admission after discharge from an emergency department in acute pyelonephritis
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Kang, C, Kim, K, Lee, JH, Jo, YH, Park, JW, Lee, SH, Kim, YJ, Rhee, JE, and Kim, DH
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- 2015
19. Stress Analysis of Self-Tightness Metal Sealing Against Ultrahigh Pressure Medium
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Zhao, M. J., Zhu, P. C., Li, Z., Liu, Z., and Kang, C.
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- 2022
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20. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, 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K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, J, Rosenkranz, K, Telma, K, Tocci, N, Wilkinson-Ryan, I, Bokenkamp, M, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, KA, Osterberg, EC, Riley, C, Srikanth, P, Barbour, J, Blazer, D, DiLalla, GA, Fayanju, O, Hwang, ES, Kahmke, R, Kazaure, H, Lazarides, A, Lee, W, Lidsky, M, Menendez, C, Moris, D, Plichta, J, Pradhan, MC, Puscas, L, Rice, HE, Rocke, D, Rosenberger, L, Scheri, R, Smith, BD, Stang, MT, Tolnitch, L, Turnage, K, Visgauss, J, Walton, FS, Watts, T, Zani, S, Farma, J, Cardona, K, Russell, MC, Clark, J, Kwon, D, Goel, N, Kronenfeld, J, Bigelow, B, Etchill, E, Gabre-Kidan, A, Jenny, H, Kent, A, Ladd, MR, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Kaafarani, H, Naar, L, Qadan, M, Brown, L, Ganly, I, Mullinax, JE, Alpert, N, Gillezeau, C, Miles, DDS, Taioli, E, Cha, DE, Gleeson, E, Horn, C, Sarpel, U, Gusani, N, Hazelton, J, Maines, J, Oh, JS, Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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21. The Efficacy of Percutaneous Transhepatic Gallbladder Drainage Combined with Gallbladder-Preserving Cholecystolithotomy in High-Risk Patients with Acute Calculous Cholecystitis [Corrigendum]
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Kang C, Zhang J, Hou S, Wang J, Li X, Chi X, Shan H, Zhang Q, and Liu T
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percutaneous transhepatic gallbladder drainage ,ptgd ,gallbladder-preserving cholecystolithotomy ,gpc ,high-risk acute calculous cholecystitis. ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Kang C, Zhang J, Hou S, et al. J Inflamm Res. 2022;15:2901–2910. The authors have advised an error was made in the author list on page 2901, specifically, the indication of which authors contributed equally to this work. The correct author list and affiliations are as follows. Chunbo Kang,* Jie Zhang,* Shiyang Hou, Jinlei Wang, Xubin Li, Xiaowei Li, Xiaoqian Chi, Haifeng Shan, Qijun Zhang, Tiejun Liu General Surgery Department, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, 100144, People’s Republic of China *These authors contributed equally to this work The authors apologize for this error.
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- 2023
22. Development and evaluation of deep learning–based segmentation of histologic structures in the kidney cortex with multiple histologic stains
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Sedor, J., Dell, K., Schachere, M., Negrey, J., Lemley, K., Lim, E., Srivastava, T., Garrett, A., Sethna, C., Laurent, K., Appel, G., Toledo, M., Barisoni, L., Greenbaum, L., Wang, C., Kang, C., Adler, S., Nast, C., LaPage, J., Stroger, John H., Jr., Athavale, A., Itteera, M., Neu, A., Boynton, S., Fervenza, F., Hogan, M., Lieske, J., Chernitskiy, V., Kaskel, F., Kumar, N., Flynn, P., Kopp, J., Blake, J., Trachtman, H., Zhdanova, O., Modersitzki, F., Vento, S., Lafayette, R., Mehta, K., Gadegbeku, C., Johnstone, D., Quinn-Boyle, S., Cattran, D., Hladunewich, M., Reich, H., Ling, P., Romano, M., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., LaVigne, J., Derebail, V., Gibson, K., Froment, A., Grubbs, S., Holzman, L., Meyers, K., Kallem, K., Lalli, J., Sambandam, K., Wang, Z., Rogers, M., Jefferson, A., Hingorani, S., Tuttle, K., Bray, M., Kelton, M., Cooper, A., Freedman, B., Lin, J.J., Jayapandian, Catherine P., Chen, Yijiang, Janowczyk, Andrew R., Palmer, Matthew B., Cassol, Clarissa A., Sekulic, Miroslav, Hodgin, Jeffrey B., Zee, Jarcy, Hewitt, Stephen M., O’Toole, John, Toro, Paula, Sedor, John R., Barisoni, Laura, and Madabhushi, Anant
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- 2021
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23. Development of a new analytical model for circular concrete ring segments with dry joints under combined effects.
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Hartwig, S., Kang, C., Fürll, F., Klein, F., Classen, M., and Marx, S.
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- *
SHEARING force , *TORQUE , *WIND turbines , *TORSION , *COMPUTER simulation - Abstract
Previous models of circular ring segment joints have been inadequate in describing their loading capacity due to the lack of consideration for the interaction between shear force and bending moment. Consequently, these models have led to over‐ or underestimation of the joints' capacity. The increasing use of dry joint connection technology in wind turbine towers and prefabricated segmental bridge constructions necessitates the development of advanced computational models for these connections. This study presents a new model that considers the effects of bending moment, shear force, and torsion on the loading capacity of circular ring segment joints. Numerical simulations were conducted to validate the developed model under different load combinations, and the results demonstrate excellent agreement between the model predictions and numerical simulations. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Risk Factors and the Usual Source of Care on Non-Adherence to Antihypertensive Drugs in Immigrants with Hypertension
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Cho H, Jeong S, Kang C, Kang HJ, and Jang S
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usual source of care ,hypertension ,immigrants ,health care strategy ,Medicine (General) ,R5-920 - Abstract
Hyemin Cho,1,* Sohyun Jeong,2,3,* Cinoo Kang,4 Hee-Jin Kang,1 Suhyun Jang,1 Sunmee Jang1 1College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon, Republic of Korea; 2Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; 3Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; 4Department of Biostatics and Epidemiology, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea*These authors contributed equally to this workCorrespondence: Sunmee JangCollege of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, 191 Hambakmoero, Yeonsu-Gu, Incheon 21936, South KoreaTel +82-32-820-4941Fax +82-32-820-4829Email smjang@gachon.ac.krBackground: Immigrants are vulnerable to suboptimal health care utilization including non-adherence of medication use. Thus, we aimed to identify the potential risk factors of non-adherence and evaluate whether utilizing a usual source of care was associated with medication adherence in immigrants.Methods: We utilized the Korea National Health Insurance Claims Database between 2012 and 2015. Cases were immigrants who had antihypertensive prescriptions at the time of hypertension diagnosis in 2012. Controls were native-born Koreans with hypertension who were 1:1 matched to immigrants by age, sex, and Charlson comorbidity index. We used the medication possession ratio for three years to assess the adherence to antihypertensive drugs. The likelihood of non-adherence was evaluated between cases and controls by multivariate linear regression models stratified by age, sex, and number of clinic visits. We assessed the potential risk factors of non-adherence in immigrants by multivariate linear regression and logistic regression models, respectively.Results: In total, 4114 immigrants and 4114 matched native-born Koreans with hypertension were included. The mean MPR was significantly lower in immigrants (56% vs 70%, p< 0.0001). Immigrants showed almost two times the level of non-adherence as native-born Koreans (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.83– 2.21). Stratified analyses on non-adherence presented the highest non-adherence (2.28 times) in immigrants in the younger group (30– 49 years old) and the lowest non-adherence in immigrants in 65 and old group where the risk was 1.69 times higher than native Korean with the same age. The absence of a usual source of care significantly increased medication non-adherence by 1.31 to 1.58 times among immigrants.Conclusion: When the number of visited clinics increased, the degree of non-adherence increased consistently. Therefore, the systematization of registering with primary care (a usual source of care) might be a modifiable health care strategy to improve health care outcomes in immigrants.Keywords: usual source of care, hypertension, immigrants, health care strategy
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- 2020
25. Perceived usefulness and ease of use of fundoscopy by medical students: a randomised crossover trial of six technologies (eFOCUS 1)
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Dunn, H. P., Kang, C. J., Marks, S., Witherow, J. L., Dunn, S. M., Healey, P. R., and White, A. J.
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- 2021
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26. Probability-driven transmission expansion planning with high-penetration renewable power generation: A case study in northwestern China
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Liang, Z., Chen, H., Chen, S., Lin, Z., and Kang, C.
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- 2019
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27. Fluoroquinolones versus trimethoprim-sulfamethoxazole for the treatment of Stenotrophomonas maltophilia infections: a systematic review and meta-analysis
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Ko, J.-H., Kang, C.-I., Cornejo-Juárez, P., Yeh, K.-M., Wang, C.-H., Cho, S.Y., Gözel, M.G., Kim, S.-H., Hsueh, P.-R., Sekiya, N., Matsumura, Y., Lee, D.-G., Cho, S.-Y., Shiratori, S., Kim, Y.-J., Chung, D.R., and Peck, K.R.
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- 2019
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28. Photothermal effects of NaYF4:Yb,Er@PE3@Fe3O4 superparamagnetic nanoprobes in the treatment of melanoma
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Wang X, Kang C, Pan Y, and Jiang R
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upconversion nanoparticles ,near infrared ,photothermal therapy ,melanoma ,heat shock protein 70 (HSP70) ,Medicine (General) ,R5-920 - Abstract
Xue Wang,1 Chunyang Kang,2 Ying Pan,1 Rihua Jiang31Department of Obstetrics & Gynecology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Neurology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of China; 3Department of Dermatology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of ChinaObjective: The study aimed to synthesize superparamagnetic NaYF4:Yb,Er@PE3@Fe3O4 upconversion nanoprobes and to study their photothermal effects for the treatment of malignant melanoma.Methods: Morphological characteristics of the synthesized nanoprobes were examined by scanning electron microscopy. Their biocompatibility and biodistribution profiles were assessed through blood routine/biochemistry tests and the inductively coupled plasma/optical emission spectrometry-based analysis of tissue metal elements. Their photothermal conversion efficiency and their potential as contrast agents for upconversion luminescence (UCL)/magnetic resonance imaging (MRI) dual-modal imaging were tested. Efficacy in photothermal therapy, which was achieved by combining nanoprobes with near-infrared (NIR) irradiation, was evaluated in both A375 cell line and BALB/c mice models. The underlying mechanisms were interrogated by molecular approaches including the MTT assay, flow cytometry, semiquantitative PCR, western blot, and immunohistochemistry.Results: 1) Our synthesized NaYF4:Yb,Er@PE3@Fe3O4 nanoprobes exhibited a uniform cubic morphology with a diameter of ∼50 nm. Subcutaneous administration led to no severe, long-lasting adverse effects in mice, possibly due to complete removal of these nanomaterials within one month. 2) Our nanoprobes possessed superior photothermal conversion efficiency and strong contrasting effects during UCL/MRI dual-modal imaging, corroborating their applications in imaging-guided photothermal therapy. 3) Combinatorial treatment of these nanoprobes with NIR irradiation induced profound apoptosis/necrosis in A375 cells. Similarly, the same treatment modality led to strong therapeutic effects in BALB/c mice implanted with A375 tumor xenografts. Mechanistic studies suggested an involvement of heat shock protein 70 in mediating the observed antitumor effects of our nanoprobes.Conclusion: Our study describes a convenient method to synthesize a new type of superparamagnetic upconversion nanoprobes, which possess high biocompatibility and can be used in imaging-guided photothermal therapy for the treatment of malignant melanoma. Importantly, our findings will promote clinical applications of NaYF4:Yb,Er@PE3@Fe3O4 as novel theranostic agents in treating melanoma and many other tumors.Keywords: upconversion nanoparticles, near infrared, photothermal therapy, melanoma, heat shock protein 70
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- 2019
29. Subcutaneous sparganosis mimicking soft tissue tumor: a case report
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Hwang JM, Hwang DS, Kang C, and Lee JW
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Spirometra mansoni ,sparganosis ,subcutaneous ,thigh ,Medicine (General) ,R5-920 - Abstract
Jung-Mo Hwang, Deuk-Soo Hwang, Chan Kang, Jae-Won Lee Department of Orthopaedic Surgery, Chungnam National University Hospital, Daejeon, South Korea Background: Sparganosis is a rare parasitic disease of humans caused by invasion of human tissue by plerocercoid tapeworm larvae (spargana) of the genus Spirometra species. This parasite commonly invades subcutaneous tissue but can appear in any tissue of the body. Case presentation: Here, we report a case of a 33-year-old woman presented with a migrating painful swelling and erythema in right thigh for 6 months, which was initially misdiagnosed as soft tissue tumor. Magnetic resonance imaging revealed a multiple elongated tubular tracts in the medial aspect of right thigh, from which a long, wrinkled, whitish worm was surgically removed. The parasite was histopathologically identified as Spirometra mansoni. Conclusion: Sparganosis is rare and physicians have little experience, so if suspected, should be included among the list of differential diagnosis and special serological test should be recommended before surgery. Keywords: Spirometra mansoni, sparganosis, subcutaneous, thigh
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- 2019
30. Clinical predictors of methicillin-resistance and their impact on mortality associated with Staphylococcus aureus bacteraemia
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Wi, Y. M., Rhee, J. Y., Kang, C. I., Chung, D. R., Song, J. H., and Peck, K. R.
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- 2018
31. Growth of pure wurtzite InGaAs nanowires for photovoltaic and energy harvesting applications
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Kang, H.-K., Kim, J.Y., Noh, M.-S., Kang, C.-Y., Kim, Y.D., Cho, M.-H., and Song, J.D.
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- 2018
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32. Experimental Investigation of Effects of Polishing Process on Surface Residual Stress of TC4 Blade Based on Sensitivity Analysis
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Chen, Z., Shi, Y., Lin, X., Yu, T., Zhao, P., and Kang, C.
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- 2019
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33. Influenza Surveillance in Korea: Establishment and First Results of an Epidemiological and Virological Surveillance Scheme
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Kang, C. and Park, O.
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- 2007
34. Emergence of an extended-spectrum 𝛽-lactamase-producing serotype K1 Klebsiella pneumoniae ST23 strain from Asian countries
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CHEONG, H. S., CHUNG, D. R., PARK, M., KIM, S. H., KO, K. S., HA, Y. E., KANG, C. I., PECK, K. R., and SONG, J. H.
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- 2017
35. Pathogenesis of and Immunity to a New Influenza A (H5N1) Virus Isolated from Duck Meat
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Lu, X. H., Cho, D., Hall, H., Rowe, T., Mo, I. P., Sung, H. W., Kim, W. J., Kang, C., Cox, N., Klimov, A., and Katz, J. M.
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- 2003
36. Status of the AMoRE Experiment Searching for Neutrinoless Double Beta Decay Using Low-Temperature Detectors
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Jo, H. S., Choi, S., Danevich, F. A., Fleischmann, A., Jeon, J. A., Kang, C. S., Kang, W. G., Kim, G. B., Kim, H. J., Kim, H. L., Kim, I., Kim, S. K., Kim, S. R., Kim, Y. H., Kim, Y. D., Kornoukhov, V., Kwon, D. H., Lee, C., Lee, H. J., Lee, M. K., Lee, S. H., Oh, S. Y., So, J. H., and Yoon, Y. S.
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- 2018
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37. Vibration Mitigation for a Cryogen-Free Dilution Refrigerator for the AMoRE-Pilot Experiment
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Lee, C., Jo, H. S., Kang, C. S., Kim, G. B., Kim, I., Kim, Y. H., Lee, H. J., and So, J. H.
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- 2018
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38. Trigger Study on the AMoRE-Pilot Detector
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Kim, I., Choi, S. H., Jeon, J. A., Jo, H. S., Kang, C. S., Kim, G. B., Kim, H. L., Kim, S. R., Kim, Y. H., Kwon, D. H., Lee, C., Lee, H. J., Lee, S. H., Oh, S. Y., So, J. H., and Yoon, Y. S.
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- 2018
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39. Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation
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Kang C, Wei L, Song B, Chen L, Liu J, Deng B, Pan X, and Shao L
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tantalum nanoparticles (Ta-NPs) ,osteoblast ,autophagy ,proliferation ,Medicine (General) ,R5-920 - Abstract
Chengrong Kang,1,2 Limin Wei,1 Bin Song,1 Liangjiao Chen,3 Jia Liu,1 Bin Deng,4 Xuan Pan,2 Longquan Shao1 1Department of Stomatology, Nanfang Hospital, Southern Medical University, 2Department of Stomatology, The First Affiliated Hospital of Guangdong Pharmaceutical University, 3Department of Orthodontics, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, 4Department of Stomatology, The General Hospital of People’s Liberation Army, Beijing, China Abstract: Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, and they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) that were deposited on the surface of a porous Ta implant are inevitably released and come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior and implant stabilization. However, the interaction of Ta-NPs with osteoblasts has not been clearly investigated. This study aimed to investigate the effect of Ta-NPs on cell proliferation and their underlying mechanism. The Cell Counting Kit-8 (CCK-8) assay was used to measure the cell viability of MC3T3-E1 mouse osteoblasts and showed that Ta-NP treatment could increase cell viability. Then, confocal microscopy, Western blotting, and transmission electron microscopy were used to confirm the autophagy induced by Ta-NPs, and evidence of autophagy induction was observed as positive LC3 puncta, high-LC3-II expression, and autophagic vesicle ultrastructures. The CCK-8 assay revealed that the cell viability was further increased and decreased by the application of an autophagy inducer and inhibitor, respectively. In addition, pre-treatment with autophagy inhibitor 3-methyladenine (3-MA) inhibited the Ta-NP-induced autophagy. These results indicate that the Ta-NPs can promote cell proliferation, that an autophagy inducer can further strengthen this effect and that an autophagy inhibitor can weaken this effect. In conclusion, autophagy was involved in Ta-NP-induced cell proliferation and had a promoting effect. Keywords: tantalum nanoparticles, osteoblast, autophagy, proliferation
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- 2017
40. Effects of Inefficient Cleavage of the Signal Sequence of HIV-1 gp120 on its Association with Calnexin, Folding, and Intracellular Transport
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Li, Yan, Luo, Lizhong, Ou, Wei-Jia, Thomas, David Y., and Kang, C. Yong
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- 1996
41. Technical advances in studying cardiac electrophysiology – Role of rabbit models
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Kang, C., Brennan, J.A., Kuzmiak-Glancy, S., Garrott, K.E., Kay, M.W., and Efimov, I.R.
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- 2016
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42. Maternal Mortality Ratios in 2852 Chinese Counties, 1996-2015, and Achievement of Millennium Development Goal 5 in China: A Subnational Analysis of the Global Burden of Disease Study in 2016
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Liang, J., Li, X., Kang, C., Wang, Y., Kulikoff, X.R., Coates, M.M., Ng, M., Luo, S., Mu, Y., Wang, X., Zhou, R., Liu, X., Zhang, Y., Zhou, Y., Zhou, M., Li, Q., Liu, Z., Dai, L., Li, M., Zhang, Y., Deng, K., Zeng, X., Deng, C., Yi, L., Zhu, J., Murray, C.J.L., and Wang, H.
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- 2019
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43. First results from the AMoRE-Pilot neutrinoless double beta decay experiment
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Alenkov, V., Bae, H. W., Beyer, J., Boiko, R. S., Boonin, K., Buzanov, O., Chanthima, N., Cheoun, M. K., Chernyak, D. M., Choe, J. S., Choi, S., Danevich, F. A., Djamal, M., Drung, D., Enss, C., Fleischmann, A., Gangapshev, A. M., Gastaldo, L., Gavriljuk, Yu. M., Gezhaev, A. M., Grigoryeva, V. D., Gurentsov, V. I., Gylova, O., Ha, C., Ha, D. H., Ha, E. J., Hahn, I. S., Jang, C. H., Jeon, E. J., Jeon, J. A., Jo, H. S., Kaewkhao, J., Kang, C. S., Kang, S. J., Kang, W. G., Kazalov, V. V., Kempf, S., Khan, A., Khan, S., Kim, D. Y., Kim, G. W., Kim, H. B., Kim, H. J., Kim, H. L., Kim, H. S., Kim , I., Kim, S. C., Kim, S. G., Kim, S. K., Kim, S. R., Kim, W. T., Kim, Y. D., Kim, Y. H., Kirdsiri, K., Ko, Y. J., Kobychev, V. V., Kornoukhov, V., Kuzminov, V. V., Kwon, D. H., Lee, C., Lee, E. K., Lee, H. J., Lee, H. S., Lee, J. S., Lee, J. Y., Lee, K. B., Lee, M. H., Lee, M. K., Lee, S. W., Lee, S. W., Lee, S. H., Leonard, D., Li, J., Li, J., Li, Y., Limkitjaroenporn, P., Makarov, E. P., Oh, S. Y., Oh, Y. M., Olsen, S. L., Pabitra, A., Panasenko, S. I., Pandey, I., Park, C. W., Park, H. K., Park, H. S., Park, K. S., Park, S. Y., Poda, D. V., Polischuk, O. G., Prihtiadi, H., Ra, S. J., Ratkevich, S. S., Rooh, G., Sari, M. B., Seo, K. M., Shin, J. W., Shin, K. A., Shlegel, V. N., Siyeon, K., So, J. H., Son, J. K., Srisittipokakun, N., Sujita, K., Tretyak, V. I., Wirawan, R., Woo, K. R., Yoon, Y. S., Yue, Q., and Zaman, S. U.
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- 2019
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44. Effects of Livin on Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of HT-29 Colorectal Cancer Cells.
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MA, C., JIA, W., SUN, H., and KANG, C.
- Subjects
COLORECTAL cancer ,EPITHELIAL-mesenchymal transition ,CANCER cells ,MATRIX metalloproteinases ,POLYMERASE chain reaction - Abstract
Colorectal cancer is a frequent malignancy, so its corresponding behaviors are essential to be understood deeply. This work was developed to explore the impacts of Livin on proliferation, migration, invasion, and epithelial-mesenchymal transition of HT-29 colorectal cancer cells. Colorectal cancer cells were extracted from pathological specimens collected from 80 colorectal cancer patients treated at our institution from June 2017 to June 2022. HT-29 human colorectal cancer cells were undertaken as the research materials. Real-time immunofluorescence polymerase chain reaction, Western blot, cell counting kit-8 experiments, cell scratch assays, and Transwell experiments were performed to assess the proliferation, migration, invasion, and epithelial-mesenchymal transition-related markers of the colorectal cancer cells. Livin expression in colorectal cancer cells increased greatly in contrast to that in healthy cells (p<0.05). Compared to normal HT-29, the overexpression of Livin promoted the proliferation, migration, and invasion abilities of colorectal cancer cells, exhibiting great differences (p<0.05). Moreover, levels of matrix metalloproteinase 2, vimentin, slug, and snail in colorectal cancer cells were sharply upregulated (p<0.05), while that of E-cadherin was remarkably downregulated (p<0.05) in contrast to the conditions in normal cells. The findings in this work revealed the crucial role of Livin in HT-29 colorectal cancer cells, suggesting its potential to be a target for colorectal cancer treatment. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
- View/download PDF
45. Heterocyclization Reactions of Imidazo[1,2-a]pyrimidine Analogues (A Review).
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He, L., Liu, J., Zhao, H. L., and Kang, C. M.
- Subjects
PYRIMIDINES ,PHARMACEUTICAL chemistry ,DRUG synthesis ,IMIDAZOLES ,CHEMICAL synthesis ,PYRIMIDINE derivatives ,DRUG development - Abstract
Imidazo[1,2-a]pyrimidine derivatives are a class of biologically active parent nucleus structures containing both imidazole and pyrimidine rings, which are important intermediates for the synthesis of a variety of drugs. This class of structures has attracted a lot of attention of researchers, and more and more synthetic strategies have been developed and reported. Currently, the main synthetic strategies are one-pot multi-component methods, microwave radiation, ultrasonic irradiation and other auxiliary Knoevenagel condensation and Michael addition methods to obtain these compounds, with the aim of achieving high yields, low time consumption and environmental friendliness. This review comprehensively summarizes the various synthetic methods as well as mechanism recently reported for the construction of this remarkable backbone structure and further used for the development of new chemical synthesis strategies and drug development as it has a wide range of applications in medicinal chemistry. In order to provide some impetus to the research of synthetic methods for this structure. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
46. Suggested new breakpoints of anti-MERS-CoV antibody ELISA titers: performance analysis of serologic tests
- Author
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Ko, J.-H., Müller, M. A., Seok, H., Park, G. E., Lee, J. Y., Cho, S. Y., Ha, Y. E., Baek, J. Y., Kim, S. H., Kang, J.-M., Kim, Y.-J., Jo, I. J., Chung, C. R., Hahn, M.-J., Drosten, C., Kang, C.-I., Chung, D. R., Song, J.-H., Kang, E.-S., and Peck, K. R.
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- 2017
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47. Empirical combination of a β-lactam to vancomycin may not improve outcomes of methicillin-susceptible Staphylococcus aureus bacteremia, compared to vancomycin monotherapy
- Author
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Park, G. E., Ko, J.-H., Cho, S. Y., Ha, Y. E., Lee, N. Y., Kang, C.-I., Chung, D. R., Song, J.-H., and Peck, K. R.
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- 2017
- Full Text
- View/download PDF
48. agr functionality affects clinical outcomes in patients with persistent methicillin-resistant Staphylococcus aureus bacteraemia
- Author
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Kang, C. K., Kim, Y. K., Jung, S.-I., Park, W. B., Song, K.-H., Park, K.-H., Choe, P. G., Jang, H.-C., Lee, S., Kim, Y.-S., Kwak, Y. G., Kwon, K. T., Kiem, S., Kim, C.-J., Kim, E. S., Kim, H. B., and the Korea INfectious Diseases (KIND) study group
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- 2017
- Full Text
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49. Identification of covalent active site inhibitors of dengue virus protease
- Author
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Koh-Stenta X, Joy J, Wang SF, Kwek PZ, Wee JLK, Wan KF, Gayen S, Chen AS, Kang C, Lee MA, Poulsen A, Vasudevan SG, Hill J, and Nacro K
- Subjects
flavivirus protease ,small molecule optimization ,covalent inhibitor ,active site binding ,pyrazole ester derivatives ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Xiaoying Koh-Stenta,1 Joma Joy,1 Si Fang Wang,1 Perlyn Zekui Kwek,1 John Liang Kuan Wee,1 Kah Fei Wan,2 Shovanlal Gayen,1 Angela Shuyi Chen,1 CongBao Kang,1 May Ann Lee,1 Anders Poulsen,1 Subhash G Vasudevan,3 Jeffrey Hill,1 Kassoum Nacro11Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore; 2Novartis Institute for Tropical Diseases, Singapore; 3Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, SingaporeAbstract: Dengue virus (DENV) protease is an attractive target for drug development; however, no compounds have reached clinical development to date. In this study, we utilized a potent West Nile virus protease inhibitor of the pyrazole ester derivative class as a chemical starting point for DENV protease drug development. Compound potency and selectivity for DENV protease were improved through structure-guided small molecule optimization, and protease-inhibitor binding interactions were validated biophysically using nuclear magnetic resonance. Our work strongly suggests that this class of compounds inhibits flavivirus protease through targeted covalent modification of active site serine, contrary to an allosteric binding mechanism as previously described.Keywords: flavivirus protease, small molecule optimization, covalent inhibitor, active site binding, pyrazole ester derivatives
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- 2015
50. Base deficit is a predictor of mortality in organophosphate insecticide poisoning
- Author
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Lee, SB, Kang, C, Kim, DH, Kim, T, Lee, SH, Jeong, JH, kim, SC, Rhee, DY, and Lim, D
- Published
- 2018
- Full Text
- View/download PDF
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