10 results on '"Kalnak, Nelli"'
Search Results
2. Developmental language disorder – heritability and genetic correlations with other disorders affecting language
- Author
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Banasik, Karina, Bay, Jakob, Kjærgaard Boldsen, Jens, Brodersen, Thorsten, Brunak, Søren, Demur, Alfonso Buil, Nordahl Christoffersen, Lea Arregui, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Mikkelsen, Dorte Helenius, Hindhede, Lotte, Hjalgrim, Henrik, von Stemann, Jakob Hjorth, Jensen, Bitten Aagaard, Schork, Andrew Joseph, Kaspersen, Kathrine, Kjerulff, Bertram Dalskov, Kongstad, Mette, Mikkelsen, Susan, Mikkelsen, Christina, Nissen, Janna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Elgaard Quinn, Liam James, Rafnar, Þórunn, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Sørensen, Erik, Stefansson, Kari, Stefánsson, Hreinn, Thørner, Lise Wegner, Þorsteinsdóttir, Unnur, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Christoffersen, Lea Arregui Nordahl, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Gísladóttir, Rósa S., and Walters, G. Bragi
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- 2024
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3. Developmental language disorder – a comprehensive study of more than 46,000 individuals
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Nudel, Ron, Christensen, Rikke Vang, Kalnak, Nelli, Schwinn, Michael, Banasik, Karina, Dinh, Khoa Manh, Erikstrup, Christian, Pedersen, Ole Birger, Burgdorf, Kristoffer Sølvsten, Ullum, Henrik, Ostrowski, Sisse Rye, Hansen, Thomas Folkmann, and Werge, Thomas
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- 2023
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4. Latent Semantic Analysis Discriminates Children with Developmental Language Disorder (DLD) from Children with Typical Language Development
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Bååth, Rasmus, Sikström, Sverker, Kalnak, Nelli, Hansson, Kristina, and Sahlén, Birgitta
- Abstract
Computer based analyses offer a possibility for objective methods to assess semantic-linguistic quality of narratives at the text level. The aim of the present study is to investigate whether a semantic language impairment index (SELIMI) based on latent semantic analysis (LSA) can discriminate between children with developmental language disorder (DLD) and children with typical language development. Spoken narratives from 54 children with DLD and 54 age matched controls with typical language development were summarized in a semantic representation generated using LSA. A statistical model was trained to discriminate between children with DLD and children with typical language development, given the semantic vector representing each individual child's narrative. The results show that SELIMI could distinguish between children with DLD and children with typical language development significantly better than chance and thus has a potential to complement traditional analyses focussed on form or on the word level.
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- 2019
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5. Listening and Processing Skills in Young School Children with a History of Developmental Phonological Disorder.
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Kalnak, Nelli and Nakeva von Mentzer, Cecilia
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CONFIDENCE intervals ,MANN Whitney U Test ,WORD deafness ,T-test (Statistics) ,PEARSON correlation (Statistics) ,PHONETICS ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,CHI-squared test ,RESEARCH funding ,LISTENING ,DATA analysis software ,ODDS ratio ,CHILD development deviations ,CHILDREN - Abstract
There is a lack of longitudinal studies on the broad-based outcomes in children with Developmental Phonological Disorder (DPD). The aim of this study was to investigate listening and processing skills in a clinical sample of 7-to-10-year-old children diagnosed with DPD in their preschool years and compare these to same-aged typically developing (TD) children. The Evaluation of Children's Listening and Processing Skills (ECLiPS) was completed by parents of 115 children with DPD and by parents of 46 TD children. The total ECLiPS mean score, and the five subscale mean scores, the proportion of children with clinically significant difficulties (≤10th percentile), and the proportion of children with co-occurrence of clinically significant difficulties on more than one subscale, were calculated. Results showed that the ECLiPS mean scores did not differ between the groups. There was no difference between groups regarding language and literacy, but a higher proportion of children with DPD than TD had difficulties in the total score, speech, and auditory processing, environmental and auditory sensitivity, and pragmatic and social skills. In addition, 33.9% of children with DPD had clinically significant difficulties in two or more subscales compared to 10.9% of TD children. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Assessment fidelity of a language screening instrument for 4-year-olds.
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Dahlén, Johanna, Drevenhorn, Eva, and Kalnak, Nelli
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LANGUAGE disorder diagnosis ,MEDICAL screening ,MANN Whitney U Test ,MEDICAL protocols ,PEARSON correlation (Statistics) ,CHILD health services ,NURSES ,DESCRIPTIVE statistics ,DATA analysis software ,CHILDREN - Abstract
The aim of the study was to explore the assessment fidelity of Språkfyran, a language screening instrument for four-year-old children. Språkfyran is a mandatory part of the healthcare program within the Swedish Child Health Service (CHS) and is offered to all four-year-olds in the region Scania in Sweden. The study was based on structured observations of twenty-four specialist CHS nurses' adherence to the Språkfyran protocol during screening. All the observed nurses deviated from the test protocol. There was a large variation in the number of deviations from the test protocol per nurse, with the highest number of deviations occurring for three specific testing items. Significantly more deviations were made with four-year-old bilingual children as opposed to four-year-old monolingual children. Half of the nurses did not use the test protocol. There is a clear need to improve the assessment fidelity of Språkfyran. Both the training that the nurses are offered, and the development of the test, are essential in securing the aim of high-quality work within the CHS. Support from experts in child speech-language development and disorders is suggested to be available at the CHS in Sweden. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Description and prediction of reading decoding skills in Swedish children with Developmental Language Disorder.
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Kalnak, Nelli and Sahlén, Birgitta
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MEMORY , *CROSS-sectional method , *MULTIPLE regression analysis , *DEVELOPMENTAL disabilities , *REGRESSION analysis , *INTERVIEWING , *LANGUAGE acquisition , *PEARSON correlation (Statistics) , *T-test (Statistics) , *DESCRIPTIVE statistics , *DATA analysis software , *READING , *FAMILY history (Medicine) , *CHILDREN - Abstract
Research is lacking in terms of reading decoding skills among clinical samples of Swedish-speaking children with Developmental Language Disorder (DLD). The present cross-sectional study included a sample of 61 children (8-12 years) with DLD attending school language units, years 1 to 5. Our purpose was to study reading decoding skills and predictors for decoding, such as a phonological processing skill (nonword repetition), working memory, and a family history of literacy problems. The results on a combined measure of the word and nonword decoding indicated that only 18% of the children had age-adequate decoding skills. The proportion of age-adequate decoders did not change noticeably with the school year. The participants' decoding skills showed larger deviations to test norm means with higher school years. Hierarchical regression analysis showed that the best predictors of decoding skills were measures of working memory and nonword repetition, followed by school year. These factors significantly contributed to the variance in decoding among our sample of children with DLD. A family history of literacy problems made no contribution to the variance. Conclusions: The findings emphasize the necessity of assessing and following up on literacy development in children with DLD. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Past-tense inflection of non-verbs: a potential clinical marker of developmental language disorder in Swedish children.
- Author
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Kalnak, Nelli, Löwgren, Karolina, and Hansson, Kristina
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CHILD development deviations , *STATISTICS , *ANALYSIS of variance , *CONFIDENCE intervals , *COMPARATIVE grammar , *CASE-control method , *SPEECH evaluation , *MANN Whitney U Test , *LANGUAGE acquisition , *T-test (Statistics) , *DESCRIPTIVE statistics , *RESEARCH funding , *DATA analysis , *FAMILY history (Medicine) ,RISK factors - Abstract
In this paper, we explore the performance of past-tense inflection of non-verbs (NVI) in children with developmental language disorder (DLD) and in typically developing controls, to investigate its accuracy as a clinical marker for Swedish-speaking children with DLD. Further, we investigate the relationship between NVI, nonword-repetition, and family history. The sample consists of 36 children with DLD (mean age 9;5 years) and 60 controls (mean age 9;2 years). The DLD group performed significantly lower than the controls on the NVI task, with a large effect size of the difference (d = 1.52). Analysis of the clinical accuracy of NVI resulted in 80.6% sensitivity and 76.6% specificity. NVI was significantly and moderately associated with nonword-repetition in the controls, but not in the DLD group. A positive family history, 80.6% in the DLD group and 6.9% in the controls, was associated with lower performance on NVI. When controlling for group (DLD and controls), a non-significant association between family history and performance on the NVI task was found. NVI is a potential clinical marker of DLD in Swedish school-aged children, but the current NVI task does not reach the level of being acceptable. Further development of the NVI task is warranted to improve its accuracy. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Nonword Repetition – A Clinical Marker for Specific Language Impairment in Swedish Associated with Parents’ Language-Related Problems.
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Kalnak, Nelli, Peyrard-Janvid, Myriam, Forssberg, Hans, and Sahlén, Birgitta
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LANGUAGE disorders , *REPETITION (Learning process) , *PERFORMANCE evaluation , *LANGUAGE ability testing , *DISEASE prevalence , *LOGISTIC regression analysis - Abstract
First, we explore the performance of nonword repetition (NWR) in children with specific language impairment (SLI) and typically developing children (TD) in order to investigate the accuracy of NWR as a clinical marker for SLI in Swedish-speaking school-age children. Second, we examine the relationship between NWR, family aggregation, and parental level of education in children with SLI. A sample of 61 children with SLI, and 86 children with TD, aged 8–12 years, were administered an NWR test. Family aggregation, measured as the prevalence of language and/or literacy problems (LLP) in parents of the children with SLI, was based on family history interviews. The sensitivity and specificity of nonword repetition was analyzed in a binary logistic regression, cut-off values were established with ROC curves, and positive and negative likelihood ratios reported. Results from the present study show that NWR distinguishes well between Swedish-speaking school-children with and without SLI. We found 90.2% sensitivity and 97.7% specificity at a cut-off level of −2 standard deviations for binary scoring of nonwords. Differences between the SLI and TD groups showed large effect sizes for the two scoring measures binary (d = 2.11) and percent correct consonants (PCC) (d = 1.79). The children with SLI were split into two subgroups: those with no parents affected with LLP (n = 12), and those with one or both parents affected (n = 49). The subgroup consisting of affected parents had a significantly lower score on NWR binary (p = .037), and there was a great difference between the subgroups (d = 0.7). When compared to the TD group, the difference from the subgroup with affected parents was almost one standard deviation larger (d = 2.47) than the difference from the TD to the subgroup consisting of non-affected parents (d = 1.57). Our study calls for further exploration of the complex interaction between family aggregation, language input, and phenotypes of SLI. [ABSTRACT FROM AUTHOR]
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- 2014
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10. Developmental language disorder – heritability and genetic correlations with other disorders affecting language.
- Author
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Nudel, Ron, Chrsitensen, Rikke Vang, Kalnak, Nelli, Lundberg, Mischa, Schwinn, Michael, Sørensen, Erik, Mikkelsen, Christina, Nissen, Janna, Christoffersen, Lea Arregui Nordahl, Kjerulff, Bertram Dalskov, Hansen, Thomas Folkmann, Burgdorf, Kristoffer Sølvsten, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Gísladóttir, Rósa S., Walters, G. Bragi, Stefánsson, Hreinn, Ostrowski, Sisse Rye, and Werge, Thomas
- Abstract
• SNP-based heritability of DLD was significant and estimated to be 27–52 % using genome-based restricted maximum likelihood and LD score regression. • No significant genetic correlation was found between DLD and other conditions in which spoken language and communication may be affected, namely, ASD, ADHD and schizophrenia. • DLD has a distinct genetic profile, not strongly associated with spoken-language traits measured in the general population. Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support. We estimated SNP-based heritabilities for DLD and genetic correlations with disorders which may involve spoken language deficits and traits related to spoken language. We found significant heritability estimates for DLD ranging from ∼27 % to ∼52 %, depending on the method used. We found no significant evidence for genetic correlation with the investigated disorders or traits, although the strongest effect was observed for a negative genetic correlation between DLD and nonword repetition ability. To our knowledge, this study reports the first significant heritability estimate for DLD from molecular genetic data. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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