Search

Hypoglycemia is associated with increased activity in the low-frequency bands in the electroencephalogram (EEG). We investigated whether hypoglycemia awareness and unawareness are associated with different hypoglycemia-associated EEG changes in patients with type 1 diabetes. Twenty-four patients participated in the study: 10 with normal hypoglycemia awareness and 14 with hypoglycemia unawareness. The patients were studied at normoglycemia (5-6 mmol/L) and hypoglycemia (2.0-2.5 mmol/L), and during recovery (5-6 mmol/L) by hyperinsulinemic glucose clamp. During each 1-h period, EEG, cognitive function, and hypoglycemia symptom scores were recorded, and the counterregulatory hormonal response was measured. Quantitative EEG analysis showed that the absolute amplitude of the ϑ band and α-ϑ band up to doubled during hypoglycemia with no difference between the two groups. In the recovery period, the ϑ amplitude remained increased. Cognitive function declined equally during hypoglycemia in both groups and during recovery reaction time was still prolonged in a subset of tests. The aware group reported higher hypoglycemia symptom scores and had higher epinephrine and cortisol responses compared with the unaware group. In patients with type 1 diabetes, EEG changes and cognitive performance during hypoglycemia are not affected by awareness status during a single insulin-induced episode with hypoglycemia. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article reviews the Website, Oxford Reference, available at http://www.oxfordreference.com/.

The article reviews the web site Oxford Classical Dictionary at classics.oxfordre.com.

The article reviews the web site ABC-CLIO Historical Abstracts available at http://www.abc-clio.com/.

Reviews the Web site Voice of the Shuttle by Alan Liu.

Reviews the database Oxford Reference Online accessible from the Web site oxfordreference.com.

The article reviews the website Pleiades: A Community-Built Gazetteer Group of Ancient Places, located at http://pleiades.stoa.org, from the Ancient World Mapping Center and the Institute for the Study of the Ancient World.

The article reviews the website Propylaeum, located at www.propylaeum.de/en from the Bavarian State Library, Munich, et. al.

The article reviews the website Encyclopaedia of the Hellenic World, located at http://www.ehw.gr/ehw/forms/Default.aspx, from the Foundation of the Hellenic World.