5 results on '"Jonah Cool"'
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2. A guide to the BRAIN Initiative Cell Census Network data ecosystem
- Author
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Michael Hawrylycz, Maryann E. Martone, Giorgio A. Ascoli, Jan G. Bjaalie, Hong-Wei Dong, Satrajit S. Ghosh, Jesse Gillis, Ronna Hertzano, David R. Haynor, Patrick R. Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A. Miller, Partha P. Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L. Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H. Scheuermann, Shawn Zheng Kai Tan, Carol L. Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L. Athey, Cody Baker, Katherine S. Baker, Pamela M. Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D’Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R. Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P. Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O. Halchenko, Nomi L. Harris, Brian R. Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A. Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L. Mathews, Chris Mezias, Michael I. Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J. Mungall, Joshua Orvis, Maja A. Puchades, Lei Qu, Joseph P. Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T. J. van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W. Jim Zheng, and Brian Zingg
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell types in controlled ways and to understand their variation and vulnerability in brain disorders. The BRAIN Initiative Cell Census Network (BICCN) is an integrated network of data-generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization. Emphasis of the BICCN is on the whole mouse brain with demonstration of prototype feasibility for human and nonhuman primate (NHP) brains. Here, we provide a guide to the cellular and spatial approaches employed by the BICCN, and to accessing and using these data and extensive resources, including the BRAIN Cell Data Center (BCDC), which serves to manage and integrate data across the ecosystem. We illustrate the power of the BICCN data ecosystem through vignettes highlighting several BICCN analysis and visualization tools. Finally, we present emerging standards that have been developed or adopted toward Findable, Accessible, Interoperable, and Reusable (FAIR) neuroscience. The combined BICCN ecosystem provides a comprehensive resource for the exploration and analysis of cell types in the brain. Characterizing cellular diversity is necessary to understand the function of different cell types in the brain. This Consensus View provides a guide to the cellular and spatial approaches used in cell type surveys by the BRAIN Initiative Cell Census Network (BICCN), as well as information on accessing and using the BICCN data and its extensive resources.
- Published
- 2023
3. Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.
- Author
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Samantha A Jameson, Anirudh Natarajan, Jonah Cool, Tony DeFalco, Danielle M Maatouk, Lindsey Mork, Steven C Munger, and Blanche Capel
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Genetics ,QH426-470 - Abstract
The divergence of distinct cell populations from multipotent progenitors is poorly understood, particularly in vivo. The gonad is an ideal place to study this process, because it originates as a bipotential primordium where multiple distinct lineages acquire sex-specific fates as the organ differentiates as a testis or an ovary. To gain a more detailed understanding of the process of gonadal differentiation at the level of the individual cell populations, we conducted microarrays on sorted cells from XX and XY mouse gonads at three time points spanning the period when the gonadal cells transition from sexually undifferentiated progenitors to their respective sex-specific fates. We analyzed supporting cells, interstitial/stromal cells, germ cells, and endothelial cells. This work identified genes specifically depleted and enriched in each lineage as it underwent sex-specific differentiation. We determined that the sexually undifferentiated germ cell and supporting cell progenitors showed lineage priming. We found that germ cell progenitors were primed with a bias toward the male fate. In contrast, supporting cells were primed with a female bias, indicative of the robust repression program involved in the commitment to XY supporting cell fate. This study provides a molecular explanation reconciling the female default and balanced models of sex determination and represents a rich resource for the field. More importantly, it yields new insights into the mechanisms by which different cell types in a single organ adopt their respective fates.
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- 2012
- Full Text
- View/download PDF
4. Testis formation in the fetal mouse: dynamic and complexde novotubulogenesis
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Jonah Cool, Tony DeFalco, and Blanche Capel
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Cell type ,Male sex determination ,Morphogenesis ,Organogenesis ,Cell Biology ,Anatomy ,Biology ,Cell sorting ,Sertoli cell ,Cell biology ,Testis determining factor ,medicine.anatomical_structure ,medicine ,Primordium ,Molecular Biology ,Developmental Biology - Abstract
Soon after Sry initiates male sex determination, cells in XY gonads undergo an unusual process of de novo cord formation that results in the organization of Sertoli cells into epithelial tubules enclosing germ cells and partitioning mesenchymal cells and vasculature to the interstitial space of the testis. Recent experiments investigating this dynamic process in four dimensions have begun to shed new light on the collective interactions of multiple cell types during morphogenesis of testis cords. WIREs Dev Biol 2012 doi: 10.1002/wdev.62 This article is categorized under: Establishment of Spatial and Temporal Patterns > Cell Sorting and Boundary Formation Gene Expression and Transcriptional Hierarchies > Sex Determination Vertebrate Organogenesis > From a Tubular Primordium: Non-Branched
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- 2012
- Full Text
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5. Mixed Signals: Development of the Testis.
- Author
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Jonah Cool
- Subjects
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CELLS , *TESTIS , *PROTEINS , *SMOOTH muscle , *TRANSCRIPTION factors - Abstract
Induction and patterning of the testis occurs over a brief window of time. Before male-specific morphogenesis, the gonad primordium is bipotential and capable of developing into either an ovary or testis. However, expression of the transcription factor SRY initiates male development and induces patterning, proliferation, and epithelialization specific to the testis. Male sex determination begins with commitment of Sertoli cells via autonomous and nonautonomous mechanisms. These mechanisms have recently been shown to both promote the male fate and simultaneously repress ovarian development. A second critical event in the development of the testis is the epithelialization of testis cords. After their specification, Sertoli cells epithelialize and surround the male germ line to form large looping structures bound by extracellular matrix. Cells excluded from cord structures are called interstitial cells and comprise several different cell types, including steroidogenic cells, endothelial cells, and a smooth muscle cell that directly surround the cords. Numerous male-specific signaling pathways influence testis cord morphogenesis and specification of distinct cell types, although a coherent progression of events is unclear. In this article we focus on signals in the male gonad that first are responsible for the specification of Sertoli cells, and second for the specification and patterning of interstitial cells. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
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