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A magnetic separation-based immunosensor for deoxynivalenol assay, coupled with a nano-affinity cleaning up for instrumental confirmation, was developed. Maltose-binding protein with mimic epitope of DON was coupled to CdSe/ZnS quantum dot nanobeads for fluorescent reporter. Graphene oxide was linked with magnetic nanoparticles and protein G for immunomagnetic adsorbent. The magnetic separation of reporter could be inhibited by DON so the fluorescent remained in the solution indicates a good quantitative correlation to DON concentration. The DON separated by immune adsorbent can be cleaned up for instrumental confirmation. The optimized immunosensor showed results as follows: the linear range was in 0.3–3000 ng mL−1. The limits of detection (S/N = 3) were 0.50, 1.0, and 3.0 ng mL−1 in different backgrounds. The recoveries for DON-spiked samples range from 78.7% to 88.5%. Both results of UPLC-MS/MS based on affinity column purification and coupled with nano-affinity cleaning up showed a good agreement with the current immunosensor.

An immuno-separated assay for ochratoxin A detection coupled with a nano-affinity cleaning up for LC-confirmation was developed. Firstly, ochratoxin A was modified to quantum dot beads for immuno-fluorescent reporters. Secondly, Fe3O4 magnetic nanoparticles were conjugated with protein G for immuno-magnetic adsorbents. The immuno-separation of fluorescent reporters by magnetic adsorbents could be completed by ochratoxin A, so the fluorescent reporters released from the immune complex indicate a linear correlation with the concentration of ochratoxin A. Furthermore, the immuno-separated ochratoxin A can be eluted from magnetic adsorbent for LC-conformation. The optimized assay showed results as follows: the quantitative range of the immuno-separated assay was 0.03–100 ng mL−1 of ochratoxin A. The recoveries for spiked samples ranged from 78.2% to 91.4%, with the relative standard deviation (RSD) being 11.9%~15.3%. Statistical analysis indicated no significant difference between the HPLC-FLD results based on commercial affinity column and by nano-affinity cleaning up.

In this paper, Tin (Ⅳ) oxide nanoparticles/graphene (SnO2/GR) nanocomposites were prepared via vacuum thermo treatment of Tin (0) and graphene oxide (GO). A redox reaction would occur readily in this process, in which the novel oxygen donor: GO could act as the oxidizing agent to oxidize Tin (0) to Tin (Ⅳ), meanwhile, the graphene precursor: GO would be simultaneously reduced to graphene by Tin (0) readily. The resulted composites were characterized by Fourier transform infrared spectrometry, scanning electron microscopy, and X-ray diffraction spectroscopy ect.. The novel SnO2/GR nanocomposites could combine both advantages of inorganic metal nanoparticles and graphene for near infrared spectroscopy (NIR) light absorption to generate heat, which fosters SnO2/GR a special candidate for photothermal ablation therapy (PTA) with NIR. Further investigations show that the SnO2/GR nanocomposites with NIR features could provide viable option for enhancing the thermal deposition and specificity of hyperthermia treatments for elimination of human prostate cancer (PC3).

In this paper, Tin (IV) oxide nanoparticles/graphene (SnO2/GR) nanocomposites were prepared via vacuum thermo treatment of Tin (0) and graphene oxide (GO). A redox reaction would occur readily in this process, in which the novel oxygen donor: GO could act as the oxidizing agent to oxidize Tin (0) to Tin (IV), meanwhile, the graphene precursor: GO would be simultaneously reduced to graphene by Tin (0) readily. The resulted composites were characterized by Fourier transform infrared spectrometry, scanning electron microscopy, and X-ray diffraction spectroscopy ect.. The novel SnO2/GR nanocomposites could combine both advantages of inorganic metal nanoparticles and graphene for near infrared spectroscopy (NIR) light absorption to generate heat, which fosters SnO2/GR a special candidate for photothermal ablation therapy (PTA) with NIR. Further investigations show that the SnO2/GR nanocomposites with NIR features could provide viable option for enhancing the thermal deposition and specificity of hyperthermia treatments for elimination of human prostate cancer (PC3). [ABSTRACT FROM AUTHOR]

The article presents a research study which aims to explore the effects of polyhdyroxylated derivatives of fullerene. The methods used in the study includes pathological analysis, cytological analysis and biochemical assays. Results showed that a large part of the fulluerenols were scattered in lungs which shows the potential usage as an inhaled drug. It concludes that the results will provide toxicology insights into the future use of polyhdyroxylated fullerenols as inhaled drugs.

Efficient and selective palladium porphyrins-catalyzed olimerization of tert-butyl acetylene to form (3Z,5Z)-2,2,7,7-tetramethyl-3,6-dihalo-3,5-octadiene has been developed in environment-friendly ionic liquids. The reaction proceeded readily with effective recycling of the ionic liquids and easy isolation of the products. [ABSTRACT FROM AUTHOR]

The title compound, C16H12N2O6·2C3H7NO, lies across a crystallographic inversion centre which is situated at the midpoint of the central N—N bond. The substitution at the C=N bond adopts a trans configuration and it is essentially coplanar with the benzene ring [N—C—C—C torsion angles = −173.9 (4) and 6.4 (6)°]. All torsion angles involving non-H atoms are close to 180°. Intramolecular O—H...O and weak C—H...O hydrogen bonds form S(6) and S(5) ring motifs, respectively, while intermolecular O—H...O and weak C—H...O hydrogen bonds connect the Schiff base molecule to solvent dimethylformamide molecules.