19 results on '"Jiang, Xiao-Han"'
Search Results
2. Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits
- Author
-
Lu, Xue-Mei, Yu, Xiao-Fen, Li, Guo-Qiang, Qu, Ming-Hao, Wang, Huan, Liu, Chuang, Man, Yu-Ping, Jiang, Xiao-Han, Li, Mu-Zi, Wang, Jian, Chen, Qi-Qi, Lei, Rui, Zhao, Cheng-Cheng, Zhou, Yun-Qiu, Jiang, Zheng-Wang, Li, Zuo-Zhou, Zheng, Shang, Dong, Chang, Wang, Bai-Lin, Sun, Yan-Xiang, Zhang, Hui-Qin, Li, Jie-Wei, Mo, Quan-Hui, Zhang, Ying, Lou, Xin, Peng, Hai-Xu, Yi, Ya-Ting, Wang, He-Xin, Zhang, Xiu-Jun, Wang, Yi-Bo, Wang, Dan, Li, Li, Zhang, Qiong, Wang, Wen-Xia, Liu, Yongbo, Gao, Lei, Wu, Jin-Hu, and Wang, Yan-Chang
- Published
- 2024
- Full Text
- View/download PDF
3. Tissue-specificity of RNA editing in plant: analysis of transcripts from three tobacco (Nicotiana tabacum) varieties
- Author
-
Fang, Jing, Jiang, Xiao-Han, Wang, Teng-Fei, Zhang, Xiu-Jun, and Zhang, Ai-Di
- Published
- 2021
- Full Text
- View/download PDF
4. Acacetin protects against cardiac remodeling after myocardial infarction by mediating MAPK and PI3K/Akt signal pathway
- Author
-
Chang, Wei, Wu, Qing-Qing, Xiao, Yang, Jiang, Xiao-Han, Yuan, Yuan, Zeng, Xiao-Feng, and Tang, Qi-Zhu
- Published
- 2017
- Full Text
- View/download PDF
5. Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition
- Author
-
Wu, Qing-Qing, Xiao, Yang, Jiang, Xiao-Han, Yuan, Yuan, Yang, Zheng, Chang, Wei, Bian, Zhou-Yan, and Tang, Qi-Zhu
- Published
- 2017
- Full Text
- View/download PDF
6. Compliance with Oral Nutritional Supplementation among Gastric Cancer Patients at Nutritional Risk: A Cross-Sectional Study.
- Author
-
Jiang, Xiao-han, Chen, Xi-jie, Chen, Shi, Chen, Jia-min, Yuan, Xiu-hong, Lin, Yi-jia, Chen, Yong-he, Wen, Yue-e, and Peng, Jun-sheng
- Subjects
- *
STOMACH tumors , *STATISTICS , *PREOPERATIVE care , *SCIENTIFIC observation , *CROSS-sectional method , *MULTIVARIATE analysis , *SOCIAL factors , *DIETARY supplements , *CANCER patients , *DIET therapy , *PATIENT compliance , *LONGITUDINAL method - Abstract
To explore compliance with oral nutritional supplementation (ONS) and to identify the risk factors for noncompliance among gastric cancer patients based on the health belief model (HBM) This prospective, observational study included gastric cancer patients at nutritional risk who were prescribed ONS from July to September 2020. Demographic factors, clinical factors, ONS-related factors, social factors and variables derived from the HBM were collected. The outcome of interest was compliance with ONS, which was measured by self-reported intake of ONS. Uni- and multivariate analyses of potential risk factors for noncompliance were performed. A total of 162 gastric cancer patients in the preoperative and adjuvant chemotherapy periods were analyzed. The compliance rate with ONS was 24.7%. Univariate analysis identified thirteen variables as risk factors for decreased compliance. Multivariate logistic analysis indicated that ONS compliance was independently associated with the treatment period, perceived barriers to ONS, the motivation to take ONS, and the timing of taking ONS. This study showed that overall ONS compliance among gastric cancer patients was notably low. Patients in the chemotherapy treatment period who took ONS at random times each day perceived more barriers to taking ONS and had a lower level of motivation were associated with lower compliance with ONS. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
7. Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration.
- Author
-
Song, Wen‐Yu, Jiang, Xiao‐Han, Ding, Ying, Wang, Yan, Zhou, Ming‐Xuan, Xia, Yun, Zhang, Chen‐Yu, Yin, Chong‐Chong, Qiu, Chen, Li, Kai, Sun, Peng, Han, Xiao, Song, Wen-Yu, Jiang, Xiao-Han, Zhou, Ming-Xuan, Zhang, Chen-Yu, and Yin, Chong-Chong
- Subjects
- *
HEPARANASE , *STREPTOZOTOCIN , *PANCREATIC beta cells , *ISLANDS of Langerhans , *CELL death , *TYPE 1 diabetes , *HEPARAN sulfate , *MICE , *RESEARCH , *ANIMAL experimentation , *RESEARCH methodology , *DIABETES , *EVALUATION research , *INSULIN , *COMPARATIVE studies , *GLYCOSIDASES , *RESEARCH funding - Abstract
Background and Purpose: Intra-islet heparan sulfate (HS) plays an important role in the maintenance of pancreatic islet function. The aim of this study was to investigate the effect mechanism of HS loss on the functioning of islets in diabetic mice.Experimental Approach: The hypoglycaemic effect of a heparanase inhibitor, OGT2115, was tested in a streptozotocin-induced diabetic mouse model. The islets in pancreatic sections were also stained to reveal their morphology. An insulinoma cell line (MIN6) and primary isolated murine islets were used to investigate the effect of OGT2115 in vitro.Key Results: Intra-islet HS was clearly lost in streptozotocin-induced diabetic mice due to the increased heparanase expression in damaged islets. OGT2115 prevented intra-islet HS loss and improved the glucose profile and insulin secretion in streptozotocin-treated mice. The apoptosis of pancreatic beta cells and the infiltration of mononuclear macrophages, CD4- and CD8-positive T-cells in islets was reduced by OGT2115 in streptozotocin-treated mice, but OGT2115 did not alter the direct streptozotocin-induced damage in vitro. The expression of heparanase was increased in high glucose-treated isolated islets but not in response to direct streptozotocin stimulation. Further experiments showed that high glucose stimuli could decreased expression of PPARγ in cultured islets, thereby relieving the PPARγ-induced inhibition of heparanase gene expression.Conclusion and Implications: Hyperglycaemia could cause intra-islet HS loss by elevating the expression of heparanase, thereby aggravating inflammatory cell infiltration and islet damage. Inhibition of heparanase might provide benefit for pancreatic beta cell protection in Type 1 diabetes. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
8. Optimal Nutrition Formulas for Patients Undergoing Surgery for Colorectal Cancer: A Bayesian Network Analysis.
- Author
-
Jiang, Xiao-han, Chen, Xi-jie, Wang, Xin-you, Chen, Yun-zhi, Xie, Qin-qin, and Peng, Jun-sheng
- Subjects
- *
COLON tumors , *ONLINE information services , *LENGTH of stay in hospitals , *UNSATURATED fatty acids , *INFORMATION storage & retrieval systems , *MEDICAL databases , *MEDICAL information storage & retrieval systems , *CONFIDENCE intervals , *SYSTEMATIC reviews , *SURGICAL complications , *ARGININE , *CANCER patients , *DIET therapy , *COMPARATIVE studies , *DIETARY supplements , *OMEGA-3 fatty acids , *MEDLINE , *ODDS ratio , *GLUTAMINE ,RECTUM tumors - Abstract
Optimal nutrition formulas for colorectal cancer patients underwent surgery remains uncertainty. We constructed an indirect comparison study to assess comparative efficacy of different immunonutrition formulas and standard nutrition in colorectal cancer patients underwent surgery. PubMed, the Cochrane Library, EMBASE, ClinicalTrials.gov and Web of Science databases were searched to identify RCTs that compared immunonutrition with standard nutrition or different immunonutrition formulas. Data on length of hospital stays (LOS), infectious complications (IC), noninfectious complications (NIC) and anastomotic leakage (AL) were extracted from the included RCTs for Bayesian network analysis using a random-effect model. Twelve articles that included 1032 individuals were incorporated into this study. The indirect comparison confirmed the potential improvement of arginine-based immunonutrition on IC (odds ratios [OR] = 0.43, 95%confidence interval [CI]: 0.17 to 0.95), glutamine on NIC (OR = 0.07 CI: 0.00 to 0.78) and LOS (MD=-3.91 CI: −6.33 to -1.69) and omega-3 polyunsaturated fatty acids on LOS (OR=-3.49 CI: −5.46 to -1.00). Results indicated that glutamine had the highest probability of reducing complications and hospital stays. As for colorectal cancer patients underwent surgery, this indirect comparison suggested some superiority of glutamine. Future more RCTs with larger scale are required to provide evidence for the optimal immunonutrition formulas. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
9. One-pot synthesis of magnetic, macro/mesoporous bioactive glasses for bone tissue engineering
- Author
-
Dan Wang, Huiming Lin, Jingjie Jiang, Xiao Han, Wei Guo, Xiaodan Wu, Yingxue Jin and Fengyu Qu
- Subjects
Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biotechnology ,TP248.13-248.65 - Abstract
Magnetic and macro/mesoporous bioactive glasses were synthesized by a one-pot method via a handy salt leaching technique. It was identified to be an effective and simple synthetic strategy. The non-ionic triblock copolymer, poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (P123), was used as the structure directing agent for mesoporous structure but also as the reductant to reduce the iron source into magnetic iron oxide. The prepared materials exhibited excellent super-paramagnetic property with interconnected macroporous (200–300 μm) and mesoporous (3.4 nm) structure. Furthermore, their outstanding drug storage/release properties and rapid (5) induction of hydroxyapatite growth ability were investigated after immersing in simulated body fluid solution at 37 °C. Notably, the biocompatibility assessment confirmed that the materials obtained presented good biocompatibility and enhanced adherence of HeLa cells. Herein, the novel materials are expected to have potential application for bone tissue engineering.
- Published
- 2013
- Full Text
- View/download PDF
10. Effects of art therapy in cancer care: A systematic review and meta‐analysis.
- Author
-
Jiang, Xiao‐Han, Chen, Xi‐Jie, Xie, Qin‐Qin, Feng, Yong‐Shen, Chen, Shi, and Peng, Jun‐Sheng
- Subjects
- *
PREVENTION of mental depression , *TUMOR treatment , *ART therapy , *CANCER patient medical care , *CANCER patient psychology , *CONFIDENCE intervals , *MEDICAL databases , *INFORMATION storage & retrieval systems , *MEDICAL information storage & retrieval systems , *MEDLINE , *META-analysis , *ONLINE information services , *HEALTH outcome assessment , *QUALITY of life , *RESEARCH funding , *SYSTEMATIC reviews , *DATA analysis software , *DESCRIPTIVE statistics , *CANCER fatigue ,ANXIETY prevention - Abstract
Objective: To evaluate the effect of art therapy on cancer patients' quality of life and physical and psychological symptoms. Methods: The databases PubMed, Embase, Web of Science, The Cochrane Library, Clinical Trial.gov, the China National Knowledge Infrastructure (CNKI), Wanfang and the Chinese Biomedical Literature Database (CBM) were searched from their inception up to 20 August 2019. Trials examining the effects of art therapy on physical and psychological symptoms and quality of life versus a control group were included. The methodological quality of the included randomised controlled trials was assessed using the risk of bias tool of Cochrane Handbook. Meanwhile, the Newcastle‐Ottawa Quality Assessment Scale (NOS) was used to evaluate the methodological quality of the non‐randomised studies. Results: Twelve studies involving 587 cancer patients were included. The results revealed that art therapy significantly reduced anxiety symptoms (standard mean difference [SMD] = −0.46, 95% confidence interval [CI] [−0.90, 0.02], p =.04), depression symptoms (SMD = −0.47, 95% CI [−0.72, 0.21], p <.01), and fatigue (SMD = −0.38, 95% CI [−0.68, −0.09], p =.01) in cancer patients. Art therapy also significantly improved the quality of life of cancer patients (SMD = 0.43, 95% CI [0.18, 0.68], p <.01). Conclusions: Art therapy had a positive effect on quality of life and symptoms in cancer patients and can be used as a complementary treatment for cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
11. Phospholipase C inhibits apoptosis of porcine oocytes cultured in vitro.
- Author
-
Chen, Hua Li, Cheng, Jian Yong, Yang, You Fu, Li, Yuan, Jiang, Xiao Han, Yang, Li, Wu, Lin, Shi, Meihong, Liu, Boyang, Duan, Jiaxin, Li, Xiaoya, and Li, Qing Wang
- Published
- 2020
- Full Text
- View/download PDF
12. Reliability of Assessing Non-severe Elevation of Intracranial Pressure Using Optic Nerve Sheath Diameter and Transcranial Doppler Parameters.
- Author
-
Chen, Li-min, Wang, Li-juan, Shi, Lin, Chen, Hong-xiu, Jiang, Xiao-han, Chen, Qian-qian, and Xing, Ying-qi
- Subjects
OPTIC nerve ,INTRACRANIAL pressure ,DIAMETER ,PRESSURE measurement ,INTRACRANIAL hypertension - Abstract
Background/Aims: Non-invasive measurement of intracranial pressure (ICP) using ultrasound has garnered increasing attention. This study aimed to compare the reliability of ultrasonographic measurement of optic nerve sheath diameter (ONSD) and transcranial Doppler (TCD) in detecting potential ICP elevations. Methods: Patients who needed lumbar puncture (LP) in the Department of Neurology were recruited from December 2016 to July 2017. The ONSD and TCD measurements were completed before LP. Results: One hundred sixty-five participants (mean age, 41.96 ± 14.64 years; 80 men; 29 patients with elevated ICP) were included in this study. The mean ICP was 170 ± 52 mmH
2 O (range, 75–400 mmH2 O). Univariate analyses revealed that ICP was non-significantly associated with TCD parameters and significantly associated with ONSD (r = 0.60, P < 0.001). The mean ONSD of the elevated ICP group was significantly higher than that of the normal ICP group (4.53 ± 0.40 mm vs. 3.97 ± 0.23 mm; P < 0.001). Multivariate linear regression determined that the difference between ICP and ONSD is significant. Conclusions: In the early stage of intracranial hypertension, ONSD is more reliable for evaluating ICP than TCD. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
13. Aucubin protects against pressure overload‐induced cardiac remodelling <italic>via</italic> the β3‐adrenoceptor–neuronal NOS cascades.
- Author
-
Wu, Qing‐Qing, Xiao, Yang, Duan, Ming‐Xia, Yuan, Yuan, Jiang, Xiao‐Han, Yang, Zheng, Liao, Hai‐Han, Deng, Wei, and Tang, Qi‐Zhu
- Subjects
EUCOMMIA ulmoides ,OXIDATIVE stress ,PHYSIOLOGICAL stress ,MYOCARDIAL infarction diagnosis ,HEART failure ,PHENYLEPHRINE ,DIAGNOSIS - Abstract
Background and Purpose: Aucubin, the predominant component of Eucommia ulmoides Oliv., has been shown to have profound effects on oxidative stress. As oxidative stress has previously been demonstrated to contribute to acute and chronic myocardial injury, we tested the effects of aucubin on cardiac remodelling and heart failure. Experimental Approach: Initially, H9c2 cardiomyocytes and neonatal rat cardiomyocytes pretreated with aucubin (1, 3, 10, 25 and 50 μM) were challenged with phenylephrine. Secondly, the transverse aorta was constricted in C57/B6 and neuronal NOS (nNOS)‐knockout mice, then aucubin (1 or 5 mg·kg
−1 body weight day−1 ) was injected i.p. for 25 days. Hypertrophy was evaluated by assessing morphological changes, echocardiographic parameters, histological analyses and hypertrophic markers. Oxidative stress was evaluated by examining ROS generation, oxidase activity and NO generation. NOS expression was determined by Western blotting. Key Results: Aucubin effectively suppressed cardiac remodelling; in mice, aucubin substantially inhibited pressure overload‐induced cardiac hypertrophy, fibrosis and inflammation, whereas knocking out nNOS abolished these cardioprotective effects of aucubin. Blocking or knocking down the β3 ‐adrenoceptor abolished the protective effects of aucubinin vitro . Furthermore, aucubin enhanced the protective effects of a β3 ‐adrenoceptor agonistin vitro by increasing cellular cAMP levels, whereas treatment with an adenylate cyclase (AC) inhibitor abolished the cardioprotective effects of aucubin. Conclusions and Implications: Aucubin suppresses oxidative stress during cardiac remodelling by increasing the expression of nNOS in a process that requires activation of the β3 ‐adrenoceptor/AC/cAMP pathway. These findings suggest that aucubin could have potential as a treatment for cardiac remodelling and heart failure. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
14. Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study.
- Author
-
Xiao-han Jiang, Si-bo Wang, Qian Tian, Chi Zhong, Guan-ling Zhang, Ya-jie Li, Pan Lin, Yong You, Rong Guo, Ying-hua Cui, Ying-qi Xing, Jiang, Xiao-Han, Wang, Si-Bo, Tian, Qian, Zhong, Chi, Zhang, Guan-Ling, Li, Ya-Jie, Lin, Pan, You, Yong, and Guo, Rong
- Subjects
MIGRAINE ,WHITE matter (Nerve tissue) ,BRAIN imaging ,MAGNETIC resonance imaging ,DISEASE prevalence ,VASCULAR diseases ,DISEASE risk factors ,ATRIAL septal defects ,BRAIN ,CEREBRAL ischemia ,COMPARATIVE studies ,DEGENERATION (Pathology) ,INFARCTION ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,TRANSCRANIAL Doppler ultrasonography ,EVALUATION research ,EQUIPMENT & supplies ,CROSS-sectional method ,DISEASE complications - Abstract
Background: Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs.Methods: We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Participants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status. RLS was classified into four grades (Grade 0 = Negative; Grade I = 1 ≤ microbubbles (MBs) ≤ 10; Grade II = MBs > 10 and no curtain; Grade III = curtain). Silent brain ischemic infarctions (SBI) and white matter hyperintensities (WMHs) were evaluated on MRI.Results: We found no significant differences between migraineurs with RLS and migraineurs without RLS in subclinical ischemic brain lesions.SBI and WMHs did not increase with the size of the RLS(p for trend for SBI = 0.066, p for trend for WMHs = 0.543). Furthermore, curtain RLS in migraineurs was a risk factor for the presence of SBI (p = 0.032, OR = 3.47; 95%CI: 1.12-10.76). There was no association between RLS and the presence of WMHs.Conclusion: Overall, RLS is not associated with increased SBI or WMHs in migraineurs. However, when RLS is present as a curtain pattern, it is likely to be a risk factor for SBIs in migraineurs.Trial Registration: No. NCT02425696 ; registered on April 21, 2015. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
15. Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy.
- Author
-
Xiao, Yang, Yang, Zheng, Wu, Qing‐Qing, Jiang, Xiao‐Han, Yuan, Yuan, Chang, Wei, Bian, Zhou Yan, Zhu, Jin Xiu, and Tang, Qi‐Zhu
- Published
- 2017
- Full Text
- View/download PDF
16. B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury.
- Author
-
Li, Guo-xun, Jiang, Xiao-han, Zang, Jing-nan, Zhu, Ben-zhi, Jia, Cong-cong, Niu, Kun-wei, Liu, Xia, Jiang, Rui, and Wang, Bing
- Subjects
- *
NEUTROPHILS , *PROTEIN deficiency , *P-selectin glycoprotein ligand-1 , *NF-kappa B , *LUNG injuries , *PROTEIN receptors - Abstract
Acute lung injury (ALI) and its more severe condition acute respiratory distress syndrome (ARDS) are critical life-threatening disorders characterized by an excessive influx of neutrophils into the alveolar space. Neutrophil infiltration is a multi-step process involving the sequential engagement of adhesion molecules. The adhesion molecule CD11b/CD18 acts as an important role in the recruitment of neutrophils to lung tissues in the ALI model. B-cell receptor associated protein 31 (BAP31), an endoplasmic reticulum transmembrane protein, has been reported to regulate the cellular anterograde transport of CD11b/CD18 in human neutrophils. To explore how BAP31 regulates CD11b/CD18 in mouse neutrophils, we constructed myeloid-specific BAP31 knockdown mice in this study. Biological investigations indicated that BAP31 deficiency could significantly alleviated lung injury, as evidenced by the improved histopathological morphology, reduced pulmonary wet/dry weight ratio, inhibited myeloperoxidase level and decreased neutrophil counts in the bronchoalveolar lavage fluid. Further studies clarified that BAP31 deficiency obviously down-regulated the expression of CD11b/CD18 and P-selectin glycoprotein ligand-1 (PSGL-1) by deactivating the nuclear factor kappa B (NF-κB) signaling pathway. Collectively, our results revealed that BAP31 depletion exerted a protective effect on ALI, which was possibly dependent on the attenuation of neutrophil adhesion and infiltration by blocking the expression of adhesion molecules CD11b/CD18 and PSGL-1. These findings implied the potential of BAP31 as an appealing protein to mediate the occurrence of ALI. [Display omitted] • Myeloid-specific BAP31 depletion alleviated LPS-induced ALI in mice. • BAP31 deficiency reduced neutrophil-endothelial cell adhesion. • BAP31 knockdown downregulated the expressions of CD11b/CD18 and PSGL-1. • BAP31 depletion blocked NF-κB signaling cascades in mice neutrophils. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Acupuncture for irritable bowel syndrome: Study protocol of a prospective, multicentre, registry study in real-world settings.
- Author
-
Shi, Yun-zhou, Ye, Kun, Chen, Min, Xie, Xin, Fan, Xi-yi, Xie, Chao-rong, Tao, Qing-feng, Hua, Can, Wu, Qin-ping, Jiang, Xiao-han, Wan, Yu-ying, Li, Zhi-gang, Zheng, Hui, and Yu, Shu-guang
- Abstract
Acupuncture is a complex intervention influenced by many factors, and its effectiveness in treating irritable bowel syndrome (IBS) in the real world is unknown. Therefore, we will conduct a registry study to evaluate the effectiveness and safety of acupuncture alone or as adjunctive therapy for IBS in real-world settings. This is a prospective multicentre registry study. At least 788 patients will be recruited from 6 medical centres. Patients who are diagnosed with IBS, aged over 18 years, and voluntarily sign the informed consent form will be recruited. The interventions will include acupuncture or without acupuncture therapy for IBS. The primary outcome will be the IBS symptom severity score, and the secondary outcomes will include adequate relief of global IBS symptoms, the Bristol Stool Form Scale, the weekly frequency of defecation, the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale. All information will be collected through the Epi Info™7 data platform. Propensity score matching will be used to control for potential confounding factors. The generalized additive mixed model will be used to analyse the curative effect. We posit that the treatment should not be less than 3 times, and 1 follow-up is an effective case. This study protocol describes the first large-scale, multicentre patient registry of acupuncture for IBS. The findings of the study will confirm the effectiveness and safety of acupuncture alone or as adjunctive therapy in treating IBS and provide the characteristics of acupuncture implementation, the conditions related to more acupuncture benefit, and identify the key factors affecting the clinical effectiveness of acupuncture treatment for IBS in the real world. Chinese Clinical Trial Registry, ChiCTR2100045329. Registered date on 12 April 2021. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
18. ChemInform Abstract: Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water.
- Author
-
Wang, Dong‐Chao, Wang, Hai‐Xia, Hao, Er‐Jun, Jiang, Xiao‐Han, Xie, Ming‐Sheng, Qu, Gui‐Rong, and Guo, Hai‐Ming
- Published
- 2016
- Full Text
- View/download PDF
19. Inside Back Cover: Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016).
- Author
-
Wang, Dong ‐ Chao, Wang, Hai ‐ Xia, Hao, Er ‐ Jun, Jiang, Xiao ‐ Han, Xie, Ming ‐ Sheng, Qu, Gui ‐ Rong, and Guo, Hai ‐ Ming
- Subjects
OXINDOLES ,INDOLINE - Abstract
The cover picture, provided by Hai ‐ Ming Guo, Gui ‐ Rong Qu and co ‐ workers, illustrates a palladium ‐ catalyzed domino HeckSonogashira process in water. Using this strategy, a series of 3 ‐ (4 ‐ aminobut ‐ 2ynyl)oxindole derivatives with an all ‐ carbon quaternary center at the 3 ‐ position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5 ‐ HT7 receptor antagonist. Details can be found in the Update on pages 494 – 499 (D. ‐ C. Wang, H. ‐ X. Wang, E. ‐ J. Hao, X. ‐ H. Jiang, M. ‐ S. Xie, G. ‐ R. Qu, H. ‐ M. Guo, Adv. Synth. Catal. 2016, 358, 494 – 499; DOI: 10.1002/adsc.201500887). [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.