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Resumen: Introducción: El objetivo del trabajo fue conocer el comportamiento de los biomarcadores ecográficos de densidad fascicular y fuerza muscular en pacientes con esclerosis lateral amiotrófica (ELA). Métodos: Estudio piloto, observacional y transversal sobre 14 pacientes con ELA (mujeres; 28,6%) y 14 controles. Se tomaron ecografías bilaterales transversales en el abductor corto del pulgar (ACP) y tibial anterior (TA) con registro del grosor muscular (GM) en reposo, en contracción y diferencia de engrosamiento. En los nervios mediano, ciático y peroneo común se analizaron el área de sección transversal (AST), el número de fascículos (NF) y la densidad fascicular (DF). Los análisis se realizaron anidados por lateralidad. Resultados: El acuerdo intra-interobservador en los recuentos de fascículos fue muy bueno con un error mínimo detectable

Introduction: The aim of this study was to determine the behaviour of ultrasound biomarkers of fascicle density and muscle strength in patients with amyotrophic lateral sclerosis (ALS). Methods: We conducted an observational, cross-sectional pilot study of 14 patients with ALS (28.6% women) and 14 controls. Bilateral cross-sectional ultrasound scans were performed in the abductor pollicis brevis (APB) and tibialis anterior (TA) muscles, with recording of muscle thickness (MT) at rest and in contraction, and the difference in thickness. In the median, sciatic, and common peroneal nerves, we analysed the cross-sectional area (CSA), number of fascicles (NF) and fascicle density (FD). Analyses were nested by laterality. Results: Intra- and interrater agreement regarding NF was very good, with a minimum detectable error of

Introduction This Crisis Intervention Team was born in October 2018 with the aim of intensifying the treatment of people in psychiatric crisis situation. Objectives Provide an intensive and early assessment and approach in a timely manner. It also provides home care if necessary. Methods The team intensively performs scheduled visits, emergencys, telephone interventions and home care. It is in constant coordination with other structures of the mental health and socio-health network. Results A total of 83 patients have been included in our team since its inception. The youngest was 17 years old and the oldest 83 years old (exceptional case in evaluation). The mean age was 45.6 years. 67.4% were female (56 women) and 32.5% male (27 men). The delay in care did not exceed 48 hours. 200 patients were evaluated into suicide protocol, with ages ranging from 15 to 85 years, with a mean age of 45.4 years. The delay in care does not exceed 10 days. Conclusions This is a team that offers a rapid response, dedicates the necessary time for a correct evaluation of the risk, of the evolution and tries to establish a therapeutic alliance in record time. It is able to tolerate a certain degree of uncertainty, manage and tolerate the level of risk. He stands out for being flexible and dynamic in order to be able to adapt to the patients and theirs circumstances. This requires empathy, closeness and commitment. Disclosure No significant relationships.

In order to understand photosynthetic responses of pomegranate plants (Punica granatum L.) to salinity, an experiment was conducted with three varieties, 'Mollar de Elche', 'Valenciana', and 'Wonderful', irrigated with seven salt concentrations (0, 40, 60, 80, 100, 120, and 140 mM NaCl). At the end of the experiment, parameters of gas exchange, chlorophyll fluorescence, water relations, and sugar and chloride concentrations were measured in leaves. As the concentration of NaCl increased, the concentration of Cl- in leaves was elevated, and the CO2 assimilation rate, stomatal conductance, variable fluorescence/maximum fluorescence ratio, PSII quantum yield, and total soluble sugars decreased. In 'Valenciana', the decrease of the net assimilation of CO2 could occur due to the closure of stomata, while in 'Mollar' and 'Wonderful', this was due to damage caused by Cl- toxicity. The study of carbohydrates also suggests a different behavior of carbon metabolism in the three varieties.

Desde el 2006 se observa un incremento poblacional importante de Oiketicus platensis Berg en los bosques de caldén de la provincia de La Pampa. Los objetivos del presente trabajo fueron: 1) caracterizar la comunidad de parasitoides larvales, 2) determinar qué especies de parasitoide son más abundantes. El estudio se llevó a cabo en 3 sitios de la provincia pertenecientes a la región togreográfica del Espinal. El muestreo de larvas se extendió desde noviembre de 2012 hasta marzo de 2013. En total, 17 especies de parasitoides fueron identificadas. Se reconocieron 15 especies de avispas parasitoides pertenecientes a 9 familias: Eulophidae, Encyrtidae, Eurytomidae, Eupelmidae, Torymidae, Chalcididae, Ichneumonidae, Baconidae y Bethylidae. Además, se identificaron 2 especies de moscas parasitoides pertenecientes a la familia Tachinidae. Los parasitoides aparecieron un mes después del nacimiento de las larvas. El porcentaje de parasitoidismo larval fue de 17,6%, con predominancia (81,6%) de moscas parasitoides.

The El Salvador earthquake of February 13th 2001 (Mw 6.6) was associated with the tectonic rupture of the El Salvador Fault Zone. Paleoseismic studies of the El Salvador Fault Zone undertaken after this earthquake provide a basis for examining the longer history of surface rupturing earthquakes on the fault. Trenching at five sites along the San Vicente segment, a 21km-long and up to 2km-wide central section of the El Salvador Fault Zone, shows that surface fault rupture has occurred at least seven times during the past 8ka. Single-event displacements identified at each trench vary from several decimetres to at least 3.7m. Fault trace mapping, geomorphic analysis, and paleoseismic studies indicate a maximum magnitude for the El Salvador Fault Zone is c. Mw 7.6, with a recurrence interval of around 800yr. Earthquakes of Mw 6.6 or smaller, such as the February 2001 event are unlikely to be identified in the paleoseismic trenches, so our observations represent the minimum number of moderate to large earthquakes that have occurred on this part of the El Salvador Fault Zone. We observe significant variability in single-event displacement in the trenches, which we interpret as possible cascade rupture of several segments of the El Salvador Fault Zone. Combining displacements of river courses and the timing of events revealed in the trenches, we calculate a slip rate of c. 4mm/yr for El Salvador Fault Zone, identifying the fault zone as a major tectonic feature of the region, and a major source of seismic hazard and risk in El Salvador.

The altarpiece appenred as didactic iconography placed behind the main altar. But the valomtion that the Council of Trent gave to the Eucharist made this the predominant objective in the baroque period. Sheme, monstrance and tabeinacle are usually terms equivalent to the place where the sacred forms are kept. But the tabernacle has an additional meaning: momentality, It has the shape of a tower; the upper part is the monstrance, a transparent recipient in which the sucred form is placed for everlasting worship. The form is visible in the monstrance that is generally presented in a theatrical manner (scene), with a small curtain or revolving body. The altarpiece is part of the theatrical scenery, which helps to create more emotion when the holy sacrament is shown.

The Vatican Pavlion at the 1992 World Fair of Seville, Expo 92, was devoted to explain the evangelizatiori of America, illustrated with works of art, books, and maps brought from different collections and archives. The Pavilion gathered a great deal of materials, ranging from creations of great artists to specimens of popular art. The exhibition payed attention to cultural and geographical aspects of evangelization, and showed grammar and vocabulary books beside examples of cartography. The scope of faith with Christ as protagonist, was represented by a series of masterpieces by El Greco, Caravaggio, Murillo or Goya. Besides, it also liad a memory to principal names relaten to the discovery, and to the activities of evangelization carried out by ecclesiastics and missionaries, with the exhibition of documents, plans, paintings, sculptures and gold and silver works.

The Hispanic Baroque has one of its main exhibitions in the retable, to which scholars are paying an increasing attention. This paper outlines the study of the typology or order of the whole. artending first to such important elements as the tabernacle and the manifestador [manifester, exhibitor], i.e. the Eucharisric core, both having a main significance during the baroque rima, beside the special effects of the transparents. We continue with the analysis of the structural tipology, with a starting point in the rerable of El Escorial and other models in the palladian line which one devoloped mainly in the frame-retable (this type will produce very baroque creations). From the middle of the XVIIth century onwards, there is a turn to the primacy of an only order, also advancing to the irlerease of the bench and to the use of revisted columns. This type of an only order and with semicircular attic or rop is the commonest in Spain, though there exists a logical range of variations. Furthermore. the retable may apperit hacked against a right wall, but also against curved or polygonal presbytey, to cover in completely up to the vault and to form a concave structure with a shell crown which defines the typical riche-rerable. The tendency in the tabole is to stress the central part, which constitutes the agglutinating element of the structure, though there still persist several bodies. This the priority. is given to the titular image's niche. After the structural typology in follows an analysis of the typology of contents, with definitions of the reliquary-. rosay-, and painting support-, retables, and the big transparernts. Finally, we study the baldachin and its variations: exent baldachins. not exent ones. baldachin- retable and half baldachin.

Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE−/−) mice. Male ApoE−/− mice received vehicle (control), low-level lipopolysaccharide (LPS), or recombinant human SAA by i.p. injection every third day for 2 weeks. Heart, aorta and kidney were harvested between 3 days and 18 weeks after treatment. SAA administration increased vascular cell adhesion molecule (VCAM)-1 expression and circulating monocyte chemotactic protein (MCP)-1 and decreased aortic cyclic guanosine monophosphate (cGMP), consistent with SAA inhibiting nitric oxide bioactivity. In addition, binding of labeled leukocytes to excised aorta increased as monitored using an ex vivo leukocyte adhesion assay. Renal injury was evident 4 weeks after commencement of SAA treatment, manifesting as increased plasma urea, urinary protein, oxidized lipids, urinary kidney injury molecule (KIM)-1 and multiple cytokines and chemokines in kidney tissue, relative to controls. Phosphorylation of nuclear-factor-kappa-beta (NFκB-p-P65), tissue factor (TF), and macrophage recruitment increased in kidneys from ApoE−/− mice 4 weeks after SAA treatment, confirming that SAA elicited a pro-inflammatory and pro-thrombotic phenotype. These data indicate that SAA impairs endothelial and renal function in ApoE−/− mice in the absence of a high-fat diet.

Polyketides are an important group of secondary metabolites, many of which have important industrial applications in the food and pharmaceutical industries. Polyketides are synthesized from one of three classes of enzymes differentiated by their biochemical features and product structure: type I, type II or type III polyketide synthases (PKSs). Plant type III PKS enzymes, which will be the main focus of this review, are relatively small homodimeric proteins that catalyze iterative decarboxylative condensations of malonyl units with a CoA-linked starter molecule. This review will describe the plant type III polyketide synthetic pathway, including the synthesis of chalcones, stilbenes and curcuminoids, as well as recent work on the synthesis of these polyketides in heterologous organisms. The limitations and bottlenecks of heterologous expression as well as attempts at creating diversity through the synthesis of novel “unnatural” polyketides using type III PKSs will also be discussed. Although synthetic production of plant polyketides is still in its infancy, their potential as useful bioactive compounds makes them an extremely interesting area of study.