1. Electrophysiological registration of phonological perception in the subthalamic nucleus of patients with Parkinson’s Disease
- Author
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Annelies Aerts, Patrick Santens, M. De Letter, L. De Taeye, Paul Boon, D. Van Roost, Sarah Vanhoutte, Robrecht Raedt, P. van Mierlo, and J. Van Borsel
- Subjects
Male ,Linguistics and Language ,Parkinson's disease ,Deep brain stimulation ,Speech perception ,Deep Brain Stimulation ,Cognitive Neuroscience ,media_common.quotation_subject ,medicine.medical_treatment ,Experimental and Cognitive Psychology ,Local field potential ,Language and Linguistics ,Antiparkinson Agents ,Levodopa ,Speech and Hearing ,Subthalamic Nucleus ,Perception ,Basal ganglia ,medicine ,Humans ,Aged ,media_common ,Parkinson Disease ,Middle Aged ,medicine.disease ,Subthalamic nucleus ,Electrophysiology ,Evoked Potentials, Auditory ,Speech Perception ,Female ,Psychology ,Neuroscience ,psychological phenomena and processes - Abstract
Phonological processing is usually associated with the activation of cortical areas, especially in the left cerebral hemisphere. This study examined if phonologically elicited evoked potentials can be recorded directly from the subthalamic nucleus in patients with Parkinson’s Disease (PD). Seven PD patients who had undergone implantation of deep brain electrodes for the stimulation of the subthalamic nucleus were included. Local field potentials were recorded in a pre-attentive auditory phonological task, an attentive auditory phonological discrimination task, and a word recognition task. Auditory evoked potentials related to phonological, but not lexical processing, could be demonstrated in the subthalamic nucleus for all three tasks. Only minor changes were found after levodopa administration. This study demonstrates that the subthalamic nucleus is involved in early phonological perception, which puts the subthalamic nucleus in a position to modify phonological perception in a larger cortico-subcortical network.
- Published
- 2014
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