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We study plasma transport at a thin magnetopause (MP), described hereafter as a thin current sheet (TCS), observed by Cluster at the southern cusp on 13 February 2001 around 20:01 UT. The Cluster observations generally agree with the predictions of the Gas Dynamic Convection Field (GDCF) model in the magnetosheath (MSH) up to the MSH boundary layer, where significant differences are seen. We find for the MP a normal roughly along the GSE x-axis, which implies a clear departure from the local average MP normal, a ~90 km thickness and an outward speed of 35 km/s. Two populations are identified in the MSH boundary layer: the first one roughly perpendicular to the MSH magnetic field, which we interpret as the "incident" MSH plasma, the second one mostly parallel to B. Just after the MP crossing a velocity jet is observed with a peak speed of 240 km/s, perpendicular to B, with MA=3 and β>10 (peak value 23). The magnetic field clock angle rotates by 70° across the MP. Ex is the main electric field component on both sides of the MP, displaying a bipolar signature, positive on the MSH side and negative on the opposite side, corresponding to a ~300 V electric potential jump across the TCS. The E×B velocity generally coincides with the perpendicular velocity measured by CIS; however, in the speed jet a difference between the two is observed, which suggests the need for an extra flow source. We propose that the MP TCS can act locally as an obstacle for low-energy ions (

Proceeding with the analysis of Amata et al. (2005), we suggest that the general feature for the local transport at a thin magnetopause (MP) consists of the penetration of ions from the magnetosheath with gyroradius larger than the MP width, and that, in crossing it, the transverse potential difference at the thin current sheet (TCS) is acquired by these ions, providing a field-particle energy exchange without parallel electric fields. It is suggested that a part of the surface charge is self-consistently produced by deflection of ions in the course of inertial drift in the non-uniform electric field at MP. Consideration of the partial moments of ions with different energies demonstrates that the protons having gyroradii of roughly the same size or larger than the MP width carry fluxes normal to MP that are about 20% of the total flow in the plasma jet under MP. This is close to the excess of the ion transverse velocity over the cross-field drift speed in the plasma flow just inside MP (Amata et al., 2005), which conforms to the contribution of the finite-gyroradius inflow across MP. A linkage through the TCS between different plasmas results from the momentum conservation of the higher-energy ions. If the finite-gyroradius penetration occurs along the MP over ~1.5 RE from the observation site, then it can completely account for the formation of the jet under the MP. To provide the downstream acceleration of the flow near the MP via the cross-field drift, the weak magnetic field is suggested to rotate from its nearly parallel direction to the unperturbed flow toward being almost perpendicular to the accelerated flow near the MP. We discuss a deceleration of the higher-energy ions in the MP normal direction due to the interaction with finite-scale electric field bursts in the magnetosheath flow frame, equivalent to collisions, providing a charge separation. These effective collisions, with a nonlinear frequency proxy of the order of the proton cyclotron one, in extended turbulent zones are a promising alternative in place of the usual parallel electric fields invoked in the macro-reconnection scenarios. Further cascading towards electron scales is supposed to be due to unstable parallel electron currents, which neutralize the potential differences, either resulted from the ion- burst interactions or from the inertial drift. The complicated MP shape suggests its systematic velocity departure from the local normal towards the average one, inferring domination for the MP movement of the non-local processes over the small-scale local ones. The measured Poynting vector indicates energy transmission from the MP into the upstream region with the waves triggering impulsive downstream flows, providing an input into the local flow balance and the outward movement of the MP. Equating the transverse electric field inside the MP TCS by the Hall term in the Ohm's law implies a separation of the different plasmas primarily by the Hall current, driven by the respective part of the TCS surface charge. The Hall dynamics of TCS can operate either without or as a part of a macro-reconnection with the magnetic field annihilation.

Abstract Background In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) and resistance to rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambique and Tanzania investigates the effect of Truenat platform/MTB assays (intervention arm) combined with rapid communication of results compared to standard of care on TB diagnosis and treatment initiation for microbiologically confirmed TB at 7 days from enrolment. Methods The Tuberculosis Close the Gap, Increase Access, and Provide Adequate Therapy (TB-CAPT) CORE trial employs a pragmatic cluster randomized controlled design to evaluate the impact of a streamlined strategy for delivery of Truenat platform/MTB assays testing at primary health centers. Twenty-nine centers equipped with TB microscopy units were selected to participate in the trial. Among them, fifteen health centers were randomized to the intervention arm (which involves onsite molecular testing using Truenat platform/MTB assays, process process optimization to enable same-day TB diagnosis and treatment initiation, and feedback on Molbio platform performance) or the control arm (which follows routine care, including on-site sputum smear microscopy and the referral of sputum samples to off-site Xpert testing sites). The primary outcome of the study is the absolute number and proportion of participants with TB microbiological confirmation starting TB treatment within 7 days of their first visit. Secondary outcomes include time to bacteriological confirmation, health outcomes up to 60 days from first visit, as well as user preferences, direct cost, and productivity analyses. Ethics and dissemination TB-CAPT CORE trial has been approved by regulatory and ethical committees in Mozambique and Tanzania, as well as by each partner organization. Consent is informed and voluntary, and confidentiality of participants is maintained throughout. Study findings will be presented at scientific conferences and published in peer-reviewed international journals. Trial Registration US National Institutes of Health’s ClinicalTrials.gov, NCT04568954. Registered 23 September 2020.

We present multi spacecraft measurements in the magnetosheath (MSH) and in the solar wind (SW) by Interball, Cluster and Polar, demonstrating that coherent structures with magnetosonic Mach number up to 3 – Supermagnetosonic Plasma Streams (SPS) – generate transient and anomalous boundary dynamics, which may cause substantial displacements of the magnetospheric boundaries and the riddling of peripheral boundary layers. In this regard, for the first time, we describe a direct plasma penetration into the flank boundary layers, which is a candidate for being the dominant transport mechanism for disturbed MSH periods. Typically SPS's have a ram pressure exceeding by several times that of the SW and lead to long-range correlations between processes at the bow shock (BS) and at the magnetopause (MP) on one side and between MSH and MP boundary layers on the other side. We demonstrate that SPS's can be observed both near the BS and near the MP and argue that they are often triggered by hot flow anomalies (HFA), which represent local obstacles to the SW flow and can induce the SPS generation as a means for achieving a local flow balance. Finally, we also discuss other causes of SPS's, both SW-induced and intrinsic to the MSH. SPS's appear to be universal means for establishing a new equilibrium between flowing plasmas and may also prove to be important for astrophysical and fusion applications.

Itaconic acid (IA) is considered as an important intermediate in the synthesis of bio-based chemicals and fuels. It can be produced under nitrogen-limited conditions from glucose by aerobic fermentation with the fungus Ustilago maydis (U. maydis). A metabolic model of this organism is developed to identify optimal operating conditions for a continuous fermentation which maximizes the overall itaconic acid yield. Experimental studies show that IA is only produced under nitrogen limitation. In order to capture this behaviour, the model should not only include the common metabolic pathways such as glycolysis, the pentose phosphate pathway and the tricarbonic acid cycle, but it should also comprise the amino acid metabolism as well as nucleotide and chitin synthesis. Since it has been shown experimentally that nitrogen limitation leads to changes in the elemental composition of the biomass, this effect must also be considered in the model. In this contribution, we will present a metabolic model accounting for these phenomena and compare model predictions with experimental results. A metabolic flux analysis carried out with the model clearly shows that nitrogen-free compounds such as IA acid are expressed by an overflow metabolism as soon as a nitrogen limitation occurs.