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1,397 results on '"Ishida T."'

1. Development of a data overflow protection system for Super-Kamiokande to maximize data from nearby supernovae

Author

Mori, M., Abe, K., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Okamoto, K., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Megias, G. D., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Locke, S., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Ishizuka, T., Nakamura, T., Jang, J. S., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Scott, M., Sztuc, A. A., Uchida, Y., Berardi, V., Catanesi, M. G., Radicioni, E., Calabria, N. F., Langella, A., Machado, L. N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Edwards, R., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Kotsar, Y., Ozaki, H., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Bronner, C., Feng, J., Hu, J. R., Hu, Z., Kawaune, M., Kikawa, T., LiCheng, F., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Lakshmi, S. M., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Jung, C. K., Shi, W., Wilking, M. J., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Kitagawa, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S., Okazawa, H., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Nakamura, K. D., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Martens, K., Tsui, K. M., Vagins, M. R., Valls, C. J., Xia, J., Kuze, M., Izumiyama, S., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ommura, Y., Shigeta, N., Shinoki, M., Suganuma, T., Yamauchi, K., Yoshida, T., Martin, J. F., Tanaka, H. A., Towstego, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Prouse, N. W., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Hadley, D., Nicholson, M., Flaherty, M. O', Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Pintaudi, G., Sano, S., Suzuki, S., and Wada, K.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics, High Energy Physics - Experiment
Abstract

Neutrinos from very nearby supernovae, such as Betelgeuse, are expected to generate more than ten million events over 10\,s in Super-Kamokande (SK). At such large event rates, the buffers of the SK analog-to-digital conversion board (QBEE) will overflow, causing random loss of data that is critical for understanding the dynamics of the supernova explosion mechanism. In order to solve this problem, two new DAQ modules were developed to aid in the observation of very nearby supernovae. The first of these, the SN module, is designed to save only the number of hit PMTs during a supernova burst and the second, the Veto module, prescales the high rate neutrino events to prevent the QBEE from overflowing based on information from the SN module. In the event of a very nearby supernova, these modules allow SK to reconstruct the time evolution of the neutrino event rate from beginning to end using both QBEE and SN module data. This paper presents the development and testing of these modules together with an analysis of supernova-like data generated with a flashing laser diode. We demonstrate that the Veto module successfully prevents DAQ overflows for Betelgeuse-like supernovae as well as the long-term stability of the new modules. During normal running the Veto module is found to issue DAQ vetos a few times per month resulting in a total dead time less than 1\,ms, and does not influence ordinary operations. Additionally, using simulation data we find that supernovae closer than 800~pc will trigger Veto module resulting in a prescaling of the observed neutrino data., Comment: 28 pages, 18 figures. Submitted to PTEP

Published
2024
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2. Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes

Author

Sugimoto, T., Araki, A., Fujita, H., Fujita, K., Honda, K., Inagaki, N., Ishida, T., Kato, J., Kishi, M., Kishino, Y., Kobayashi, K., Kouyama, K., Kuroda, Y., Kuwahata, S., Matsumoto, N., Murakami, T., Noma, H., Ogino, J., Ogura, M., Ohishi, M., Shimada, H., Sugimoto, K., Takenaka, T., Tamura, Y., Tokuda, H., Uchida, K., Umegaki, H., and Sakurai, Takashi

Published
2024
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3. Second gadolinium loading to Super-Kamiokande

Author

Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Hosokawa, K., Ieki, K., Ikeda, M., Kameda, J., Kanemura, Y., Kaneshima, R., Kashiwagi, Y., Kataoka, Y., Miki, S., Mine, S., Miura, M., Moriyama, S., Nakano, Y., Nakahata, M., Nakayama, S., Noguchi, Y., Sato, K., Sekiya, H., Shiba, H., Shimizu, K., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Tanaka, H., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Tomiya, T., Wang, X., Yoshida, S., Fernandez, P., Labarga, L., Ospina, N., Zaldivar, B., Pointon, B. W., Kearns, E., Raaf, J. L., Wan, L., Wester, T., Bian, J., Griskevich, N. J., Smy, M. B., Sobel, H. W., Takhistov, V., Yankelevich, A., Hill, J., Jang, M. C., Lee, S. H., Moon, D. H., Park, R. G., Bodur, B., Scholberg, K., Walter, C. W., Beauchene, A., Drapier, O., Giampaolo, A., Mueller, Th. A., Santos, A. D., Paganini, P., Quilain, B., Rogly, R., Nakamura, T., Jang, J. S., Machado, L. N., Learned, J. G., Choi, K., Iovine, N., Cao, S., Anthony, L. H. V., Martin, D., Prouse, N. W., Scott, M., Uchida, Y., Berardi, V., Calabria, N. F., Catanesi, M. G., Radicioni, E., Langella, A., De Rosa, G., Collazuol, G., Iacob, F., Mattiazzi, M., Ludovici, L., Gonin, M., Perisse, L., Pronost, G., Fujisawa, C., Maekawa, Y., Nishimura, Y., Okazaki, R., Akutsu, R., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Bhuiyan, N., Burton, G. T., Di Lodovico, F., Gao, J., Goldsack, A., Katori, T., Migenda, J., Ramsden, R. M., Xie, Z., Zsoldos, S., Suzuki, A. T., Takagi, Y., Takeuchi, Y., Zhong, H., Feng, J., Feng, L., Hu, J. R., Hu, Z., Kawaue, M., Kikawa, T., Mori, M., Nakaya, T., Wendell, R. A., Yasutome, K., Jenkins, S. J., McCauley, N., Mehta, P., Tarant, A., Wilking, M. J., Fukuda, Y., Itow, Y., Menjo, H., Ninomiya, K., Yoshioka, Y., Lagoda, J., Mandal, M., Mijakowski, P., Prabhu, Y. S., Zalipska, J., Jia, M., Jiang, J., Shi, W., Yanagisawa, C., Harada, M., Hino, Y., Ishino, H., Koshio, Y., Nakanishi, F., Sakai, S., Tada, T., Tano, T., Ishizuka, T., Barr, G., Barrow, D., Cook, L., Samani, S., Wark, D., Holin, A., Nova, F., Jung, S., Yang, B. S., Yang, J. Y., Yoo, J., Fannon, J. E. P., Kneale, L., Malek, M., McElwee, J. M., Thiesse, M. D., Thompson, L. F., Wilson, S. T., Okazawa, H., Lakshmi, S. M., Kim, S. B., Kwon, E., Seo, J. W., Yu, I., Ichikawa, A. K., Tairafune, S., Nishijima, K., Eguchi, A., Nakagiri, K., Nakajima, Y., Shima, S., Taniuchi, N., Watanabe, E., Yokoyama, M., de Perio, P., Fujita, S., Jesus-Valls, C., Martens, K., Tsui, K. M., Vagins, M. R., Xia, J., Izumiyama, S., Kuze, M., Matsumoto, R., Terada, K., Ishitsuka, M., Ito, H., Ommura, Y., Shigeta, N., Shinoki, M., Yamauchi, K., Yoshida, T., Gaur, R., Gousy-Leblanc, V., Hartz, M., Konaka, A., Li, X., Chen, S., Xu, B. D., Zhang, B., Posiadala-Zezula, M., Boyd, S. B., Edwards, R., Hadley, D., Nicholson, M., O'Flaherty, M., Richards, B., Ali, A., Jamieson, B., Amanai, S., Marti, Ll., Minamino, A., Suzuki, S., Scovell, P. R., Meehan, E., Bandac, I., Pena-Garay, C., Perez, J., Gileva, O., Lee, E. K., Leonard, D. S., Sakakieda, Y., Sakaguchi, A., Sueki, K., Takaku, Y., and Yamasaki, S.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The first loading of gadolinium (Gd) into Super-Kamiokande in 2020 was successful, and the neutron capture efficiency on Gd reached 50\%. To further increase the Gd neutron capture efficiency to 75\%, 26.1 tons of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was additionally loaded into Super-Kamiokande (SK) from May 31 to July 4, 2022. As the amount of loaded $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$ was doubled compared to the first loading, the capacity of the powder dissolving system was doubled. We also developed new batches of gadolinium sulfate with even further reduced radioactive impurities. In addition, a more efficient screening method was devised and implemented to evaluate these new batches of $\rm Gd_2(\rm SO_4)_3\cdot \rm 8H_2O$. Following the second loading, the Gd concentration in SK was measured to be $333.5\pm2.5$ ppm via an Atomic Absorption Spectrometer (AAS). From the mean neutron capture time constant of neutrons from an Am/Be calibration source, the Gd concentration was independently measured to be 332.7 $\pm$ 6.8(sys.) $\pm$ 1.1(stat.) ppm, consistent with the AAS result. Furthermore, during the loading the Gd concentration was monitored continually using the capture time constant of each spallation neutron produced by cosmic-ray muons,and the final neutron capture efficiency was shown to become 1.5 times higher than that of the first loaded phase, as expected., Comment: 34 pages, 13 figures, submitted to Nuclear Inst. and Methods in Physics Research, A

Published
2024
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5. Measurements of neutrino oscillation parameters from the T2K experiment using $3.6\times10^{21}$ protons on target

Author

The T2K Collaboration, Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Monsalve, S. Alonso, Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Chong, P. S., Christodoulou, G., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Dalmazzone, C., Daret, T., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fedorova, D., Fedotov, S., Feltre, M., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fukuda, Y., Fusshoeller, K., Giannessi, L., Giganti, C., Glagolev, V., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Henaff, D., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Jonsson, P., Joshi, S., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kiseeva, V., Kisiel, J., Kobata, T., Kobayashi, H., Kobayashi, T., Koch, L., Kodama, S., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamoureux, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Lee, Y., Lin, C., Lin, S. -K., Litchfield, R. P., Liu, S. L., Li, W., Longhin, A., Long, K. R., Moreno, A. Lopez, Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Metelko, C., Mezzetto, M., Miller, E., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, P., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakamura, K. D., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimori, S., Nishimura, Y., Nishizaki, K., Nosek, T., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okinaga, W., Okumura, K., Okusawa, T., Ospina, N., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Pupilli, F., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ramírez, M. A., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Roy, N., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smyczek, D., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tairafune, S., Takayasu, S., Takeda, A., Takeuchi, Y., Takifuji, K., Tanaka, H. K., Tanihara, Y., Tani, M., Teklu, A., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M., Vargas, D., Varghese, M., Vasseur, G., Vilela, C., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yamamoto, T., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yoshimura, N., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.

Subjects
High Energy Physics - Experiment
Abstract

The T2K experiment presents new measurements of neutrino oscillation parameters using $19.7(16.3)\times10^{20}$ protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional $4.7\times10^{20}$ POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on $\sin^2\theta_{13}$ and the impact of priors on the $\delta_\mathrm{CP}$ measurement. Both analyses prefer the normal mass ordering and upper octant of $\sin^2\theta_{23}$ with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on $\sin^2\theta_{13}$ from reactors, $\sin^2\theta_{23}=0.561^{+0.021}_{-0.032}$ using Feldman--Cousins corrected intervals, and $\Delta{}m^2_{32}=2.494_{-0.058}^{+0.041}\times10^{-3}~\mathrm{eV^2}$ using constant $\Delta\chi^{2}$ intervals. The CP-violating phase is constrained to $\delta_\mathrm{CP}=-1.97_{-0.70}^{+0.97}$ using Feldman--Cousins corrected intervals, and $\delta_\mathrm{CP}=0,\pi$ is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than $2\sigma$ credible level using a flat prior in $\delta_\mathrm{CP}$, and just below $2\sigma$ using a flat prior in $\sin\delta_\mathrm{CP}$. When the external constraint on $\sin^2\theta_{13}$ is removed, $\sin^2\theta_{13}=28.0^{+2.8}_{-6.5}\times10^{-3}$, in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.

Published
2023
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6. International registry on aortic balloon occlusion in major trauma: Partial inflation does not improve outcomes in abdominal trauma

Author

Sadeghi, M., Pirouzram, A., Toivola, A., Skoog, P., Idoguchi, K., Kon, Y., Ishida, T., Matsumura, Y., Matsumoto, J., Maszkowski, M., Bersztel, A., Caragounis, E.C., Bachmann, T., Falkenberg, M., Handolin, L., Chang, S.W., Hecht, A., Hebron, D., Shaked, G., Bala, M., Coccolini, F., Ansaloni, L., Hoencamp, R., Özlüer, Y.E., Hilbert-Carius, Peter, Reva, V., Oosthuizen, G., Szarka, E., Manchev, V., Wannatoop, T., Ordoñez, C.A., Larzon, T., Nilsson, K.F., Paran, Maya, McGreevy, David, Hörer, Tal M., Khan, Mansoor, Dudkiewicz, Mickey, and Kessel, Boris

Published
2024
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8. Factors Associated with Low Inter-Session Reliability of Conditioned Pain Modulation in Older People with or Without Chronic Musculoskeletal Pain

Author

Uzawa H, Ishii H, Ishida T, Shida T, Furuyama H, and Nishida Y

Subjects
inter-session reliability, conditioned pain modulation, older people, autonomic nervous system, chronic musculoskeletal pain, Medicine (General), R5-920
Abstract

Hironobu Uzawa,1 Hideaki Ishii,1 Takeki Ishida,1 Takashi Shida,2,3 Hiroto Furuyama,4 Yusuke Nishida1 1Department of Physical Therapy, International University of Health and Welfare, Narita, Chiba, Japan; 2Department of Medical Technology and Science, International University of Health and Welfare, Narita, Chiba, Japan; 3Research Team for Promoting Independence and Mental Health, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan; 4Department of Rehabilitation, International University of Health and Welfare Narita Hospital, Narita, Chiba, JapanCorrespondence: Hironobu Uzawa, Department of Physical Therapy, International University of Health and Welfare, 4-3, Kozunomori, Narita, Chiba, 286-8686, Japan, Tel/Fax +81-746-20-7716, Email h.uzawa@iuhw.ac.jpPurpose: Conditioned pain modulation (CPM) is a measurement of the descending pain pathways that inhibit or facilitate afferent noxious stimuli. The reliability of CPM in older individuals with or without chronic musculoskeletal pain has not been sufficiently reported. This study aimed to examine the inter-session reliability of CPM in these cohorts and the factors in CPM reliability.Patients and Methods: Individuals aged 65 or older were recruited in Narita, Japan. The measurements were performed on separate days 2 weeks apart (sessions 1 and 2). Each participant’s hand was immersed in cold water, and we measured pressure pain threshold (PPT) before and after the immersion. The ratio before and after PPT measurements was presented as CPM index. The autonomic activities (heart rate variability, heart rate, and blood pressure) were simultaneously measured. An absolute reliability of CPM index was analyzed by the adjusted two-way analysis of variance (ANOVA) and the Bland Altman plot, and relative reliability was analyzed by intraclass correlation coefficient (ICC). Spearman’s rho correlation and the adjusted multivariate regression analysis were utilized for examining the CPM reliability factors.Results: Thirty-two participants were divided into two groups: chronic pain (n=19) and non-chronic pain (n=13) groups. The mean difference between session 1 and 2 in CPM index showed a systematic error in the chronic pain group at 17.3 (confidence interval, CI: 15.0 to 19.7), but none in the non-chronic pain group at 3.7 (CI: − 0.02 to 7.4). The adjusted two-way ANOVA for CPM index did not identify any differences. ICC was not significant at p=− 0.247 in the non-chronic and 0.167 in chronic pain. Multivariate regression analysis revealed total power and low/high frequencies as significant factors for CPM index.Conclusion: This study identified low inter-session reliability in older adults with chronic musculoskeletal pain and autonomic nervous system activities as factors in CPM reliability.Keywords: inter-session reliability, conditioned pain modulation, older people, autonomic nervous system, chronic musculoskeletal pain

Published
2023

9. Search for solar electron anti-neutrinos due to spin-flavor precession in the Sun with Super-Kamiokande-IV

Author

Abe, K., Bronner, C., Hayato, Y., Ikeda, M., Imaizumi, S., Ito, H., Kameda, J., Kataoka, Y., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakajima, Y., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Yano, T., Akutsu, R., Han, S., Kajita, T., Okumura, K., Tashiro, T., Wang, R., Xia, J., Bravo-Berguño, D., Labarga, L., Marti, Ll., Zaldivar, B., Blaszczyk, F.d.M., Kearns, E., Raaf, J.L., Stone, J.L., Wan, L., Wester, T., Pointon, B.W., Bian, J., Griskevich, N.J., Kropp, W.R., Locke, S., Mine, S., Smy, M.B., Sobel, H.W., Takhistov, V., Weatherly, P., Hill, J., Kim, J.Y., Lim, I.T., Park, R.G., Bodur, B., Scholberg, K., Walter, C.W., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Gonin, M., Mueller, Th.A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J.S., Learned, J.G., Anthony, L.H.V., Sztuc, A.A., Uchida, Y., Berardi, V., Catanesi, M.G., Radicioni, E., Calabria, N.F., Machado, L.N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Ospina, N., Ludovici, L., Nishimura, Y., Cao, S., Friend, M., Hasegawa, T., Ishida, T., Jakkapu, M., Kobayashi, T., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Nakano, Y., Shiozawa, T., Suzuki, A.T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Ichikawa, A.K., Kikawa, T., Mori, M., Nakaya, T., Wendell, R.A., Yasutome, Y., Fernandez, P., McCauley, N., Mehta, P., Pritchard, A., Tsui, K.M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Mijakowski, P., Jung, C.K., Vilela, C., Wilking, M.J., Yanagisawa, C., Harada, M., Hagiwara, K., Horai, T., Ishino, H., Ito, S., Koshio, Y., Ma, W., Piplani, N., Sakai, S., Kuno, Y., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Simpson, C., Wark, D., Nova, F., Boschi, T., Di Lodovico, F., Taani, M., Migenda, J., Sedgwick, S. Molina, Zsoldos, S., Yang, J.Y., Jenkins, S.J., Malek, M., McElwee, J.M., Stone, O., Thiesse, M.D., Thompson, L.F., Okazawa, H., Kim, S.B., Yu, I., Nishijima, K., Koshiba, M., Iwamoto, K., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M.R., Izumiyama, S., Kuze, M., Tanaka, M., Yoshida, T., Inomoto, M., Ishitsuka, M., Matsumoto, R., Ohta, K., Shinoki, M., Martin, J.F., Tanaka, H.A., Towstego, T., Hartz, M., Konaka, A., de Perio, P., Prouse, N.W., Chen, S., Xu, B.D., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sasaki, R., and Posiadala-Zezula, M.

Published
2022
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10. First gadolinium loading to Super-Kamiokande

Author

Abe, K., Bronner, C., Hayato, Y., Hiraide, K., Ikeda, M., Imaizumi, S., Kameda, J., Kanemura, Y., Kataoka, Y., Miki, S., Miura, M., Moriyama, S., Nagao, Y., Nakahata, M., Nakayama, S., Okada, T., Okamoto, K., Orii, A., Pronost, G., Sekiya, H., Shiozawa, M., Sonoda, Y., Suzuki, Y., Takeda, A., Takemoto, Y., Takenaka, A., Tanaka, H., Watanabe, S., Yano, T., Han, S., Kajita, T., Okumura, K., Tashiro, T., Xia, J., Megias, G.D., Bravo-Berguño, D., Labarga, L., Marti, Ll., Zaldivar, B., Pointon, B.W., Blaszczyk, F.d.M., Kearns, E., Raaf, J.L., Stone, J.L., Wan, L., Wester, T., Bian, J., Griskevich, N.J., Kropp, W.R., Locke, S., Mine, S., Smy, M.B., Sobel, H.W., Takhistov, V., Hill, J., Kim, J.Y., Lim, I.T., Park, R.G., Bodur, B., Scholberg, K., Walter, C.W., Bernard, L., Coffani, A., Drapier, O., Hedri, S. El, Giampaolo, A., Gonin, M., Mueller, Th.A., Paganini, P., Quilain, B., Ishizuka, T., Nakamura, T., Jang, J.S., Learned, J.G., Anthony, L.H.V., Martin, D., Scott, M., Sztuc, A.A., Uchida, Y., Cao, S., Berardi, V., Catanesi, M.G., Radicioni, E., Calabria, N.F., Machado, L.N., De Rosa, G., Collazuol, G., Iacob, F., Lamoureux, M., Mattiazzi, M., Ospina, N., Ludovici, L., Maekawa, Y., Nishimura, Y., Friend, M., Hasegawa, T., Ishida, T., Kobayashi, T., Jakkapu, M., Matsubara, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Boschi, T., Gao, J., Di Lodovico, F., Migenda, J., Taani, M., Zsoldos, S., Kotsar, Y., Nakano, Y., Ozaki, H., Shiozawa, T., Suzuki, A.T., Takeuchi, Y., Yamamoto, S., Ali, A., Ashida, Y., Feng, J., Hirota, S., Kikawa, T., Mori, M., Nakaya, T., Wendell, R.A., Yasutome, K., Fernandez, P., McCauley, N., Mehta, P., Tsui, K.M., Fukuda, Y., Itow, Y., Menjo, H., Niwa, T., Sato, K., Tsukada, M., Lagoda, J., Lakshmi, S.M., Mijakowski, P., Zalipska, J., Jiang, J., Jung, C.K., Vilela, C., Wilking, M.J., Yanagisawa, C., Hagiwara, K., Harada, M., Horai, T., Ishino, H., Ito, S., Kitagawa, F., Koshio, Y., Ma, W., Piplani, N., Sakai, S., Barr, G., Barrow, D., Cook, L., Goldsack, A., Samani, S., Wark, D., Nova, F., Yang, J.Y., Jenkins, S.J., Malek, M., McElwee, J.M., Stone, O., Thiesse, M.D., Thompson, L.F., Okazawa, H., Kim, S.B., Seo, J.W., Yu, I., Ichikawa, A.K., Nishijima, K., Koshiba, M., Iwamoto, K., Nakajima, Y., Ogawa, N., Yokoyama, M., Martens, K., Vagins, M.R., Kuze, M., Izumiyama, S., Yoshida, T., Inomoto, M., Ishitsuka, M., Ito, H., Kinoshita, T., Matsumoto, R., Ohta, K., Shinoki, M., Suganuma, T., Martin, J.F., Tanaka, H.A., Towstego, T., Akutsu, R., Hartz, M., Konaka, A., de Perio, P., Prouse, N.W., Chen, S., Xu, B.D., Posiadala-Zezula, M., Hadley, D., O’Flaherty, M., Richards, B., Jamieson, B., Walker, J., Minamino, A., Pintaudi, G., Sano, S., and Sasaki, R.

Published
2022
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14. Phospholipase Cβ3 Expressed in Mouse DRGs is Involved in Inflammatory and Postoperative Pain

Author

Ide S, Kawamata T, Ishida K, Fuseya S, Ishida T, Sugiyama Y, Kawamata M, and Tanaka S

Subjects
phospholipase cβ3, inflammatory pain, postoperative pain, thermal hyperalgesia, mechanical hyperalgesia, Medicine (General), R5-920
Abstract

Susumu Ide,1 Tomoyuki Kawamata,1,2 Kumiko Ishida,1 Satoshi Fuseya,1 Takashi Ishida,1 Yuki Sugiyama,1 Mikito Kawamata,1 Satoshi Tanaka1 1Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 2Department of Anesthesiology, Wakayama Medical University, Wakayama, JapanCorrespondence: Susumu Ide; Satoshi TanakaDepartment of Anesthesiology and Resuscitology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, JapanTel +812-6337-2670Fax +812-6335-2734Email ide@shinshu-u.ac.jp; s_tanaka@shinshu-u.ac.jpBackground: Previous studies suggested that phospholipase Cβ 3 (PLCβ 3), which is a common downstream component in the signaling cascade, plays an important role in peripheral mechanisms of perception including nociception. However, detailed profiles of PLCβ 3-expressing dorsal root ganglion (DRG) neurons and involvement of PLCβ 3 in inflammatory and postoperative pain have not been fully investigated.Purpose: We evaluated neurochemical char0acteristics of PLCβ 3-expressing DRG neurons in mice and then we examined the effects of selective knockdown of PLCβ 3 expression in DRGs on inflammatory and postoperative pain.Methods: Male C57BL/6-strain mice were used. For the inflammatory model, each mouse received subcutaneous injection of complete Freund’s adjuvant (CFA) in the left hindpaw. For the postoperative pain model, a plantar incision was made in the left hindpaw. PLCβ 3 antisense oligodeoxynucleotide or PLCβ 3 mismatch oligodeoxynucleotide was intrathecally administered once a day for three consecutive days in each model. The time courses of thermal hyperalgesia and mechanical hyperalgesia were investigated. Changes in PLCβ 3 protein levels in DRGs were evaluated by Western blotting.Results: Immunohistochemical analysis showed that high proportion of the PLCβ 3-positive profiles were biotinylated isolectin B4-positive or transient receptor potential vanilloid subfamily 1-positive. PLCβ 3 protein level in DRGs during CFA-induced inflammation was comparable to that at baseline. Intrathecal administration of PLCβ 3 antisense oligodeoxynucleotide, which significantly suppressed PLCβ 3 expression in DRGs, did not affect pain thresholds in normal conditions but inhibited CFA-induced thermal and mechanical hyperalgesia both at the early and late phases compared to that in mismatch oligodeoxynucleotide-treated mice. Intrathecal administration of PLCβ 3 antisense oligodeoxynucleotide also inhibited surgical incision-induced thermal and mechanical hyperalgesia.Conclusion: Our results uncover a unique role of PLCβ 3 in the development and maintenance of inflammatory pain induced by CFA application and in those of surgical incision-induced pain, although PLCβ 3 does not play a major role in thermal nociception or mechanical nociception in normal conditions.Keywords: phospholipase Cβ 3, inflammatory pain, postoperative pain, thermal hyperalgesia, mechanical hyperalgesia

Published
2020

15. Measurements of the T2K neutrino beam properties using the INGRID on-axis near detector

Author

Abe, K., Abgrall, N., Ajima, Y., Aihara, H., Albert, J. B., Andreopoulos, C., Andrieu, B., Anerella, M. D., Aoki, S., Araoka, O., Argyriades, J., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Badertscher, A., Barbi, M., Barker, G. J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S., Berardi, V., Berger, B. E., Bertram, I., Besnier, M., Beucher, J., Beznosko, D., Bhadra, S., Blaszczyk, F. d. M., Blocki, J., Blondel, A., Bojechko, C., Bouchez, J., Boyd, S. B., Bravar, A., Bronner, C., Brook-Roberge, D. G., Buchanan, N., Budd, H., Calvet, D., Cartwright, S. L., Carver, A., Castillo, R., Catanesi, M. G., Cazes, A., Cervera, A., Chavez, C., Choi, S., Christodoulou, G., Coleman, J., Collazuol, G., Coleman, W., Connolly, K., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davies, G. S., Davis, S., Day, M., De Rosa, G., de André, J. P. A. M., de Perio, P., Dealtry, T., Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Tran, P. Dinh, Dobson, J., Dore, U., Drapier, O., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Dziomba, M., Emery, S., Ereditato, A., Escallier, J. E., Escudero, L., Esposito, L. S., Fechner, M., Ferrero, A., Finch, A. J., Frank, E., Fujii, Y., Fukuda, Y., Galymov, V., Ganetis, G. L., Gannaway, F. C., Gaudin, A., Gendotti, A., George, M., Giffin, S., Giganti, C., Gilje, K., Ghosh, A. K., Golan, T., Goldhaber, M., Gomez-Cadenas, J. J., Gomi, S., Gonin, M., Grant, N., Grant, A., Gumplinger, P., Guzowski, P., Haesler, A., Haigh, M. D., Hamano, K., Hansen, C., Hansen, D., Hara, T., Harrison, P. F., Hartfiel, B., Hartz, M., Haruyama, T., Hasegawa, T., Hastings, N. C., Hatzikoutelis, A., Hayashi, K., Hayato, Y., Hearty, C., Helmer, R. L., Henderson, R., Higashi, N., Hignight, J., Hillairet, A., Hirose, E., Holeczek, J., Horikawa, S., Hyndman, A., Ichikawa, A. K., Ieki, K., Ieva, M., Iida, M., Ikeda, M., Ilic, J., Imber, J., Ishida, T., Ishihara, C., Ishii, T., Ives, S. J., Iwasaki, M., Iyogi, K., Izmaylov, A., Jamieson, B., Johnson, R. A., Joo, K. K., Jover-Manas, G. V., Jung, C. K., Kaji, H., Kajita, T., Kakuno, H., Kameda, J., Kaneyuki, K., Karlen, D., Kasami, K., Kato, I., Kawamuko, H., Kearns, E., Khabibullin, M., Khanam, F., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kim, J., Kim, J. Y., Kim, S. B., Kimura, N., Kirby, B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Koike, S., Konaka, A., Kormos, L. L., Korzenev, A., Koseki, K., Koshio, Y., Kouzuma, Y., Kowalik, K., Kravtsov, V., Kreslo, I., Kropp, W., Kubo, H., Kubota, J., Kudenko, Y., Kulkarni, N., Kurimoto, Y., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lee, K. P., Le, P. T., Levy, J. M., Licciardi, C., Lim, I. T., Lindner, T., Litchfield, R. P., Litos, M., Longhin, A., Lopez, G. D., Loverre, P. F., Ludovici, L., Lux, T., Macaire, M., Mahn, K., Makida, Y., Malek, M., Manly, S., Marchionni, A., Marino, A. D., Marone, A. J., Marteau, J., Martin, J. F., Maruyama, T., Maryon, T., Marzec, J., Masliah, P., Mathie, E. L., Matsumura, C., Matsuoka, K., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K. S., McGrew, C., McLachlan, T., Messina, M., Metcalf, W., Metelko, C., Mezzetto, M., Mijakowski, P., Miller, C. A., Minamino, A., Mineev, O., Mine, S., Missert, A. D., Mituka, G., Miura, M., Mizouchi, K., Monfregola, L., Moreau, F., Morgan, B., Moriyama, S., Muir, A., Murakami, A., Muratore, J. F., Murdoch, M., Murphy, S., Myslik, J., Nagai, N., Nakadaira, T., Nakahata, M., Nakai, T., Nakajima, K., Nakamoto, T., Nakamura, K., Nakayama, S., Nakaya, T., Naples, D., Navin, M. L., Nelson, B., Nicholls, T. C., Nielsen, C., Nishikawa, K., Nishino, H., Nitta, K., Nobuhara, T., Nowak, J. A., Obayashi, Y., Ogitsu, T., Ohhata, H., Okamura, T., Okumura, K., Okusawa, T., Oser, S. M., Otani, M., Owen, R. A., Oyama, Y., Ozaki, T., Pac, M. Y., Palladino, V., Paolone, V., Paul, P., Payne, D., Pearce, G. F., Perkin, J. D., Pettinacci, V., Pierre, F., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J. -M., Poutissou, R., Przewlocki, P., Qian, W., Raaf, J. L., Radicioni, E., Ratoff, P. N., Raufer, T. M., Ravonel, M., Raymond, M., Retiere, F., Robert, A., Rodrigues, P. A., Rondio, E., Roney, J. M., Rossi, B., Roth, S., Rubbia, A., Ruterbories, D., Sabouri, S., Sacco, R., Sakashita, K., Sánchez, F., Sarrat, A., Sasaki, K., Scholberg, K., Schwehr, J., Scott, M., Scully, D. I., Seiya, Y., Sekiguchi, T., Sekiya, H., Shibata, M., Shimizu, Y., Shiozawa, M., Short, S., Siyad, M., Smith, R. J., Smy, M., Sobczyk, J. T., Sobel, H., Sorel, M., Stahl, A., Stamoulis, P., Steinmann, J., Still, B., Stone, J., Stodulski, M., Strabel, C., Sulej, R., Suzuki, A., Suzuki, K., Suzuki, S., Suzuki, S. Y., Suzuki, Y., Swierblewski, J., Szeglowski, T., Szeptycka, M., Tacik, R., Tada, M., Taguchi, M., Takahashi, S., Takeda, A., Takenaga, Y., Takeuchi, Y., Tanaka, K., Tanaka, H. A., Tanaka, M., Tanaka, M. M., Tanimoto, N., Tashiro, K., Taylor, I., Terashima, A., Terhorst, D., Terri, R., Thompson, L. F., Thorley, A., Toki, W., Tobayama, S., Tomaru, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Walding, J. J., Waldron, A. V., Walter, C. W., Wanderer, P. J., Wang, J., Ward, M. A., Ward, G. P., Wark, D., Wascko, M. O., Weber, A., Wendell, R., West, N., Whitehead, L. H., Wikström, G., Wilkes, R. J., Wilking, M. J., Williamson, Z., Wilson, J. R., Wilson, R. J., Wongjirad, T., Yamada, S., Yamada, Y., Yamamoto, A., Yamamoto, K., Yamanoi, Y., Yamaoka, H., Yamauchi, T., Yanagisawa, C., Yano, T., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zmuda, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

Precise measurement of neutrino beam direction and intensity was achieved based on a new concept with modularized neutrino detectors. INGRID (Interactive Neutrino GRID) is an on-axis near detector for the T2K long baseline neutrino oscillation experiment. INGRID consists of 16 identical modules arranged in horizontal and vertical arrays around the beam center. The module has a sandwich structure of iron target plates and scintillator trackers. INGRID directly monitors the muon neutrino beam profile center and intensity using the number of observed neutrino events in each module. The neutrino beam direction is measured with accuracy better than 0.4 mrad from the measured profile center. The normalized event rate is measured with 4% precision., Comment: 32 pages, 27 figures, submitted to Nucl. Instr. and Meth. A

Published
2011
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18. Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

Author

Mészáros T, Kozma GT, Shimizu T, Miyahara K, Turjeman K, Ishida T, Barenholz Y, Urbanics R, and Szebeni J

Subjects
adverse drug reactions, immunotoxicity, nanoparticles, pseudoallergy, anaphylatoxins, PIM cells, phagocytosis, Medicine (General), R5-920
Abstract

Tamás Mészáros,1,2,* Gergely Tibor Kozma,2,* Taro Shimizu,3 Koga Miyahara,3 Keren Turjeman,4 Tatsuhiro Ishida,3 Yechezkel Barenholz,4 Rudolf Urbanics,1,2 János Szebeni1,2,5 1Nanomedicine Research and Education Center, Department of Pathophysiology, Semmelweis University, Budapest, Hungary; 2SeroScience Ltd, Budapest, Hungary; 3Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan; 4Laboratory of Membrane and Liposome Research, Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel; 5Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary *These authors contributed equally to this work Background: It has been proposed that many hypersensitivity reactions to nanopharmaceuticals represent complement (C)-activation-related pseudoallergy (CARPA), and that pigs provide a sensitive animal model to study the phenomenon. However, a recent study suggested that pulmonary hypertension, the pivotal symptom of porcine CARPA, is not mediated by C in cases of polystyrene nanoparticle (PS-NP)-induced reactions.Goals: To characterize PS-NPs and reexamine the contribution of CARPA to their pulmonary reactivity in pigs.Study design: C activation by 200, 500, and 750 nm (diameter) PS-NPs and their opsonization were measured in human and pig sera, respectively, and correlated with hemodynamic effects of the same NPs in pigs in vivo.Methods: Physicochemical characterization of PS-NPs included size, ζ-potential, cryo-transmission electron microscopy, and hydrophobicity analyses. C activation in human serum was measured by ELISA and opsonization of PS-NPs in pig serum by Western blot and flow cytometry. Pulmonary vasoactivity of PS-NPs was quantified in the porcine CARPA model.Results: PS-NPs are monodisperse, highly hydrophobic spheres with strong negative surface charge. In human serum, they caused size-dependent, significant rises in C3a, Bb, and sC5b-9, but not C4d. Exposure to pig serum led within minutes to deposition of C5b-9 and opsonic iC3b on the NPs, and opsonic iC3b fragments (C3dg, C3d) also appeared in serum. PS-NPs caused major hemodynamic changes in pigs, primarily pulmonary hypertension, on the same time scale (minutes) as iC3b fragmentation and opsonization proceeded. There was significant correlation between C activation by different PS-NPs in human serum and pulmonary hypertension in pigs.Conclusion: PS-NPs have extreme surface properties with no relevance to clinically used nanomedicines. They can activate C via the alternative pathway, entailing instantaneous opsonization of NPs in pig serum. Therefore, rather than being solely C-independent reactivity, the mechanism of PS-NP-induced hypersensitivity in pigs may involve C activation. These data are consistent with the “double-hit” concept of nanoparticle-induced hypersensitivity reactions involving both CARPA and C-independent pseudoallergy. Keywords: adverse drug reactions, immunotoxicity, nanoparticles, pseudoallergy, anaphylatoxins, PIM cells, phagocytosis

Published
2018

19. Plasma ropivacaine concentration after TAP block in a patient with cardiac and renal failure

Author

Ishida T, Tanaka S, Sakamoto A, Hirabayashi T, and Kawamata M

Subjects
Transversus abdominis plane block, plasma concentration of ropivacaine, cardiac and renal failure, central nervous toxicity, Anesthesiology, RD78.3-87.3
Abstract

Takashi Ishida, Satoshi Tanaka, Akiyuki Sakamoto, Takanobu Hirabayashi, Mikito Kawamata Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan Abstract: We report a successful ultrasound-guided transversus abdominis plane (TAP) block as an analgesic option for minor abdominal surgery in a 66-year-old patient with cardiac, respiratory, and renal dysfunction caused by primary systemic amyloidosis. Bilateral TAP blocks with 120 mg (1.8 mg/kg) of ropivacaine provided sufficient intra- and postoperative analgesia for insertion of a continuous ambulatory peritoneal dialysis catheter. However, the plasma concentration of ropivacaine reached a maximum of 2.5 µg/mL at 15 minutes after the TAP block, a concentration that was potentially neurotoxic. Although apparent signs of local anesthetic systemic toxicity (LAST) such as convulsion or changes in an electrocardiogram were not observed, the patient became drowsy after the TAP block, which might be one of the mild symptoms of LAST. A TAP block by itself can thus be an anesthetic option for patients undergoing minor abdominal surgery. However, cardiac and renal dysfunction might influence the pharmacokinetics of a local anesthetic used, and attention should be paid to the possibility of LAST even with a low dose of a local anesthetic for patients with cardiac and renal failure. Keywords: transversus abdominis plane block, plasma concentration of ropivacaine, cardiac failure, renal dysfunction, central nervous toxicity

Published
2018

21. Tumor immune microenvironment and nivolumab efficacy in EGFR mutation-positive non-small-cell lung cancer based on T790M status after disease progression during EGFR-TKI treatment

Author

Haratani, K., Hayashi, H., Tanaka, T., Kaneda, H., Togashi, Y., Sakai, K., Hayashi, K., Tomida, S., Chiba, Y., Yonesaka, K., Nonagase, Y., Takahama, T., Tanizaki, J., Tanaka, K., Yoshida, T., Tanimura, K., Takeda, M., Yoshioka, H., Ishida, T., Mitsudomi, T., Nishio, K., and Nakagawa, K.

Published
2017
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24. The FOREST detector for meson photoproduction experiments at ELPH

Author

Ishikawa, T., Fujimura, H., Fukasawa, H., Hashimoto, R., Ishida, T., Kaida, S., Kasagi, J., Kawano, A., Kuwasaki, S., Maeda, K., Miyahara, F., Mochizuki, K., Nakabayashi, T., Nakamura, A., Nawa, K., Ogushi, S., Okada, Y., Okamura, K., Onodera, Y., Saito, Y., Sakamoto, Y., Sato, M., Shimizu, H., Sugai, H., Suzuki, K., Takahashi, S., Tsuchikawa, Y., Yamazaki, H., and Yonemura, H.

Published
2016
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25. Real-time supernova neutrino burst monitor at Super-Kamiokande

Author

Abe, K., Haga, Y., Hayato, Y., Ikeda, M., Iyogi, K., Kameda, J., Kishimoto, Y., Miura, M., Moriyama, S., Nakahata, M., Nakano, Y., Nakayama, S., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Tanaka, H., Tomura, T., Ueno, K., Wendell, R.A., Yokozawa, T., Irvine, T., Kajita, T., Kametani, I., Kaneyuki, K., Lee, K.P., McLachlan, T., Nishimura, Y., Richard, E., Okumura, K., Labarga, L., Fernandez, P., Berkman, S., Tanaka, H.A., Tobayama, S., Gustafson, J., Kearns, E., Raaf, J.L., Stone, J.L., Sulak, L.R., Goldhaber, M., Carminati, G., Kropp, W.R., Mine, S., Weatherly, P., Renshaw, A., Smy, M.B., Sobel, H.W., Takhistov, V., Ganezer, K.S., Hartfiel, B.L., Hill, J., Keig, W.E., Hong, N., Kim, J.Y., Lim, I.T., Akiri, T., Himmel, A., Scholberg, K., Walter, C.W., Wongjirad, T., Ishizuka, T., Tasaka, S., Jang, J.S., Learned, J.G., Matsuno, S., Smith, S.N., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A.T., Takeuchi, Y., Bronner, C., Hirota, S., Huang, K., Ieki, K., Kikawa, T., Minamino, A., Murakami, A., Nakaya, T., Suzuki, K., Takahashi, S., Tateishi, K., Fukuda, Y., Choi, K., Itow, Y., Mitsuka, G., Mijakowski, P., Hignight, J., Imber, J., Jung, C.K., Yanagisawa, C., Wilking, M.J., Ishino, H., Kibayashi, A., Koshio, Y., Mori, T., Sakuda, M., Yamaguchi, R., Yano, T., Kuno, Y., Tacik, R., Kim, S.B., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Suda, Y., Totsuka, Y., Yokoyama, M., Martens, K., Marti, Ll., Vagins, M.R., Martin, J.F., de Perio, P., Konaka, A., Chen, S., Zhang, Y., Connolly, K., and Wilkes, R.J.

Published
2016
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27. A fast profile monitor with scintillating fiber hodoscopes for high-intensity photon beams

Author

Ishikawa, T., Fujimura, H., Hamano, H., Hashimoto, R., Honda, Y., Ishida, T., Kaida, S., Kanda, H., Kido, S., Matsumura, Y., Miyabe, M., Mizutani, K., Nagasawa, I., Nakamura, A., Nanbu, K., Nawa, K., Ogushi, S., Shibasaki, Y., Shimizu, H., Sugai, H., Suzuki, K., Takahashi, K., Takahashi, S., Taniguchi, Y., Tokiyasu, A.O., Tsuchikawa, Y., and Yamazaki, H.

Published
2016
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28. Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing

Author

Doi Y, Abu Lila AS, Matsumoto H, Okada T, Shimizu T, and Ishida T

Subjects
tumor microenvironment, metronomic chemotherapy, S-1, liposome, nanocarrier, EPR effect, Medicine (General), R5-920
Abstract

Yusuke Doi,1 Amr S Abu Lila,1–3 Haruna Matsumoto,1 Tomoko Okada,1 Taro Shimizu,1 Tatsuhiro Ishida1 1Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt; 3Department of Pharmaceutics, Faculty of Pharmacy, Hail University, Hail, Saudi Arabia Abstract: The efficient delivery of nanocarrier-based cancer therapeutics into tumor tissue is problematic. Structural abnormalities, tumor vasculature heterogeneity, and elevated intratumor pressure impose barriers against the preferential accumulation of nanocarrier-based cancer therapeutics within tumor tissues and, consequently, compromise their therapeutic efficacy. Recently, we have reported that metronomic S-1, orally available tegafur formulation, dosing synergistically augmented the therapeutic efficacy of oxaliplatin (l-OHP)-containing PEGylated liposome without increasing the toxicity in animal model. However, the exact mechanism behind such synergistic effect was not fully elucidated. In this study, therefore, we tried to shed the light on the contributions of metronomic S-1 dosing to the enhanced accumulation and/or spatial distribution of PEGylated liposome within tumor tissue. Tumor priming with metronomic S-1 treatment induced a potent apoptotic response against both angiogenic endothelial cells and tumor cells adjacent to tumor blood vessels, resulting in enhanced tumor blood flow via transient normalization of tumor vasculature, along with alleviation of intratumor pressure. Such a change in the tumor microenvironment imparted by S-1 treatment allows efficient delivery of PEGylated liposome to tumor tissue and permits their deep penetration/distribution into the tumor mass. Such a priming effect of S-1 dosing can be exploited as a promising strategy to enhance the therapeutic efficacy of nanocarrier-based cancer therapeutics suffering from inadequate/heterogeneous delivery to tumor tissues. Keywords: tumor microenvironment, metronomic chemotherapy, S-1, liposome, nanocarrier, EPR effect

Published
2016

29. Safety and effectiveness of daily teriparatide in a prospective observational study in patients with osteoporosis at high risk of fracture in Japan: final report

Author

Nishikawa A, Ishida T, Taketsuna M, Yoshiki F, and Enomoto H

Subjects
Keywords Parathyroid Hormone, Bone Biomarkers, Bone Mineral Density, Quality of Life, Safety, Geriatrics, RC952-954.6
Abstract

Atsushi Nishikawa,1 Takehiro Ishida,2 Masanori Taketsuna,3 Fumito Yoshiki,4 Hiroyuki Enomoto4 1Global Patient Safety Japan, Quality and Patient Safety, 2Clinical Development Operations and Innovations, Medicine Development Unit Japan, 3Asia Pacific Statistical Sciences, Medicine Development Unit Japan, 4Medical Sciences, Medicines Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan Abstract: This postmarketing surveillance study assessed the safety and effectiveness of teriparatide in patients with osteoporosis at high risk of fracture in Japan. The patients received teriparatide 20 µg daily by subcutaneous injection, for a maximum of 24 months. Safety and effectiveness analyses were based on data from 1,847 patients who were predominantly female (92.6%) with a mean age of 75.4 years. A total of 157 adverse drug reactions (ADRs) were reported in 140 (7.58%) patients; the most common ADRs were hyperuricemia, nausea, and dizziness. Only six (0.32%) patients reported serious ADRs, the most common being nausea (two patients; 0.1%). Persistence with teriparatide treatment was 60.8% and 39.1% at 18 and 24 months, respectively. There were significant increases in biomarkers for bone formation (procollagen type I N-terminal propeptide and bone-specific alkaline phosphatase) and bone resorption (collagen type I cross-linked C telopeptide and tartrate-resistant acid phosphatase 5b) throughout the study. These were accompanied by significant increases in bone mineral density and low incidences of new vertebral and nonvertebral fractures. Patient-reported measurements for health-related quality of life revealed significant improvements from baseline in back pain and overall health-related quality of life (Short Form-8™ health survey). The results of this 24-month postmarketing surveillance study imply that teriparatide has a favorable safety profile and is effective in the treatment of patients with osteoporosis at high risk of fracture in Japan. Teriparatide may also be a useful treatment for osteoporosis in other societies with aging populations. Keywords: parathyroid hormone, bone biomarkers, bone mineral density, quality of life, safety

Published
2016

30. Development and operational experience of magnetic horn system for T2K experiment

Author

Sekiguchi, T., Bessho, K., Fujii, Y., Hagiwara, M., Hasegawa, T., Hayashi, K., Ishida, T., Ishii, T., Kobayashi, H., Kobayashi, T., Koike, S., Koseki, K., Maruyama, T., Matsumoto, H., Nakadaira, T., Nakamura, K., Nakayoshi, K., Nishikawa, K., Oyama, Y., Sakashita, K., Shibata, M., Suzuki, Y., Tada, M., Takahashi, K., Tsukamoto, T., Yamada, Y., Yamanoi, Y., Yamaoka, H., Ichikawa, A.K., Kubo, H., Butcher, Z., Coleman, S., Missert, A., Spitz, J., Zimmerman, E.D., Tzanov, M., and Bartoszek, L.

Published
2015
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34. Supernova Relic Neutrino search with neutron tagging at Super-Kamiokande-IV

Author

Zhang, H., Abe, K., Hayato, Y., Iyogi, K., Kameda, J., Kishimoto, Y., Miura, M., Moriyama, S., Nakahata, M., Nakano, Y., Nakayama, S., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Tomura, T., Ueno, K., Yokozawa, T., Wendell, R.A., Kaji, H., Kajita, T., Kaneyuki, K., Lee, K.P., Nishimura, Y., Okumura, K., McLachlan, T., Labarga, L., Barkman, S., Tanaka, T.S., Tobayama, S., Kearns, E., Raaf, J.L., Stone, J.L., Sulak, L.R., Goldhaber, M., Bays, K., Carminati, G., Kropp, W.R., Mine, S., Renshaw, A., Smy, M.B., Sobel, H.W., Ganezer, K.S., Hill, J., Keig, W.E., Jang, J.S., Kim, J.Y., Lim, I.T., Akiri, T., Scholberg, K., Walter, C.W., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J.G., Matsuno, S., Smith, S.N., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A.T., Takeuchi, Y., Ieki, K., Ikeda, M., Kikawa, H., Huang, K., Minamino, A., Murakami, A., Nakaya, T., Suzuki, K., Takahashi, S., Fukuda, Y., Choi, K., Itow, Y., Mitsuka, G., Mijakowski, P., Hignight, J., Imber, J., Jung, C.K., Taylor, I., Yanagisawa, C., Ishino, H., Kibayashi, A., Koshio, Y., Mori, T., Sakuda, M., Yamaguchi, R., Yano, T., Kuno, Y., Tacik, R., Kim, S.B., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Totsuka, Y., Yokoyama, M., Martens, K., Marti, Ll., Vagins, M.R., Martin, J.F., dePerio, P., Konaka, A., Wilking, M.J., Chen, S., Sui, H., Yang, Z., Zhang, Y., Connolly, K., Dziomba, M., and Wilkes, R.J.

Published
2015
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35. Perioperative management of hemophilia patients receiving total hip and knee arthroplasty: a complication report of two cases

Author

Tateiwa T, Takahashi Y, Ishida T, Kubo K, Masaoka T, Shishido T, Sano K, and Yamamoto K

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Toshiyuki Tateiwa,1 Yasuhito Takahashi,1,2 Tsunehito Ishida,1 Kosuke Kubo,1 Toshinori Masaoka,1 Takaaki Shishido,1 Keiji Sano,1 Kengo Yamamoto11Department of Orthopedic Surgery, 2Department of Bone and Joint Biomaterial Research, Tokyo Medical University, Tokyo, JapanAbstract: It has been recognized that perioperative hemostasis management after joint-replacement surgery for hemophilia patients is complicated and cumbersome, due to the necessity of rigorous monitoring for clotting-factor levels throughout the infusion. Between 2005 and 2014, we examined seven patients with hemophilia A (ten joints: six hips and four knees) receiving total hip or knee arthroplasty (THA or TKA) for hemophilic arthropathy. One male patient (31 years old) showed an intra-articular hematoma formation after THA (case 1). In another male patient (46 years old) receiving TKA, the postoperative trough factor VIII level became lower significantly than reference levels (80%–100% for the 5–10 postoperative days) recommended by the guidelines from the Japanese Society on Thrombosis and Hemostasis, despite sufficient coagulant based on the guidelines being administered (case 2). In the latter patient, deep infection and hematoma formation were observed postoperatively. In this article, we provide a detailed clinical report regarding these two complication cases at the early postoperative periods, and the management of bleeding control for hemophilia patients is discussed.Keywords: hemophilia A, arthroplasty, clotting factor VIII levels, hematoma, infection

Published
2015

40. Calibration of the Super-Kamiokande detector

Author

Abe, K., Hayato, Y., Iida, T., Iyogi, K., Kameda, J., Kishimoto, Y., Koshio, Y., Marti, Ll., Miura, M., Moriyama, S., Nakahata, M., Nakano, Y., Nakayama, S., Obayashi, Y., Sekiya, H., Shiozawa, M., Suzuki, Y., Takeda, A., Takenaga, Y., Tanaka, H., Tomura, T., Ueno, K., Wendell, R.A., Yokozawa, T., Irvine, T.J., Kaji, H., Kajita, T., Kaneyuki, K., Lee, K.P., Nishimura, Y., Okumura, K., McLachlan, T., Labarga, L., Kearns, E., Raaf, J.L., Stone, J.L., Sulak, L.R., Berkman, S., Tanaka, H.A., Tobayama, S., Goldhaber, M., Bays, K., Carminati, G., Kropp, W.R., Mine, S., Renshaw, A., Smy, M.B., Sobel, H.W., Ganezer, K.S., Hill, J., Keig, W.E., Jang, J.S., Kim, J.Y., Lim, I.T., Hong, N., Akiri, T., Albert, J.B., Himmel, A., Scholberg, K., Walter, C.W., Wongjirad, T., Ishizuka, T., Tasaka, S., Learned, J.G., Matsuno, S., Smith, S.N., Hasegawa, T., Ishida, T., Ishii, T., Kobayashi, T., Nakadaira, T., Nakamura, K., Nishikawa, K., Oyama, Y., Sakashita, K., Sekiguchi, T., Tsukamoto, T., Suzuki, A.T., Takeuchi, Y., Huang, K., Ieki, K., Ikeda, M., Kikawa, T., Kubo, H., Minamino, A., Murakami, A., Nakaya, T., Otani, M., Suzuki, K., Takahashi, S., Fukuda, Y., Choi, K., Itow, Y., Mitsuka, G., Miyake, M., Mijakowski, P., Tacik, R., Hignight, J., Imber, J., Jung, C.K., Taylor, I., Yanagisawa, C., Idehara, Y., Ishino, H., Kibayashi, A., Mori, T., Sakuda, M., Yamaguchi, R., Yano, T., Kuno, Y., Kim, S.B., Yang, B.S., Okazawa, H., Choi, Y., Nishijima, K., Koshiba, M., Totsuka, Y., Yokoyama, M., Martens, K., Vagins, M.R., Martin, J.F., de Perio, P., Konaka, A., Wilking, M.J., Chen, S., Heng, Y., Sui, H., Yang, Z., Zhang, H., Zhenwei, Y., Connolly, K., Dziomba, M., and Wilkes, R.J.

Published
2014
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42. Recent Results from the T2K Experiment

Author

Abe, K., Abgrall, N., Aihara, H., Akiri, T., Andreopoulos, C., Aoki, S., Ariga, A., Ariga, T., Assylbekov, S., Autiero, D., Barbi, M., Barker, G.J., Barr, G., Bass, M., Batkiewicz, M., Bay, F., Bentham, S.W., Berardi, V., Berger, B.E., Berkman, S., Bertram, I., Bhadra, S., Blaszczyk, F.D.M., Blondel, A., Bojechko, C., Boyd, S.B., Brailsford, D., Bravar, A., Bronner, C., Buchanan, N., Calland, R.G., Caravaca Rodríguez, J., Cartwright, S.L., Castillo, R., Catanesi, M.G., Cervera, A., Cherdack, D., Christodoulou, G., Clifton, A., Coleman, J., Coleman, S.J., Collazuol, G., Connolly, K., Cremonesi, L., Curioni, A., Dabrowska, A., Danko, I., Das, R., Davis, S., de Perio, P., De Rosa, G., Dealtry, T., Dennis, S.R., Densham, C., Di Lodovico, F., Di Luise, S., Drapier, O., Duboyski, T., Dufour, F., Dumarchez, J., Dytman, S., Dziewiecki, M., Emery, S., Ereditato, A., Escudero, L., Finch, A.J., Frank, E., Friend, M., Fujii, Y., Fukuda, Y., Furmanski, A.P., Galymov, V., Gaudin, A., Giffin, S., Giganti, C., Gilje, K., Golan, T., Gomez-Cadenas, J.J., Gonin, M., Grant, N., Gudin, D., Hadley, D.R., Haesler, A., Haigh, M.D., Hamilton, P., Hansen, D., Hara, T., Hartz, M., Hasegawa, T., Hastings, N.C., Hayato, Y., Hearty, C., Helmer, R.L., Hierholzer, M., Hignight, J., Hillairet, A., Himmel, A., Hiraki, T., Hirota, S., Holeczek, J., Horikawa, S., Huang, K., Ichikawa, A.K., Ieki, K., Ieva, M., Ikeda, M., Imber, J., Insler, J., Irvine, T.J., Ishida, T., Ishii, T., Ives, S.J., Iyogi, K., Izmaylov, A., Jacob, A., Jamieson, B., Johnson, R.A., Jo, J.H., Jonsson, P., Joo, K.K., Jung, C.K., Kaboth, A.C., Kajita, T., Kakuno, H., Kameda, J., Kanazawa, Y., Karlen, D., Karpikov, I., Kearns, E., Khabibullin, M., Khotjantsev, A., Kielczewska, D., Kikawa, T., Kilinski, A., Kim, J., Kim, S.B., Kisiel, J., Kitching, P., Kobayashi, T., Kogan, G., Kolaceke, A., Konaka, A., Kormos, L.L., Korzenev, A., Koseki, K., Koshio, Y., Kreslo, I., Kropp, W., Kubo, H., Kudenko, Y., Kumaratunga, S., Kurjata, R., Kutter, T., Lagoda, J., Laihem, K., Laveder, M., Lawe, M., Lazos, M., Lee, K.P., Licciardi, C., Lim, I.T., Lindner, T., Lister, C., Litchfield, R.P., Longhin, A., Lopez, G.D., Ludovici, L., Macaire, M., Magaletti, L., Mahn, K., Malek, M., Manly, S., Marino, A.D., Marteau, J., Martin, J.F., Maruyama, T., Marzec, J., Masliah, P., Mathie, E.L., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., McFarland, K.S., McGrew, C., Metelko, C., Mijakowski, P., Miller, C.A., Minamino, A., Mineev, O., Mine, S., Missert, A., Miura, M., Monfregola, L., Moriyama, S., Mueller, Th.A., Murakami, A., Murdoch, M., Murphy, S., Myslik, J., Nagasaki, T., Nakadaira, T., Nakahata, M., Nakai, T., Nakamura, K., Nakayama, S., Nakaya, T., Nakayoshi, K., Nielsen, C., Nirkko, M., Nishikawa, K., Nishimura, Y., OʼKeeffe, H.M., Ohta, R., Okumura, K., Okusawa, T., Oryszczak, W., Oser, S.M., Otani, M., Owen, R.A., Oyama, Y., Pac, M.Y., Palladino, V., Paolone, V., Payne, D., Pearce, G.F., Perevozchikov, O., Perkin, J.D., Petrov, Y., Pinzon Guerra, E.S., Pistillo, C., Plonski, P., Poplawska, E., Popov, B., Posiadala, M., Poutissou, J.-M., Poutissou, R., Przewlocki, P., Quilain, B., Radicioni, E., Ratoff, P.N., Ravonel, M., Rayner, M.A.M., Redij, A., Reeves, M., Reinherz-Aronis, E., Retiere, F., Robert, A., Rodrigues, P.A., Rondio, E., Roth, S., Rubbia, A., Ruterbories, D., Sacco, R., Sakashita, K., Sánchez, F., Scantamburlo, E., Scholberg, K., Schwehr, J., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shiozawa, M., Short, S., Shustrov, Y., Sinclair, P., Smith, B., Smith, R.J., Smy, M., Sobczyk, J.T., Sobel, H., Sorel, M., Southwell, L., Stamoulis, P., Steinmann, J., Still, B., Suda, Y., Suzuki, A., Suzuki, K., Suzuki, S.Y., Suzuki, Y., Szeglowski, T., Tacik, R., Tada, M., Takahashi, S., Takeda, A., Takeuchi, Y., Tanaka, H.A., Tanaka, M.M., Taylor, I.J., Terhorst, D., Terri, R., Thompson, L.F., Thorley, A., Tobayama, S., Toki, W., Tomura, T., Totsuka, Y., Touramanis, C., Tsukamoto, T., Tzanov, M., Uchida, Y., Ueno, K., Vacheret, A., Vagins, M., Vasseur, G., Wachala, T., Waldron, A.V., Walter, C.W., Wark, D., Wascko, M.O., Weber, A., Wendell, R., Wilkes, R.J., Wilking, M.J., Wilkinson, C., Williamson, Z., Wilson, J.R., Wilson, R.J., Wongjirad, T., Yamada, Y., Yamamoto, K., Yanagisawa, C., Yen, S., Yershov, N., Yokoyama, M., Yuan, T., Zalewska, A., Zalipska, J., Zambelli, L., Zaremba, K., Ziembicki, M., Zimmerman, E.D., Zito, M., and Żmuda, J.

Published
2014
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45. Significance of measurement of serum trough level and anti‐drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohnʼs disease: a subanalysis of the DIAMOND trial

Author

Nakase, H., Motoya, S., Matsumoto, T., Watanabe, K., Hisamatsu, T., Yoshimura, N., Ishida, T., Kato, S., Nakagawa, T., Esaki, M., Nagahori, M., Matsui, T., Naito, Y., Kanai, T., Suzuki, Y., Nojima, M., Watanabe, M., Hibi, T., Andoh, Akira, Ashida, Toshifumi, Endo, Katsuya, Endo, Yutaka, Esaki, Motohiro, Fujita, Hiroshi, Fujiya, Mikihiro, Haruma, Ken, Hibi, Toshifumi, Hiraoka, Sakiko, Hirata, Ichiro, Hisamatsu, Tadakazu, Honda, Yutaka, Iijima, Hideki, Iizuka, Bunei, Ikeya, Kentaro, Inoue, Takuya, Inoue, Shuji, Ishida, Tetsuya, Ishiguro, Yo, Ishihara, Shunji, Ito, Hiroaki, Iwakiri, Ryuichi, Kagaya, Takashi, Kanai, Takanori, Kashida, Hiroshi, Kato, Shingo, Kato, Jun, Katsurada, Takehiko, Kinjyo, Fukunori, Kobayashi, Kiyonori, Kodama, Mayumi, Kunisaki, Reiko, Kurahara, Koichi, Kurokami, Takafumi, Kyouwon, Lee, Matsuda, Koichiro, Matsueda, Kazuhiro, Matsui, Toshiyuki, Matsumoto, Takayuki, Mitsuyama, Keiichi, Mizokami, Yuji, Motoya, Satoshi, Naito, Yuji, Nakagawa, Tomoo, Nakamura, Shiro, Nakase, Hiroshi, Nojima, Masanori, Nomura, Masafumi, Ogawa, Atsuhiro, Okazaki, Kazuichi, Otsuka, Kazuaki, Sakuraba, Hirotake, Saruta, Masayuki, Sasaki, Makoto, Shirai, Takayuki, Suga, Tomoaki, Sugimura, Kazuhito, Sugiyama, Toshiro, Suzuki, Yasuo, Takeshima, Fuminao, Tamaki, Hiroyuki, Tanaka, Shinji, Tanida, Satoshi, Tominaga, Keiichi, Tomizawa, Taku, Watanabe, Kenji, Watanabe, Mamoru, Yamamoto, Shojiro, Yamashita, Masaki, Yoshida, Atsushi, and Yoshimura, Naoki

Published
2017
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47. Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task

Author

Hirosawa R, Narumoto J, Sakai Y, Nishida S, Ishida T, Nakamae T, Takei Y, and Fukui K

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Rikuei Hirosawa,1 Jin Narumoto,1 Yuki Sakai,1 Seiji Nishida,2 Takuya Ishida,1 Takashi Nakamae,1 Yuichi Takei,3 Kenji Fukui1 1Department of Psychiatry, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 2Maizuru Medical Center, Kyoto, 3Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan Background: Near-infrared spectroscopy has helped our understanding of the neurobiological mechanisms of psychiatric disorders and has advantages including noninvasiveness, lower cost, and ease of use compared with other imaging techniques, like functional magnetic resonance imaging. The verbal fluency task is the most common and well established task used to assess cognitive activation during near-infrared spectroscopy. Recent functional neuroimaging studies have shown that the orbitofrontal cortex and other brain regions, including the dorsolateral prefrontal cortex, may play important roles in the pathophysiology of obsessive-compulsive disorder (OCD). This study aimed to evaluate hemodynamic responses in the dorsolateral prefrontal cortex in patients with OCD using near-infrared spectroscopy during the verbal fluency task and to compare these with dorsolateral prefrontal cortex responses in healthy controls. Methods: Twenty patients with OCD and 20 controls matched for age, gender, handedness, and estimated intelligence quotient participated in this study. The verbal fluency task was used to elicit near-infrared spectroscopic activation and consisted of a 30-second pre-task, followed by three repetitions of a 20-second verbal fluency task (total 60 seconds), followed by a 70-second post-task period. The near-infrared spectroscopy experiment was conducted on the same day as surveys of obsessive-compulsive symptoms, depression, and anxiety. Z-scores for changes in the concentration of oxygenated hemoglobin were compared between the OCD patients and controls in 14 channels set over the left and right dorsolateral prefrontal cortex and frontopolar areas. Results: During the verbal fluency task, significant task-related activation was detected in both the OCD group and the controls. Changes in oxygenated hemoglobin concentration in the right dorsolateral prefrontal cortex were significantly smaller in the OCD group than in the controls, but were not statistically significant after correction for multiple comparisons. Conclusion: Patients with OCD have reduced prefrontal, especially right dorsolateral prefrontal, cortical hemodynamic responses as measured by near-infrared spectroscopy during the verbal fluency task. These results support the hypothesis that the dorsolateral prefrontal cortex plays a role in the pathophysiology of OCD. Keywords: functional neuroimaging, near-infrared spectroscopy, obsessive-compulsive disorder, prefrontal hemodynamic response, verbal fluency task, dorsolateral prefrontal cortex

Published
2013

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