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331 results on '"Irvin, Marguerite"'

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1. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

2. A methylation risk score for chronic kidney disease: a HyperGEN study

4. Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

5. Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood

6. Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers

7. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

10. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

11. Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas

12. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

13. Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study

14. Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

15. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

16. Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

17. Returning integrated genomic risk and clinical recommendations: The eMERGE study

18. Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants

19. Genetic diversity fuels gene discovery for tobacco and alcohol use

20. Stroke genetics informs drug discovery and risk prediction across ancestries

22. Genome-wide polygenic score to predict chronic kidney disease across ancestries

23. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

24. Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.

25. Blood Pressure on Ambulatory Monitoring and Risk for Cardiovascular Disease and All-Cause Mortality: Ecological Validity or Measurement Reliability?

26. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

27. Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

28. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study

29. Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

30. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

32. Rare coding variants in RCN3 are associated with blood pressure

33. Whole genome sequence analysis of blood lipid levels in >66,000 individuals

34. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

36. The power of genetic diversity in genome-wide association studies of lipids

37. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

40. Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies Suggestive Loci for Sodium Intake, Potassium Intake, and Their Ratio Measured from 24-Hour or Half-Day Urine Samples

41. Coagulation factor VIII: Relationship to cardiovascular disease risk and whole genome sequence and epigenome‐wide analysis in African Americans

44. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

45. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

47. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

49. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

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