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139 results on '"Ioffe, Olga"'

1. Mixed clear cell/endometrioid and clear cell/serous carcinoma of the uterus are clinicopathologically similar to pure clear cell carcinoma: An NRG Oncology/Gynecologic Oncology Group (GOG-210) study of 311 women

Author

Hagemann, Ian S., Deng, Wei, Zaino, Richard J., Powell, Matthew A., Gunderson Jackson, Camille, Cosgrove, Casey, Mathews, Cara, Pearl, Michael L., Waggoner, Steven, Ghebre, Rahel, Lele, Shashikant, Guntupalli, Saketh, Secord, Angeles Alvarez, Ioffe, Olga, Rasty, Golnar, Singh, Meenakshi, Soslow, Robert, Creasman, William, and Mutch, David G.

Published
2023
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2. The presence of an endometrioid component does not alter the clinicopathologic profile or survival of patients with uterine serous cancer: A gynecologic oncology group (GOG/NRG) study of 934 women

Author

Hagemann, Ian S., Deng, Wei, Zaino, Richard J., Powell, Matthew A., Gunderson, Camille, Cosgrove, Casey, Mathews, Cara, Pearl, Michael L., Waggoner, Steven, Ghebre, Rahel, Lele, Shashikant, Guntupalli, Saketh, Secord, Angeles Alvarez, Ioffe, Olga, Park, Kay, Rasty, Golnar, Singh, Meenakshi, Soslow, Robert, Creasman, William, and Mutch, David G.

Published
2021
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5. The Current State of Communication of Urgent and Significant, Unexpected Diagnoses in Anatomic Pathology: Results of an Association of Directors of Anatomic and Surgical Pathology Survey

Author

Staats, Paul N., Parkash, Vinita, Otis, Christopher N., Sharma, Poonam, Ioffe, Olga, and Bracamonte, Erika R.

Subjects
Biomedical laboratories, Health
Abstract

Context.--The concept of critical diagnoses in anatomic pathology is relatively recent and rigorous study of the issue is quite limited. The College of American Pathologists and Association of Directors of Anatomic and Surgical Pathology issued a consensus statement in 2012. There has been no multi-institutional study of communication policies since then. Objective.--To survey the policies of anatomic pathology laboratories regarding communication of critical values. Design.--A survey of the Association of Directors of Anatomic and Surgical Pathology membership was performed using a 14-question electronic survey tool. Results.--Responses were received from 38 institutions. Thirty-five of 38 (92%) had a policy on anatomic pathology critical values. Twenty-five of 38 (66%) respondents had read the College of American Pathologists/Association of Directors of Anatomic and Surgical Pathology consensus statement. Twelve of 38 (32%) institutions divided critical values into 2 categories, of which 9 used the College of American Pathologists/ Association of Directors of Anatomic and Surgical Pathology terminology; 24 used only a single term, of which 11 used critical value. There was substantial variation in the diagnoses that were considered critical. A direct phone call to the responsible provider was uniformly considered an acceptable means of communication; all other methods had mixed or low support. The most common time frame was same day; many laboratories did not specify a timeframe. Most laboratories document date, time, and person to whom the result was communicated in the final report or an addendum report. Eighteen of 38 (47%) laboratories report an auditing mechanism for communication. Conclusions.--Policies for communication of critical/ urgent/significant, unexpected results in anatomic pathology are the norm. However, there remains significant variation between institutions in the details of these policies. (Arch Pathol Lab Med. 2020;144:1067-1074; doi: 10.5858/arpa.2019-0436-OA), Communication of critical values to providers has long been an established practice in clinical pathology. More than a decade ago, questions began to be raised in the literature about the [...]

Published
2020
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7. Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group study

Author

Devor, Eric J., Miecznikowski, Jeffrey, Schickling, Brandon M., Gonzalez-Bosquet, Jesus, Lankes, Heather A., Thaker, Premal, Argenta, Peter A., Pearl, Michael L., Zweizig, Susan L., Mannel, Robert S., Brown, Amy, Ramirez, Nilsa C., Ioffe, Olga B., Park, Kay J., Creasman, William T., Birrer, Michael J., Mutch, David, and Leslie, Kimberly K.

Published
2017
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10. Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade)

Author

Singh, Naveena, Hirschowitz, Lynn, Zaino, Richard, Alvarado-Cabrero, Isabel, Duggan, Maire A., Ali-Fehmi, Rouba, Euscher, Elizabeth, Hecht, Jonathan L., Horn, Lars-Christian, Ioffe, Olga, Matias-Guiu, Xavier, McCluggage, W. Glenn, Mikami, Yoshiki, Ordi, Jaume, Parkash, Vinita, Quddus, M. Ruhul, Quick, Charles M., Staebler, Annette, Zaloudek, Charles, Nucci, Marisa, Malpica, Anais, and Oliva, Esther

Published
2019
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16. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

Author

Terunuma, Atsushi, Putluri, Nagireddy, Mishra, Prachi, Mathe, Ewy A., Dorsey, Tiffany H., Yi, Ming, Issaq, Haleem J., Zhou, Ming, Killian, J. Keith, Stevenson, Holly S., Karoly, Edward D., Chan, King, Samanta, Susmita, Prieto, DaRue, Hsu, Tiffany Y.T., Kurley, Sarah J., Putluri, Vasanta, Sonavane, Rajni, Edelman, Daniel C., Wulff, Jacob, Starks, Adrienne M., Yang, Yinmeng, Kittles, Rick A., Yfantis, Harry G., Lee, Dong H., Ioffe, Olga B., Schiff, Rachel, Stephens, Robert M., Meltzer, Paul S., Veenstra, Timothy D., Westbrook, Thomas F., Sreekumar, Arun, and Ambs, Stefan

Subjects
Methylation -- Research, Glutamine -- Research -- Health aspects, Breast cancer -- Prognosis -- Research -- Care and treatment -- Development and progression, Health care industry
Abstract

Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors using an untargeted discovery approach and validation of key metabolites. The oncometabolite 2-hydroxyglutarate (2HG) accumulated at high levels in a subset of tumors and human breast cancer cell lines. We discovered an association between increased 2HG levels and MYC pathway activation in breast cancer, and further corroborated this relationship using MYC overexpression and knockdown in human mammary epithelial and breast cancer cells. Further analyses revealed globally increased DNA methylation in 2HG-high tumors and identified a tumor subtype with high tissue 2HG and a distinct DNA methylation pattern that was associated with poor prognosis and occurred with higher frequency in African-American patients. Tumors of this subtype had a stem cell-like transcriptional signature and tended to overexpress glutaminase, suggestive of a functional relationship between glutamine and 2HG metabolism in breast cancer. Accordingly, 13C-labeled glutamine was incorporated into 2HG in cells with aberrant 2HG accumulation, whereas pharmacologic and siRNA-mediated glutaminase inhibition reduced 2HG levels. Our findings implicate 2HG as a candidate breast cancer oncometabolite associated with MYC activation and poor prognosis., Introduction Gene expression profiling studies of breast cancer led to the discovery of disease subtypes and expression patterns that are predictive of disease outcome (1-3). Recently, metabolomics emerged as a [...]

Published
2014
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29. Proliferative rate in endoscopic ultrasound fine-needle aspiration of pancreatic endocrine tumors: correlation with clinical behavior

Author

Alexiev, Borislav A., Darwin, Peter E., Goloubeva, Olga, and Ioffe, Olga B.

Subjects
Cell proliferation -- Research, Tumor markers -- Analysis, Pancreatic tumors -- Diagnosis, Pancreatic tumors -- Development and progression, Pancreatic tumors -- Research, Biopsy, Needle -- Usage, Biopsy, Needle -- Research, Endoscopic ultrasonography -- Usage, Endoscopic ultrasonography -- Research, Health
Published
2009

48. Human muscle stem cells are refractory to aging.

Author

Novak, James S., Mázala, Davi A. G., Nearing, Marie, Hindupur, Ravi, Uapinyoying, Prech, Habib, Nayab F., Dickson, Tessa, Ioffe, Olga B., Harris, Brent T., Fidelia‐Lambert, Marie N., Rossi, Christopher T., Hill, D. Ashely, Wagner, Kathryn R., Hoffman, Eric P., and Partridge, Terence A.

Subjects
HUMAN stem cells, AGING, SARCOPENIA, SATELLITE cells, MUSCLE regeneration, CELL physiology, MUSCLE mass, MYOBLASTS
Abstract

Age‐related loss of muscle mass and strength is widely attributed to limitation in the capacity of muscle resident satellite cells to perform their myogenic function. This idea contains two notions that have not been comprehensively evaluated by experiment. First, it entails the idea that we damage and lose substantial amounts of muscle in the course of our normal daily activities. Second, it suggests that mechanisms of muscle repair are in some way exhausted, thus limiting muscle regeneration. A third potential option is that the aged environment becomes inimical to the conduct of muscle regeneration. In the present study, we used our established model of human muscle xenografting to test whether muscle samples taken from cadavers, of a range of ages, maintained their myogenic potential after being transplanted into immunodeficient mice. We find no measurable difference in regeneration across the range of ages investigated up to 78 years of age. Moreover, we report that satellite cells maintained their myogenic capacity even when muscles were grafted 11 days postmortem in our model. We conclude that the loss of muscle mass with increasing age is not attributable to any intrinsic loss of myogenicity and is most likely a reflection of progressive and detrimental changes in the muscle microenvironment such as to disfavor the myogenic function of these cells. [ABSTRACT FROM AUTHOR]

Published
2021
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