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Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with variable clinical outcomes and prediction of prognosis remains important for long-term remission. We performed serial serum soluble interleukin-2 receptor (sIL-2R) measurement pretreatment and before each cycle of the treatment in 599 patients with de novo DLBCL. Genomic and transcriptomic features were analyzed by 223 DNA- and 227 RNA-sequencing, respectively. Applying the cut-off value to sIL-2R pretreatment and cycle 2 (C2) level, patients were classified into FINE subtype (pretreatment low level) with good prognosis, RES subtype (pretreatment high level and C2 low level) with intermediate prognosis, and RET subtype (pretreatment high level and C2 high level) with poor prognosis, independent of International Prognostic Index. In "others" genetic subtype, dynamic change of sIL-2R showed prognostic significance and genetic features. Compared with FINE subtype, RES subtype had increased ARID1A and MYD88 mutations, and RET subtype had increased KMT2D, LYN and SOCS1 mutations. RES and RET subtypes showed significant enrichment in oncogenic pathways, such as ERK, NF-κB, JAK-STAT, and immune-associated pathways. As for tumor microenvironment, RES subtype exhibited increased recruiting activity of CD8 + T, T helper 1, and natural killer cells, and RET subtype with increased recruiting activity of CD4 + T and regulatory T cells in silico. There was a positive correlation between transcripts of IL-2R and immune checkpoint expressions including PD-1 and CTLA-4. Our findings identified that dynamic change of sIL-2R, with this simple and easy detection method in peripheral blood, had long-term prognostic effect and specific relation to microenvironment alterations in DLBCL. [ABSTRACT FROM AUTHOR]

Two recent reports in the New England Journal of Medicine highlight the successful application of novel targeted therapies to improve the clinical outcomes of diffuse large B-cell lymphoma (DLBCL). These findings encourage us to pursue further mechanism-based therapeutic uses to make DLBCL curable in the era of precision medicine. [ABSTRACT FROM AUTHOR]

This research presents the modelling and simulation method of the visible imaging characteristics for a space target. The surface of the space target is divided into facets in order to improve the modelling precision. Based on the consideration of the mixing-material of the solar panel, the measuring method of the equivalent BRDF is proposed, from which we achieve the measurement and modelling of the equivalent BRDF of the solar panel. To reflect the operate mode of the solar panel pointing to the sun, a calculation method of panel normal vector is proposed based on the principle of maximum light efficiency. The simulation of the detection signal is carried out according to the OTF and the photoelectric response model. The results show that the proposed modelling method can simulate the imaging characteristics of space targets with a complex structure, as well as correctly reflect the movement characteristics of the on-orbit satellite. [ABSTRACT FROM AUTHOR]