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Abstract Surface acoustic wave (SAW) gas sensors based on the acoustoelectric effect exhibit wide application prospects for in situ gas detection. However, establishing accurate models for calculating the scattering parameters of SAW gas sensors remains a challenge. Here, we present a coupling of modes (COM) model that includes the acoustoelectric effect and specifically explains the nonmonotonic variation in the center frequency with respect to the sensing film’s sheet conductivity. Several sensing parameters of the gas sensors, including the center frequency, insertion loss, and phase, were experimentally compared for accuracy and practicality. Finally, the frequency of the phase extremum (FPE) shift was determined to vary monotonically, and the range of selectable test points was wide, making the FPE an appropriate response parameter for leveraging in SAW gas sensors. The simulation results of the COM model were highly consistent with the experimental results. Our study is proposed to provide theoretical guidance for the future development of gas SAW sensors.

Recently, lithium niobate thin film laterally excited bulk wave resonators (XBARs) have attracted much attention because of their advantage of high frequency and outstanding electromechanical coupling factor (K2) enabling wide filter bandwidths. These can satisfy the increasing 5G communication demand. However, their large temperature coefficient limits their development to some extent. To improve their temperature stability with little K2 reduction, this paper has proposed a sandwiched structure for temperature compensated XBARs (TC XBARs). This structure includes the top silicon dioxide (SiO2) layer and the bottom SiO2 layer. One layer can improve temperature stability, and the other layer can increase K2. The optimized XBARs have a temperature coefficient of frequency (TCF) of −90.77 ppm⁄°C. The common two-layer TC XBARs can achieve a TCF of −22 ppm⁄°C sacrificing K2 to 8%. However, the proposed sandwiched TC XBARs can achieve a K2 of 12.15 and a TCF of −28.94 ppm⁄°C simultaneously, with a large FoM. Meanwhile, spurious modes can be suppressed in the sandwiched structure. Thus, this sandwiched structure can provide a good solution for the high performance of XBARs.

Abstract Background Sexual violence is far more prevalent in most societies than is usually suspected in daily life. However, no study has systematically summarized the global prevalence rate and the major outcomes of sexual violence against women. Methods We directed a wide-raging search in the PubMed, Embase, and Web of Science, catalogs since the beginning to December 2022 for relevant reports about the incidence of sexual fighting touching females. The occurrence frequency was assessed with a random-effects model. The heterogeneity was estimated with I 2 values. Differences by research features were assessed over subgroup evaluation and meta-regression. Results A total of 32 cross-sectional studies were included (a total of 19,125 participants). The pooled sexual violence rate was 0.29 (95% CI = 0.25–0.34). Subgroup analyses found that there was a higher rate of sexual violence against women in 2010–2019 period (0.33, 95% CI = 0.27–0.37), developing countries (0.32, 95% CI = 0.28–0.37), and interview (0.39, 95% CI = 0.29–0.49). The analysis found that more than half of women (0.56, 95% CI = 0.37–0.75) had post-traumatic stress disorder (PTSD) after experiencing sexual violence, and only a third of women considered seeking support (0.34, 95% CI = 0.13–0.55). Conclusions Nearly one out of every three (29%) women around the world has been a victim of sexual violence in their life. This current study investigated the status and characteristics of sexual violence against women, which could provide an important reference for police and emergency health services management.

Surface acoustic wave (SAW) technology has been extensively explored for wireless communication, sensors, microfluidics, photonics, and quantum information processing. However, due to fabrication issues, the frequencies of SAW devices are typically limited to within a few gigahertz, which severely restricts their applications in 5G communication, precision sensing, photonics, and quantum control. To solve this critical problem, we propose a hybrid strategy that integrates a nanomanufacturing process (i.e., nanolithography) with a LiNbO3/SiO2/SiC heterostructure and successfully achieve a record-breaking frequency of about 44 GHz for SAW devices, in addition to large electromechanical coupling coefficients of up to 15.7%. We perform a theoretical analysis and identify the guided higher order wave modes generated on these slow-on-fast SAW platforms. To demonstrate the superior sensing performance of the proposed ultra-high-frequency SAW platforms, we perform micro-mass sensing and obtain an extremely high sensitivity of approximately 33151.9 MHz·mm2·μg−1, which is about 1011 times higher than that of a conventional quartz crystal microbalance (QCM) and about 4000 times higher than that of a conventional SAW device with a frequency of 978 MHz.

Abstract Current state-of-the-art stretchable/flexible sensors have received stringent demands on sensitivity, flexibility, linearity, and wide-range measurement capability. Herein, we report a methodology of strain sensors based on graphene/Ecoflex composites by modulating multiscale/hierarchical wrinkles on flexible substrates. The sensor shows an ultra-high sensitivity with a gauge factor of 1078.1, a stretchability of 650%, a response time of ~140 ms, and a superior cycling durability. It can detect wide-range physiological signals including vigorous body motions, pulse monitoring and speech recognition, and be used for monitoring of human respirations in real-time using a cloud platform, showing a great potential for the healthcare internet of things. Complex gestures/sign languages can be precisely detected. Human-machine interface is demonstrated by using a sensor-integrated glove to remotely control an external manipulator to remotely defuse a bomb. This study provides strategies for real-time/long-range medical diagnosis and remote assistance to perform dangerous tasks in industry and military fields.

The thermophysical parameters of lunar soil can be inferred from the temperature field during the invasion process of reconnaissance projectile. This paper adopts a two-dimensional axisymmetric model to reconstruct the projectile invasion process. An optimized particle swarm optimization method is then used to retrieve the thermophysical parameters of lunar soil. When the reconnaissance projectile penetrates the lunar interior, it rubs against the lunar soil and generates heat, which diffuses between the projectile body and the lunar soil. The sensors inside the reconnaissance projectile measure the temperature variation of the projectile body to inverse the thermophysical parameters. This paper carried out physical modeling of the penetration process of reconnaissance projectile. A two-dimensional axisymmetric simulation model is constructed for the physical process, and the adaptive inertial weight particle swarm algorithm is adopted. The inversion experiment of lunar soil thermophysical parameters based on the simulation model shows that the inversion error is less than 10%, which verifies the feasibility of this method.

During drilling into the soil, the rotating mechanical structure will be affected by soil particles and external disturbances, affecting the health of the rotating mechanical structure. Therefore, real-time monitoring of the operational status of rotating mechanical structures is of great significance. This paper proposes a working state recognition method based on Mel-spectrum and transfer learning, which uses the mechanical vibration signal’s time domain and frequency domain information to identify the mechanical structure’s working state. Firstly, we cut the signal at window length, and then the Mel-spectrum of the truncated signal is obtained through the Fourier transform and Mel-scale filter bank. Finally, we adopted the method of transfer learning. The pre-trained model VGG16 is adjusted to extract and classify the features of the Mel-spectrum. Experimental results show that the framework maintains an accuracy of more than 90% for vibration signals under minor window conditions, which verifies the real-time reliability of the method.

Abstract Background Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon cancer is still unclear. The aim of this study is to investigate whether IRF4 participates in the immune response in colon cancer. Methods We compared the expression of IRF4, the number of regulatory T cells (Tregs) and macrophages in the colon cancer tissues and paracancerous colon tissues from colon cancer patients. Colon cancer mouse model was established by inoculation with colon cancer cells (SW480) as a xenograft tumor, and we observed tumor growth of colon cancer. Furthermore, the mechanism of action of IRF4 in transdifferentiation of Tregs into macrophage-like cells and the effect of IRF4 on colon cancer cells were investigated in vitro. Results IRF4 was severely down-regulated in the colon cancer tissues. Colon cancer tissues exhibited an increase in the number of regulatory T cells (Tregs) and macrophages. Furthermore, IRF4 overexpression repressed proliferation, migration and invasion of colon cancer cells (SW480 and HT116 cells). Moreover, IRF4 up-regulation ameliorated tumor growth of colon cancer by promoting the transdifferentiation of Tregs into macrophage-like cells through inhibition of BCL6 expression. Exosomes derived from colon cancer cells repressed IRF4 expression in Tregs by transmitting miR-27a-3p, miR-30a-5p and miR-320c. Conclusions IRF4 overexpression promoted the transdifferentiation of Tregs into macrophage-like cells to inhibit the occurrence and development of colon cancer. Thus, IRF4 may be a potential target for colon cancer treatment.

Tire pressure monitoring is essential to driving safety. Indirect tire pressure monitoring system (TPMS) is a cost-effective alternative to direct tire pressure monitoring system. Its performance depends on the algorithm for data pre-processing and analysis which is normally complicated, sensitive to initial calibration with limited working range. In this work, four tests were carried out with Baojun 530 with a different deflated tire in each case. Speed data read through ABS CAN bus was analyzed and traditional frequency based method was employed to identify the deflated tire. To simplify the data pre-processing and improve response speed and working range, a new artificial neural network (ANN) based method was also proposed to identify deflated tire based on speed data point collected through antilock brake system (ABS) sensors in tests. A long short-term memory (LSTM) network was developed to locate the deflated tire with an accuracy of 0.83 after training for individual data points. And performance of this method can be further improved by employing a soft voting mechanism with 3 LSTM networks. In proposed ANN based method, benchmark data from properly inflated tire is not required, which makes it a promising solution for multiple deflated tires cases which is challenging for traditional frequency-based method.

Abstract Background The goal of this study was to delineate the patterns of distant metastasis from colon adenocarcinoma (CAC) and evaluate the survival differences by metastatic patterns. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we extracted patients diagnosed with stage IV CAC between 2010 and 2016. Kaplan‐Meier survival curves were plotted with log‐rank tests to compare overall survival (OS) of patients with different metastatic patterns. Univariate and multivariate Cox proportional hazards regression models were used to evaluate the effects of different metastatic patterns on survival outcomes in terms of OS and disease‐specific survival (DSS). Results A total of 26 170 patients were analyzed. The 3‐ and 5‐year OS were 20.7% and 10.5%, respectively, for patients with stage IV CAC. The most common distant metastatic site was the liver, followed by the lung, bone, and brain, but the frequency differed greatly by histology subtypes. The site of metastasis was a significant prognostic factor for OS and DSS in patients with stage IV CAC, independent of the number of metastatic sites and other clinical and demographic prognostic factors. Using liver‐only metastasis as reference, lung‐only metastasis was associated with better OS (hazard ratio [HR] = 0.82, 95% confidence interval [CI], 0.71‐0.94) and DSS (HR = 0.75, 95% CI, 0.64‐0.88). Older age, black race, unmarried status, grade III/IV tumors, advanced tumor‐node‐metastasis (TNM) stage, proximal colon, elevated preoperative carcinoembryonic antigen (CEA), no surgery of the primary site, and no chemotherapy were independent predictors of poor OS. Conclusions The site of distant metastasis and number of metastasis site were independent prognostic factors for survival of patients with stage IV CAC. This study highlights the need for diverse treatment strategies for patients with different metastatic patterns.

With the fast evolution of wireless and networking communication technology, applications of surface acoustic wave (SAW), or Rayleigh wave, resonators are proliferating with fast shrinking sizes and increasing frequencies. It is inevitable that the smaller resonators will be under a strong electric field with induced large deformation, which has to be described in wave propagation equations with the consideration of nonlinearity. In this study, the formal nonlinear equations of motion are constructed by introducing the nonlinear constitutive relation and strain components in a standard procedure, and the equations are simplified by the extended Galerkin method through the elimination of harmonics. The wave velocity of the nonlinear SAW is obtained from approximated nonlinear equations and boundary conditions through a rigorous solution procedure. It is shown that if the amplitude is small enough, the nonlinear results are consistent with the linear results, demonstrating an alternative procedure for nonlinear analysis of SAW devices working in nonlinear state.

Nitrogen dioxide is one origin of air pollution from fossil fuels with the potential to cause great harm to human health in low concentrations. Therefore, low-cost, low-power-consumption sensors for low-concentration NO2 detection are essential. Herein, heterojunction by SnO2 quantum wires, a traditional metal oxide NO2 sensing material, and Ti3C2Tx MXene, a novel type of 2D layered material, was synthesized using a simple solvothermal method for enhancing gas-sensing performance and reducing operating temperature. The operating temperature was reduced to 80 °C, with a best performance of 27.8 and a fast response and recovery time (11 s and 23 s, respectively). The SnO2 and Ti3C2Tx MXene composite exhibits high speed and low detection limit due to the construction of the heterojunction with high conductive Ti3C2Tx MXene. The selectivity and stability of gas sensors are carried out. This could enable the realization of fast response, high-sensitivity, and selective NO2 sensing under low operating temperatures.

A highly sensitive and precise Love wave mode surface acoustic wave (SAW) immunosensor based on an ST-cut 90°X quartz substrate and an SiO2 wave-guiding layer was developed to detect cancer-related biomarkers of carcinoembryonic antigens (CEAs). A delay line structure of the SAW device with a resonant frequency of 196 MHz was designed/fabricated, and its surface was functionalized through CEA antibody immobilization. The CEA antibodies were bound with gold nanoparticles and CEA antibodies to form a sandwich structure, which significantly amplified the mass loading effect and enhanced the maximum responses by 30 times. The center frequency of the Love wave immunosensor showed a linear response as a function of the CEA concentration in the range of 0.2–5 ng/mL. It showed a limit of detection of 0.2 ng/mL, and its coefficient of determination was 0.983. The sensor also showed minimal interference from nonspecific adsorptions, thus demonstrating its promise for point-of-care applications for cancer biomarkers.

We propose an ultrasensitive leaky surface acoustic wave (LSAW) immunosensor based on molybdenum disulfide @ cuprous oxide—gold (MoS2@Cu2O-Au) nanoparticles and subsequent gold staining for the detection of alpha-fetoprotein (AFP). MoS2@Cu2O-Au nanoparticles, with their large specific surface area and good biocompatibility, not only capture the secondary antibodies (Ab2) but also amplify the mass loading effect of the acoustic wave sensor in the detection of AFP. The immunosensor signals are further amplified upon injection of gold staining solution. The developed immunosensor achieved a low detection limit of 5.5 and 25.0 pg/mL with and without gold staining, respectively. The immunosensor demonstrated its efficiency for the quantitative detection of AFP in complex biological fluids, including human serum and saliva samples, with excellent selectivity and long-term stability, showing great potential for the quantification of AFP in clinical diagnosis.

Surface acoustic wave (SAW) devices are one of the indispensable components in the radio frequency (RF) front-end of mobile phones. With the development of mobile communication technology, the requirements for linear specification of devices are more and more strict. Nonlinear distortions of SAW devices have a serious influence on the application of mobile RF modules. To satisfy the strict requirement of linearity of communication system, it is necessary to understand the generation mechanism of nonlinearity and study the accurate modeling, appropriate measurement methods, and nonlinear response elimination technology. In this paper, we summarize the research progress on the nonlinearity of SAW devices in recent years from four aspects: the generation mechanism, simulation methods, measurement system, and suppression technology. The nonlinear harmonics with the nonlinear Mason equivalent circuit model are simulated. Furthermore, harmonics and intermodulation signals of SAW filters are tested by the authors. Thanks to these research studies, it is of great significance to the development of future RF front-end modules with high linear SAW devices.

Surface acoustic wave (SAW) sensors have been applied in various areas with many advantages, such as their small size, high sensitivity and wireless and passive form. Love wave mode sensors, an important kind of SAW sensor, are mostly used in biology and chemistry monitoring, as they can be used in a liquid environment. Common Love wave mode sensors consist of a delay line with waveguide and sensitive layers. To extend the application of Love wave mode sensors, this article reports a novel Love wave mode sensor consisting of a waveguide layer with microphononic crystals (PnCs). To analyze the properties of the new structure, the band structure was calculated, and transmission was obtained by introducing delay line structures and quasi-three-dimensional models. Furthermore, devices with a traditional structure and novel structure were fabricated. The results show that, by introducing the designed microstructure of phononic crystals in the waveguide layer, the attenuation was barely increased, and the frequency was shifted by a small amount. In the liquid environmental experiments, the novel structure with micro PnCs shows even better character than the traditional one. Moreover, the introduced microstructure can be extended to microreaction tanks for microcontrol. Therefore, this novel Love wave mode sensor is a promising application for combining acoustic sensors and microfluidics.

Phononic crystals with phononic band gaps varying in different parameters represent a promising structure for sensing. Equipping microchannel sensors with phononic crystals has also become a great area of interest in research. For building a microchannels system compatible with conventional micro-electro-mechanical system (MEMS) technology, SU-8 is an optimal choice, because it has been used in both fields for a long time. However, its mechanical properties are greatly affected by temperature, as this affects the phononic bands of the phononic crystal. With this in mind, the viscous dissipation in microchannels of flowing liquid is required for application. To solve the problem of viscous dissipation, this article proposes a simulation model that considers the heat transfer between fluid and microchannel and analyzes the frequency domain properties of phononic crystals. The results show that when the channel length reaches 1 mm, the frequency shift caused by viscous dissipation will significantly affect detecting accuracy. Furthermore, the temperature gradient also introduces some weak passbands into the band gap. This article proves that viscous dissipation does influence the band gap of phononic crystal chemical sensors and highlights the necessity of temperature compensation in calibration. This work may promote the application of microchannel chemical sensors in the future.

Distributed acoustic sensing based on phase-sensitive optical time-domain reflectometry (Φ-OTDR) has been widely used in many fields. Phase demodulation of the Φ-OTDR signal is essential for undistorted acoustic measurement. Digital coherent detection is a universal method to implement phase demodulation, but it may cause severe computational burden. In this paper, analog I/Q demodulation is introduced into the Φ-OTDR based DAS system to solve this problem, which can directly obtain the I and Q components of the beat signal without any digital processing, meaning that the computational cost can be sharply reduced. Besides, the sampling frequency of the data acquisition card can theoretically be lower than the beat frequency as the spectrum aliasing would not affect the demodulation results, thus further reducing the data volume of the system. Experimental results show that the proposed DAS system can demodulate the phase signal with good linearity and wide frequency response range. It can also adequately recover the sound signal sensed by the optical fiber, indicating that it can be a promising solution for computational-cost-sensitive distributed acoustic sensing applications.

The accurate analysis of periodic surface acoustic wave (SAW) structures by combined finite element method and boundary element method (FEM/BEM) is important for SAW design, especially in the extraction of couple-of-mode (COM) parameters. However, the time cost is very large. With the aim to accelerate the calculation of SAW FEM/BEM analysis, some optimization algorithms for the FEM and BEM calculation have been reported, while the optimization for the solution to the final FEM/BEM equations which is also with a large amount of calculation is hardly reported. In this paper, it was observed that the coefficient matrix of the final FEM/BEM equations for the periodic SAW structures was similar to a Toeplitz matrix. A fast algorithm based on the Trench recursive algorithm for the Toeplitz matrix inversion was proposed to speed up the solution of the final FEM/BEM equations. The result showed that both the time and memory cost of FEM/BEM was reduced furtherly.

In this study, a Dirac cone is yielded at the corner of the Brillouin zone of a two-dimensional solid phononic crystal, which consists of a triangular array of hexagonal steel with a trilobal hole drilled in the center. With the rotation of the trilobal hole, the Dirac degeneracy switches between the deterministic form and accidental form. Every Dirac point is the critical state of a topological phase transition process, which occurs six times within an angular period of $120^\circ .$ This structure offers a flexible way to achieve topological transitions and provides multiple routes to construct an interface that supports valley-dependent edge states between two topologically distinct PCs. The associated backscattering suppressed wave propagation along the multiple curved interface channels is also demonstrated. In addition, our design shows the robust propagation of topological interface states against the perturbation of the structure. This study could potentially be significant in the design of acoustic devices for practical applications, such as acoustic signal lossless transport and tunable multi-channel sound transmission.

An accurate and fast simulation tool plays an important role in the design of wireless passive impedance-loaded surface acoustic wave (SAW) sensors which have received much attention recently. This paper presents a finite transducer analysis method for wireless passive impedance-loaded SAW sensors. The finite transducer analysis method uses a numerically combined finite element method-boundary element method (FEM/BEM) model to analyze non-periodic transducers. In non-periodic transducers, FEM/BEM was the most accurate analysis method until now, however this method consumes central processing unit (CPU) time. This paper presents a faster algorithm to calculate the bulk wave part of the equation coefficient which usually requires a long time. A complete non-periodic FEM/BEM model of the impedance sensors was constructed. Modifications were made to the final equations in the FEM/BEM model to adjust for the impedance variation of the sensors. Compared with the conventional method, the proposed method reduces the computation time efficiently while maintaining the same high degree of accuracy. Simulations and their comparisons with experimental results for test devices are shown to prove the effectiveness of the analysis method.

Location error and false alarm are noticeable problems in fiber distributed acoustic sensing systems based on phase-sensitive optical time-domain reflectometry (Φ-OTDR). A novel method based on signal kurtosis is proposed to locate and discriminate perturbations in Φ-OTDR systems. The spatial kurtosis (SK) along the fiber is firstly obtained by calculating the kurtosis of acoustic signals at each position of the fiber in a short time period. After the moving average on the spatial dimension, the spatial average kurtosis (SAK) is then obtained, whose peak can accurately locate the center of the vibration segment. By comparing the SAK value with a certain threshold, we may to some degree discriminate the instantaneous destructive perturbations from the system noise and certain ambient environmental interferences. The experimental results show that, comparing with the average of the previous localization methods, the SAK method improves the pencil-break and digging locating signal-to-noise ratio (SNR) by 16.6 dB and 17.3 dB, respectively; and decreases the location standard deviation by 7.3 m and 9.1 m, respectively. For the instantaneous destructive perturbation (pencil-break and digging) detection, the false alarm rate can be as low as 1.02%, while the detection probability is maintained as high as 95.57%. In addition, the time consumption of the SAK method is adequate for a real-time Φ-OTDR system.

A surface acoustic wave based passive temperature sensor capable of multiple access is investigated. Binary Phase Shift Keying (BPSK) codes of eight chips were implemented using a reflective delay line scheme on a Y-Z LiNbO3 piezoelectric substrate. An accurate simulation based on the combined finite- and boundary element method (FEM/BEM) was performed in order to determine the optimum design parameters. The scaling factor ‘s’ and time delay factor ‘τ’ were extracted using signal processing techniques based on the wavelet transform of the correlation function, and then evaluated at various ambient temperatures. The scaling factor ‘s’ gave a more stable and reliable response to temperature than the time delay factor ‘τ’. Preliminary results show that the sensor response is fast and consistent subject to ambient temperature and it exhibits good linearity of 0.9992 with temperature varying from 0 to 130 °C.

Application of resonant single-phase unidirectional transducers (RSPUDTs) to the development of low-loss surface acoustic wave (SAW) filters with constant group delay in transition bands and in the passband is studied. The group delay deviation of 20 ns is realized over the range of plusmin 8 MHz at the center frequency of 512 MHz.

Film bulk acoustic resonators as a newer generation of acoustic wave resonators have been a proper replacement of traditional resonators for frequency control and sensor applications with a fast adoption in mobile communication and other major consumer electronics. Extensive research work on the materials, processing, structure, and design has contributed to the phenomenal growth of film bulk acoustic resonators. As a procedure for the selection of optimal design parameters, we started from the layered structures of film bulk acoustic resonators with a one-dimensional model, i.e., only considering the thickness of resonators for the calculation of vibration frequencies in order to support the resonator design. The resonant frequency of thickness-extension mode -- a key parameter of resonators -- was obtained through the consideration of the elastic and piezoelectric properties of each layer in the resonators structure. It has been proven through numerical examples that in this way we gain an effective approach to the accurate determination of resonant frequency. Clearly, the method based on film bulk acoustic resonators is also helpful for the early stage of product design in the selection of some essential parameters and later combinations for device upgrades. [ABSTRACT FROM AUTHOR]

As a special wave mode propagating in the interface between an infinite elastic solid and fluid, the Scholte waves are well known for their existence and frequency with distinct properties. The analysis and features are usually presented through the formulation in Cartesian coordinates, while the essential features of the phase velocity and wave patterns are also similar in other coordinates on the basis of equivalence. A variation of the Scholte wave features with a coordinate framework should be examined for possible insights related to mathematical solutions and applications besides the known properties. Using a systematic formulation with cylindrical coordinates and subsequent solutions in the Bessel functions, it is proved that the Scholte waves will attenuate with the increase of a radius in an axisymmetric case, which is different from the results in the Cartesian coordinate system. In addition, the particle trajectory will also vary due to the changes of the waveform. The examination of such features in a systematic analysis should play a prominent role in engineering applications of wave propagation associated with cylindrical solids. [ABSTRACT FROM AUTHOR]

The aim of this study is to explain the mechanism of alopolysaccharide protecting ulceralive colitis in cells and animal models. We divided this study into two parts: cell and animal research parts. In the cell research, HT-29 cells were divided into normal group, model group, aloe polysacchride group and positive drug group, the cell model was used by tumor necrosis factor- α (TNF-α) combine with LPS, detecting IL-6 concentration of difference groups by Elisa testing, Apoptosis of each group was detected by flow cytometry. We detected JAK2 and STAT-3 gene expressions of difference groups by RT-PCR. WB assay was used to detect the expression of JAK2, p-JAK2, STAT-3 and p-STAT3 protein in the cells of each group. In animal experiment, SD rats were divided into normal group, model control group, aloe polysaccharide group and positive drug group. A rat model of colitis was established with 2,4,6- three nitrobenzene sulfonic acid (TNBS). IL-6 concentrations of difference groups were measured by Elisa test, and compared the colon length of difference groups, H&E staining observation of colon tissue changes in each group. We observed JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression in colon tissues by immuno histochemistry and measured JAK2 and STAT-3 gene expression of difference groups by RT-PCR. We found IL-6 concentration and cell apoptosis rate of Model group were significantly up-regulation compared with normal group ( P < 0.05 , respectively ) in the cell experiment. Compared with Model group, The IL-6 concentration and apoptosis rate of aloe polysaccharide group and positive drug group were significantly down-regulation ( P < 0.05 , respectively ). In the gene expression, JAK2 and STAT-3 expression of aloe polysaccharide group and positive drug group were higher than model group ( P < 0.05 , respectively ). JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of Aloe polysaccharide group and positive drug group were lower than model group. In animal experiment, compared with model group, The serum IL-6 concentration of aloe polysaccharide group and positive drug group were significantly decreased ( P < 0.05 , respectively ), colon length was improved by drug treated, The HE stain of aloe polysaccharide and positive drug group were significantly improved. In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group ( P < 0.05 , respectively ). Depending on the results, We supposed Aloe polysaccharide could effectively control the apoptosis of colonic tissues by inhibiting the JAK2/STAT-3 signaling pathway in vovo and vitro. [ABSTRACT FROM AUTHOR]

We propose an on-chip film bulk acoustic resonator (FBAR) device based pressure sensor with a simple cavity structure. By sealing the back trench cavity of the FBAR device, the FBAR device become sensitive to the outside environmental pressure. The pressure sensor possesses two resonant peaks with high quality factors and coupling coefficients, which exhibit different temperature coefficients of frequency, and could be used as on-chip temperature compensation. The results show that mode 1 resonant peak of the FBAR pressure sensor has a pressure sensitivity of 1.642 ppm kPa−1, while that of mode 2 resonant peak is 0.1764 ppm kPa−1. Both of the two resonant peaks have high pressure response linearity above 0.999 in the pressure ranges of 17 kPa to 101 kPa and 101 kPa to 400 kPa. A method for temperature calibration is provided. The pressure sensor is simple in package and small in dimension, and the output data is frequency, which can easily be transmitted wirelessly, demonstrating great potential for applications such as the tire pressure monitor system. [ABSTRACT FROM AUTHOR]

Line-defect piezoelectric phononic crystals (PCs) show good potential applications in surface acoustic wave (SAW) MEMS devices for RF communication systems. To analyze the SAW characteristics in line-defect two-dimensional (2D) piezoelectric PCs, optical methods are commonly used. However, the optical instruments are complex and expensive, whereas conventional electrical methods can only measure SAW transmission of the whole device and lack spatial resolution. In this paper, we propose a new electrical experimental method with multiple receiving interdigital transducers (IDTs) to detect the SAW field distribution, in which an array of receiving IDTs of equal aperture was used to receive the SAW. For this new method, SAW delay lines with perfect and line-defect 2D Al/128°YXLiNbO3 piezoelectric PCs on the transmitting path were designed and fabricated. The experimental results showed that the SAW distributed mainly in the line-defect region, which agrees with the theoretical results. [ABSTRACT FROM AUTHOR]

A novel structure design of a surface acoustic wave (SAW) micro-optic-electro-mechanical-system (MOEMS) strain sensor with a light readout unit is presented in this paper. By measuring the polarization intensity ratio of the TE/TM mode outputted from the waveguide, the strain produced from an object can be measured precisely. The basic working principle of the SAW MOEMS strain sensor is introduced and the mathematical model of the strain sensor system is established. The SAW characteristics effected by the strain sensor are mathematically deduced. The coupling coefficient between the SAW modes and light modes can be calculated based on the theory of coupling modes. The conversion coefficient of polarized light modes is obtained. Due to the restrictions of the specific parameters of the device, the level of technology and the material characteristics, the sensitivity of the strain sensor system is calculated through simulation as 0.1 με, with a dynamic range of 0 ~ ±50 με. [ABSTRACT FROM AUTHOR]