Search

Your search keyword '"Hofmeyr, G. Justus"' showing total 743 results
Start Over Author "Hofmeyr, G. Justus" Search Limiters Peer Reviewed
743 results on '"Hofmeyr, G. Justus"'

1. Effects of the WHO Labour Care Guide on cesarean section in India: a pragmatic, stepped-wedge, cluster-randomized pilot trial

Author

Vogel, Joshua P., Pujar, Yeshita, Vernekar, Sunil S., Armari, Elizabeth, Pingray, Veronica, Althabe, Fernando, Gibbons, Luz, Berrueta, Mabel, Somannavar, Manjunath, Ciganda, Alvaro, Rodriguez, Rocio, Bendigeri, Savitri, Kumar, Jayashree Ashok, Patil, Shruti Bhavi, Karinagannanavar, Aravind, Anteen, Raveendra R., Mallappa Ramachandrappa, Pavithra, Shetty, Shukla, Bommanal, Latha, Haralahalli Mallesh, Megha, Gaddi, Suman S., Chikkagowdra, Shaila, Raghavendra, Bellara, Homer, Caroline S. E., Lavender, Tina, Kushtagi, Pralhad, Hofmeyr, G. Justus, Derman, Richard, and Goudar, Shivaprasad

Published
2024
Full Text
View/download PDF

2. Factors influencing postpartum haemorrhage detection and management and the implementation of a new postpartum haemorrhage care bundle (E-MOTIVE) in Kenya, Nigeria, and South Africa

Author

Forbes, Gillian, Akter, Shahinoor, Miller, Suellen, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G Justus, Moran, Neil, Singata-Madliki, Mandisa, Dankishiya, Faisal, Gwako, George, Osoti, Alfred, Thomas, Eleanor, Gallos, Ioannis, Mammoliti, Kristie-Marie, Devall, Adam, Coomarasamy, Arri, Althabe, Fernando, Atkins, Lou, Bohren, Meghan A, and Lorencatto, Fabiana

Subjects
Biomedical and Clinical Sciences, Psychology, Clinical Research, Behavioral and Social Science, Health Services, Health and social care services research, 8.1 Organisation and delivery of services, Good Health and Well Being, Humans, Female, Postpartum Hemorrhage, Patient Care Bundles, Maternal Death, Kenya, Nigeria, South Africa, Postpartum haemorrhage, Maternal health, Low- and middle-income countries, Clinical care bundle, Formative research, Qualitative interviews, Behaviour Change Wheel, Implementation interventions, Information and Computing Sciences, Medical and Health Sciences, Health Policy & Services, Biomedical and clinical sciences
Abstract

BackgroundPostpartum haemorrhage (PPH) is the leading cause of global maternal deaths, accounting for 30-50% of maternal deaths in sub-Saharan Africa. Most PPH-related deaths are preventable with timely detection and initiation of care, which may be facilitated by using a clinical care bundle. We explore influences on current PPH detection and management and on the future implementation of a new PPH bundle (E-MOTIVE) in low-resource, high-burden settings.MethodsSemi-structured qualitative interviews based on the Theoretical Domains Framework were conducted with 45 healthcare providers across nine hospitals in Nigeria, Kenya and South Africa, to identify barriers and enablers to current PPH detection and management and future implementation of a new PPH care bundle. Data were analysed using thematic and framework analysis. The Behaviour Change Wheel was used to identify potential interventions to address identified barriers and enablers.ResultsInfluences on current PPH detection and management fell under 12 domains: Environmental Context and Resources (drug and staff shortages), Skills (limited in-service training), Knowledge (variable understanding of the recommended practice), Behaviour Regulation (limited quality improvement culture), Beliefs about Consequences (drawbacks from inaccurate detection), Emotion (stress from the unpredictability of PPH), Social Influence (teamwork), Memory, Attention and Decision-making (limited guideline use), Social/Professional Role and Identity (role clarity), Beliefs about Capabilities (confidence in managing PPH), Reinforcement (disciplinary procedures) and Goals (PPH as a priority). Influences on bundle uptake included: Beliefs about Consequences (perceived benefits of new blood loss measurement tool), Environmental Context and Resources (high cost of drugs and new tools), Memory, Attention and Decision-making (concerns about whether bundle fits current practice), Knowledge (not understanding 'bundled' approach), Social Influence (acceptance by women and staff) and Intention (limited acceptance of 'bundled' approach over existing practice). These influences were consistent across countries. Proposed interventions included: Education, Training, Modelling (core and new skills), Enablement (monitoring uptake), Persuasion (leadership role) and Environmental Restructuring (PPH emergency trolley/kit).ConclusionsA wide range of individual, socio-cultural and environmental barriers and enablers to improving PPH detection and management exist in these settings. We identified a range of interventions that could improve PPH care and the implementation of new care bundles in this context.Trial registrationClinicalTrials.gov : NCT04341662.

Published
2023

3. High Levels of Pretreatment HIV-1 Drug Resistance Mutations Among South African Women Who Acquired HIV During a Prospective Study

Author

Beesham, Ivana, Parikh, Urvi M, Mellors, John W, Davey, Dvora L Joseph, Heffron, Renee, Palanee-Phillips, Thesla, Bosman, Shannon L, Beksinska, Mags, Smit, Jennifer, Ahmed, Khatija, Makkan, Heeran, Selepe, Pearl, Louw, Cheryl, Kotze, Philip, Hofmeyr, G Justus, Singata‐Madliki, Mandisa, Rees, Helen, Baeten, Jared M, and Wallis, Carole

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Antimicrobial Resistance, Clinical Research, HIV/AIDS, Infectious Diseases, Clinical Trials and Supportive Activities, Genetics, Development of treatments and therapeutic interventions, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, Drug Resistance, Viral, Female, Genotype, HIV Infections, HIV Seropositivity, HIV-1, Humans, Mutation, Prospective Studies, Reverse Transcriptase Inhibitors, South Africa, Young Adult, antiretroviral resistance, women, pretreatment resistance, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundPretreatment HIV drug resistance (PDR) undermines individual treatment success and threatens the achievement of UNAIDS 95-95-95 targets. In many African countries, limited data are available on PDR as detection of recent HIV infection is uncommon and access to resistance testing is limited. We describe the prevalence of PDR among South African women with recent HIV infection from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial.MethodsHIV-uninfected, sexually active women, aged 18-35 years, and seeking contraception were enrolled in the ECHO Trial at sites in South Africa, from 2015 to 2018. HIV testing was done at trial entry and repeated quarterly. We tested stored plasma samples collected at HIV diagnosis from women who seroconverted during follow-up and had a viral load >1000 copies/mL for antiretroviral resistant mutations using a validated laboratory-developed population genotyping assay, which sequences the full protease and reverse transcriptase regions. Mutation profiles were determined using the Stanford Drug Resistance Database.ResultsWe sequenced 275 samples. The median age was 23 years, and majority (98.9%, n = 272) were infected with HIV-1 subtype C. The prevalence of surveillance drug resistance mutations (SDRMs) was 13.5% (n = 37). Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations were found in 12.4% of women (n = 34). Few women had NRTI (1.8%, n = 5) and protease inhibitor (1.1%, n = 3) mutations. Five women had multiple NRTI and NNRTI SDRMs.ConclusionsThe high levels of PDR, particularly to NNRTIs, strongly support the recent change to the South African national HIV treatment guidelines to transition to a first-line drug regimen that excludes NNRTIs.

Published
2022

5. Detection and management of postpartum haemorrhage: Qualitative evidence on healthcare providers' knowledge and practices in Kenya, Nigeria, and South Africa

Author

Akter, Shahinoor, Forbes, Gillian, Miller, Suellen, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G Justus, Moran, Neil, Singata-Madliki, Mandisa, Amole, Taiwo Gboluwaga, Gwako, George, Osoti, Alfred, Thomas, Eleanor, Gallos, Ioannis, Mammoliti, Kristie-Marie, Coomarasamy, Arri, Althabe, Fernando, Lorencatto, Fabiana, and Bohren, Meghan A

Subjects
Biomedical and Clinical Sciences, Midwifery, Public Health, Health Sciences, Reproductive Medicine, Prevention, Clinical Research, Health Services, 8.1 Organisation and delivery of services, Health and social care services research, Good Health and Well Being, maternal health, postpartum haemorrhage, maternal mortality, qualitative research, formative research, clinical care bundles, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

BackgroundPostpartum haemorrhage (PPH) is the leading cause of maternal death globally. Most PPH deaths can be avoided with timely detection and management; however, critical challenges persist. A multi-country cluster-randomised trial (E-MOTIVE) will introduce a clinical care bundle for early detection and first-response PPH management in hospital settings. This formative qualitative study aimed to explore healthcare providers' knowledge and practices of PPH detection and management after vaginal birth, to inform design and implementation of E-MOTIVE.MethodsBetween July 2020-June 2021, semi-structured qualitative interviews were conducted with 45 maternity healthcare providers (midwives, nurses, doctors, managers) of nine hospitals in Kenya, Nigeria, and South Africa. A thematic analysis approach was used.ResultsFour key themes were identified, which varied across contexts: in-service training on emergency obstetric care; limited knowledge about PPH; current approaches to PPH detection; and current PPH management and associated challenges. PPH was recognised as an emergency but understanding of PPH varied. Early PPH detection was limited by the subjective nature of visual estimation of blood loss. Lack of expertise on PPH detection and using visual estimation can result in delays in initiation of PPH management. Shortages of trained staff and essential resources, and late inter-hospital referrals were common barriers to PPH management.ConclusionThere are critical needs to address context-specific barriers to early and timely detection and management of PPH in hospital settings. These findings will be used to develop evidence-informed implementation strategies, such as improved in-service training, and objective measurement of blood loss, which are key components of the E-MOTIVE trial (Trial registration: ClinicalTrials.gov: NCT04341662).

Published
2022

6. Formative research to design an implementation strategy for a postpartum hemorrhage initial response treatment bundle (E-MOTIVE): study protocol

Author

Bohren, Meghan A, Lorencatto, Fabiana, Coomarasamy, Arri, Althabe, Fernando, Devall, Adam J, Evans, Cherrie, Oladapo, Olufemi T, Lissauer, David, Akter, Shahinoor, Forbes, Gillian, Thomas, Eleanor, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G Justus, Al-beity, Fadhlun Alwy, Kasturiratne, Anuradhani, Kumarendran, Balachandran, Mammoliti, Kristie-Marie, Vogel, Joshua P, Gallos, Ioannis, and Miller, Suellen

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Research, Prevention, Behavioral and Social Science, Good Health and Well Being, Female, Humans, Kenya, Motivation, Nigeria, Postpartum Hemorrhage, Pregnancy, South Africa, Sri Lanka, Tanzania, Maternal health, Postpartum hemorrhage, Obstetric hemorrhage, Care bundle, Formative research, Maternal mortality, Behavior change, Implementation, Intervention development, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Reproductive medicine, Public health
Abstract

BackgroundPostpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. When PPH occurs, early identification of bleeding and prompt management using evidence-based guidelines, can avert most PPH-related severe morbidities and deaths. However, adherence to the World Health Organization recommended practices remains a critical challenge. A potential solution to inefficient and inconsistent implementation of evidence-based practices is the application of a 'clinical care bundle' for PPH management. A clinical care bundle is a set of discrete, evidence-based interventions, administered concurrently, or in rapid succession, to every eligible person, along with teamwork, communication, and cooperation. Once triggered, all bundle components must be delivered. The E-MOTIVE project aims to improve the detection and first response management of PPH through the implementation of the "E-MOTIVE" bundle, which consists of (1) Early PPH detection using a calibrated drape, (2) uterine Massage, (3) Oxytocic drugs, (4) Tranexamic acid, (5) Intra Venous fluids, and (6) genital tract Examination and escalation when necessary. The objective of this paper is to describe the protocol for the formative phase of the E-MOTIVE project, which aims to design an implementation strategy to support the uptake of this bundle into practice.MethodsWe will use behavior change and implementation science frameworks [e.g. capability, opportunity, motivation and behavior (COM-B) and theoretical domains framework (TDF)] to guide data collection and analysis, in Kenya, Nigeria, South Africa, Sri Lanka, and Tanzania. There are four methodological components: qualitative interviews; surveys; systematic reviews; and design workshops. We will triangulate findings across data sources, participant groups, and countries to explore factors influencing current PPH detection and management, and potentially influencing E-MOTIVE bundle implementation. We will use these findings to develop potential strategies to improve implementation, which will be discussed and agreed with key stakeholders from each country in intervention design workshops.DiscussionThis formative protocol outlines our strategy for the systematic development of the E-MOTIVE implementation strategy. This focus on implementation considers what it would take to support roll-out and implementation of the E-MOTIVE bundle. Our approach therefore aims to maximize internal validity in the trial alongside future scalability, and implementation of the E-MOTIVE bundle in routine practice, if proven to be effective.Trial registrationClinicalTrials.gov: NCT04341662.

Published
2021

7. Neglected medium-term and long-term consequences of labour and childbirth: a systematic analysis of the burden, recommended practices, and a way forward

Author

Vogel, Joshua P, Jung, Jenny, Lavin, Tina, Simpson, Grace, Kluwgant, Dvora, Abalos, Edgardo, Diaz, Virginia, Downe, Soo, Filippi, Veronique, Gallos, Ioannis, Galadanci, Hadiza, Katageri, Geetanjali, Homer, Caroline S E, Hofmeyr, G Justus, Liabsuetrakul, Tippawan, Morhason-Bello, Imran O, Osoti, Alfred, Souza, João Paulo, Thakar, Ranee, Thangaratinam, Shakila, and Oladapo, Olufemi T

Published
2024
Full Text
View/download PDF

10. A cost-effectiveness analysis of early detection and bundled treatment of postpartum hemorrhage alongside the E-MOTIVE trial

Author

Williams, Eleanor V., primary, Goranitis, Ilias, additional, Oppong, Raymond, additional, Perry, Samuel J., additional, Devall, Adam J., additional, Martin, James T., additional, Mammoliti, Kristie-Marie, additional, Beeson, Leanne E., additional, Sindhu, Kulandaipalayam N., additional, Galadanci, Hadiza, additional, Alwy Al‑beity, Fadhlun, additional, Qureshi, Zahida, additional, Hofmeyr, G. Justus, additional, Moran, Neil, additional, Fawcus, Sue, additional, Mandondo, Sibongile, additional, Middleton, Lee, additional, Hemming, Karla, additional, Oladapo, Olufemi T., additional, Gallos, Ioannis D., additional, Coomarasamy, Arri, additional, and Roberts, Tracy E., additional

Published
2024
Full Text
View/download PDF

12. What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight

Author

Awoyemi, Toluwalase, Ayede, Adejumoke I., Bastola, Kalpana, Bhutta, Zulfiqar A., Blencowe, Hannah, Christian, Parul, David, Anna, Hunter, Patricia, Isojärvi, Jaana, Katz, Joanne, De Costa, Ayesha, Erchick, Daniel J., Gibson, Sarah, Goncalves, Bronner P., Gravett, Michael G., Hadji, Maryam, Hazel, Elizabeth, Hofmeyr, G Justus, Kozuki, Naoko, Lee, Anne CC., Magge, Hema, Manasyan, Albert, Mohiddin, Abdulrahman, Morrison, Melissa, Muthiani, Yvonne, Nabwera, Helen, Nakimuli, Annettee, Okong, Pius, Prendergast, Andrew J., Simon, Jonathon, Temmerman, Marleen, Yan, Jian, Koivu, Annariina M., Haapaniemi, Tiia, Askari, Sufia, Bhandari, Nita, Black, Robert E., Chico, R. Matthew, Dewey, Kathryn G., Duggan, Christopher P., Klein, Nigel, Kumar, Somesh, Lawn, Joy E., Manji, Karim, Näsänen-Gilmore, Pieta K., Salasibew, Mihretab, Semrau, Katherine E.A., Ashorn, Ulla, and Ashorn, Per

Published
2023
Full Text
View/download PDF

13. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author

Ashorn, Per, Black, Robert E, Lawn, Joy E, Ashorn, Ulla, Klein, Nigel, Hofmeyr, G Justus, Temmerman, Marleen, Askari, Sufia, Ohuma, Eric O, Moller, Ann-Beth, Bradley, Ellen, Chakwera, Samuel, Hussain-Alkhateeb, Laith, Lewin, Alexandra, Okwaraji, Yemisrach B, Retno Mahanani, Wahyu, White Johansson, Emily, Lavin, Tina, Estevez Fernandez, Diana, Gatica Domínguez, Giovanna, de Costa, Ayesha, Cresswell, Jenny A, Krasevec, Julia, Blencowe, Hannah, Requejo, Jennifer, Moran, Allisyn C, Pingray, Veronica, Cormick, Gabriela, Gibbons, Luz, Belizan, José, Guevel, Carlos, Warrilow, Kara, Gordon, Adrienne, Flenady, Vicki, Sexton, Jessica, Lawford, Harriet, Paixao, Enny S., Rocha Falcão, Ila, Lima Barreto, Mauricio, Lisonkova, Sarka, Wen, Qi, Mardones, Francisco, Caulier-Cisterna, Raúl, Acuña, José, Velebil, Petr, Jirova, Jitka, Horváth-Puhó, Erzsébet, Sørensen, Henrik Toft, Sakkeus, Luule, Abuladze, Liili, Gissler, Mika, Moradi-Lakeh, Maziar, Heidarzadeh, Mohammad, Khalili, Narjes, A. Yunis, Khalid, Al Bizri, Ayah, Nakad, Pascale, Devi Karalasingam, Shamala, R Jeganathan, J Ravichandran, binti Baharum, Nurakman, Suárez-Idueta, Lorena, Barranco Flores, Arturo, Gonzalez Roldan, Jesus F, Lopez Alvarez, Sonia, van Dijk, Aimée E., Broeders, Lisa, Huicho, Luis, Quezada Pinedo, Hugo G, Cajachagua-Torres, Kim N, Carrillo-Larco, Rodrigo M, Tarazona Meza, Carla Estefania, Guzman-Vilca, Wilmer Cristobal, Olukade, Tawa O., Ali, Hamdy A., Alyafei, Fawziya, AlQubaisi, Mai, Alturk, Mohamad R, Kim, Ho Yeon, Cho, Geum Joon, Razaz, Neda, Söderling, Jonas, Smith, Lucy K, Kurinczuk, Jennifer J, Matthews, Ruth J, Manktelow, Bradley N, Draper, Elizabeth S, Fenton, Alan C, Lowry, Estelle, Rowland, Neil, Wood, Rachael, Monteath, Kirsten, Pereyra, Isabel, Pravia, Gabriella, Davis, Celina, Clarke, Samantha, Wu, Lee S.F., Yoshida, Sachiyo, Bahl, Rajiv, Grandi, Carlos, Labrique, Alain B, Rashid, Mabhubur, Ahmed, Salahuddin, Roy, Arunangshu D., Haque, Rezwanul, Shaikh, Saijuddin, Baqui, Abdullah H., Saha, Samir K., Khanam, Rasheda, Rahman, Sayedur, Shapiro, Roger, Zash, Rebecca, Silveira, Mariângela F., Buffarini, Romina, Kolsteren, Patrick, Lachat, Carl, Huybregts, Lieven, Roberfroid, Dominique, Zeng, Lingxia, Zhu, Zhonghai, He, Jianrong, Qui, Xiu, Gebreyesus, Seifu H., Tesfamariam, Kokeb, Bekele, Delayehu, Chan, Grace, Baye, Estifanos, Workneh, Firehiwot, Asante, Kwaku P., Boanmah-Kaali, Ellen, Adu-Afarwuah, Seth, Dewey, Kathryn G., Gyaase, Stephaney, Wylie, Blair J., Kirkwood, Betty R., Manu, Alexander, Thulasiraj, Ravilla D, Tielsch, James, Chowdhury, Ranadip, Taneja, Sunita, Babu, Giridhara R, Shriyan, Prafulla, Maleta, Kenneth, Mangani, Charles, Acevedo-Gallegos, Sandra, Rodriguez-Sibaja, Maria J., Khatry, Subarna K., LeClerq, Steven C., Mullany, Luke C., Jehan, Fyezah, Ilyas, Muhammad, Rogerson, Stephen J., Unger, Holger W., Ghosh, Rakesh, Musange, Sabine, Ramokolo, Vundli, Zembe-Mkabile, Wanga, Lazzerini, Marzia, Mohamed, Rishard, Wang, Dongqing, Fawzi, Wafaie W., Minja, Daniel T.R., Schmiegelow, Christentze, Masanja, Honorati, Smith, Emily, Lusingu, John P.A., Msemo, Omari A., Kabole, Fathma M., Slim, Salim N., Keentupthai, Paniya, Mongkolchati, Aroonsri, Kajubi, Richard, Kakuru, Abel, Waiswa, Peter, Walker, Dilys, Hamer, Davidson H., Semrau, Katherine E.A., Chaponda, Enesia B., Chico, R. Matthew, Banda, Bowen, Musokotwane, Kebby, Manasyan, Albert, Pry, Jake M., Chasekwa, Bernard, Humphrey, Jean, Shamim, Abu Ahmed, Christian, Parul, Ali, Hasmot, Klemm, Rolf D.W., Massie, Alan B., Mitra, Maithili, Mehra, Sucheta, Schulze, Kerry J., Shamim, Abu Amed, Sommer, Alfred, Ullah, Barkat, West, Keith P., Jr, Begum, Nazma, Chowdhury, Nabidul Haque, Islam, Shafiqul, Mitra, Dipak Kumar, Quaiyum, Abdul, Diseko, Modiegi, Makhema, Joseph, Cheng, Yue, Guo, Yixin, Yuan, Shanshan, Roro, Meselech, Shikur, Bilal, Goddard, Frederick, Haneuse, Sebastien, Hunegnaw, Bezawit, Berhane, Yemane, Worku, Alemayehu, Kaali, Seyram, Arnold, Charles D., Jack, Darby, Amenga-Etego, Seeba, Hurt, Lisa, Shannon, Caitlin, Soremekun, Seyi, Bhandari, Nita, Martines, Jose, Mazumder, Sarmila, Ana, Yamuna, R, Deepa, Hallamaa, Lotta, Pyykkö, Juha, Lumbreras-Marquez, Mario I., Mendoza-Carrera, Claudia E., Hussain, Atiya, Karim, Muhammad, Kausar, Farzana, Mehmood, Usma, Nadeem, Naila, Nisar, Muhammad Imran, Sajid, Muhammad, Mueller, Ivo, Ome-Kaius, Maria, Butrick, Elizabeth, Sayinzoga, Felix, Mariani, Ilaria, Urassa, Willy, Theander, Thor, Deloron, Phillippe, Nielsen, Birgitte Bruun, Muhihi, Alfa, Noor, Ramadhani Abdallah, Bygbjerg, Ib, Moeller, Sofie Lykke, Aftab, Fahad, Ali, Said M., Dhingra, Pratibha, Dhingra, Usha, Dutta, Arup, Sazawal, Sunil, Suleiman, Atifa, Mohammed, Mohammed, Deb, Saikat, Kamya, Moses R., Nakalembe, Miriam, Mulowooz, Jude, Santos, Nicole, Biemba, Godfrey, Herlihy, Julie M., Mbewe, Reuben K., Mweena, Fern, Yeboah-Antwi, Kojo, Bruce, Jane, Chandramohan, Daniel, Prendergast, Andrew, Idueta, Lorena Suárez, Hazel, Elizabeth, Erchick, Daniel J, Yargawa, Judith, Katz, Joanne, Lee, Anne C C, Diaz, Mike, Salasibew, Mihretab, Hayashi, Chika, and Borghi, Elaine

Published
2023
Full Text
View/download PDF

15. Small vulnerable newborns—big potential for impact

Author

Okwaraji, Yemisrach, Krasevec, Julia, Bradley, Ellen, Conkle, Joel, Stevens, Gretchen, Gatica, Giovanna, Ohuma, Eric O., Coffey, Chris, Estevez Dominguez, Diana, Blencowe, Hannah, Kimathi, Ben, Moller, Ann Beth, Lewin, Alexandra, Hussain-Alkhateeb, Laith, Dalmiya, Nita, Lawn, Joy E., Borghi, Elaine, Hayashi, Chika, Ashorn, Per, Ashorn, Ulla, Muthiani, Yvonne, Aboubaker, Samira, Askari, Sufia, Bahl, Rajiv, Black, Robert E, Duggan, Christopher P, Hofmeyr, G Justus, Kennedy, Stephen H, Klein, Nigel, Lawn, Joy E, Shiffman, Jeremy, Simon, Jonathon, and Temmerman, Marleen

Published
2023
Full Text
View/download PDF

19. Strategies for optimising early detection and obstetric first response management of postpartum haemorrhage at caesarean birth: a modified Delphi-based international expert consensus

Author

Pingray, Verónica, primary, Williams, Caitlin R, additional, Al-beity, Fadhlun M Alwy, additional, Abalos, Edgardo, additional, Arulkumaran, Sabaratnam, additional, Blumenfeld, Alejandro, additional, Carvalho, Brendan, additional, Deneux-Tharaux, Catherine, additional, Downe, Soo, additional, Dumont, Alexandre, additional, Escobar, Maria Fernanda, additional, Evans, Cherrie, additional, Fawcus, Sue, additional, Galadanci, Hadiza S, additional, Hoang, Diem-Tuyet Thi, additional, Hofmeyr, G Justus, additional, Homer, Caroline, additional, Lewis, Ayodele G, additional, Liabsuetrakul, Tippawan, additional, Lumbiganon, Pisake, additional, Main, Elliott K, additional, Maua, Judith, additional, Muriithi, Francis G, additional, Nabhan, Ashraf Fawzy, additional, Nunes, Inês, additional, Ortega, Vanesa, additional, Phan, Thuan N Q, additional, Qureshi, Zahida P, additional, Sosa, Claudio, additional, Varallo, John, additional, Weeks, Andrew D, additional, Widmer, Mariana, additional, Oladapo, Olufemi T, additional, Gallos, Ioannis, additional, Coomarasamy, Arri, additional, Miller, Suellen, additional, and Althabe, Fernando, additional

Published
2024
Full Text
View/download PDF

20. Effects of injectable contraception with depot medroxyprogesterone acetate or norethisterone enanthate on estradiol levels and menstrual, psychological and behavioral measures relevant to HIV risk: The WHICH randomized trial

Author

Singata-Madliki, Mandisa, primary, Smit, Jenni, additional, Beksinska, Mags, additional, Balakrishna, Yusentha, additional, Avenant, Chanel, additional, Beesham, Ivana, additional, Seocharan, Ishen, additional, Batting, Joanne, additional, Hapgood, Janet P., additional, and Hofmeyr, G. Justus, additional

Published
2024
Full Text
View/download PDF

24. Misreporting contraceptive use and the association of peak study progestin levels with weight and BMI among women randomized to the progestin-only injectable contraceptives DMPA-IM and NET-EN

Author

Avenant, Chanel, primary, Bick, Alexis J., additional, Skosana, Salndave B., additional, Dlamini, Sigcinile, additional, Balakrishna, Yusentha, additional, Moliki, Johnson Mosoko, additional, Singata-Madliki, Mandisa, additional, Hofmeyr, G. Justus, additional, Smit, Jenni, additional, Beksinska, Mags, additional, Beesham, Ivana, additional, Seocharan, Ishen, additional, Batting, Joanne, additional, Chen, Pai-Lien, additional, Storbeck, Karl-Heinz, additional, Africander, Donita, additional, and Hapgood, Janet P., additional

Published
2023
Full Text
View/download PDF

25. Neglected medium-term and long-term consequences of labour and childbirth: a systematic analysis of the burden, recommended practices, and a way forward

Author

Vogel, Joshua P, primary, Jung, Jenny, additional, Lavin, Tina, additional, Simpson, Grace, additional, Kluwgant, Dvora, additional, Abalos, Edgardo, additional, Diaz, Virginia, additional, Downe, Soo, additional, Filippi, Veronique, additional, Gallos, Ioannis, additional, Galadanci, Hadiza, additional, Katageri, Geetanjali, additional, Homer, Caroline S E, additional, Hofmeyr, G Justus, additional, Liabsuetrakul, Tippawan, additional, Morhason-Bello, Imran O, additional, Osoti, Alfred, additional, Souza, João Paulo, additional, Thakar, Ranee, additional, Thangaratinam, Shakila, additional, and Oladapo, Olufemi T, additional

Published
2023
Full Text
View/download PDF

26. Vulnerabilities and reparative strategies during pregnancy, childbirth, and the postpartum period: moving from rhetoric to action

Author

Sheikh, Jameela, primary, Allotey, John, additional, Kew, Tania, additional, Khalil, Halimah, additional, Galadanci, Hadiza, additional, Hofmeyr, G Justus, additional, Abalos, Edgardo, additional, Vogel, Joshua P., additional, Lavin, Tina, additional, Souza, João Paulo, additional, Kaur, Inderjeet, additional, Ram, Uma, additional, Betran, Ana Pilar, additional, Bohren, Meghan A., additional, Oladapo, Olufemi T., additional, and Thangaratinam, Shakila, additional

Published
2023
Full Text
View/download PDF

27. Factors affecting the implementation of calcium supplementation strategies during pregnancy to prevent pre-eclampsia: a mixed-methods systematic review

Author

Cormick, Gabriela, primary, Moraa, Hellen, additional, Zahroh, Rana Islamiah, additional, Allotey, John, additional, Rocha, Thaís, additional, Peña-Rosas, Juan Pablo, additional, Qureshi, Zahida P, additional, Hofmeyr, G Justus, additional, Mistry, Hema, additional, Smits, Luc, additional, Vogel, Joshua Peter, additional, Palacios, Alfredo, additional, Gwako, George N, additional, Abalos, Edgardo, additional, Larbi, Koiwah Koi, additional, Carroli, Guillermo, additional, Riley, Richard, additional, Snell, Kym IE, additional, Thorson, Anna, additional, Young, Taryn, additional, Betran, Ana Pilar, additional, Thangaratinam, Shakila, additional, and Bohren, Meghan A, additional

Published
2023
Full Text
View/download PDF

28. Incorporating oral PrEP into standard prevention services for South African women: a nested interrupted time-series study

Author

Gichangi, Peter B, Heller, Kate B, Mbandazayo, Nomthandazo, Morrison, Charles S, Nanda, Kavita, Scoville, Caitlin W, Shears, Kathleen, Steyn, Petrus S, Taylor, Douglas, Thomas, Katherine K, Kiarie, James, Justman, Jessica, Nhlabatsi, Zelda, Bekker, Linda-Gail, Nair, Gonasagrie, Hofmeyr, G Justus, Singata-Madliki, Mandisa, Selepe, Raesibe Agnes Pearl, Sibiya, Sydney, Phiri Kasaro, Margaret, Stringer, Jeffrey, Mugo, Nelly R, Donnell, Deborah, Beesham, Ivana, Welch, Julia D, Heffron, Renee, Pleaner, Melanie, Kidoguchi, Lara, Palanee-Phillips, Thesla, Ahmed, Khatija, Baron, Deborah, Bukusi, Elizabeth A, Louw, Cheryl, Mastro, Timothy D, Smit, Jennifer, Batting, Joanne R, Malahleha, Mookho, Bailey, Veronique C, Beksinska, Mags, Rees, Helen, and Baeten, Jared M

Published
2021
Full Text
View/download PDF

30. Sexual behaviour among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: Data from the ECHO randomized trial.

Author

Hofmeyr, G. Justus, Singata-Madliki, Mandisa, Batting, Joanne, Steyn, Petrus, Thomas, Katherine K., Issema, Rodal, Beesham, Ivana, Mbatsane, Enough, Morrison, Charles, Deese, Jen, Smit, Jenni, Philip, Neena, Palanee-Phillips, Thesla, Reddy, Krishnaveni, Onono, Maricianah, Mastro, Timothy D., and Baeten, Jared M.

Subjects
*HUMAN sexuality, *CONTRACEPTION, *COPPER intrauterine contraceptives, *INTRAUTERINE contraceptives, *UNSAFE sex, *SEXUAL intercourse, *MEDROXYPROGESTERONE
Abstract

Background: Contraceptive use has complex effects on sexual behaviour and mood, including those related to reduced concerns about unintended pregnancy, direct hormonal effects and effects on endogenous sex hormones. We set out to obtain robust evidence on the relative effects of three contraceptive methods on sex behaviours, which is important for guiding contraceptive choice and future contraceptive developments. Methods: This is a secondary analysis of data from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) randomized trial in which 7,829 HIV-uninfected women from 12 sites in Eswatini, Kenya, South Africa and Zambia seeking contraception were randomly assigned to intramuscular depot-medroxyprogesterone acetate (DMPA-IM), the copper intrauterine device (Cu-IUD) or the levonorgestrel (LNG) implant. Data collected for 12 to 18 months using 3-monthly behavioural questionnaires that relied on recall from the preceding 3 months, were used to estimate relative risk of post-baseline sex behaviours, as well as sexual desire and menstrual bleeding between randomized groups using modified Poisson regression. Results: We observed small but generally consistent effects wherein DMPA-IM users reported lower prevalence of specified high risk sexual behaviours than implant users than Cu-IUD users (the '>' and '<' symbols indicate statistically significant differences): multiple sex partners 3.6% < 4.8% < 6.2% respectively; new sex partner 3.0% < 4.0% <5.3%; coital acts 16.45, 16.65, 17.12 (DMPA-IM < Cu-IUD); unprotected sex 65% < 68%, 70%; unprotected sex past 7 days 33% <36%, 37%; sex during vaginal bleeding 7.1%, 7.1% < 8.9%; no sex acts 4.1%, 3.8%, 3.4% (DMPA-IM > Cu-IUD); partner has sex with others 10% < 11%, 11%. The one exception was having any sex partner 96.5%, 96.9% < 97.4% (DMPA-IM < Cu-IUD). Decrease in sexual desire was reported by 1.6% > 1.1% >0.5%; amenorrhoea by 49% > 41% >12% and regular menstrual pattern by 26% <35% < 87% respectively. Conclusions: These findings suggest that women assigned to DMPA-IM may have a modest decrease in libido and sexual activity relative to the implant, and the implant relative to the Cu-IUD. We found more menstrual disturbance with DMPA-IM than with the implant (and as expected, both more than the Cu-IUD). These findings are important for informing the contraceptive choices of women and policymakers and highlight the need for robust comparison of the effects of other contraceptive methods as well. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. Effects of depot medroxyprogesterone acetate, the copper IUD and the levonorgestrel implant on testosterone, sex hormone binding globulin and free testosterone levels: ancillary study of the ECHO randomized clinical trial.

Author

Hofmeyr, G. Justus, Singata-Madliki, Mandisa, Batting, Joanne, Balakrishna, Yusentha, and Morroni, Chelsea

Subjects
*INTRAUTERINE contraceptives, *SEX hormones, *ETHINYL estradiol, *COPPER intrauterine contraceptives, *UNSAFE sex, *MEDROXYPROGESTERONE
Abstract

Background: Robust information on relative effects of hormonal contraceptives on endogenous androgens is important for understanding beneficial and adverse effects, method choice and development of new methods. Methods: In this ancillary study at the East London, South Africa site of the ECHO multicentre randomized trial, we compared effects of three contraceptive methods on serum androgen levels among contraceptive users aged 18 to 35 years. Participants were allocated by centrally-managed randomization to open label depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD) or levonorgestrel implant. The primary outcome was free testosterone at 6 months. Results: We analysed stored baseline and 6-month serum samples in 398/615 participants (DMPA-IM 131/205, IUD 135/205 and implant 132/205). Median testosterone levels at baseline were DMPA-IM 0.82, IUD 0.9 and implant 0.87 nmol/L; at 6 months, DMPA 0.68 (lower than IUD, mean percentage difference 28.35, (p < 0.001), IUD 0.86 (unchanged) and implant 0.66, lower than IUD, mean percentage difference − 22.98, p < 0.001). Median SHBG levels at baseline were DMPA 52.4, IUD 50.5 and implant 55.75 nmol/L; at 6 months, DMPA 40.65, lower than IUD (mean percentage difference 21.19, p = 0.005), IUD 49.1 (unchanged), and implant 23.35 nmol/L, lower than IUD (mean percentage difference − 50.04, p < 0.001 and than DMPA (mean percentage difference − 39.45, p < 0.001). Free testosterone levels at baseline were DMPA 10, IUD 12 and implant 11 pmol/L; at 6 months, DMPA 11, less than IUD (mean percentage difference 13.53, p = 0.047), IUD 12 and implant 14, higher than IUD (mean percentage difference 14.15, p = 0.038) and than DMPA, (mean percentage difference 29.60, p < 0.001). Conclusions: This is the first randomized trial to show lower SHBG and higher free testosterone with the levonorgestrel implant than with DMPA, and contrasts with reports of increased SHBG with combined oral ethinyl estradiol/levonorgestrel use, and reduced androgens (and impaired sexual function) reported with the etonorgestrel implant. The higher free testosterone with the LNG implant might improve sexual function, mood and bone health as well as increasing side-effects such as acne and hirsutism, and is consistent with the greater sexual activity (with respect to multiple sex partners, new sex partner and unprotected sex) with the implant compared with DMPA documented in the ECHO study. ECHO trial registration: ClinicalTrials.gov, number NCT02550067 15/09/2015. Plain English summary: Contraception, or family planning, is central to the role of women in societies. It is most important to have accurate information on the relative side-effects of various contraceptive options in order to empower women to make informed choices regarding their preferred method. Hormonal contraceptives contain various forms of the female sex hormones, estrogens and/or progestogens. These hormones have direct effects on the users, as well as modifying the levels of the users' own circulating sex hormones, both the 'female' and the 'male' sex hormones (androgens). In this study, consenting participants requesting contraception, were allocated randomly to receive either depot medroxyprogesterone acetate (DMPA-IM) a 3-monthly progestogen injection, the copper intrauterine device (IUD), a non-hormonal contraceptive inserted within the womb, or the levonorgestrel implant, a device placed under the skin which releases a progestogen for 5 years. We measured the participants' androgen levels after 6 months, and found for the first time that the active form of testosterone (free testosterone) was 29% higher with the implant than with DMPA-IM. The level with the IUD was intermediate, and significantly different from the other two methods. This finding is relevant to the effects experienced by users of these methods, because free testosterone has effects on sexual function, bone health and mood, as well as on conditions such as acne and hair distribution patterns. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Evidence-based antenatal interventions to reduce the incidence of small vulnerable newborns and their associated poor outcomes

Author

Hofmeyr, G Justus, primary, Black, Robert E, additional, Rogozińska, Ewelina, additional, Heuer, Austin, additional, Walker, Neff, additional, Ashorn, Per, additional, Ashorn, Ulla, additional, Bhandari, Nita, additional, Bhutta, Zulfiqar A, additional, Koivu, Annariina, additional, Kumar, Somesh, additional, Lawn, Joy E, additional, Munjanja, Stephen, additional, Näsänen-Gilmore, Pieta, additional, Ramogola-Masire, Doreen, additional, Temmerman, Marleen, additional, Klein, Nigel, additional, Hofmeyr, G Justus, additional, and Askari, Sufia, additional

Published
2023
Full Text
View/download PDF

35. Third stage of labor: evidence-based practice for prevention of adverse maternal and neonatal outcomes

Author

Hersh, Alyssa R., primary, Carroli, Guillermo, additional, Hofmeyr, G. Justus, additional, Garg, Bharti, additional, Gülmezoglu, Metin, additional, Lumbiganon, Pisake, additional, De Mucio, Bremen, additional, Saleem, Sarah, additional, Festin, Mario Philip R., additional, Mittal, Suneeta, additional, Rubio-Romero, Jorge Andres, additional, Chipato, Tsungai, additional, Valencia, Catalina, additional, and Tolosa, Jorge E., additional

Published
2023
Full Text
View/download PDF

36. Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage

Author

Gallos, Ioannis, primary, Devall, Adam, additional, Martin, James, additional, Middleton, Lee, additional, Beeson, Leanne, additional, Galadanci, Hadiza, additional, Alwy Al-beity, Fadhlun, additional, Qureshi, Zahida, additional, Hofmeyr, G. Justus, additional, Moran, Neil, additional, Fawcus, Sue, additional, Sheikh, Lumaan, additional, Gwako, George, additional, Osoti, Alfred, additional, Aswat, Ashraf, additional, Mammoliti, Kristie-Marie, additional, Sindhu, Kulandaipalayam N., additional, Podesek, Marcelina, additional, Horne, Isobelle, additional, Timms, Rebecca, additional, Yunas, Idnan, additional, Okore, Jenipher, additional, Singata-Madliki, Mandisa, additional, Arends, Edna, additional, Wakili, Aminu A., additional, Mwampashi, Ard, additional, Nausheen, Sidrah, additional, Muhammad, Shah, additional, Latthe, Pallavi, additional, Evans, Cherrie, additional, Akter, Shahinoor, additional, Forbes, Gillian, additional, Lissauer, David, additional, Meher, Shireen, additional, Weeks, Andrew, additional, Shennan, Andrew, additional, Ammerdorffer, Anne, additional, Williams, Eleanor, additional, Roberts, Tracy, additional, Widmer, Mariana, additional, Oladapo, Olufemi T., additional, Lorencatto, Fabiana, additional, Bohren, Meghan A., additional, Miller, Suellen, additional, Althabe, Fernando, additional, Gülmezoglu, Metin, additional, Smith, Jeffrey M., additional, Hemming, Karla, additional, and Coomarasamy, Arri, additional

Published
2023
Full Text
View/download PDF

39. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting

Author

Lawn, Joy E, primary, Ohuma, Eric O, additional, Bradley, Ellen, additional, Idueta, Lorena Suárez, additional, Hazel, Elizabeth, additional, Okwaraji, Yemisrach B, additional, Erchick, Daniel J, additional, Yargawa, Judith, additional, Katz, Joanne, additional, Lee, Anne C C, additional, Diaz, Mike, additional, Salasibew, Mihretab, additional, Requejo, Jennifer, additional, Hayashi, Chika, additional, Moller, Ann-Beth, additional, Borghi, Elaine, additional, Black, Robert E, additional, Blencowe, Hannah, additional, Ashorn, Per, additional, Lawn, Joy E, additional, Ashorn, Ulla, additional, Klein, Nigel, additional, Hofmeyr, G Justus, additional, Temmerman, Marleen, additional, Askari, Sufia, additional, Chakwera, Samuel, additional, Hussain-Alkhateeb, Laith, additional, Lewin, Alexandra, additional, Retno Mahanani, Wahyu, additional, White Johansson, Emily, additional, Lavin, Tina, additional, Estevez Fernandez, Diana, additional, Gatica Domínguez, Giovanna, additional, de Costa, Ayesha, additional, Cresswell, Jenny A, additional, Krasevec, Julia, additional, Moran, Allisyn C, additional, Pingray, Veronica, additional, Cormick, Gabriela, additional, Gibbons, Luz, additional, Belizan, José, additional, Guevel, Carlos, additional, Warrilow, Kara, additional, Gordon, Adrienne, additional, Flenady, Vicki, additional, Sexton, Jessica, additional, Lawford, Harriet, additional, Paixao, Enny S., additional, Rocha Falcão, Ila, additional, Lima Barreto, Mauricio, additional, Lisonkova, Sarka, additional, Wen, Qi, additional, Mardones, Francisco, additional, Caulier-Cisterna, Raúl, additional, Acuña, José, additional, Velebil, Petr, additional, Jirova, Jitka, additional, Horváth-Puhó, Erzsébet, additional, Sørensen, Henrik Toft, additional, Sakkeus, Luule, additional, Abuladze, Liili, additional, Gissler, Mika, additional, Moradi-Lakeh, Maziar, additional, Heidarzadeh, Mohammad, additional, Khalili, Narjes, additional, A. Yunis, Khalid, additional, Al Bizri, Ayah, additional, Nakad, Pascale, additional, Devi Karalasingam, Shamala, additional, R Jeganathan, J Ravichandran, additional, binti Baharum, Nurakman, additional, Suárez-Idueta, Lorena, additional, Barranco Flores, Arturo, additional, Gonzalez Roldan, Jesus F, additional, Lopez Alvarez, Sonia, additional, van Dijk, Aimée E., additional, Broeders, Lisa, additional, Huicho, Luis, additional, Quezada Pinedo, Hugo G, additional, Cajachagua-Torres, Kim N, additional, Carrillo-Larco, Rodrigo M, additional, Tarazona Meza, Carla Estefania, additional, Guzman-Vilca, Wilmer Cristobal, additional, Olukade, Tawa O., additional, Ali, Hamdy A., additional, Alyafei, Fawziya, additional, AlQubaisi, Mai, additional, Alturk, Mohamad R, additional, Kim, Ho Yeon, additional, Cho, Geum Joon, additional, Razaz, Neda, additional, Söderling, Jonas, additional, Smith, Lucy K, additional, Kurinczuk, Jennifer J, additional, Matthews, Ruth J, additional, Manktelow, Bradley N, additional, Draper, Elizabeth S, additional, Fenton, Alan C, additional, Lowry, Estelle, additional, Rowland, Neil, additional, Wood, Rachael, additional, Monteath, Kirsten, additional, Pereyra, Isabel, additional, Pravia, Gabriella, additional, Davis, Celina, additional, Clarke, Samantha, additional, Wu, Lee S.F., additional, Yoshida, Sachiyo, additional, Bahl, Rajiv, additional, Grandi, Carlos, additional, Labrique, Alain B, additional, Rashid, Mabhubur, additional, Ahmed, Salahuddin, additional, Roy, Arunangshu D., additional, Haque, Rezwanul, additional, Shaikh, Saijuddin, additional, Baqui, Abdullah H., additional, Saha, Samir K., additional, Khanam, Rasheda, additional, Rahman, Sayedur, additional, Shapiro, Roger, additional, Zash, Rebecca, additional, Silveira, Mariângela F., additional, Buffarini, Romina, additional, Kolsteren, Patrick, additional, Lachat, Carl, additional, Huybregts, Lieven, additional, Roberfroid, Dominique, additional, Zeng, Lingxia, additional, Zhu, Zhonghai, additional, He, Jianrong, additional, Qui, Xiu, additional, Gebreyesus, Seifu H., additional, Tesfamariam, Kokeb, additional, Bekele, Delayehu, additional, Chan, Grace, additional, Baye, Estifanos, additional, Workneh, Firehiwot, additional, Asante, Kwaku P., additional, Boanmah-Kaali, Ellen, additional, Adu-Afarwuah, Seth, additional, Dewey, Kathryn G., additional, Gyaase, Stephaney, additional, Wylie, Blair J., additional, Kirkwood, Betty R., additional, Manu, Alexander, additional, Thulasiraj, Ravilla D, additional, Tielsch, James, additional, Chowdhury, Ranadip, additional, Taneja, Sunita, additional, Babu, Giridhara R, additional, Shriyan, Prafulla, additional, Maleta, Kenneth, additional, Mangani, Charles, additional, Acevedo-Gallegos, Sandra, additional, Rodriguez-Sibaja, Maria J., additional, Khatry, Subarna K., additional, LeClerq, Steven C., additional, Mullany, Luke C., additional, Jehan, Fyezah, additional, Ilyas, Muhammad, additional, Rogerson, Stephen J., additional, Unger, Holger W., additional, Ghosh, Rakesh, additional, Musange, Sabine, additional, Ramokolo, Vundli, additional, Zembe-Mkabile, Wanga, additional, Lazzerini, Marzia, additional, Mohamed, Rishard, additional, Wang, Dongqing, additional, Fawzi, Wafaie W., additional, Minja, Daniel T.R., additional, Schmiegelow, Christentze, additional, Masanja, Honorati, additional, Smith, Emily, additional, Lusingu, John P.A., additional, Msemo, Omari A., additional, Kabole, Fathma M., additional, Slim, Salim N., additional, Keentupthai, Paniya, additional, Mongkolchati, Aroonsri, additional, Kajubi, Richard, additional, Kakuru, Abel, additional, Waiswa, Peter, additional, Walker, Dilys, additional, Hamer, Davidson H., additional, Semrau, Katherine E.A., additional, Chaponda, Enesia B., additional, Chico, R. Matthew, additional, Banda, Bowen, additional, Musokotwane, Kebby, additional, Manasyan, Albert, additional, Pry, Jake M., additional, Chasekwa, Bernard, additional, Humphrey, Jean, additional, Shamim, Abu Ahmed, additional, Christian, Parul, additional, Ali, Hasmot, additional, Klemm, Rolf D.W., additional, Massie, Alan B., additional, Mitra, Maithili, additional, Mehra, Sucheta, additional, Schulze, Kerry J., additional, Shamim, Abu Amed, additional, Sommer, Alfred, additional, Ullah, Barkat, additional, West, Keith P., additional, Begum, Nazma, additional, Chowdhury, Nabidul Haque, additional, Islam, Shafiqul, additional, Mitra, Dipak Kumar, additional, Quaiyum, Abdul, additional, Diseko, Modiegi, additional, Makhema, Joseph, additional, Cheng, Yue, additional, Guo, Yixin, additional, Yuan, Shanshan, additional, Roro, Meselech, additional, Shikur, Bilal, additional, Goddard, Frederick, additional, Haneuse, Sebastien, additional, Hunegnaw, Bezawit, additional, Berhane, Yemane, additional, Worku, Alemayehu, additional, Kaali, Seyram, additional, Arnold, Charles D., additional, Jack, Darby, additional, Amenga-Etego, Seeba, additional, Hurt, Lisa, additional, Shannon, Caitlin, additional, Soremekun, Seyi, additional, Bhandari, Nita, additional, Martines, Jose, additional, Mazumder, Sarmila, additional, Ana, Yamuna, additional, R, Deepa, additional, Hallamaa, Lotta, additional, Pyykkö, Juha, additional, Lumbreras-Marquez, Mario I., additional, Mendoza-Carrera, Claudia E., additional, Hussain, Atiya, additional, Karim, Muhammad, additional, Kausar, Farzana, additional, Mehmood, Usma, additional, Nadeem, Naila, additional, Nisar, Muhammad Imran, additional, Sajid, Muhammad, additional, Mueller, Ivo, additional, Ome-Kaius, Maria, additional, Butrick, Elizabeth, additional, Sayinzoga, Felix, additional, Mariani, Ilaria, additional, Urassa, Willy, additional, Theander, Thor, additional, Deloron, Phillippe, additional, Nielsen, Birgitte Bruun, additional, Muhihi, Alfa, additional, Noor, Ramadhani Abdallah, additional, Bygbjerg, Ib, additional, Moeller, Sofie Lykke, additional, Aftab, Fahad, additional, Ali, Said M., additional, Dhingra, Pratibha, additional, Dhingra, Usha, additional, Dutta, Arup, additional, Sazawal, Sunil, additional, Suleiman, Atifa, additional, Mohammed, Mohammed, additional, Deb, Saikat, additional, Kamya, Moses R., additional, Nakalembe, Miriam, additional, Mulowooz, Jude, additional, Santos, Nicole, additional, Biemba, Godfrey, additional, Herlihy, Julie M., additional, Mbewe, Reuben K., additional, Mweena, Fern, additional, Yeboah-Antwi, Kojo, additional, Bruce, Jane, additional, Chandramohan, Daniel, additional, and Prendergast, Andrew, additional

Published
2023
Full Text
View/download PDF

40. The ethical, economic, and developmental imperative to prevent small vulnerable newborns and stillbirths: essential actions to improve the country and global response

Author

Mohiddin, Abdu, primary, Semrau, Katherine E A, additional, Simon, Jonathon, additional, Langlois, Etienne V, additional, Shiffman, Jeremy, additional, Nabwera, Helen, additional, Hofmeyr, G Justus, additional, Lawn, Joy E, additional, Black, Robert E, additional, Askari, Sufia, additional, Klein, Nigel, additional, Ashorn, Ulla, additional, Ashorn, Per, additional, and Temmerman, Marleen, additional

Published
2023
Full Text
View/download PDF

41. Small vulnerable newborns—big potential for impact

Author

Ashorn, Per, primary, Ashorn, Ulla, additional, Muthiani, Yvonne, additional, Aboubaker, Samira, additional, Askari, Sufia, additional, Bahl, Rajiv, additional, Black, Robert E, additional, Dalmiya, Nita, additional, Duggan, Christopher P, additional, Hofmeyr, G Justus, additional, Kennedy, Stephen H, additional, Klein, Nigel, additional, Lawn, Joy E, additional, Shiffman, Jeremy, additional, Simon, Jonathon, additional, Temmerman, Marleen, additional, Okwaraji, Yemisrach, additional, Krasevec, Julia, additional, Bradley, Ellen, additional, Conkle, Joel, additional, Stevens, Gretchen, additional, Gatica, Giovanna, additional, Ohuma, Eric O., additional, Coffey, Chris, additional, Estevez Dominguez, Diana, additional, Blencowe, Hannah, additional, Kimathi, Ben, additional, Moller, Ann Beth, additional, Lewin, Alexandra, additional, Hussain-Alkhateeb, Laith, additional, Lawn, Joy E., additional, Borghi, Elaine, additional, and Hayashi, Chika, additional

Published
2023
Full Text
View/download PDF

42. Biological and pathological mechanisms leading to the birth of a small vulnerable newborn

Author

Hunter, Patricia J, primary, Awoyemi, Toluwalase, additional, Ayede, Adejumoke I, additional, Chico, R Matthew, additional, David, Anna L, additional, Dewey, Kathryn G, additional, Duggan, Christopher P, additional, Gravett, Michael, additional, Prendergast, Andrew J, additional, Ramakrishnan, Usha, additional, Ashorn, Per, additional, Klein, Nigel, additional, Black, Robert E, additional, Lawn, Joy E, additional, Ashorn, Ulla, additional, Hofmeyr, G Justus, additional, Temmerman, Marleen, additional, and Askari, Sufia, additional

Published
2023
Full Text
View/download PDF

44. Maternal weight and birth outcomes among women on antiretroviral treatment from conception in a birth surveillance study in Botswana

Author

Zash, Rebecca, Caniglia, Ellen C., Diseko, Modiegi, Mayondi, Gloria, Mabuta, Judith, Luckett, Rebecca, Hofmeyr, G Justus, Morroni, Chelsea, Ramogola?Masire, Doreen, Williams, Paige L., Zera, Chloe, Wylie, Blair J., Makhema, Joseph, Lockman, Shahin, and Shapiro, Roger L.

Subjects
Weight gain -- Health aspects, Antiviral agents -- Complications and side effects, Pregnancy, Complications of -- Risk factors, HIV infection -- Complications and side effects -- Drug therapy, Health
Abstract

: Introduction: Antiretrovirals such as dolutegravir (DTG) and tenofovir alafenamide (TAF) have been associated with excessive weight gain. The objective of this study was to understand the potential impact of ART‐associated weight gain on pregnancy outcomes among women living with HIV. Methods: Using data from the Tsepamo birth outcomes surveillance study in Botswana, we evaluated the relationship between maternal weight (and weight gain) and severe birth outcomes (very preterm delivery 4000 g) and maternal hypertension. We estimated the relative risk of each outcome by baseline weight (first weight in pregnancy Results: Of 22,828 women on ART at conception with singleton deliveries between August 2014 and April 2020, 16,300 (71.4%) had a weight measured 90 kg) was associated with increased risk of macrosomia (aRR 3.24, 95% CI 2.36, 4.44) and maternal hypertension (aRR 1.79, 95% CI 1.62, 1.97). Baseline weight was not associated with stillbirth or early neonatal death. For all outcomes, second trimester weight gain showed weaker associations than did baseline weight. Duration of pre‐pregnancy ART (years) was associated with higher baseline weight for DTG but not for EFV, and the risk of maternal hypertension by baseline weight category was higher for DTG than EFV for all strata. Conclusions: ART regimens associated with weight gain may reduce the number of women at risk for certain severe adverse pregnancy outcomes associated with low weight but increase the number at risk of macrosomia and maternal hypertension. Further research could determine whether weight‐based ART treatment strategies improve maternal and child health., INTRODUCTION Multiple studies have reported that tenofovir alafenamide (TAF) and dolutegravir (DTG) are associated with clinically significant weight gain, with risk of treatment‐emergent obesity (body mass index, or BMI, >30) [...]

Published
2021
Full Text
View/download PDF

45. Improving postpregnancy contraceptive method choice and long-acting reversible contraception provision in Botswana: a quality improvement pilot

Author

Hofmeyr, G Justus, primary, Ryan, Rebecca Jane, additional, Mussa, Aamirah, additional, Bame, Bame, additional, Malima, Sifelani, additional, Moloi, Thabo, additional, Luckett, Rebecca, additional, Memo, Ndiwo B, additional, Moreri-Ntshabele, Badani, additional, Nassali, Mercy Nkuba, additional, Jamieson, Modimowame, additional, Kime, Kyungu M, additional, and Morroni, Chelsea, additional

Published
2023
Full Text
View/download PDF

46. Pre-eclampsia

Author

Mol, Ben W J, Roberts, Claire T, Thangaratinam, Shakila, Magee, Laura A, de Groot, Christianne J M, and Hofmeyr, G Justus

Published
2016
Full Text
View/download PDF

47. Extended pre-exposure prophylaxis with lopinavir–ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trial

Author

Van de Perre, Philippe, Nagot, Nicolas, Vallo, Roselyne, Marechal, Valerie, Peries, Marianne, Neveu, Dorine, Foulongne, Vincent, Segondy, Michel, Blanche, Stephane, Treluyer, Jean-Marc, Hirt, Deborah, Tumwine, James K, Ndeezi, Grace, Karamagi, Charles, Musoke, Philippa, Mugaba, Proscovia M, Kwagala, Mary, Murungi, Joan, Muweesi, Hawa Nabuuma, Ninsiima, Evelyn, Baryeija, Simon, Juma, Frederic, Kata, Caleb Bwengye, Katushabe, Stuart, Meda, Nicolas, Ouédraogo, Rasmata, Yé, Diarra, Somé, Eric, Traoré, Hugues A, Nadembega, Christelle, Konaté, Justin, Zongo, Arsène, Ouédraogo, Abass, Néboua, Désiré, Bélemviré, Aissatou, Bambara, Armel, Boncoungou, Justine, Zoungrana, Danielle, Nikodem, Cheryl, Hofmeyr, Justus, Harper, Kim, Jackson, Debra, Sanders, David, Singata, Mandisa, Aku, Amwe, Okegbe-Eze, Collins, Williams, Xoliswa, Mshweshwe, Nolundi, Henge, Vatiswa, Gomba, Fikiswa, Gundu, Tapiwa, Khondowe, Oswell, Kankasa, Chipepo, Mwiya, Mwiya, Lusaka, Mildred, Chizyuka, Mary, Phiri, Mary, Imakando, Billies, Musaku, Mwenechanya, Kapasa, Monica, Rutagwera, David, Clement, Gondwe, Mwaba, Hilton Mwila, Matoba, Japhet, Siuluta, Chafye, Chola, Katai, Mwamutanda, Patricia, Tylleskär, Thorkild, Sommerfelt, Halvor, Engebretsen, Ingunn, Klungsøyr, Jørn, van den Broeck, Jan, Blume, Jörn, Rekacewicz, Claire, Hofmeyr, G Justus, Traore, Hugues, Sunday, Amwe, Some, Eric, Neboua, Desire, Maréchal, Valérie, Engebretsen, Ingunn M S, Lombard, Carl, and Blanche, Stéphane

Published
2016
Full Text
View/download PDF

48. Additional file 1 of Factors influencing postpartum haemorrhage detection and management and the implementation of a new postpartum haemorrhage care bundle (E-MOTIVE) in Kenya, Nigeria, and South Africa

Author

Forbes, Gillian, Akter, Shahinoor, Miller, Suellen, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G. Justus, Moran, Neil, Singata-Madliki, Mandisa, Dankishiya, Faisal, Gwako, George, Osoti, Alfred, Thomas, Eleanor, Gallos, Ioannis, Mammoliti, Kristie-Marie, Devall, Adam, Coomarasamy, Arri, Althabe, Fernando, Atkins, Lou, Bohren, Meghan A., and Lorencatto, Fabiana

Abstract

Additional file 1. Consolidated criteria for reporting qualitative studies (COREQ): 32-item checklist

Published
2023
Full Text
View/download PDF

49. Additional file 2 of Factors influencing postpartum haemorrhage detection and management and the implementation of a new postpartum haemorrhage care bundle (E-MOTIVE) in Kenya, Nigeria, and South Africa

Author

Forbes, Gillian, Akter, Shahinoor, Miller, Suellen, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G. Justus, Moran, Neil, Singata-Madliki, Mandisa, Dankishiya, Faisal, Gwako, George, Osoti, Alfred, Thomas, Eleanor, Gallos, Ioannis, Mammoliti, Kristie-Marie, Devall, Adam, Coomarasamy, Arri, Althabe, Fernando, Atkins, Lou, Bohren, Meghan A., and Lorencatto, Fabiana

Abstract

Additional file 2. In-depth interview guide: healthcare providers

Published
2023
Full Text
View/download PDF

50. Additional file 3 of Factors influencing postpartum haemorrhage detection and management and the implementation of a new postpartum haemorrhage care bundle (E-MOTIVE) in Kenya, Nigeria, and South Africa

Author

Forbes, Gillian, Akter, Shahinoor, Miller, Suellen, Galadanci, Hadiza, Qureshi, Zahida, Fawcus, Sue, Hofmeyr, G. Justus, Moran, Neil, Singata-Madliki, Mandisa, Dankishiya, Faisal, Gwako, George, Osoti, Alfred, Thomas, Eleanor, Gallos, Ioannis, Mammoliti, Kristie-Marie, Devall, Adam, Coomarasamy, Arri, Althabe, Fernando, Atkins, Lou, Bohren, Meghan A., and Lorencatto, Fabiana

Abstract

Additional file 3. Additional File 3 Full list of key barriers and enablers of PPH detection and management in Nigeria, Kenya and South Africa

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results