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549 results on '"Hoffmann, Markus"'

1. Spermidine is essential for fasting-mediated autophagy and longevity

Author

Hofer, Sebastian J., Daskalaki, Ioanna, Bergmann, Martina, Friščić, Jasna, Zimmermann, Andreas, Mueller, Melanie I., Abdellatif, Mahmoud, Nicastro, Raffaele, Masser, Sarah, Durand, Sylvère, Nartey, Alexander, Waltenstorfer, Mara, Enzenhofer, Sarah, Faimann, Isabella, Gschiel, Verena, Bajaj, Thomas, Niemeyer, Christine, Gkikas, Ilias, Pein, Lukas, Cerrato, Giulia, Pan, Hui, Liang, YongTian, Tadic, Jelena, Jerkovic, Andrea, Aprahamian, Fanny, Robbins, Christine E., Nirmalathasan, Nitharsshini, Habisch, Hansjörg, Annerer, Elisabeth, Dethloff, Frederik, Stumpe, Michael, Grundler, Franziska, Wilhelmi de Toledo, Françoise, Heinz, Daniel E., Koppold, Daniela A., Rajput Khokhar, Anika, Michalsen, Andreas, Tripolt, Norbert J., Sourij, Harald, Pieber, Thomas R., de Cabo, Rafael, McCormick, Mark A., Magnes, Christoph, Kepp, Oliver, Dengjel, Joern, Sigrist, Stephan J., Gassen, Nils C., Sedej, Simon, Madl, Tobias, De Virgilio, Claudio, Stelzl, Ulrich, Hoffmann, Markus H., Eisenberg, Tobias, Tavernarakis, Nektarios, Kroemer, Guido, and Madeo, Frank

Published
2024
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2. Dynamics of magnetization at infinite temperature in a Heisenberg spin chain

Author

Rosenberg, Eliott, Andersen, Trond, Samajdar, Rhine, Petukhov, Andre, Hoke, Jesse, Abanin, Dmitry, Bengtsson, Andreas, Drozdov, Ilya, Erickson, Catherine, Klimov, Paul, Mi, Xiao, Morvan, Alexis, Neeley, Matthew, Neill, Charles, Acharya, Rajeev, Allen, Richard, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Atalaya, Juan, Bardin, Joseph, Bilmes, A., Bortoli, Gina, Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Broughton, Michael, Buckley, Bob B., Buell, David, Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chang, Hung-Shen, Chen, Zijun, Chiaro, Benjamin, Chik, Desmond, Cogan, Josh, Collins, Roberto, Conner, Paul, Courtney, William, Crook, Alexander, Curtin, Ben, Debroy, Dripto, Barba, Alexander Del Toro, Demura, Sean, Di Paolo, Agustin, Dunsworth, Andrew, Earle, Clint, Farhi, E., Fatemi, Reza, Ferreira, Vinicius, Flores, Leslie, Forati, Ebrahim, Fowler, Austin, Foxen, Brooks, Garcia, Gonzalo, Genois, Élie, Giang, William, Gidney, Craig, Gilboa, Dar, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan, Habegger, Steve, Hamilton, Michael, Hansen, Monica, Harrigan, Matthew, Harrington, Sean, Heu, Paula, Hill, Gordon, Hoffmann, Markus, Hong, Sabrina, Huang, Trent, Huff, Ashley, Huggins, William, Ioffe, Lev, Isakov, Sergei, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Juhas, Pavol, Kafri, D., Khattar, Tanuj, Khezri, Mostafa, Kieferová, Mária, Kim, Seon, Kitaev, Alexei, Klots, Andrey, Korotkov, Alexander, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Lau, Kim Ming, Laws, Lily, Lee, Joonho, Lee, Kenneth, Lensky, Yuri, Lester, Brian, Lill, Alexander, Liu, Wayne, Livingston, William P., Locharla, A., Mandrà, Salvatore, Martin, Orion, Martin, Steven, McClean, Jarrod, McEwen, Matthew, Meeks, Seneca, Miao, Kevin, Mieszala, Amanda, Montazeri, Shirin, Movassagh, Ramis, Mruczkiewicz, Wojciech, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Niu, M., O'Brien, Thomas, Omonije, Seun, Opremcak, Alex, Potter, Rebecca, Pryadko, Leonid, Quintana, Chris, Rhodes, David, Rocque, Charles, Rubin, N., Saei, Negar, Sank, Daniel, Sankaragomathi, Kannan, Satzinger, Kevin, Schurkus, Henry, Schuster, Christopher, Shearn, Michael, Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Sivak, Volodymyr, Skruzny, Jindra, Smith, Clarke, Somma, Rolando, Sterling, George, Strain, Doug, Szalay, Marco, Thor, Douglas, Torres, Alfredo, Vidal, Guifre, Villalonga, Benjamin, Heidweiller, Catherine Vollgraff, White, Theodore, Woo, Bryan, Xing, Cheng, Yao, Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhang, Yaxing, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Babbush, Ryan, Bacon, Dave, Boixo, Sergio, Hilton, Jeremy, Lucero, Erik, Megrant, Anthony, Kelly, Julian, Chen, Yu, Smelyanskiy, Vadim, Khemani, Vedika, Gopalakrishnan, Sarang, Prosen, Tomaž, and Roushan, Pedram

Subjects
Quantum Physics
Abstract

Understanding universal aspects of quantum dynamics is an unresolved problem in statistical mechanics. In particular, the spin dynamics of the 1D Heisenberg model were conjectured to belong to the Kardar-Parisi-Zhang (KPZ) universality class based on the scaling of the infinite-temperature spin-spin correlation function. In a chain of 46 superconducting qubits, we study the probability distribution, $P(\mathcal{M})$, of the magnetization transferred across the chain's center. The first two moments of $P(\mathcal{M})$ show superdiffusive behavior, a hallmark of KPZ universality. However, the third and fourth moments rule out the KPZ conjecture and allow for evaluating other theories. Our results highlight the importance of studying higher moments in determining dynamic universality classes and provide key insights into universal behavior in quantum systems.

Published
2023
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4. Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Author

Groß, Rüdiger, Reßin, Hanna, von Maltitz, Pascal, Albers, Dan, Schneider, Laura, Bley, Hanna, Hoffmann, Markus, Cortese, Mirko, Gupta, Dhanu, Deniz, Miriam, Choi, Jae-Yeon, Jansen, Jenny, Preußer, Christian, Seehafer, Kai, Pöhlmann, Stefan, Voelker, Dennis R., Goffinet, Christine, Pogge-von Strandmann, Elke, Bunz, Uwe, Bartenschlager, Ralf, El Andaloussi, Samir, Sparrer, Konstantin M. J., Herker, Eva, Becker, Stephan, Kirchhoff, Frank, Münch, Jan, and Müller, Janis A.

Published
2024
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5. Measurement-induced entanglement and teleportation on a noisy quantum processor

Author

Hoke, Jesse C., Ippoliti, Matteo, Rosenberg, Eliott, Abanin, Dmitry, Acharya, Rajeev, Andersen, Trond I., Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Atalaya, Juan, Bardin, Joseph C., Bengtsson, Andreas, Bortoli, Gina, Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Broughton, Michael, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Chen, Zijun, Chiaro, Ben, Chik, Desmond, Cogan, Josh, Collins, Roberto, Conner, Paul, Courtney, William, Crook, Alexander L., Curtin, Ben, Dau, Alejandro Grajales, Debroy, Dripto M., Barba, Alexander Del Toro, Demura, Sean, Di Paolo, Augustin, Drozdov, Ilya K., Dunsworth, Andrew, Eppens, Daniel, Erickson, Catherine, Farhi, Edward, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Giang, William, Gidney, Craig, Gilboa, Dar, Giustina, Marissa, Gosula, Raja, Gross, Jonathan A., Habegger, Steve, Hamilton, Michael C., Hansen, Monica, Harrigan, Matthew P., Harrington, Sean D., Heu, Paula, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Huggins, William J., Isakov, Sergei V., Iveland, Justin, Jeffrey, Evan, Jones, Cody, Juhas, Pavol, Kafri, Dvir, Kechedzhi, Kostyantyn, Khattar, Tanuj, Khezri, Mostafa, Kieferová, Mária, Kim, Seon, Kitaev, Alexei, Klimov, Paul V., Klots, Andrey R., Korotkov, Alexander N., Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Lau, Kim-Ming, Laws, Lily, Lee, Joonho, Lee, Kenny W., Lensky, Yuri D., Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Martin, Orion, McClean, Jarrod R., McEwen, Matt, Miao, Kevin C., Mieszala, Amanda, Montazeri, Shirin, Morvan, Alexis, Movassagh, Ramis, Mruczkiewicz, Wojciech, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun H., Nguyen, Anthony, Nguyen, Murray, Niu, Murphy Yuezhen, O'Brien, Tom E., Omonije, Seun, Opremcak, Alex, Petukhov, Andre, Potter, Rebecca, Pryadko, Leonid P., Quintana, Chris, Rocque, Charles, Rubin, Nicholas C., Saei, Negar, Sank, Daniel, Sankaragomathi, Kannan, Satzinger, Kevin J., Schurkus, Henry F., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vlad, Skruzny, Jindra, Smith, W. Clarke, Somma, Rolando D., Sterling, George, Strain, Douglas, Szalay, Marco, Torres, Alfredo, Vidal, Guifre, Villalonga, Benjamin, Heidweiller, Catherine Vollgraff, White, Ted, Woo, Bryan W. K., Xing, Cheng, Yao, Z. Jamie., Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhang, Yaxing, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Harmut, Babbush, Ryan, Bacon, Dave, Boixo, Sergio, Hilton, Jeremy, Lucero, Erik, Megrant, Anthony, Kelly, Julian, Chen, Yu, Smelyanskiy, Vadim, Mi, Xiao, Khemani, Vedika, and Roushan, Pedram

Subjects
Quantum Physics, Condensed Matter - Statistical Mechanics, High Energy Physics - Theory
Abstract

Measurement has a special role in quantum theory: by collapsing the wavefunction it can enable phenomena such as teleportation and thereby alter the "arrow of time" that constrains unitary evolution. When integrated in many-body dynamics, measurements can lead to emergent patterns of quantum information in space-time that go beyond established paradigms for characterizing phases, either in or out of equilibrium. On present-day NISQ processors, the experimental realization of this physics is challenging due to noise, hardware limitations, and the stochastic nature of quantum measurement. Here we address each of these experimental challenges and investigate measurement-induced quantum information phases on up to 70 superconducting qubits. By leveraging the interchangeability of space and time, we use a duality mapping, to avoid mid-circuit measurement and access different manifestations of the underlying phases -- from entanglement scaling to measurement-induced teleportation -- in a unified way. We obtain finite-size signatures of a phase transition with a decoding protocol that correlates the experimental measurement record with classical simulation data. The phases display sharply different sensitivity to noise, which we exploit to turn an inherent hardware limitation into a useful diagnostic. Our work demonstrates an approach to realize measurement-induced physics at scales that are at the limits of current NISQ processors.

Published
2023
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6. Overcoming leakage in scalable quantum error correction

Author

Miao, Kevin C., McEwen, Matt, Atalaya, Juan, Kafri, Dvir, Pryadko, Leonid P., Bengtsson, Andreas, Opremcak, Alex, Satzinger, Kevin J., Chen, Zijun, Klimov, Paul V., Quintana, Chris, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Conner, Paul, Crook, Alexander L., Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Garcia, Gonzalo, Giang, William, Gidney, Craig, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan A., Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kelly, Julian, Kim, Seon, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, Megrant, Anthony, Mi, Xiao, Montazeri, Shirin, Morvan, Alexis, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, White, Theodore, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Smelyanskiy, Vadim, Petukhov, Andre, Korotkov, Alexander N., Sank, Daniel, and Chen, Yu

Subjects
Quantum Physics
Abstract

Leakage of quantum information out of computational states into higher energy states represents a major challenge in the pursuit of quantum error correction (QEC). In a QEC circuit, leakage builds over time and spreads through multi-qubit interactions. This leads to correlated errors that degrade the exponential suppression of logical error with scale, challenging the feasibility of QEC as a path towards fault-tolerant quantum computation. Here, we demonstrate the execution of a distance-3 surface code and distance-21 bit-flip code on a Sycamore quantum processor where leakage is removed from all qubits in each cycle. This shortens the lifetime of leakage and curtails its ability to spread and induce correlated errors. We report a ten-fold reduction in steady-state leakage population on the data qubits encoding the logical state and an average leakage population of less than $1 \times 10^{-3}$ throughout the entire device. The leakage removal process itself efficiently returns leakage population back to the computational basis, and adding it to a code circuit prevents leakage from inducing correlated error across cycles, restoring a fundamental assumption of QEC. With this demonstration that leakage can be contained, we resolve a key challenge for practical QEC at scale., Comment: Main text: 7 pages, 5 figures

Published
2022
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7. Overcoming leakage in quantum error correction

Author

Miao, Kevin C., McEwen, Matt, Atalaya, Juan, Kafri, Dvir, Pryadko, Leonid P., Bengtsson, Andreas, Opremcak, Alex, Satzinger, Kevin J., Chen, Zijun, Klimov, Paul V., Quintana, Chris, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Conner, Paul, Crook, Alexander L., Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Garcia, Gonzalo, Giang, William, Gidney, Craig, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan A., Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kelly, Julian, Kim, Seon, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, Megrant, Anthony, Mi, Xiao, Montazeri, Shirin, Morvan, Alexis, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Schurkus, Henry F., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, White, Theodore, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Smelyanskiy, Vadim, Petukhov, Andre, Korotkov, Alexander N., Sank, Daniel, and Chen, Yu

Published
2023
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8. Noise-resilient Edge Modes on a Chain of Superconducting Qubits

Author

Mi, Xiao, Sonner, Michael, Niu, Murphy Yuezhen, Lee, Kenneth W., Foxen, Brooks, Acharya, Rajeev, Aleiner, Igor, Andersen, Trond I., Arute, Frank, Arya, Kunal, Asfaw, Abraham, Atalaya, Juan, Babbush, Ryan, Bacon, Dave, Bardin, Joseph C., Basso, Joao, Bengtsson, Andreas, Bortoli, Gina, Bourassa, Alexandre, Brill, Leon, Broughton, Michael, Buckley, Bob B., Buell, David A., Burkett, Brian, Bushnell, Nicholas, Chen, Zijun, Chiaro, Benjamin, Collins, Roberto, Conner, Paul, Courtney, William, Crook, Alexander L., Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Eppens, Daniel, Erickson, Catherine, Faoro, Lara, Farhi, Edward, Fatemi, Reza, Flores, Leslie, Forati, Ebrahim, Fowler, Austin G., Giang, William, Gidney, Craig, Gilboa, Dar, Giustina, Marissa, Dau, Alejandro Grajales, Gross, Jonathan A., Habegger, Steve, Harrigan, Matthew P., Hilton, Jeremy, Hoffmann, Markus, Hong, Sabrina, Huang, Trent, Huff, Ashley, Huggins, William J., Ioffe, Lev B., Isakov, Sergei V., Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kafri, Dvir, Kechedzhi, Kostyantyn, Khattar, Tanuj, Kim, Seon, Kitaev, Alexei, Klimov, Paul V., Klots, Andrey R., Korotkov, Alexander N., Kostritsa, Fedor, Kreikebaum, J. M., Landhuis, David, Laptev, Pavel, Lau, Kim-Ming, Lee, Joonho, Laws, Lily, Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Orion, McClean, Jarrod R., McEwen, Matt, Costa, Bernardo Meurer, Miao, Kevin C., Mohseni, Masoud, Montazeri, Shirin, Morvan, Alexis, Mount, Emily, Mruczkiewicz, Wojciech, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Newman, Michael, O'Brien, Thomas E., Opremcak, Alex, Petukhov, Andre, Potter, Rebecca, Quintana, Chris, Rubin, Nicholas C., Saei, Negar, Sank, Daniel, Sankaragomathi, Kannan, Satzinger, Kevin J., Schuster, Christopher, Shearn, Michael J., Shvarts, Vladimir, Strain, Doug, Su, Yuan, Szalay, Marco, Vidal, Guifre, Villalonga, Benjamin, Vollgraff-Heidweiller, Catherine, White, Theodore, Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Zalcman, Adam, Zhang, Yaxing, Zhu, Ningfeng, Neven, Hartmut, Boixo, Sergio, Megrant, Anthony, Chen, Yu, Kelly, Julian, Smelyanskiy, Vadim, Abanin, Dmitry A., and Roushan, Pedram

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Other Condensed Matter
Abstract

Inherent symmetry of a quantum system may protect its otherwise fragile states. Leveraging such protection requires testing its robustness against uncontrolled environmental interactions. Using 47 superconducting qubits, we implement the one-dimensional kicked Ising model which exhibits non-local Majorana edge modes (MEMs) with $\mathbb{Z}_2$ parity symmetry. Remarkably, we find that any multi-qubit Pauli operator overlapping with the MEMs exhibits a uniform late-time decay rate comparable to single-qubit relaxation rates, irrespective of its size or composition. This characteristic allows us to accurately reconstruct the exponentially localized spatial profiles of the MEMs. Furthermore, the MEMs are found to be resilient against certain symmetry-breaking noise owing to a prethermalization mechanism. Our work elucidates the complex interplay between noise and symmetry-protected edge modes in a solid-state environment.

Published
2022
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9. TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma

Author

von Buchwald, Christian, Jakobsen, Kathrine Kronberg, Carlander, Amanda-Louise Fenger, Tous, Sara, Grønhøj, Christian, Rasmussen, Jacob H., Brooks, Jill, Taberna, Miren, Mena, Marisa, Morey, Francisca, Bruni, Laia, Batis, Nikolaos, Brakenhoff, Ruud H., René Leemans, C., Jong, Robert J.Baatenburg de, Klussmann, Jens Peter, Wuerdemann, Nora, Wagner, Steffen, Dalianis, Tina, Marklund, Linda, Mirghani, Haïtham, Schache, Andrew, James, Jaqueline A., Huang, Shao Hui, O’Sullivan, Brian, Nankivell, Paul, Broglie, Martina A., Hoffmann, Markus, Quabius, Elgar Susanne, Anderson, Lesley A., Craig, Stephanie G., Alemany, Laia, and Mehanna, Hisham

Published
2024
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15. Omicron subvariant BA.5 efficiently infects lung cells

Author

Hoffmann, Markus, Wong, Lok-Yin Roy, Arora, Prerna, Zhang, Lu, Rocha, Cheila, Odle, Abby, Nehlmeier, Inga, Kempf, Amy, Richter, Anja, Halwe, Nico Joel, Schön, Jacob, Ulrich, Lorenz, Hoffmann, Donata, Beer, Martin, Drosten, Christian, Perlman, Stanley, and Pöhlmann, Stefan

Published
2023
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21. Comparison of three indirect methods for verification and validation of reference intervals at eight medical laboratories: a European multicenter study

Author

Meyer Anne, Müller Robert, Hoffmann Markus, Skadberg Øyvind, Ladang Aurélie, Dieplinger Benjamin, Huf Wolfgang, Stankovic Sanja, Kapoula Georgia, and Orth Matthias

Subjects
indirect methods, reference intervals, reference limits, refiner, reflim, truncated maximum likelihood (tml), validation, verification, Medical technology, R855-855.5
Abstract

Indirect methods for the indirect estimation of reference intervals are increasingly being used, especially for validation of reference intervals, as they can be applied to routine patient data. In this study, we compare three statistically different indirect methods for the verification and validation of reference intervals in eight laboratories distributed throughout Europe.

Published
2023
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25. Safety and Immunogenicity against Ancestral, Delta and Omicron Virus Variants Following a Booster Dose of an Inactivated Whole-Virus COVID-19 Vaccine (VLA2001): Interim analysis of an open-label extension of the randomized, controlled, phase 3 COV-COMPARE trial

Author

Taucher, Christian, Lazarus, Rajeka, Dellago, Hanna, Maurer, Gabriele, Weisova, Petronela, Corbic-Ramljak, Irena, Dubischar, Katrin, Lilja, Anders, Eder-Lingelbach, Susanne, Hochreiter, Romana, Jaramillo, Juan Carlos, Junker, Helga, Krammer, Michael, Pusic, Petra, Querton, Benedicte, Larcher-Senn, Julian, Hoffmann, Markus, Pöhlmann, Stefan, and Finn, Adam

Published
2023
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26. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Author

Mahoney, Matthew, Damalanka, Vishnu C., Tartell, Michael A., Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E. Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P., Klingler, Andrea M., Rothlauf, Paul W., Thompson, Cassandra E., Lee, Melody, Klampfer, Lidija, Stallings, Christina L., Rothenberg, Marc E., Pöhlmann, Stefan, Whelan, Sean P. J., O’Donoghue, Anthony J., Craik, Charles S., and Janetka, James W.

Published
2021

29. Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

Author

Jacobsen, Henning, Strengert, Monika, Maaß, Henrike, Ynga Durand, Mario Alberto, Katzmarzyk, Maeva, Kessel, Barbora, Harries, Manuela, Rand, Ulfert, Abassi, Leila, Kim, Yeonsu, Lüddecke, Tatjana, Metzdorf, Kristin, Hernandez, Pilar, Ortmann, Julia, Heise, Jana-Kristin, Castell, Stefanie, Gornyk, Daniela, Glöckner, Stephan, Melhorn, Vanessa, Kemmling, Yvonne, Lange, Berit, Dulovic, Alex, Marsall, Patrick, Häring, Julia, Junker, Daniel, Schneiderhan-Marra, Nicole, Hoffmann, Markus, Pöhlmann, Stefan, Krause, Gérard, and Cicin-Sain, Luka

Published
2022
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30. BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19

Author

Behrens, Georg M. N., Barros-Martins, Joana, Cossmann, Anne, Ramos, Gema Morillas, Stankov, Metodi V., Odak, Ivan, Dopfer-Jablonka, Alexandra, Hetzel, Laura, Köhler, Miriam, Patzer, Gwendolyn, Binz, Christoph, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Krähling, Verena, Bernhardt, Günter, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Hammerschmidt, Swantje I., and Förster, Reinhold

Published
2022
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33. ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization.

Author

Zhang, Lu, Cheng, Hsiu-Hsin, Krüger, Nadine, Hörnich, Bojan, Graichen, Luise, Hahn, Alexander S., Schulz, Sebastian R., Jäck, Hans-Martin, Stankov, Metodi V., Behrens, Georg M. N., Müller, Marcel A., Drosten, Christian, Mörer, Onnen, Winkler, Martin Sebastian, Qian, ZhaoHui, Pöhlmann, Stefan, and Hoffmann, Markus

Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, demonstrated that zoonotic transmission of animal sarbecoviruses threatens human health but the determinants of transmission are incompletely understood. Here, we show that most spike (S) proteins of horseshoe bat and Malayan pangolin sarbecoviruses employ ACE2 for entry, with human and raccoon dog ACE2 exhibiting broad receptor activity. The insertion of a multibasic cleavage site into the S proteins increased entry into human lung cells driven by most S proteins tested, suggesting that acquisition of a multibasic cleavage site might increase infectivity of diverse animal sarbecoviruses for the human respiratory tract. In contrast, two bat sarbecovirus S proteins drove cell entry in an ACE2-independent, trypsin-dependent fashion and several ACE2-dependent S proteins could switch to the ACE2-independent entry pathway when exposed to trypsin. Several TMPRSS2-related cellular proteases but not the insertion of a multibasic cleavage site into the S protein allowed for ACE2-independent entry in the absence of trypsin and may support viral spread in the respiratory tract. Finally, the pan-sarbecovirus antibody S2H97 enhanced cell entry driven by two S proteins and this effect was reversed by trypsin while trypsin protected entry driven by a third S protein from neutralization by S2H97. Similarly, plasma from quadruple vaccinated individuals neutralized entry driven by all S proteins studied, and availability of the ACE2-independent, trypsin-dependent pathway reduced neutralization sensitivity. In sum, our study reports a pathway for entry into human cells that is ACE2-independent, can be supported by TMPRSS2-related proteases and may be associated with antibody evasion. Author summary: Bats host a wide range of coronaviruses, including those related to SARS-CoV-1 and SARS-CoV-2 (subgenus Sarbecovirus), but their ability to infect human cells remains poorly understood. Identifying sarbecoviruses with zoonotic potential and understanding the factors controlling their entry into human cells are crucial for risk assessment and antiviral development. In this study, we examined how bat sarbecovirus spike proteins facilitate entry into human cells and identified key host factors involved. Using pseudovirus particles, we show that several bat sarbecovirus spike proteins use human and animal ACE2 receptors for entry. Additionally, we confirm that some spike proteins utilize an ACE2-independent entry pathway requiring trypsin treatment and demonstrate that this process is controlled by the spike protein receptor binding domain. Furthermore, we reveal that a subset of ACE2-using bat sarbecovirus spike proteins can switch to ACE2-independent entry following trypsin exposure and show that certain human type II transmembrane serine proteases can substitute for trypsin, enabling ACE2-independent entry. Finally, we demonstrate that repeated COVID-19 vaccination generates cross-neutralizing activity against bat sarbecoviruses, though ACE2-independent entry reduces neutralization sensitivity. [ABSTRACT FROM AUTHOR]

Published
2024
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35. The road to integrate climate change projections with regional land‐use–biodiversity models.

Author

Cabral, Juliano Sarmento, Mendoza‐Ponce, Alma, da Silva, André Pinto, Oberpriller, Johannes, Mimet, Anne, Kieslinger, Julia, Berger, Thomas, Blechschmidt, Jana, Brönner, Maximilian, Classen, Alice, Fallert, Stefan, Hartig, Florian, Hof, Christian, Hoffmann, Markus, Knoke, Thomas, Krause, Andreas, Lewerentz, Anne, Pohle, Perdita, Raeder, Uta, and Rammig, Anja

Subjects
SPECIES diversity, LAND cover, CLIMATE change, SPATIAL resolution, LAND use
Abstract

Copyright of People & Nature is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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36. Network medicine-based epistasis detection in complex diseases: ready for quantum computing.

Author

Hoffmann, Markus, Poschenrieder, Julian M, Incudini, Massimiliano, Baier, Sylvie, Fritz, Amelie, Maier, Andreas, Hartung, Michael, Hoffmann, Christian, Trummer, Nico, Adamowicz, Klaudia, Picciani, Mario, Scheibling, Evelyn, Harl, Maximilian V, Lesch, Ingmar, Frey, Hunor, Kayser, Simon, Wissenberg, Paul, Schwartz, Leon, Hafner, Leon, and Acharya, Aakriti

Published
2024
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38. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Author

Kim, Yeonsu, Zheng, Xiaoyan, Eschke, Kathrin, Chaudhry, M. Zeeshan, Bertoglio, Federico, Tomić, Adriana, Krmpotić, Astrid, Hoffmann, Markus, Bar-On, Yotam, Boehme, Julia, Bruder, Dunja, Ebensen, Thomas, Brunotte, Linda, Ludwig, Stephan, Messerle, Martin, Guzman, Carlos, Mandelboim, Ofer, Hust, Michael, Pöhlmann, Stefan, Jonjić, Stipan, and Čičin-Šain, Luka

Published
2022
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39. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author

Barros-Martins, Joana, Hammerschmidt, Swantje I., Cossmann, Anne, Odak, Ivan, Stankov, Metodi V., Morillas Ramos, Gema, Dopfer-Jablonka, Alexandra, Heidemann, Annika, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Bernhardt, Günter, Münch, Jan, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Förster, Reinhold, and Behrens, Georg M. N.

Published
2021
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42. Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods

Author

Bošnjak, Berislav, Stein, Saskia Catherina, Willenzon, Stefanie, Cordes, Anne Katrin, Puppe, Wolfram, Bernhardt, Günter, Ravens, Inga, Ritter, Christiane, Schultze-Florey, Christian R., Gödecke, Nina, Martens, Jörg, Kleine-Weber, Hannah, Hoffmann, Markus, Cossmann, Anne, Yilmaz, Mustafa, Pink, Isabelle, Hoeper, Marius M., Behrens, Georg M. N., Pöhlmann, Stefan, Blasczyk, Rainer, Schulz, Thomas F., and Förster, Reinhold

Published
2021
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45. A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants.

Author

Metzdorf, Kristin, Jacobsen, Henning, Yeonsu Kim, Teixeira Alves, Luiz Gustavo, Kulkarni, Upasana, Eschke, Kathrin, Chaudhry, M. Zeeshan, Hoffmann, Markus, Bertoglio, Federico, Ruschig, Maximilian, Hust, Michael, pBrdovčak, Maja Cokarić, Materljan, Jelena, Šustić, Marko, Krmpotić, Astrid, Jonjić, Stipan, Widera, Marek, Ciesek, Sandra, Pöhlmann, Stefan, and Landthaler, Markus

Subjects
BOOSTER vaccines, SARS-CoV-2, COVID-19 pandemic, SARS-CoV-2 Omicron variant, CELLULAR immunity
Abstract

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, vaccines that would provide lasting protection against COVID-19 are needed, but are still unavailable. Cytomegaloviruses (CMVs) elicit lasting and uniquely strong immune responses. Used as vaccine vectors, they may be attractive tools that obviate the need for boosters. Therefore, we tested the murine CMV (MCMV) as a vaccine vector against COVID-19 in relevant preclinical models of immunization and challenge. We have previously developed a recombinant MCMV vaccine vector expressing the spike protein of the ancestral SARS-CoV-2 (MCMVS). In this study, we show that the MCMVS elicits a robust and lasting protection in young and aged mice. Notably, spike-specific humoral and cellular immunity was not only maintained but also even increased over a period of at least 6 months. During that time, antibody avidity continuously increased and expanded in breadth, resulting in neutralization of genetically distant variants, like Omicron BA.1. A single dose of MCMVS conferred rapid virus clearance upon challenge. Moreover, MCMVS vaccination controlled two variants of concern (VOCs), the Beta (B.1.135) and the Omicron (BA.1) variants. Thus, CMV vectors provide unique advantages over other vaccine technologies, eliciting broadly reactive and long-lasting immune responses against COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Drugst.One — a plug-and-play solution for online systems medicine and network-based drug repurposing.

Author

Maier, Andreas, Hartung, Michael, Abovsky, Mark, Adamowicz, Klaudia, Bader, Gary D, Baier, Sylvie, Blumenthal, David B, Chen, Jing, Elkjaer, Maria L, Garcia-Hernandez, Carlos, Helmy, Mohamed, Hoffmann, Markus, Jurisica, Igor, Kotlyar, Max, Lazareva, Olga, Levi, Hagai, List, Markus, Lobentanzer, Sebastian, Loscalzo, Joseph, and Malod-Dognin, Noel

Published
2024
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47. Diversification of the VH3‐53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS‐CoV‐2 virus variants.

Author

Bruhn, Matthias, Obara, Maureen, Salam, Abdus, Costa, Bibiana, Ziegler, Annett, Waltl, Inken, Pavlou, Andreas, Hoffmann, Markus, Graalmann, Theresa, Pöhlmann, Stefan, Schambach, Axel, and Kalinke, Ulrich

Subjects
IMMUNOGLOBULIN genes, SARS-CoV-2, IMMUNOLOGIC memory, B cells, COVID-19 vaccines
Abstract

COVID‐19 induces re‐circulating long‐lived memory B cells (MBC) that, upon re‐encounter with the pathogen, are induced to mount immunoglobulin responses. During convalescence, antibodies are subjected to affinity maturation, which enhances the antibody binding strength and generates new specificities that neutralize virus variants. Here, we performed a single‐cell RNA sequencing analysis of spike‐specific B cells from a SARS‐CoV‐2 convalescent subject. After COVID‐19 vaccination, matured infection‐induced MBC underwent recall and differentiated into plasmablasts. Furthermore, the transcriptomic profiles of newly activated B cells transiently shifted toward the ones of atypical and CXCR3+ B cells and several B‐cell clonotypes massively expanded. We expressed monoclonal antibodies (mAbs) from all B‐cell clones from the largest clonotype that used the VH3‐53 gene segment. The in vitro analysis revealed that some somatic hypermutations enhanced the neutralization breadth of mAbs in a putatively stochastic manner. Thus, somatic hypermutation of B‐cell clonotypes generates an anticipatory memory that can neutralize new virus variants. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

Author

Carpinteiro, Alexander, Edwards, Michael J., Hoffmann, Markus, Kochs, Georg, Gripp, Barbara, Weigang, Sebastian, Adams, Constantin, Carpinteiro, Elisa, Gulbins, Anne, Keitsch, Simone, Sehl, Carolin, Soddemann, Matthias, Wilker, Barbara, Kamler, Markus, Bertsch, Thomas, Lang, Karl S., Patel, Sameer, Wilson, Gregory C., Walter, Silke, Hengel, Hartmut, Pöhlmann, Stefan, Lang, Philipp A., Kornhuber, Johannes, Becker, Katrin Anne, Ahmad, Syed A., Fassbender, Klaus, and Gulbins, Erich

Published
2020
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49. Humoral immunity after mRNA SARS-CoV-2 omicron JN.1 vaccination.

Author

Happle, Christine, Hoffmann, Markus, Kempf, Amy, Nehlmeier, Inga, Stankov, Metodi V, Calderon Hampel, Noemi, Witte, Torsten, Pöhlmann, Stefan, Behrens, Georg M N, and Dopfer-Jablonka, Alexandra

Subjects
*SARS-CoV-2 Omicron variant, *HUMORAL immunity, *SARS-CoV-2, *MESSENGER RNA, *VACCINATION
Published
2024
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